Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0383	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0383	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0384	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0384	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0385	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0385	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0386	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0386	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0387	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	PBMCs	NA	NA	NA	NA	This induces the inflammatory response.	PBMC assay	19269175	2009	NA
PRRID_0387	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	PBMCs	NA	NA	NA	NA	This induces the inflammatory response.	PBMC assay	19269175	2009	NA
PRRID_0388	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	pDCs	NA	NA	NA	NA	This induces the inflammatory response.	NA	19269175	2009	NA
PRRID_0388	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	pDCs	NA	NA	NA	NA	This induces the inflammatory response.	NA	19269175	2009	NA
PRRID_0389	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	On stimulation, production of significant amount of IL-12, KC, and IP-10 takes place.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	Macropahges	NA	NA	NA	NA	This induces the inflammatory response.	cell-based assays	19269175	2009	NA
PRRID_0389	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	On stimulation, production of significant amount of IL-12, KC, and IP-10 takes place.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	Macropahges	NA	NA	NA	NA	This induces the inflammatory response.	cell-based assays	19269175	2009	NA
PRRID_0390	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0390	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0391	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0391	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0392	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0392	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0393	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0393	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0394	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0394	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0395	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0395	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0396	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0396	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0397	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0397	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0398	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0398	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0399	Streptococcus gordonii Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0399	Streptococcus gordonii Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0400	Viral Genome Click for more detail	Rabies virus (virus)	NA	NA	Nucleic Acid	Natural	Rabies genome is a potent activator of TLR3	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Neuronal cells	NA	O15455.fasta	O15455	904	TLR3 is involved in the spatial arrangement of rabies virus‚Äìinduced NBs and viral replication.	NA	19247444	2009	Pubchem Assay
PRRID_0400	Viral Genome Click for more detail	Rabies virus (virus)	NA	NA	Nucleic Acid	Natural	Rabies genome is a potent activator of TLR3	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Neuronal cells	NA	O15455.fasta	O15455	904	TLR3 is involved in the spatial arrangement of rabies virus‚Äìinduced NBs and viral replication.	NA	19247444	2009	Pubchem Assay
PRRID_0401	1,3 beta glucan Click for more detail	Sparassis crispa (fungi)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	Anti-tumour properties	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It can induce the phenotypic and functional maturation of DCs.	NA	20699131	2010	Pubchem Assay
PRRID_0401	1,3 beta glucan Click for more detail	Sparassis crispa (fungi)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	Anti-tumour properties	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It can induce the phenotypic and functional maturation of DCs.	NA	20699131	2010	Pubchem Assay
PRRID_0404	A46R Click for more detail	Vaccinia(virus)	MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALANIYLIVFQYLSYLDYDTIYVSIYAGTLRA	214	Protein	Natural	Suppress NF-Œ∫B activation (Bind to MyD88, TRAM, and TRIF)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppress cytokine production	NA	20672047	2010	NA
PRRID_0404	A46R Click for more detail	Vaccinia(virus)	MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALANIYLIVFQYLSYLDYDTIYVSIYAGTLRA	214	Protein	Natural	Suppress NF-Œ∫B activation (Bind to MyD88, TRAM, and TRIF)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppress cytokine production	NA	20672047	2010	NA
PRRID_0405	A52R Click for more detail	Vaccinia(virus)	MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS	190	Protein	Natural	Suppress NF-Œ∫B activation (Bind to IRAK2) and	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppress cytokine production	NA	20672047	2010	NA
PRRID_0405	A52R Click for more detail	Vaccinia(virus)	MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS	190	Protein	Natural	Suppress NF-Œ∫B activation (Bind to IRAK2) and	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppress cytokine production	NA	20672047	2010	NA
PRRID_0406	A52R Click for more detail	Vaccinia(virus)	MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS	190	Protein	Natural	Activate p38 MAPK and JNK (Bind to TRAF6)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Induce IL-10 production	NA	20672047	2010	NA
PRRID_0406	A52R Click for more detail	Vaccinia(virus)	MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS	190	Protein	Natural	Activate p38 MAPK and JNK (Bind to TRAF6)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Induce IL-10 production	NA	20672047	2010	NA
