Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0449 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvement | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0449 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvement | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0450 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | APP transgenic Mice | microglia | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | clearance of Aβ from microglial cells | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0450 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | APP transgenic Mice | microglia | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | clearance of Aβ from microglial cells | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0451 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Their binding induces Th1 response and promote an increase in IFN- | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It helps in the immunization of the mice to become more efficient | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0451 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Their binding induces Th1 response and promote an increase in IFN- | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It helps in the immunization of the mice to become more efficient | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0452 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0452 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0453 | CpG ODN 1826 Click for more detail | Bacteria | 5’-tccatgacgttcctgacgtt-3’ | 20 | Nucleic Acid | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | NA | 20696824 | 2010 | Pubchem Assay |
| PRRID_0453 | CpG ODN 1826 Click for more detail | Bacteria | 5’-tccatgacgttcctgacgtt-3’ | 20 | Nucleic Acid | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | NA | 20696824 | 2010 | Pubchem Assay |
| PRRID_0454 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It delays the onset of prion disease by degrading the prions | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0454 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It delays the onset of prion disease by degrading the prions | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0456 | CTPR-3 Click for more detail | High 5 insect cells (others) | MQVLELRNTLGSLDATDYASCLVRSLRADEKIWTFLTQSTGEINKQIADLAASQKLNPGTLGLLAFNQELLKSNFPDSRLQVSVLEECMVNYESFIQQHNAPATLEEAAKLAVVLIEKRKIAPAWRHTLLEVVNRMHLNDGKALRSVWGTAFTIIINLIKDRDEFLYDLLKLQSAEQGIESLIFAVISLPISENEKAEKLVKALQDQSAAIIEKTLSFIISINEKELAISAAQLLVGKYKIEEASEKGSKDILENLEASLQQSMLYKQIASVAQIAGDTDLASNLLEKSSAIFDAISTGIKIQNLSLLEQTANRLEFNEQVRKFQLDQANHPALAQEMASVGIVAQDQTQDELQSKPITAISQAKMINSAGNPELAKSECEKAFISIDHRTYDAAVEFVPQFNPNWNPGEMVNTLVELGAKKEALKMAASLYAKNPASLSAAQASAETYYESADYAAALPMFEYASMAGENSTPMLRQLADCYAQTGNSEACYKVRKQLVEVEAPVIPDLLQFADSAISAGRCNEVFPITSQIIKQDPMNASALTINGKAYAMTGNRDQALEFFSKAIEVGSDDADPWIGLSELQVKGGEFRQAIESLRQGLAALPADREIKRRLAEQLMDSGSASEALPLLNDLAEDDQNALIGVLQLDALKILGMPEYDAMVVSLYSKFPENEEIAQAFAAQLIKNGKHSEAKTVLQAKLSQVQSNTPTALTYAEAVVGMDVHYSGEPKSISAQEMEKVESIVDRYLEQDSDHTHAQLVKAELLVGKAKYAEAFKLYSRLLEKQTSVDKSLWERIQAGFAQSA | 805 | Protein | Natural | It act as LPS antagonist of the adipose tissue and induces the expression of p-p38 MAPK and p-ERK-2/-2 in adipocytes | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | 3T3-L1 preadipocytes | adipocytes | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20739398 | 2010 | Pubchem Assay |
| PRRID_0456 | CTPR-3 Click for more detail | High 5 insect cells (others) | MQVLELRNTLGSLDATDYASCLVRSLRADEKIWTFLTQSTGEINKQIADLAASQKLNPGTLGLLAFNQELLKSNFPDSRLQVSVLEECMVNYESFIQQHNAPATLEEAAKLAVVLIEKRKIAPAWRHTLLEVVNRMHLNDGKALRSVWGTAFTIIINLIKDRDEFLYDLLKLQSAEQGIESLIFAVISLPISENEKAEKLVKALQDQSAAIIEKTLSFIISINEKELAISAAQLLVGKYKIEEASEKGSKDILENLEASLQQSMLYKQIASVAQIAGDTDLASNLLEKSSAIFDAISTGIKIQNLSLLEQTANRLEFNEQVRKFQLDQANHPALAQEMASVGIVAQDQTQDELQSKPITAISQAKMINSAGNPELAKSECEKAFISIDHRTYDAAVEFVPQFNPNWNPGEMVNTLVELGAKKEALKMAASLYAKNPASLSAAQASAETYYESADYAAALPMFEYASMAGENSTPMLRQLADCYAQTGNSEACYKVRKQLVEVEAPVIPDLLQFADSAISAGRCNEVFPITSQIIKQDPMNASALTINGKAYAMTGNRDQALEFFSKAIEVGSDDADPWIGLSELQVKGGEFRQAIESLRQGLAALPADREIKRRLAEQLMDSGSASEALPLLNDLAEDDQNALIGVLQLDALKILGMPEYDAMVVSLYSKFPENEEIAQAFAAQLIKNGKHSEAKTVLQAKLSQVQSNTPTALTYAEAVVGMDVHYSGEPKSISAQEMEKVESIVDRYLEQDSDHTHAQLVKAELLVGKAKYAEAFKLYSRLLEKQTSVDKSLWERIQAGFAQSA | 805 | Protein | Natural | It act as LPS antagonist of the adipose tissue and induces the expression of p-p38 MAPK and p-ERK-2/-2 in adipocytes | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | 3T3-L1 preadipocytes | adipocytes | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20739398 | 2010 | Pubchem Assay |
| PRRID_0457 | Curli (amyloid fibrils) Click for more detail | E. coli strain MC4100(Bacteria) | MNTLLLLAALSSQITFNTTQQGDVYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS | 110 | Protein | Natural | The binding of curli mediates the immune respionse cooperatively | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | cervical cancer | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It elicits the immune response via NF- | ELISA | 20497180 | 2010 | NA |
| PRRID_0457 | Curli (amyloid fibrils) Click for more detail | E. coli strain MC4100(Bacteria) | MNTLLLLAALSSQITFNTTQQGDVYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS | 110 | Protein | Natural | The binding of curli mediates the immune respionse cooperatively | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | cervical cancer | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It elicits the immune response via NF- | ELISA | 20497180 | 2010 | NA |
| PRRID_0458 | cy2-labeled SitC-His Click for more detail | S. aureus (Bacteria) | NA | NA | Lipoprotein | Natural | It induce release of IL-6 in primary murine keratinocytes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Keratinocytes | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It induce intracellular accumulation of TLR2 | NA | 20679445 | 2010 | Pubchem Assay |
| PRRID_0458 | cy2-labeled SitC-His Click for more detail | S. aureus (Bacteria) | NA | NA | Lipoprotein | Natural | It induce release of IL-6 in primary murine keratinocytes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Keratinocytes | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It induce intracellular accumulation of TLR2 | NA | 20679445 | 2010 | Pubchem Assay |
| PRRID_0462 | Diacylated Lipopeptide Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | On binding to the receptor it, activates the heterocomplex of TLR2/1 and secretion of cytokines takes place | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Immunostimulation and inflammation | NA | 20797905 | 2010 | NA |
| PRRID_0462 | Diacylated Lipopeptide Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | On binding to the receptor it, activates the heterocomplex of TLR2/1 and secretion of cytokines takes place | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Immunostimulation and inflammation | NA | 20797905 | 2010 | NA |
| PRRID_0463 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | NA |
| PRRID_0463 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | NA |
| PRRID_0465 | DNA Click for more detail | EBV(virus) | NA | NA | Nucleic Acid | Natural | It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Monocytes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It provides antiviral immunity | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0465 | DNA Click for more detail | EBV(virus) | NA | NA | Nucleic Acid | Natural | It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Monocytes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It provides antiviral immunity | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0466 | DNA Click for more detail | murine CMV (virus) | GTAATCTAACCACTTGTGTGTGTGTGTGTGTGTGTCGAGTCGTGTCGTCTGTACATTTGAGTCGTGCTGTCCGCACATTTTATTTATCTTTGTTCAGTGTGTTAGATTTCCCGAGGCATGGCTTTCCAAGGTACCAGTAGGACTTTAACTCAACAGTCCTCAGCGGCTACGTCTGACGATCTTCAAAAGATATTATTTAGCCCTGAAGCCATTAAGAAAATGGCTACTGAGTGTGACCTAGGCCGGCATCACTGGATGCGCGCTGATAATGCTATTTCAGTCCGGCCCCTCGTTCCCGAAGTAACCCACGGTCGTATTGCTTCTTTCTTTAAGTCTGGATATGATGTTGGTGAATTATGCTCAAAAGGATATATGAGCGTCCCTCAAGTGTTATGTGCTGTTACTCGAACAGTTTCCACTGATGCTGAAGGGTCCCTGAGAATTTACTTAGCTGATCTAGGCGACAAGGAGTTATCTCCTATAGACGGGCAGTGCGTTTCGTTACATAACCATGATCTTCCCGCTTTGGTGTCTTTCCAACCGACGTATGATTGTCCTATGGAAACAGTTGGGAATCGTAAGCGGTGTTTTGCTGTTGTTATCGAAAGACATGGTTACATTGGGTATACCGGTACCACAGCTAGCGTGTGTAGTAATTGGCAAGCAAGGTTTTCTTCTAAGAATAACAACTACACTCATATCGCAGCTGGGAAGACTCTAGTACTACCTTTCAACAGATTAGCCGAGCAAACAAAACCGTCAGCTGTCGCTCGCCTGTTGAAATCGCAATTGAACAACATTGAATCTTCGCAATATCTGTTAACGAACGCGAAGATTAATCAAAATGCGCGTAGTGAGTCCGAGGAATTAAATGTTGAGAGCCCTCCCGCCGCAATCGGGAGTTCTTCCGCGTCCCGCTCCGAAGCCTTCAGACCGCAGGTGGTTAACGGTCTTTAGCACTTTGGTGCGTATTAGTATATAAGTATTTGTGAGTCTGTAC | 2213 | Nucleic Acid | Natural | It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | PDCs | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | It provides antiviral immunity | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0466 | DNA Click for more detail | murine CMV (virus) | GTAATCTAACCACTTGTGTGTGTGTGTGTGTGTGTCGAGTCGTGTCGTCTGTACATTTGAGTCGTGCTGTCCGCACATTTTATTTATCTTTGTTCAGTGTGTTAGATTTCCCGAGGCATGGCTTTCCAAGGTACCAGTAGGACTTTAACTCAACAGTCCTCAGCGGCTACGTCTGACGATCTTCAAAAGATATTATTTAGCCCTGAAGCCATTAAGAAAATGGCTACTGAGTGTGACCTAGGCCGGCATCACTGGATGCGCGCTGATAATGCTATTTCAGTCCGGCCCCTCGTTCCCGAAGTAACCCACGGTCGTATTGCTTCTTTCTTTAAGTCTGGATATGATGTTGGTGAATTATGCTCAAAAGGATATATGAGCGTCCCTCAAGTGTTATGTGCTGTTACTCGAACAGTTTCCACTGATGCTGAAGGGTCCCTGAGAATTTACTTAGCTGATCTAGGCGACAAGGAGTTATCTCCTATAGACGGGCAGTGCGTTTCGTTACATAACCATGATCTTCCCGCTTTGGTGTCTTTCCAACCGACGTATGATTGTCCTATGGAAACAGTTGGGAATCGTAAGCGGTGTTTTGCTGTTGTTATCGAAAGACATGGTTACATTGGGTATACCGGTACCACAGCTAGCGTGTGTAGTAATTGGCAAGCAAGGTTTTCTTCTAAGAATAACAACTACACTCATATCGCAGCTGGGAAGACTCTAGTACTACCTTTCAACAGATTAGCCGAGCAAACAAAACCGTCAGCTGTCGCTCGCCTGTTGAAATCGCAATTGAACAACATTGAATCTTCGCAATATCTGTTAACGAACGCGAAGATTAATCAAAATGCGCGTAGTGAGTCCGAGGAATTAAATGTTGAGAGCCCTCCCGCCGCAATCGGGAGTTCTTCCGCGTCCCGCTCCGAAGCCTTCAGACCGCAGGTGGTTAACGGTCTTTAGCACTTTGGTGCGTATTAGTATATAAGTATTTGTGAGTCTGTAC | 2213 | Nucleic Acid | Natural | It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | PDCs | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | It provides antiviral immunity | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0467 | DNA Click for more detail | Vaccinia(virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20709294 | 2010 | Pubchem Assay |
| PRRID_0467 | DNA Click for more detail | Vaccinia(virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20709294 | 2010 | Pubchem Assay |
| PRRID_0468 | DNA Click for more detail | Cordyceps sinensis(fungi) | TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG | 685 | Nucleic Acid | Natural | Upon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Bone marrow-derived dendritic cells (BM-DCs). | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It exhibits immunomodulating activity against Cordyceps sinensis | Luciferase assay | 20451901 | 2010 | Pubchem Assay |
| PRRID_0468 | DNA Click for more detail | Cordyceps sinensis(fungi) | TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG | 685 | Nucleic Acid | Natural | Upon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Bone marrow-derived dendritic cells (BM-DCs). | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It exhibits immunomodulating activity against Cordyceps sinensis | Luciferase assay | 20451901 | 2010 | Pubchem Assay |
| PRRID_0469 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Activates caspase-1 which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0469 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Activates caspase-1 which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0470 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | NA | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0470 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | NA | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0471 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | NA | Leucine-rich Repeat (LRR) Domain | P58682.fasta | P58682 | 1032 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0471 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | NA | Leucine-rich Repeat (LRR) Domain | P58682.fasta | P58682 | 1032 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0474 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | The activation of NF-kB, MAP kinases and IRF3 and culminates in the production of inflammatory cytokines and type I IFNs | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0474 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | The activation of NF-kB, MAP kinases and IRF3 and culminates in the production of inflammatory cytokines and type I IFNs | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0481 | dsDNA Click for more detail | Ectromelia(virus) | NA | NA | Nucleic Acid | Natural | It is necessary for IL-6 production | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | dendritic cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leads to the inflammation of the cell | NA | 20709294 | 2010 | Pubchem Assay |
| PRRID_0481 | dsDNA Click for more detail | Ectromelia(virus) | NA | NA | Nucleic Acid | Natural | It is necessary for IL-6 production | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | dendritic cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leads to the inflammation of the cell | NA | 20709294 | 2010 | Pubchem Assay |
| PRRID_0482 | dsDNA Click for more detail | Rabies virus (virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0482 | dsDNA Click for more detail | Rabies virus (virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0483 | dsDNA Click for more detail | herpes simplex virus (virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0483 | dsDNA Click for more detail | herpes simplex virus (virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0484 | dsDNA Click for more detail | vaccinia virus and murine cytomegalovirus (virus) | NA | NA | Nucleic Acid | Natural | It induces the caspase-1 activation and controls the catalytic cleavage of pro-form of the cytokine IL-1B | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | It is involved in caspase-1-mediated maturation of IL-1β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0484 | dsDNA Click for more detail | vaccinia virus and murine cytomegalovirus (virus) | NA | NA | Nucleic Acid | Natural | It induces the caspase-1 activation and controls the catalytic cleavage of pro-form of the cytokine IL-1B | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | It is involved in caspase-1-mediated maturation of IL-1β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0487 | dsDNA Click for more detail | Vaccinia(virus) | NA | NA | Nucleic Acid | Natural | It induces the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | HEK293 cells, PDCs | LRR | P58682.fasta | P58682 | 1032 | TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection. | ELISA | 20308556 | 2010 | Pubchem Assay |
| PRRID_0487 | dsDNA Click for more detail | Vaccinia(virus) | NA | NA | Nucleic Acid | Natural | It induces the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | HEK293 cells, PDCs | LRR | P58682.fasta | P58682 | 1032 | TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection. | ELISA | 20308556 | 2010 | Pubchem Assay |
| PRRID_0488 | dsDNA viruses Click for more detail | HSV, MCMV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD91 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0488 | dsDNA viruses Click for more detail | HSV, MCMV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD91 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0489 | dsRNA virus Click for more detail | RSV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | it lead to the secretion of IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0489 | dsRNA virus Click for more detail | RSV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | it lead to the secretion of IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0490 | EBV DNA Click for more detail | Epstein-Barr virus (virus) | NA | NA | Nucleic Acid | Natural | Viral nucleic acid recognition mediates IFN-α production by pDC. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Plasmacytoid Dendritic Cells | LRR | Q9NR96.fasta | Q9NR96 | 1032 | This results into the inflammatory response. | ELISA | 20178121 | 2010 | Pubchem Assay |
| PRRID_0490 | EBV DNA Click for more detail | Epstein-Barr virus (virus) | NA | NA | Nucleic Acid | Natural | Viral nucleic acid recognition mediates IFN-α production by pDC. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Plasmacytoid Dendritic Cells | LRR | Q9NR96.fasta | Q9NR96 | 1032 | This results into the inflammatory response. | ELISA | 20178121 | 2010 | Pubchem Assay |
| PRRID_0491 | EBV RNA Click for more detail | Epstein-Barr virus (virus) | NA | NA | Nucleic Acid | Natural | Viral nucleic acid recognition mediates IFN-α production by pDC. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Plasmacytoid Dendritic Cells | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | This results into the inflammatory response. | ELISA | 20178121 | 2010 | Pubchem Assay |
| PRRID_0491 | EBV RNA Click for more detail | Epstein-Barr virus (virus) | NA | NA | Nucleic Acid | Natural | Viral nucleic acid recognition mediates IFN-α production by pDC. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Plasmacytoid Dendritic Cells | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | This results into the inflammatory response. | ELISA | 20178121 | 2010 | Pubchem Assay |
| PRRID_0492 | EDA Click for more detail | Mice (others) | NA | NA | Organic Compound | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It helps in collateral vessels growth or Arteriogenesis. | NA | 20708624 | 2010 | Pubchem Assay |
| PRRID_0492 | EDA Click for more detail | Mice (others) | NA | NA | Organic Compound | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It helps in collateral vessels growth or Arteriogenesis. | NA | 20708624 | 2010 | Pubchem Assay |
| PRRID_0494 | elf18 Click for more detail | NA | NA | NA | Peptide | Natural | It bind to the FLS2 and incites the downstream cascade. | EFR | Toll-like receptor (TLR) | Arabidopsis | Plasma membrane | LRR | C0LGT6.fasta | C0LGT6 | 1031 | It caused seedling growth inhibition of arabidopsis thaliana | Growth inhibition assay | 20200150 | 2010 | Pubchem Assay |
| PRRID_0494 | elf18 Click for more detail | NA | NA | NA | Peptide | Natural | It bind to the FLS2 and incites the downstream cascade. | EFR | Toll-like receptor (TLR) | Arabidopsis | Plasma membrane | LRR | C0LGT6.fasta | C0LGT6 | 1031 | It caused seedling growth inhibition of arabidopsis thaliana | Growth inhibition assay | 20200150 | 2010 | Pubchem Assay |
| PRRID_0495 | endotoxin-free poly(I:C) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11 | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 Mice (experimental model of lung allergic exacerbation) | Airway Epithilium and Dedritic cells | Leucine-rich Repeat (LRR) Domain | Q99MB1.fasta | Q99MB1 | 905 | It significantly increased the airway hyperresponsiveness, the lung inflammation | ELISA | 20505141 | 2010 | Pubchem Assay |
| PRRID_0495 | endotoxin-free poly(I:C) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11 | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 Mice (experimental model of lung allergic exacerbation) | Airway Epithilium and Dedritic cells | Leucine-rich Repeat (LRR) Domain | Q99MB1.fasta | Q99MB1 | 905 | It significantly increased the airway hyperresponsiveness, the lung inflammation | ELISA | 20505141 | 2010 | Pubchem Assay |
| PRRID_0496 | Envelope protein Click for more detail | RSV (virus) | MEAVIKAVLTGYPGETSKKDSKKKPPATSKKDPEKTPLLPTRVNYILIIGVLVLCEVTGVRADVHLLEQPGNLWITWASRTGQTDFCLSTQSATSPFQTCLIGIPSPISEGDFKGYVSDNCTTLEPHRLVSRGIPGGPENSTTLTYQKVSCLLLKLNVSLLDEPSELQLLGSQSLPNITNITRIPSVAGGCIGFTPYDSPAGVYGWDRREVTHILLTDPGNNPFFDKASNSSKPFTVVTADRHNLFMGSEYCGAYGYRFWEMYNCSQMRQNWSICQDVWGRGPPENWCTSTGGTWVNQSKEFNETEPFSFTVNCTGSNLGNVSGCCGEPITILPPEAWVDSTQGSFTKPKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDILKILANSSRTGIRRKRSVSHLDDTCSDEVQLWGPTARIFASILAPGVAAAQALKEIERLACWSVKQANLTTSLLGDLLDDVTSIRHAVLQNRAAIDFLLLAHGHGCEDVAGMCCFNLSDHSESIQKKFQLMKEHVNKIGVDSDPIGSWLRGLFGGIGEWAVHLLKGLLLGLVVILLLVVCLPCLLQIVCGNIRKMINNSISYHTEYKKLQKAYGQPESRIV | 613 | Protein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0496 | Envelope protein Click for more detail | RSV (virus) | MEAVIKAVLTGYPGETSKKDSKKKPPATSKKDPEKTPLLPTRVNYILIIGVLVLCEVTGVRADVHLLEQPGNLWITWASRTGQTDFCLSTQSATSPFQTCLIGIPSPISEGDFKGYVSDNCTTLEPHRLVSRGIPGGPENSTTLTYQKVSCLLLKLNVSLLDEPSELQLLGSQSLPNITNITRIPSVAGGCIGFTPYDSPAGVYGWDRREVTHILLTDPGNNPFFDKASNSSKPFTVVTADRHNLFMGSEYCGAYGYRFWEMYNCSQMRQNWSICQDVWGRGPPENWCTSTGGTWVNQSKEFNETEPFSFTVNCTGSNLGNVSGCCGEPITILPPEAWVDSTQGSFTKPKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDILKILANSSRTGIRRKRSVSHLDDTCSDEVQLWGPTARIFASILAPGVAAAQALKEIERLACWSVKQANLTTSLLGDLLDDVTSIRHAVLQNRAAIDFLLLAHGHGCEDVAGMCCFNLSDHSESIQKKFQLMKEHVNKIGVDSDPIGSWLRGLFGGIGEWAVHLLKGLLLGLVVILLLVVCLPCLLQIVCGNIRKMINNSISYHTEYKKLQKAYGQPESRIV | 613 | Protein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0499 | F protein Click for more detail | Respiratory syncytial virus (virus) | LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNIC | 153 | Protein | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0499 | F protein Click for more detail | Respiratory syncytial virus (virus) | LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNIC | 153 | Protein | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0500 | F4 fimbriae Click for more detail | Enterotoxigenic Escherichia coli (F4+ ETEC) | ADWGPCRTASGDPFIFVTSFTKNIQNPTDNVTGQTYPDFYQWALGDKYSGVCECPSPNPTEARPTLYKTESTLAAGHNSTYFKITNNLEVSTRVYIANVGNVQVPFINKSNSQPGRECDQPTFGWTTGSKGQLSLYIAKPFVGEQNIPQTIIVSVFGTKKENVYSSVPISQVLLSGKVTVTQGCELAAGTSLDIDFGEYQAHDFKGRTGQPPQNVQKIQKELTFNCTNISDGVHIYLSLEGTPNAAYPSAISLGNADVGAVIEDGKGNILKPNDSNSLLEMNPGSLYEYVKRKVTTTITAYPVSTTGKLPAAGDYSGVATMHVELDGGGGGGGGGGATTDLGAKGTLKFSLKISQGHHHHHH | 364 | Protein | Natural | The binding of ligand to TLR5 ETEC induce IL-6 and IL-8 cytokine secretion by intestinal cells | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Porcine | Intestinal Epithelial Cells | Leucine-rich Repeat (LRR) Domain | C0L925.fasta | C0L925 | 844 | It induces proinflammatory responses in porcine intestinal epithelial cells | Quantitative bacterial adherence assay | 20600278 | 2010 | Pubchem Assay |
| PRRID_0500 | F4 fimbriae Click for more detail | Enterotoxigenic Escherichia coli (F4+ ETEC) | ADWGPCRTASGDPFIFVTSFTKNIQNPTDNVTGQTYPDFYQWALGDKYSGVCECPSPNPTEARPTLYKTESTLAAGHNSTYFKITNNLEVSTRVYIANVGNVQVPFINKSNSQPGRECDQPTFGWTTGSKGQLSLYIAKPFVGEQNIPQTIIVSVFGTKKENVYSSVPISQVLLSGKVTVTQGCELAAGTSLDIDFGEYQAHDFKGRTGQPPQNVQKIQKELTFNCTNISDGVHIYLSLEGTPNAAYPSAISLGNADVGAVIEDGKGNILKPNDSNSLLEMNPGSLYEYVKRKVTTTITAYPVSTTGKLPAAGDYSGVATMHVELDGGGGGGGGGGATTDLGAKGTLKFSLKISQGHHHHHH | 364 | Protein | Natural | The binding of ligand to TLR5 ETEC induce IL-6 and IL-8 cytokine secretion by intestinal cells | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Porcine | Intestinal Epithelial Cells | Leucine-rich Repeat (LRR) Domain | C0L925.fasta | C0L925 | 844 | It induces proinflammatory responses in porcine intestinal epithelial cells | Quantitative bacterial adherence assay | 20600278 | 2010 | Pubchem Assay |
| PRRID_0504 | fibrinogen and heat-shock proteins Click for more detail | Endogenous (others) | MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ | 481 | Protein | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0504 | fibrinogen and heat-shock proteins Click for more detail | Endogenous (others) | MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ | 481 | Protein | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0505 | Fibronectin Click for more detail | Endogenous (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Glycoprotein | Natural | It binds to the TLR4 and induce the release of pro-inflammatory cytokines via NF- | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Primary Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | it increases bacterial phagocytosis and intracellular killing by murine microglial cells | NA | 20599470 | 2010 | Pubchem Assay |
| PRRID_0505 | Fibronectin Click for more detail | Endogenous (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Glycoprotein | Natural | It binds to the TLR4 and induce the release of pro-inflammatory cytokines via NF- | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Primary Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | it increases bacterial phagocytosis and intracellular killing by murine microglial cells | NA | 20599470 | 2010 | Pubchem Assay |
