Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0086 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 10679411 | 2000 | NA |
| PRRID_0086 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 10679411 | 2000 | NA |
| PRRID_0104 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Scavenger receptor class A | Scavenger receptor (SR) | NA | NA | NA | NA | NA | NA | NA | NA | 1852209 | 2001 | NA |
| PRRID_0104 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Scavenger receptor class A | Scavenger receptor (SR) | NA | NA | NA | NA | NA | NA | NA | NA | 1852209 | 2001 | NA |
| PRRID_0176 | Lipopolysaccharide (LPS) Click for more detail | H. pylori (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Synthetic | It strongly binds to the DC-SIGN. | DC-SIGN | C type Lectin (CTL/CLR) | K562 cells | Dendritic cells | Lectin domain | NA | NA | NA | It induces the pathogen-driven inflammatory responses. | ELISA | 12574325 | 2003 | NA |
| PRRID_0176 | Lipopolysaccharide (LPS) Click for more detail | H. pylori (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Synthetic | It strongly binds to the DC-SIGN. | DC-SIGN | C type Lectin (CTL/CLR) | K562 cells | Dendritic cells | Lectin domain | NA | NA | NA | It induces the pathogen-driven inflammatory responses. | ELISA | 12574325 | 2003 | NA |
| PRRID_0246 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | NA | O60603.fasta | O60603 | 784 | NA | NA | 16861291 | 2006 | Pubchem Assay |
| PRRID_0246 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | NA | O60603.fasta | O60603 | 784 | NA | NA | 16861291 | 2006 | Pubchem Assay |
| PRRID_0254 | Lipopolysaccharide (LPS) Click for more detail | enterobacterial bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0254 | Lipopolysaccharide (LPS) Click for more detail | enterobacterial bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0255 | Lipopolysaccharide (LPS) Click for more detail | E.coli strain O111:B4(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0255 | Lipopolysaccharide (LPS) Click for more detail | E.coli strain O111:B4(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0256 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0256 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0303 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS binds to vitellogenin with high affinity. | Vitellogenin | Phospholipoglycoprotein | Hexagrammos otakii | Macropahes | NA | NA | NA | NA | Vg is involved in anti-infectious response, functions as an opsonin that can enhance macrophage phagocytosis. | ELISA | 18398466 | 2008 | NA |
| PRRID_0303 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS binds to vitellogenin with high affinity. | Vitellogenin | Phospholipoglycoprotein | Hexagrammos otakii | Macropahes | NA | NA | NA | NA | Vg is involved in anti-infectious response, functions as an opsonin that can enhance macrophage phagocytosis. | ELISA | 18398466 | 2008 | NA |
| PRRID_0304 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | BbFREP can specifically bind LPS. | BbFREP | Multivalent Pattern recognition receptor (PRR) | Amphioxus (Branchiostoma belcheri) | hepatic caecum | fibrinogen-like (FBG) domain | NA | NA | NA | It leads to the bacteriolytic activity via interaction with LPS. | ELISA | 18533266 | 2008 | NA |
| PRRID_0304 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | BbFREP can specifically bind LPS. | BbFREP | Multivalent Pattern recognition receptor (PRR) | Amphioxus (Branchiostoma belcheri) | hepatic caecum | fibrinogen-like (FBG) domain | NA | NA | NA | It leads to the bacteriolytic activity via interaction with LPS. | ELISA | 18533266 | 2008 | NA |
| PRRID_0305 | Lipopolysaccharide (LPS) Click for more detail | E. coli 055:B5(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Human prostate epithelial PC3 cells | LRR | O00206.fasta | O00206 | 839 | It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines. | ELISA | 18649875 | 2008 | Pubchem Assay |
| PRRID_0305 | Lipopolysaccharide (LPS) Click for more detail | E. coli 055:B5(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS promotes TGFb1 and VEGF production in human prostate epithelial PC3 cells and also LPS stimulation, leads to the increased expression of NF-KB p65 protein. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Human prostate epithelial PC3 cells | LRR | O00206.fasta | O00206 | 839 | It plays important roles in promoting prostate cancer immune escape, survival, progression, and metastasis by inducing immunosuppressive and proangiogenic cytokines. | ELISA | 18649875 | 2008 | Pubchem Assay |
| PRRID_0306 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli 0111:B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Galectin-3 directly interacts with LPS and blocks LPS-induced inflammatory response. | Galectin-3 | Pattern recognition receptor (PRR) | Mice | Bone Marrow Derived Macrophages. | NA | Q9JHE4 .fasta | Q9JHE4 | 423 | Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation, which protects the host from endotoxin shock. | ELISA | 18684969 | 2008 | Pubchem Assay |
| PRRID_0306 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli 0111:B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Galectin-3 directly interacts with LPS and blocks LPS-induced inflammatory response. | Galectin-3 | Pattern recognition receptor (PRR) | Mice | Bone Marrow Derived Macrophages. | NA | Q9JHE4 .fasta | Q9JHE4 | 423 | Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation, which protects the host from endotoxin shock. | ELISA | 18684969 | 2008 | Pubchem Assay |
| PRRID_0307 | Lipopolysaccharide (LPS) Click for more detail | Burkholderia pseudomallei(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Stimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | HEK293 cells | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It has a immunostimulatory role | ELISA | 18691413 | 2008 | Pubchem Assay |
| PRRID_0307 | Lipopolysaccharide (LPS) Click for more detail | Burkholderia pseudomallei(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Stimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | HEK293 cells | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It has a immunostimulatory role | ELISA | 18691413 | 2008 | Pubchem Assay |
| PRRID_0308 | Lipopolysaccharide (LPS) Click for more detail | Burkholderia pseudomallei(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-α, MIP-2, and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 cells | LRR | O00206.fasta | O00206 | 839 | It has a immunostimulatory role | ELISA | 18691413 | 2008 | Pubchem Assay |
| PRRID_0308 | Lipopolysaccharide (LPS) Click for more detail | Burkholderia pseudomallei(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-α, MIP-2, and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 cells | LRR | O00206.fasta | O00206 | 839 | It has a immunostimulatory role | ELISA | 18691413 | 2008 | Pubchem Assay |
| PRRID_0309 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli (055:B5) (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It leads to the activation of the transcription factor nuclear factor kappa B (NFKB) in caput and cauda epididymides. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rat | Epididymis | LRR | NA | NA | NA | Rat epididymis is fully capable of initiating an inflammatory response to lipopolysaccharide (LPS) from Escherichia coli through activation of Tolllike receptor 4. | EMSA | 18703421 | 2008 | NA |
| PRRID_0309 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli (055:B5) (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It leads to the activation of the transcription factor nuclear factor kappa B (NFKB) in caput and cauda epididymides. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rat | Epididymis | LRR | NA | NA | NA | Rat epididymis is fully capable of initiating an inflammatory response to lipopolysaccharide (LPS) from Escherichia coli through activation of Tolllike receptor 4. | EMSA | 18703421 | 2008 | NA |
| PRRID_0310 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS stimulation leads to the activation of phospholipase C | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages and Dendritic cells | NA | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in immuno inflammation. | ELISA | 18233961 | 2008 | Pubchem Assay |
| PRRID_0310 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS stimulation leads to the activation of phospholipase C | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages and Dendritic cells | NA | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in immuno inflammation. | ELISA | 18233961 | 2008 | Pubchem Assay |
| PRRID_0356 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | AgGNBPA1 | Gram-negative Bacteria-binding Protein (GNBPs) | Anopheles gambiae | salivary gland and thorax | β-1,3-glucan binding domain | NA | NA | NA | NA | in vitro bacterial binding assay | 18237283 | 2008 | NA |
| PRRID_0356 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | AgGNBPA1 | Gram-negative Bacteria-binding Protein (GNBPs) | Anopheles gambiae | salivary gland and thorax | β-1,3-glucan binding domain | NA | NA | NA | NA | in vitro bacterial binding assay | 18237283 | 2008 | NA |
| PRRID_0596 | intranigral Lipopolysaccharide (LPS) injection Click for more detail | exogenous (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | PD animal model | microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death. | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0596 | intranigral Lipopolysaccharide (LPS) injection Click for more detail | exogenous (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | PD animal model | microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death. | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0608 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | K63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagy | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Plasma Membrane | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to autophagy and hence clearance of the pathogen | NA | 20798608 | 2010 | Pubchem Assay |
| PRRID_0608 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | K63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagy | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Plasma Membrane | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to autophagy and hence clearance of the pathogen | NA | 20798608 | 2010 | Pubchem Assay |
| PRRID_0609 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | On binding to the receptor it leads to the release of an array of cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | P815 cells | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Immunostimulation and inflammation | NA | 20798518 | 2010 | Pubchem Assay |
| PRRID_0609 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | On binding to the receptor it leads to the release of an array of cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | P815 cells | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Immunostimulation and inflammation | NA | 20798518 | 2010 | Pubchem Assay |
| PRRID_0610 | Lipopolysaccharide (LPS) Click for more detail | M. tuberculosis (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Immunostimulation and inflammation | NA | 20797905 | 2010 | Pubchem Assay |
| PRRID_0610 | Lipopolysaccharide (LPS) Click for more detail | M. tuberculosis (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Immunostimulation and inflammation | NA | 20797905 | 2010 | Pubchem Assay |
| PRRID_0611 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0611 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0612 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Secretion of proinflammatory cytokines such as TFG-β and IL-6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | DF-MSCs & DP-MSCs | Tooth | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20731536 | 2010 | Pubchem Assay |
| PRRID_0612 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Secretion of proinflammatory cytokines such as TFG-β and IL-6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | DF-MSCs & DP-MSCs | Tooth | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20731536 | 2010 | Pubchem Assay |
| PRRID_0613 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lipopolysaccharides are the potent activators of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | stage 3-4 CKD and HD patients | CD14+ Monocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Immunostimulation and inflammation | NA | 20729266 | 2010 | Pubchem Assay |
| PRRID_0613 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lipopolysaccharides are the potent activators of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | stage 3-4 CKD and HD patients | CD14+ Monocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Immunostimulation and inflammation | NA | 20729266 | 2010 | Pubchem Assay |
| PRRID_0614 | Lipopolysaccharide (LPS) Click for more detail | S. aureus (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lipopolysaccharides are the potent activators of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | C57BL/6 Mice | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implants | NA | 20729214 | 2010 | Pubchem Assay |
| PRRID_0614 | Lipopolysaccharide (LPS) Click for more detail | S. aureus (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lipopolysaccharides are the potent activators of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | C57BL/6 Mice | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implants | NA | 20729214 | 2010 | Pubchem Assay |
| PRRID_0615 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lps is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0615 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lps is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0616 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli O111: B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | BCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20728433 | 2010 | Pubchem Assay |
| PRRID_0616 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli O111: B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | BCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20728433 | 2010 | Pubchem Assay |
| PRRID_0617 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Reduced HIV-1 expression and cell toxicity in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0617 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Reduced HIV-1 expression and cell toxicity in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0618 | Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Downregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0618 | Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Downregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0619 | Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR-4 Thre399Ile) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Downregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0619 | Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR-4 Thre399Ile) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Downregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0620 | Lipopolysaccharide (LPS) Click for more detail | Bacterial strains | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0620 | Lipopolysaccharide (LPS) Click for more detail | Bacterial strains | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0621 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a signaling cascade that utilizes both the MyD88- and TRIF-dependent pathways, leading to NF-kB and IRF3/7 activation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0621 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a signaling cascade that utilizes both the MyD88- and TRIF-dependent pathways, leading to NF-kB and IRF3/7 activation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0622 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | New Zealand White rabbits | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Involvement of exogenous TLR ligands during arteriogenesis | NA | 20708624 | 2010 | NA |
| PRRID_0622 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | New Zealand White rabbits | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Involvement of exogenous TLR ligands during arteriogenesis | NA | 20708624 | 2010 | NA |
| PRRID_0623 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver disease | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macropahges | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the inflammation of the cells | NA | 20706677 | 2010 | Pubchem Assay |
| PRRID_0623 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver disease | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macropahges | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the inflammation of the cells | NA | 20706677 | 2010 | Pubchem Assay |
| PRRID_0624 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | produce a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0624 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | produce a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0625 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces the expression of nociceptin, an opioid-related neuropeptide | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0625 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces the expression of nociceptin, an opioid-related neuropeptide | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0626 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Microglia | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0626 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Microglia | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0627 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | CNS | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampus | NA | 20706642 | 2010 | NA |
| PRRID_0627 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | CNS | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampus | NA | 20706642 | 2010 | NA |
| PRRID_0628 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | AD Mice's hippocampus | microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Involved in the clearance of Aβ deposits in the brain | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0628 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | AD Mice's hippocampus | microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Involved in the clearance of Aβ deposits in the brain | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0629 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induced the secretion of IL-6 and IL-9 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0629 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induced the secretion of IL-6 and IL-9 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0630 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | I-ankyrin-repeats | ankyrin-repeats | Mice | small intestine, trachea, cornea, and conjunctiva, liver and kidney tissue | NA | NA | NA | NA | suppress the production of proinflammatory cytokines | NA | 20703156 | 2010 | NA |