PRRID_0407	acylated LprA Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Induced IL-8 secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0407	acylated LprA Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Induced IL-8 secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0408	acylated LprG Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Delivery of glycolipds to TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0408	acylated LprG Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Delivery of glycolipds to TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0412	Arabinosylated lipoarabinomannan (Ara-LAM) Click for more detail	Mycobacterium tuberculosis (Bacteria)	NA	NA	Glycolipid	Natural	It triggers downstream signalling via MyD88, lead to the ativation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Leishmania donovani infected Mice	macropahge	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis	EMSA and ELISA	20500089	2010	Pubchem Assay
PRRID_0412	Arabinosylated lipoarabinomannan (Ara-LAM) Click for more detail	Mycobacterium tuberculosis (Bacteria)	NA	NA	Glycolipid	Natural	It triggers downstream signalling via MyD88, lead to the ativation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Leishmania donovani infected Mice	macropahge	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis	EMSA and ELISA	20500089	2010	Pubchem Assay
PRRID_0414	AtPep1 Click for more detail	Arabidopsis thaliana(plant)	ATKVKAKQRGKEKVSSGRPGQHN	23	Peptide	Natural	It triggers a receptor-dependent transient depolarization through activation of plasma membrane anion channels.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0414	AtPep1 Click for more detail	Arabidopsis thaliana(plant)	ATKVKAKQRGKEKVSSGRPGQHN	23	Peptide	Natural	It triggers a receptor-dependent transient depolarization through activation of plasma membrane anion channels.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0415	AtPep2 Click for more detail	NA	DNKAKSKKRDKEKPSSGRPGQTNSVPNAAIQVYKED	36	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0415	AtPep2 Click for more detail	NA	DNKAKSKKRDKEKPSSGRPGQTNSVPNAAIQVYKED	36	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0416	AtPep3 Click for more detail	NA	EIKARGKNKTKPTPSSGKGGKHN	23	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0416	AtPep3 Click for more detail	NA	EIKARGKNKTKPTPSSGKGGKHN	23	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0417	AtPep4 Click for more detail	NA	NA	NA	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0417	AtPep4 Click for more detail	NA	NA	NA	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0418	AtPep5 Click for more detail	NA	NA	NA	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0418	AtPep5 Click for more detail	NA	NA	NA	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0419	AtPep6 Click for more detail	NA	NA	NA	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0419	AtPep6 Click for more detail	NA	NA	NA	Peptide	Synthetic	It increase cytosolic calcium and activate chloride channels followed by membrane depolarization in a strictly receptor-dependent manner.	PEPR1	Toll-like receptor (TLR)	Arabidopsis	Plasma membrane	LRR	NA	NA	NA	It caused seedling growth inhibition of arabidopsis thaliana	Growth inhibition assay	20200150	2010	NA
PRRID_0421	Bacterial Antigen Click for more detail	B. abortus 544(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0421	Bacterial Antigen Click for more detail	B. abortus 544(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0423	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0423	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0426	Bacterial DNA Click for more detail	Porphyromonas gingivalis and Tannerella forsythia (Bacteria)	NA	NA	Nucleic Acid	Natural	It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytic cells (THP-1 cells)	LRR	Q9NR96.fasta	Q9NR96	1032	Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway.	ELISA	20331800	2010	Pubchem Assay
PRRID_0426	Bacterial DNA Click for more detail	Porphyromonas gingivalis and Tannerella forsythia (Bacteria)	NA	NA	Nucleic Acid	Natural	It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytic cells (THP-1 cells)	LRR	Q9NR96.fasta	Q9NR96	1032	Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway.	ELISA	20331800	2010	Pubchem Assay
PRRID_0429	BV-nucleic acid Click for more detail	Baculovirus(virus)	NA	NA	Nucleic Acid	Natural	It leads to increased expression of cytokine IL-12 p40	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	Macrophage-like cell line (HD11)	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	This results into the inflammatory response, which leads to clearance of pathogen	NA	20471186	2010	NA
PRRID_0429	BV-nucleic acid Click for more detail	Baculovirus(virus)	NA	NA	Nucleic Acid	Natural	It leads to increased expression of cytokine IL-12 p40	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	Macrophage-like cell line (HD11)	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	This results into the inflammatory response, which leads to clearance of pathogen	NA	20471186	2010	NA
PRRID_0434	Cinnamaldehyde Click for more detail	China Medicine (Group) Shanghai Chemical Reagent(others)	C1=CC=C(C=C1)C=CC=O	NA	Drug	Synthetic	It inhibits the NF-	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC)	Heart	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It has antiviral effects on VMC through its metabolite, cinnamic acid.	NA	20460981	2010	NA
PRRID_0434	Cinnamaldehyde Click for more detail	China Medicine (Group) Shanghai Chemical Reagent(others)	C1=CC=C(C=C1)C=CC=O	NA	Drug	Synthetic	It inhibits the NF-	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC)	Heart	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It has antiviral effects on VMC through its metabolite, cinnamic acid.	NA	20460981	2010	NA
PRRID_0435	CL097 Click for more detail	derivative of the imidazoquinoline compound R848(others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	The binding induces the production of IL-6, IL-10, TNF-‚ç∫ and IL-23	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	Lamina propria DCs obtained from the human GI tract	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It induces intestinal inflammation and potentially alter the homeostatic response to commensal flora	NA	20483758	2010	NA
PRRID_0435	CL097 Click for more detail	derivative of the imidazoquinoline compound R848(others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	The binding induces the production of IL-6, IL-10, TNF-‚ç∫ and IL-23	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	Lamina propria DCs obtained from the human GI tract	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It induces intestinal inflammation and potentially alter the homeostatic response to commensal flora	NA	20483758	2010	NA
PRRID_0436	Compound A Click for more detail	NA	NA	NA	Chemical Compunds	Synthetic	it induces IL-6 production in murine macrophage	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0436	Compound A Click for more detail	NA	NA	NA	Chemical Compunds	Synthetic	it induces IL-6 production in murine macrophage	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0437	Compound B Click for more detail	3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It casues inflammation in the respective cells	ELISA	20504771	2010	Pubchem Assay
PRRID_0437	Compound B Click for more detail	3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It casues inflammation in the respective cells	ELISA	20504771	2010	Pubchem Assay
PRRID_0438	Compound C Click for more detail	3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It casues inflammation in the respective cells	ELISA	20504771	2010	Pubchem Assay
PRRID_0438	Compound C Click for more detail	3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It casues inflammation in the respective cells	ELISA	20504771	2010	Pubchem Assay
PRRID_0439	Compound E Click for more detail	N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0439	Compound E Click for more detail	N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0440	Compound F Click for more detail	N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0440	Compound F Click for more detail	N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0441	core protein Click for more detail	Hepatitis C Virus (virus)	MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA	319	Protein	Natural	Induce cytokines responses through nuclear translocation of nuclear factor-kB (NF-kB) subunits	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Antigen presenting cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It reduces the IL-6 production in these cells	NA	20677943	2010	Pubchem Assay
PRRID_0441	core protein Click for more detail	Hepatitis C Virus (virus)	MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA	319	Protein	Natural	Induce cytokines responses through nuclear translocation of nuclear factor-kB (NF-kB) subunits	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Antigen presenting cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It reduces the IL-6 production in these cells	NA	20677943	2010	Pubchem Assay
PRRID_0442	core protein Click for more detail	Hepatitis C Virus (virus)	MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA	319	Protein	Natural	Activate MAP kinase pathway, NF-Œ∫B, and AP-1	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocytes and Kupffer cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Dysfunction of pDCs by enhanced production of IL-10 and TNF- Œ±	NA	20672047	2010	Pubchem Assay
PRRID_0442	core protein Click for more detail	Hepatitis C Virus (virus)	MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA	319	Protein	Natural	Activate MAP kinase pathway, NF-Œ∫B, and AP-1	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocytes and Kupffer cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Dysfunction of pDCs by enhanced production of IL-10 and TNF- Œ±	NA	20672047	2010	Pubchem Assay
PRRID_0443	CpG DNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0443	CpG DNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0444	CpG DNA motifs Click for more detail	Virus, Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Inflammation	NA	20692289	2010	NA
PRRID_0444	CpG DNA motifs Click for more detail	Virus, Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Inflammation	NA	20692289	2010	NA
PRRID_0445	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0445	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0446	CpG motif Click for more detail	HSV-1 (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It recognize and raise the inflammatory response	NA	20713890	2010	Pubchem Assay
PRRID_0446	CpG motif Click for more detail	HSV-1 (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It recognize and raise the inflammatory response	NA	20713890	2010	Pubchem Assay
PRRID_0447	CpG motif Click for more detail	HSV-2 (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	Q9BXR5.fasta	Q9BXR5	811	It recognize and raise the inflammatory response	NA	20713890	2010	Pubchem Assay
PRRID_0447	CpG motif Click for more detail	HSV-2 (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	Q9BXR5.fasta	Q9BXR5	811	It recognize and raise the inflammatory response	NA	20713890	2010	Pubchem Assay
PRRID_0448	CpG motif Click for more detail	murine CMV (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It recognize and raise the inflammatory response	NA	20713890	2010	NA
PRRID_0448	CpG motif Click for more detail	murine CMV (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It recognize and raise the inflammatory response	NA	20713890	2010	NA

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