| PRRID_0506 | FimH Click for more detail | Escherichia coli strain EC99 (O78) (Bacteria) | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ | 300 | Protein | Natural | It activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicity | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Natural Killer cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It aids innate protection against cancer or microbial infections. | Chromium (51Cr) release assay for NK cytotoxicity | 20442710 | 2010 | Pubchem Assay |
| PRRID_0506 | FimH Click for more detail | Escherichia coli strain EC99 (O78) (Bacteria) | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ | 300 | Protein | Natural | It activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicity | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Natural Killer cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It aids innate protection against cancer or microbial infections. | Chromium (51Cr) release assay for NK cytotoxicity | 20442710 | 2010 | Pubchem Assay |
| PRRID_0507 | FimH Click for more detail | Escherichia coli strain EC99 (O78) (Bacteria) | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ | 300 | Protein | Natural | It activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicity | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Natural Killer cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It aids innate protection against cancer or microbial infections. | Chromium (51Cr) release assay for NK cytotoxicity | 20442710 | 2010 | Pubchem Assay |
| PRRID_0507 | FimH Click for more detail | Escherichia coli strain EC99 (O78) (Bacteria) | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ | 300 | Protein | Natural | It activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicity | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Natural Killer cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It aids innate protection against cancer or microbial infections. | Chromium (51Cr) release assay for NK cytotoxicity | 20442710 | 2010 | Pubchem Assay |
| PRRID_0508 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0508 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0510 | Flagellin Click for more detail | Salmonella muenchen (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates NF-KB and MAPKs and induced significant production of the different cytokines | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | Liver, Lung, Kideny, Intestine | Leucine-rich Repeat (LRR) Domain | Q9JLF7.fasta | Q9JLF7 | 859 | It has the role in the inflammation. | NA | 20731882 | 2010 | Pubchem Assay |
| PRRID_0510 | Flagellin Click for more detail | Salmonella muenchen (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates NF-KB and MAPKs and induced significant production of the different cytokines | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | Liver, Lung, Kideny, Intestine | Leucine-rich Repeat (LRR) Domain | Q9JLF7.fasta | Q9JLF7 | 859 | It has the role in the inflammation. | NA | 20731882 | 2010 | Pubchem Assay |
| PRRID_0511 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It results into the inflammatory response | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0511 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It results into the inflammatory response | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0513 | Flagellin Click for more detail | Motile Bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It itriggers the up-regulation of co-stimulatory signals and Ag-presenting molecules | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocytes, mDCs, Langerhans cells, T cells and NK cells | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leads to the induction of DC maturation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0513 | Flagellin Click for more detail | Motile Bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It itriggers the up-regulation of co-stimulatory signals and Ag-presenting molecules | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocytes, mDCs, Langerhans cells, T cells and NK cells | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leads to the induction of DC maturation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0514 | Flagellin Click for more detail | Salmonella typhimurium(Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | induced the secretion of IL-6 and IL-10 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0514 | Flagellin Click for more detail | Salmonella typhimurium(Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | induced the secretion of IL-6 and IL-10 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0515 | Flagellin Click for more detail | Human respiratory syncytial virus (RSV) | NA | NA | Protein | Natural | Activate NF-κB | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Induce IL-1, IL-6, IL-8, and RANTES | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0515 | Flagellin Click for more detail | Human respiratory syncytial virus (RSV) | NA | NA | Protein | Natural | Activate NF-κB | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Induce IL-1, IL-6, IL-8, and RANTES | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0516 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0516 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0519 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP4 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0519 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP4 | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0520 | Flagellin (L94A) Click for more detail | Pseudomonas aeruginosa (Bacteria) | GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP | 434 | Protein | Natural | It elicits EGFR signaling in a TGF-a–related pathway, which leads to the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs). | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Human corneal epithelial cells (HCECs) | LRR | O60602.fasta | O60602 | 858 | It stimulates mucosal surface innate immune response. | ELISA | 20195469 | 2010 | Pubchem Assay |
| PRRID_0520 | Flagellin (L94A) Click for more detail | Pseudomonas aeruginosa (Bacteria) | GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP | 434 | Protein | Natural | It elicits EGFR signaling in a TGF-a–related pathway, which leads to the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs). | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Human corneal epithelial cells (HCECs) | LRR | O60602.fasta | O60602 | 858 | It stimulates mucosal surface innate immune response. | ELISA | 20195469 | 2010 | Pubchem Assay |
| PRRID_0525 | FSL-1 Click for more detail | Mycoplasma (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | FSL-1 binds to the heterocomplex of TLR2 and TLR6 and activates the downstream signalling | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | Q9BXR5.fasta | Q9BXR5 | 811 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0525 | FSL-1 Click for more detail | Mycoplasma (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | FSL-1 binds to the heterocomplex of TLR2 and TLR6 and activates the downstream signalling | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | Q9BXR5.fasta | Q9BXR5 | 811 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0526 | FSL-1 Click for more detail | Mycoplasma salivarium (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | embryonic mouse telencephalon and NPC | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | its activation inhibits NPC proliferation and decreases cell proliferation. | NA | 20456021 | 2010 | Pubchem Assay |
| PRRID_0526 | FSL-1 Click for more detail | Mycoplasma salivarium (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | embryonic mouse telencephalon and NPC | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | its activation inhibits NPC proliferation and decreases cell proliferation. | NA | 20456021 | 2010 | Pubchem Assay |
| PRRID_0527 | G-rich oligonucleotides Click for more detail | Human respiratory syncytial virus (RSV) | NA | NA | Protein | Natural | Suppress NF-κB activation | Toll-like receptor 2/4/9 (TLR2/4/9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0527 | G-rich oligonucleotides Click for more detail | Human respiratory syncytial virus (RSV) | NA | NA | Protein | Natural | Suppress NF-κB activation | Toll-like receptor 2/4/9 (TLR2/4/9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |