Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0922Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANATLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219554432011NA
PRRID_0922Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANATLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219554432011NA
PRRID_0923Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANATLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219498662011NA
PRRID_0923Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANATLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219498662011NA
PRRID_0924Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)neutrophils, macrophages, and dendritic cellsTIR domain- containing adaptor protein-inducing IFN-Q9QUK6.fastaQ9QUK6835triggers the innate immune response and leads to the induction of adaptive immunityNA219497732011Pubchem Assay
PRRID_0924Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)neutrophils, macrophages, and dendritic cellsTIR domain- containing adaptor protein-inducing IFN-Q9QUK6.fastaQ9QUK6835triggers the innate immune response and leads to the induction of adaptive immunityNA219497732011Pubchem Assay
PRRID_0925lipoprotein or lipopeptides

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Gram-positive bacteriaNANALipidSyntheticelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219498662011NA
PRRID_0925lipoprotein or lipopeptides

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Gram-positive bacteriaNANALipidSyntheticelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219498662011NA
PRRID_0926Lipoproteins/lipopeptides

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BacteriaNANALipidNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0926Lipoproteins/lipopeptides

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BacteriaNANALipidNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0927Lipoproteins/lipopeptides

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Different bacterial pathogens(Bacteria)NANALipidNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0927Lipoproteins/lipopeptides

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Different bacterial pathogens(Bacteria)NANALipidNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0928Lipoteichoic Acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0928Lipoteichoic Acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0929Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0929Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0930Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0930Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0931Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0931Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0932Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticup-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanB cells, dendritic cells, microglia, astrocytesNAQ9NYK1.fastaQ9NYK11049TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219825582011Pubchem Assay
PRRID_0932Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticup-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanB cells, dendritic cells, microglia, astrocytesNAQ9NYK1.fastaQ9NYK11049TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219825582011Pubchem Assay
PRRID_0933Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticup-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANANANANANATLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219554432011NA
PRRID_0933Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticup-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANANANANANATLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219554432011NA
PRRID_0936monophosphoryl lipid A (MPL)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1OCC2C(C(C(C(O2)O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCNALipidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Balb/c miceSpleen and lungNAP58681.fastaP586811050plays a fundamental role in pathogen recognition and activation of innate immunityELISA219638722011Pubchem Assay
PRRID_0936monophosphoryl lipid A (MPL)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1OCC2C(C(C(C(O2)O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCNALipidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Balb/c miceSpleen and lungNAP58681.fastaP586811050plays a fundamental role in pathogen recognition and activation of innate immunityELISA219638722011Pubchem Assay
PRRID_0937mRNA

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Endogenous (others)NANANucleic AcidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAQ9NYK1.fastaQ9NYK11049TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligandsNA219825582011Pubchem Assay
PRRID_0937mRNA

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Endogenous (others)NANANucleic AcidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAQ9NYK1.fastaQ9NYK11049TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligandsNA219825582011Pubchem Assay
PRRID_0940Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNAIntracellular TIR domainsO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219592642011Pubchem Assay
PRRID_0940Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNAIntracellular TIR domainsO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219592642011Pubchem Assay
PRRID_0941Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Drosophila melanogasterNAIntracellular TIR domainsNANANATLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219592642011NA
PRRID_0941Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Drosophila melanogasterNAIntracellular TIR domainsNANANATLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219592642011NA
PRRID_0942Pam2CSK4

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NACCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAdiacylated lipopeptide SyntheticBacterial lipoproteins are strong immune modulators that activate early innate host responses after infectionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNAintracellular TIR domainsQ9QUN7.fastaQ9QUN7784fundamental role in pathogen recognition and activation of innate immunityNA219592642011Pubchem Assay
PRRID_0942Pam2CSK4

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NACCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAdiacylated lipopeptide SyntheticBacterial lipoproteins are strong immune modulators that activate early innate host responses after infectionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNAintracellular TIR domainsQ9QUN7.fastaQ9QUN7784fundamental role in pathogen recognition and activation of innate immunityNA219592642011Pubchem Assay
PRRID_0943Pam2CSK4

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NACCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAdiacylated lipopeptide SyntheticBacterial lipoproteins are strong immune modulators that activate early innate host responses after infectionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNAIntracellular TIR domainsO60603.fastaO60603784fundamental role in pathogen recognition and activation of innate immunityNA219592642011Pubchem Assay
PRRID_0943Pam2CSK4

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NACCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAdiacylated lipopeptide SyntheticBacterial lipoproteins are strong immune modulators that activate early innate host responses after infectionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNAIntracellular TIR domainsO60603.fastaO60603784fundamental role in pathogen recognition and activation of innate immunityNA219592642011Pubchem Assay
PRRID_0944Pam2CSK4

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NACCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAdiacylated lipopeptide SyntheticBacterial lipoproteins are strong immune modulators that activate early innate host responses after infectionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Drosophila melanogasterNAIntracellular TIR domainsNANANAfundamental role in pathogen recognition and activation of innate immunityN219592642011NA
PRRID_0944Pam2CSK4

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NACCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAdiacylated lipopeptide SyntheticBacterial lipoproteins are strong immune modulators that activate early innate host responses after infectionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Drosophila melanogasterNAIntracellular TIR domainsNANANAfundamental role in pathogen recognition and activation of innate immunityN219592642011NA
PRRID_0945Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipoproteinSyntheticMimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-κB.Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNAintracellular TIR domainsNANANATLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6NA219592642011NA
PRRID_0945Pam3CSK4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipoproteinSyntheticMimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-κB.Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceNAintracellular TIR domainsNANANATLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6NA219592642011NA
PRRID_0946Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0946Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0947Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0947Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0948phenol-soluble modulin

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S. aureus (Bacteria)MEFVAKLFKFFKDLLGKFLGNN22ProteinNaturaltriggers immune responsesToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0948phenol-soluble modulin

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S. aureus (Bacteria)MEFVAKLFKFFKDLLGKFLGNN22ProteinNaturaltriggers immune responsesToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0949phenol-soluble modulin

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Staphylococcus epidermidis (Bacteria)MEFVAKLFKFFKDLLGKFLGNN22ProteinNaturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0949phenol-soluble modulin

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Staphylococcus epidermidis (Bacteria)MEFVAKLFKFFKDLLGKFLGNN22ProteinNaturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0951polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Balb/c miceSpleen and lungNAQ99MB1.fastaQ99MB1905TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligandsELISA219638722011Pubchem Assay
PRRID_0951polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Balb/c miceSpleen and lungNAQ99MB1.fastaQ99MB1905TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligandsELISA219638722011Pubchem Assay
PRRID_0952polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticelicit innate immune responseToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANANANANANATLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligandsNA219554432011NA
PRRID_0952polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticelicit innate immune responseToll-like receptor 3 (TLR3)Toll-like receptor (TLR)NANANANANANATLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligandsNA219554432011NA
PRRID_0953Porins

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outer membrane of bacterial cell wall (others)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalact as a pore, through which molecules can diffuseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0953Porins

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outer membrane of bacterial cell wall (others)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalact as a pore, through which molecules can diffuseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0954Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0954Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0955profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY165ProteinNaturalinduction of immune response against T. gondiiToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanMyeloid cells, uroepithelial cellsNANANANAinduces the release of interleukin 12 against T. gondii infected miceNA219825582011NA
PRRID_0955profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY165ProteinNaturalinduction of immune response against T. gondiiToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanMyeloid cells, uroepithelial cellsNANANANAinduces the release of interleukin 12 against T. gondii infected miceNA219825582011NA
PRRID_0956profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY165ProteinNaturalpotently activate the innate immune system through its specific recognition by TLR11, which plays an important role in T. gondii infection in mice Toll-like receptor 10 (TLR10)Toll-like receptor (TLR)NANANANANANATLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA219554432011NA
PRRID_0956profilin-like protein

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T. gondii (others)MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY165ProteinNaturalpotently activate the innate immune system through its specific recognition by TLR11, which plays an important role in T. gondii infection in mice Toll-like receptor 10 (TLR10)Toll-like receptor (TLR)NANANANANANATLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA219554432011NA
PRRID_0957Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANANANANANAimportant role in the immune response to viral infectionNA219498662011NA
PRRID_0957Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANANANANANAimportant role in the immune response to viral infectionNA219498662011NA
PRRID_0958Saturated fatty acids

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Endogenous (others)NANAFatty acid Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0958Saturated fatty acids

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Endogenous (others)NANAFatty acid Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0959single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanB cells, dendritic cells, microglia, astrocytesNAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA219825582011Pubchem Assay
PRRID_0959single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanB cells, dendritic cells, microglia, astrocytesNAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA219825582011Pubchem Assay
PRRID_0960single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAQ9NR97.fastaQ9NR971041important role in the immune response to viral infectionNA219825582011Pubchem Assay
PRRID_0960single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAQ9NR97.fastaQ9NR971041important role in the immune response to viral infectionNA219825582011Pubchem Assay
PRRID_0961single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANANANANANATLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219554432011NA
PRRID_0961single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)NANANANANANATLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13NA219554432011NA
PRRID_0962single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANANANANANAimportant role in the immune response to viral infectionNA219554432011NA
PRRID_0962single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 8 (TLR8)Toll-like receptor (TLR)NANANANANANAimportant role in the immune response to viral infectionNA219554432011NA
PRRID_0963Soluble factors

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Neisseria meningitidis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0963Soluble factors

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Neisseria meningitidis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0964surfactant protein-A

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Endogenous (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219825582011Pubchem Assay
PRRID_0964surfactant protein-A

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Endogenous (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219825582011Pubchem Assay
PRRID_0965Taxol

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PlantCC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)Syntheticused to treat a number of types of cancerToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0965Taxol

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PlantCC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNAPattern-associated molecular patterns (PAMPs)Syntheticused to treat a number of types of cancerToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0966Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanMyeloid cells, T, B and NK cells, microglia, astrocytesNAQ15399.fastaQ15399786NANA219825582011Pubchem Assay
PRRID_0966Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanMyeloid cells, T, B and NK cells, microglia, astrocytesNAQ15399.fastaQ15399786NANA219825582011Pubchem Assay
PRRID_0967Triacylated lipopeptides

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Bacteria and mycobacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0967Triacylated lipopeptides

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Bacteria and mycobacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0968Type III repeat extra domain A of fibronectin

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Endogenous (others)MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHVTFY749Damage-associated molecular patterns (DAMPs)Naturalpotent stimulus for collagen production, myofibroblast differentiation, and wound healing in vitro and increased the mechanical stiffness of human organotypic skin equivalentsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219825582011Pubchem Assay
PRRID_0968Type III repeat extra domain A of fibronectin

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Endogenous (others)MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHVTFY749Damage-associated molecular patterns (DAMPs)Naturalpotent stimulus for collagen production, myofibroblast differentiation, and wound healing in vitro and increased the mechanical stiffness of human organotypic skin equivalentsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMyeloid cells, microglia, astrocytes, neuronsNAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA219825582011Pubchem Assay
PRRID_0969Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEpithelial and B cells, dendritic cells, microglia, astrocyte, neuronNAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA219825582011Pubchem Assay
PRRID_0969Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEpithelial and B cells, dendritic cells, microglia, astrocyte, neuronNAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA219825582011Pubchem Assay
PRRID_0970Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANANANANANATLR9 plays a crucial role in breaking tolerance and developing autoimmunity NA219554432011NA
PRRID_0970Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANANANANANATLR9 plays a crucial role in breaking tolerance and developing autoimmunity NA219554432011NA
PRRID_0971Uropathogenic E. coli

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BacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanMyeloid cells, uroepithelial cellsNANANANATLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA219825582011NA
PRRID_0971Uropathogenic E. coli

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BacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanMyeloid cells, uroepithelial cellsNANANANATLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA219825582011NA
PRRID_0972Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0972Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMyeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neuronsNAO60603.fastaO60603784plays a fundamental role in pathogen recognition and activation of innate immunityNA219825582011Pubchem Assay
PRRID_0973Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0973Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0974Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0974Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA219554432011NA
PRRID_0975Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0975Zymosan

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FungiC(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)NANANANANANAsignificant role in the pathogenesis of severe inflammatory responses NA219554432011NA
PRRID_0976ANA773

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Anadys Pharmaceuticals (others)NANAprodrug of isatoribineSyntheticImmunostimulantToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNANAQ9NYK1.fastaQ9NYK11049Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.NA230172462012Pubchem Assay
PRRID_0976ANA773

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Anadys Pharmaceuticals (others)NANAprodrug of isatoribineSyntheticImmunostimulantToll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanNANAQ9NYK1.fastaQ9NYK11049Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.NA230172462012Pubchem Assay