| Primary information |
|---|
| PRRID | PRRID_1282 |
| Ligand Name | Flagellin |
| Source | Flagellated bacteria (Bacteria) |
| Sequence of ligand | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR |
| Length | 495 |
| Type | Protein |
| Occurence | Natural |
| Role of Ligand | most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC |
| Name of receptor | Toll-like receptor 5 (TLR5) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | medullary collecting duct (MCD) cells |
| Domain | cell surface |
| Sequence of Receptor | O60602.fasta |
| Swiss prot ID | O60602 |
| Length Of Receptor | 858 |
| Function | TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs) |
| Assay used | ELISA, adhesion and invasion assay |
| PMID | 24779433 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |
| Primary information |
|---|
| PRRID | PRRID_1282 |
| Ligand Name | Flagellin |
| Source | Flagellated bacteria (Bacteria) |
| Sequence of ligand | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR |
| Length | 495 |
| Type | Protein |
| Occurence | Natural |
| Role of Ligand | most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC |
| Name of receptor | Toll-like receptor 5 (TLR5) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | medullary collecting duct (MCD) cells |
| Domain | cell surface |
| Sequence of Receptor | O60602.fasta |
| Swiss prot ID | O60602 |
| Length Of Receptor | 858 |
| Function | TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs) |
| Assay used | ELISA, adhesion and invasion assay |
| PMID | 24779433 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |