Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0891	Fusion protein Click for more detail	Respiratory syncytial virus (virus)	MELLIHRLSAIFLTLAINALYLTSSQNITEEFYQSTCSAVSRGYFSALRTGWYTSVITIELSNIKETKCNGTDTKVKLIKQELDKYKNAVTELQLLMQNTPAANNRARREAPQYMNYTINTTKNLNVSISKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKNALLSTNKAVVSLSNGVSVLTSKVLDLKNYINNQLLPIVNQQSCRISNIETVIEFQQKNSRLLEINREFSVNAGVTTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPIYGVIDTPCWKLHTSPLCTTNIKEGSNICLTRTDRGWYCDNAGSVSFFPQADTCKVQSNRVFCDTMNSLTLPSEVSLCNTDIFNSKYDCKIMTSKTDISSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKNLYVKGEPIINYYDPLVFPSDEFDASISQVNEKINQSLAFIRRSDELLHNVNTGKSTTNIMITTIIIVIIVVLLSLIAIGLLLYCKAKNTPVTLSKDQLSGINNIAFSK	574	Protein	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0891	Fusion protein Click for more detail	Respiratory syncytial virus (virus)	MELLIHRLSAIFLTLAINALYLTSSQNITEEFYQSTCSAVSRGYFSALRTGWYTSVITIELSNIKETKCNGTDTKVKLIKQELDKYKNAVTELQLLMQNTPAANNRARREAPQYMNYTINTTKNLNVSISKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKNALLSTNKAVVSLSNGVSVLTSKVLDLKNYINNQLLPIVNQQSCRISNIETVIEFQQKNSRLLEINREFSVNAGVTTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIVRQQSYSIMSIIKEEVLAYVVQLPIYGVIDTPCWKLHTSPLCTTNIKEGSNICLTRTDRGWYCDNAGSVSFFPQADTCKVQSNRVFCDTMNSLTLPSEVSLCNTDIFNSKYDCKIMTSKTDISSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKLEGKNLYVKGEPIINYYDPLVFPSDEFDASISQVNEKINQSLAFIRRSDELLHNVNTGKSTTNIMITTIIIVIIVVLLSLIAIGLLLYCKAKNTPVTLSKDQLSGINNIAFSK	574	Protein	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21955443	2011	NA
PRRID_0908	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0908	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0909	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	neutrophils, macrophages, and dendritic cells	TIR domain- containing adaptor protein-inducing IFN-	Q9QUK6.fasta	Q9QUK6	835	triggers the innate immune response and leads to the induction of adaptive immunity	NA	21949773	2011	Pubchem Assay
PRRID_0909	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	neutrophils, macrophages, and dendritic cells	TIR domain- containing adaptor protein-inducing IFN-	Q9QUK6.fasta	Q9QUK6	835	triggers the innate immune response and leads to the induction of adaptive immunity	NA	21949773	2011	Pubchem Assay
PRRID_0948	phenol-soluble modulin Click for more detail	S. aureus (Bacteria)	MEFVAKLFKFFKDLLGKFLGNN	22	Protein	Natural	triggers immune responses	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0948	phenol-soluble modulin Click for more detail	S. aureus (Bacteria)	MEFVAKLFKFFKDLLGKFLGNN	22	Protein	Natural	triggers immune responses	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0949	phenol-soluble modulin Click for more detail	Staphylococcus epidermidis (Bacteria)	MEFVAKLFKFFKDLLGKFLGNN	22	Protein	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0949	phenol-soluble modulin Click for more detail	Staphylococcus epidermidis (Bacteria)	MEFVAKLFKFFKDLLGKFLGNN	22	Protein	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21955443	2011	NA
PRRID_0953	Porins Click for more detail	outer membrane of bacterial cell wall (others)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	act as a pore, through which molecules can diffuse	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0953	Porins Click for more detail	outer membrane of bacterial cell wall (others)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	act as a pore, through which molecules can diffuse	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0955	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	induction of immune response against T. gondii	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	Myeloid cells, uroepithelial cells	NA	NA	NA	NA	induces the release of interleukin 12 against T. gondii infected mice	NA	21982558	2011	NA
PRRID_0955	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	induction of immune response against T. gondii	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	Myeloid cells, uroepithelial cells	NA	NA	NA	NA	induces the release of interleukin 12 against T. gondii infected mice	NA	21982558	2011	NA
PRRID_0956	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	potently activate the innate immune system through its specific recognition by TLR11, which plays an important role in T. gondii infection in mice	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR11 plays a fundamental role in both the¬†innate¬†and¬†adaptive¬†immune responses, through the activation of¬†Tumor necrosis factor-alpha,the¬†Interleukin 12¬†(IL-12) response and¬†Interferon-gamma¬†(IFN-gamma) secretion.	NA	21955443	2011	NA
PRRID_0956	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	potently activate the innate immune system through its specific recognition by TLR11, which plays an important role in T. gondii infection in mice	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR11 plays a fundamental role in both the¬†innate¬†and¬†adaptive¬†immune responses, through the activation of¬†Tumor necrosis factor-alpha,the¬†Interleukin 12¬†(IL-12) response and¬†Interferon-gamma¬†(IFN-gamma) secretion.	NA	21955443	2011	NA
PRRID_0964	surfactant protein-A Click for more detail	Endogenous (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0964	surfactant protein-A Click for more detail	Endogenous (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0995	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Immunostimulant	CCR6	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	Neutralizing antibodies	NA	22982943	2012	NA
PRRID_0995	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Immunostimulant	CCR6	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	Neutralizing antibodies	NA	22982943	2012	NA
PRRID_0996	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Neutralizing antibodies	NA	22982943	2012	NA
PRRID_0996	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Neutralizing antibodies	NA	22982943	2012	NA
PRRID_1042	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	Toll/IL-1R (TIR) domain	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem_assay
PRRID_1042	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	Toll/IL-1R (TIR) domain	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem_assay
PRRID_1043	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1043	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1045	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1045	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1047	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1047	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1048	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NF-	24098508	2013	Pubchem_assay
PRRID_1048	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NF-	24098508	2013	Pubchem_assay
PRRID_1049	Flagellin Click for more detail	Pseudomonas aeruginosa (Bacteria)	MALTVNTNIASLNTQRNLNASSNDLNTSLQRLTTGYRINSAKDDAAGLQISNRLSNQISGLNVATRNANDGISLAQTAEGALQQSTNILQRIRDLALQSANGSNSDADRAALQKEVAAQQAELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTIVTGYVQLNSPTAYSVSGTGTQASQVFGNASAAQKSSVASVDISTADGAQNAIAVVDNALAAIDAQRADLGAVQNRFKNTIDNLTNISENATNARSRIKDTDFAAETAALSKNQVLQQAGTAILAQANQLPQAVLSLLR	488	Protein	Natural	involved in the upregulation of airway serous secretion	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Swine	tracheal submucosal acinar glands	NA	NA	NA	NA	TLR5 is also involved in the airway mucosal defense systems as a unique endogenous potentiator of elec- trolyte-water secretion from submucosal gland acinar cells and that NO/cGMP/cGK signaling is involved in this rapid TLR5 signaling pathway	RT-PCR, Intracellular calcium assays	24097563	2013	NA
PRRID_1049	Flagellin Click for more detail	Pseudomonas aeruginosa (Bacteria)	MALTVNTNIASLNTQRNLNASSNDLNTSLQRLTTGYRINSAKDDAAGLQISNRLSNQISGLNVATRNANDGISLAQTAEGALQQSTNILQRIRDLALQSANGSNSDADRAALQKEVAAQQAELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTIVTGYVQLNSPTAYSVSGTGTQASQVFGNASAAQKSSVASVDISTADGAQNAIAVVDNALAAIDAQRADLGAVQNRFKNTIDNLTNISENATNARSRIKDTDFAAETAALSKNQVLQQAGTAILAQANQLPQAVLSLLR	488	Protein	Natural	involved in the upregulation of airway serous secretion	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Swine	tracheal submucosal acinar glands	NA	NA	NA	NA	TLR5 is also involved in the airway mucosal defense systems as a unique endogenous potentiator of elec- trolyte-water secretion from submucosal gland acinar cells and that NO/cGMP/cGK signaling is involved in this rapid TLR5 signaling pathway	RT-PCR, Intracellular calcium assays	24097563	2013	NA
PRRID_1052	Glycolipids Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	Play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1052	Glycolipids Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	Play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1054	H protein Click for more detail	fimbriae of Escherichia coli (Bacteria)	MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ	137	Protein	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1054	H protein Click for more detail	fimbriae of Escherichia coli (Bacteria)	MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ	137	Protein	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1057	Heat-shock protein 70 Click for more detail	Host (Endogenous) (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1057	Heat-shock protein 70 Click for more detail	Host (Endogenous) (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1058	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1058	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1062	Heat-shock proteins 60 Click for more detail	Host (Endogenous) (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1062	Heat-shock proteins 60 Click for more detail	Host (Endogenous) (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1067	HMGB1 Click for more detail	Neisseria meningitidis (Bacteria)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1067	HMGB1 Click for more detail	Neisseria meningitidis (Bacteria)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1068	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1068	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1070	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1070	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1071	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	O00206.fasta	O00206	839	Polymorphisms of HMBG1 are associated with GVHD, TRM and OS	NA	23985302	2013	Pubchem_assay
PRRID_1071	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	O00206.fasta	O00206	839	Polymorphisms of HMBG1 are associated with GVHD, TRM and OS	NA	23985302	2013	Pubchem_assay
PRRID_1072	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), Toll-like receptor 9 (TLR9), RAGE and CD24	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	NA
PRRID_1072	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), Toll-like receptor 9 (TLR9), RAGE and CD24	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	NA	NA	NA	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	NA
PRRID_1125	Porins Click for more detail	Fungi	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1125	Porins Click for more detail	Fungi	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1129	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	Cell Surface (Exogenous)	Q6R5P0.fasta	Q6R5P0	926	¬†TLR11 plays a fundamental role in both the¬†innate¬†and¬†adaptive¬†immune responses, through the activation of¬†Tumor necrosis factor-alpha,the¬†Interleukin 12¬†(IL-12) response and¬†Interferon-gamma¬†(IFN-gamma) secretion.	NA	23985302	2013	Pubchem_assay
PRRID_1129	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	Cell Surface (Exogenous)	Q6R5P0.fasta	Q6R5P0	926	¬†TLR11 plays a fundamental role in both the¬†innate¬†and¬†adaptive¬†immune responses, through the activation of¬†Tumor necrosis factor-alpha,the¬†Interleukin 12¬†(IL-12) response and¬†Interferon-gamma¬†(IFN-gamma) secretion.	NA	23985302	2013	Pubchem_assay
PRRID_1173	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1173	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1180	amidation of the mesoDAP Click for more detail	PGN of Gram-positive bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Protein	Natural	activates NOD2 but not recognised by NOD2	Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R)	NOD-like receptor (NLR)	Mice	most adult tissues	intracellular receptors	Q8BHB0.fasta	Q8BHB0	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1180	amidation of the mesoDAP Click for more detail	PGN of Gram-positive bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Protein	Natural	activates NOD2 but not recognised by NOD2	Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R)	NOD-like receptor (NLR)	Mice	most adult tissues	intracellular receptors	Q8BHB0.fasta	Q8BHB0	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1181	amidation of the mesoDAP Click for more detail	PGN of Gram-positive bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Protein	Natural	activates NOD2 but not recognised by NOD2	CAD	NOD-like receptor (NLR)	Human	most adult tissues	intracellular receptors	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1181	amidation of the mesoDAP Click for more detail	PGN of Gram-positive bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Protein	Natural	activates NOD2 but not recognised by NOD2	CAD	NOD-like receptor (NLR)	Human	most adult tissues	intracellular receptors	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1192	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	CAD	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1192	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	CAD	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1193	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Caspase-1	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1193	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Caspase-1	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1194	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	HSP90	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1194	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	HSP90	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1195	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1195	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1196	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1196	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1197	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Nod-like receptor protein 12 (NLRP12)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1197	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Nod-like receptor protein 12 (NLRP12)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1198	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	RIP2	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1198	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	RIP2	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1199	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	SOCS-3	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1199	CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	SOCS-3	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1201	CARDS Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Rac1	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1201	CARDS Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	Rac1	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1202	LRR Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	DUOX2	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1202	LRR Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	DUOX2	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1203	CARDS Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	FRMPD2	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1203	CARDS Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	FRMPD2	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1276	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It directly interacts with TLR 5 and induces immune response	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	Cell Surface (Exogenous)	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24830024	2014	Pubchem_assay
PRRID_1276	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It directly interacts with TLR 5 and induces immune response	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	Cell Surface (Exogenous)	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24830024	2014	Pubchem_assay
PRRID_1277	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It directly interacts with TLR 5 and induces immune response	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	mast cells	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1277	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It directly interacts with TLR 5 and induces immune response	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	mast cells	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1278	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24807166	2014	Pubchem_assay
PRRID_1278	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24807166	2014	Pubchem_assay
PRRID_1279	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24807166	2014	Pubchem_assay
PRRID_1279	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24807166	2014	Pubchem_assay
PRRID_1280	Flagellin Click for more detail	Salmonella typhimurium(Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q5GR02.fasta	Q5GR02	862	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1280	Flagellin Click for more detail	Salmonella typhimurium(Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q5GR02.fasta	Q5GR02	862	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1281	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	medullary collecting duct (MCD) cells	cell surface	Q9JLF7.fasta	Q9JLF7	859	TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs)	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1281	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	medullary collecting duct (MCD) cells	cell surface	Q9JLF7.fasta	Q9JLF7	859	TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs)	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1282	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	medullary collecting duct (MCD) cells	cell surface	O60602.fasta	O60602	858	TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs)	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1282	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	medullary collecting duct (MCD) cells	cell surface	O60602.fasta	O60602	858	TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs)	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay

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