| PRRID_0630 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | I-ankyrin-repeats | ankyrin-repeats | Mice | small intestine, trachea, cornea, and conjunctiva, liver and kidney tissue | NA | NA | NA | NA | suppress the production of proinflammatory cytokines | NA | 20703156 | 2010 | NA |
| PRRID_0631 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | ankyrin-repeats | Human | corneal and conjunctival epithelia | NA | NA | NA | NA | suppress the production of proinflammatory cytokines | NA | 20703156 | 2010 | NA | |
| PRRID_0631 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | ankyrin-repeats | Human | corneal and conjunctival epithelia | NA | NA | NA | NA | suppress the production of proinflammatory cytokines | NA | 20703156 | 2010 | NA | |
| PRRID_0632 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rat | myocardium | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | NA | NA | 20697548 | 2010 | Pubchem Assay |
| PRRID_0632 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rat | myocardium | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | NA | NA | 20697548 | 2010 | Pubchem Assay |
| PRRID_0633 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | sCD14 | Pattern recognition receptor (PRR) | Rat | myocardium | NA | Q63691.fasta | Q63691 | 372 | NA | NF- | 20697548 | 2010 | Pubchem Assay |
| PRRID_0633 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | sCD14 | Pattern recognition receptor (PRR) | Rat | myocardium | NA | Q63691.fasta | Q63691 | 372 | NA | NF- | 20697548 | 2010 | Pubchem Assay |
| PRRID_0634 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS binds to the LGBP and induce innate immunity | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Bombyx mori | NA | NA | NA | NA | NA | It performs crucial functions in the response of anti-bacteria and fungi | NA | 20659562 | 2010 | NA |
| PRRID_0634 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS binds to the LGBP and induce innate immunity | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Bombyx mori | NA | NA | NA | NA | NA | It performs crucial functions in the response of anti-bacteria and fungi | NA | 20659562 | 2010 | NA |
| PRRID_0635 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS binds to the LGBP and induce innate immunity | Lipopolysaccharide and b-1, 3-glucan binding protein (cfLGBP) | Pattern recognition receptor (PRR) | Chlamys farreri | Hemocytes, gills and mantle | NA | NA | NA | NA | It is involved in pathogens recognition and bacterial agglutination. | NA | 20659562 | 2010 | NA |
| PRRID_0635 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS binds to the LGBP and induce innate immunity | Lipopolysaccharide and b-1, 3-glucan binding protein (cfLGBP) | Pattern recognition receptor (PRR) | Chlamys farreri | Hemocytes, gills and mantle | NA | NA | NA | NA | It is involved in pathogens recognition and bacterial agglutination. | NA | 20659562 | 2010 | NA |
| PRRID_0636 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | The binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cord blood cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0636 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | The binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cord blood cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0637 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contraction | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Intestinal Fibroblasts | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury. | Luciferase assay | 20632282 | 2010 | Pubchem Assay |
| PRRID_0637 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contraction | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Intestinal Fibroblasts | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury. | Luciferase assay | 20632282 | 2010 | Pubchem Assay |
| PRRID_0638 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0638 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0639 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli serotype 0127:B8 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Binding of LPS trigger the NFKB pathway. | cluster of differentiation 14 (CD14) | Pattern recognition receptor (PRR) | Wistar Rat | Pineal gland (pinealocytes) | NA | Q63691.fasta | Q63691 | 372 | The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF and inhibiting melatonin synthesis | NA | 20586888 | 2010 | Pubchem Assay |
| PRRID_0639 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli serotype 0127:B8 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Binding of LPS trigger the NFKB pathway. | cluster of differentiation 14 (CD14) | Pattern recognition receptor (PRR) | Wistar Rat | Pineal gland (pinealocytes) | NA | Q63691.fasta | Q63691 | 372 | The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF and inhibiting melatonin synthesis | NA | 20586888 | 2010 | Pubchem Assay |
| PRRID_0640 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli serotype 0127:B9 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Binding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytes | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Wistar Rat | Pineal gland (pinealocytes) | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory response | EMSA | 20586888 | 2010 | Pubchem Assay |
| PRRID_0640 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli serotype 0127:B9 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Binding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytes | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Wistar Rat | Pineal gland (pinealocytes) | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory response | EMSA | 20586888 | 2010 | Pubchem Assay |