Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_1601 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Male BALB/c mice | Myeloid-derived suppressor cells (MDSCs) | Intracellular receptors | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | Functional assay | 24748512 | 2014 | Pubchem_assay |
| PRRID_1601 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Male BALB/c mice | Myeloid-derived suppressor cells (MDSCs) | Intracellular receptors | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | Functional assay | 24748512 | 2014 | Pubchem_assay |
| PRRID_1602 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Male BALB/c mice | Myeloid-derived suppressor cells (MDSCs) | Intracellular receptors | P58682.fasta | P58682 | 1032 | important role in the immune response to viral infection | Functional assay | 24748512 | 2014 | Pubchem_assay |
| PRRID_1602 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Male BALB/c mice | Myeloid-derived suppressor cells (MDSCs) | Intracellular receptors | P58682.fasta | P58682 | 1032 | important role in the immune response to viral infection | Functional assay | 24748512 | 2014 | Pubchem_assay |
| PRRID_1603 | resistin (RSTN)] Click for more detail | Primates, rodents (others) | MKNLSFPLLFLFFLVPELLGSSMPLCPIDEAIDKKIKQDFNSLFPNAIKNIGLNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREEKVCHCQCARIDWTAARCCKLQVAS | 114 | Pattern-associated molecular patterns (PAMPs) | Natural | associated with atherosclerosis. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24823872 | 2014 | Pubchem_assay |
| PRRID_1603 | resistin (RSTN)] Click for more detail | Primates, rodents (others) | MKNLSFPLLFLFFLVPELLGSSMPLCPIDEAIDKKIKQDFNSLFPNAIKNIGLNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREEKVCHCQCARIDWTAARCCKLQVAS | 114 | Pattern-associated molecular patterns (PAMPs) | Natural | associated with atherosclerosis. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24823872 | 2014 | Pubchem_assay |
| PRRID_1647 | Tenascin C Click for more detail | Human (others) | MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS | 2110 | Pattern-associated molecular patterns (PAMPs) | Natural | TN-C clearly plays a role in cell signaling as evidenced by its ability to be induced during events such as trauma, inflammation, or cancer development. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Cell Surface (Exogenous) | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1647 | Tenascin C Click for more detail | Human (others) | MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS | 2110 | Pattern-associated molecular patterns (PAMPs) | Natural | TN-C clearly plays a role in cell signaling as evidenced by its ability to be induced during events such as trauma, inflammation, or cancer development. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | Cell Surface (Exogenous) | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1648 | Tenascin C Click for more detail | Human (others) | MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS | 2201 | Pattern-associated molecular patterns (PAMPs) | Natural | associated with chronic inflammatory conditions | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | fibrinogen-like domain (FBG) | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24823872 | 2014 | Pubchem_assay |
| PRRID_1648 | Tenascin C Click for more detail | Human (others) | MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS | 2201 | Pattern-associated molecular patterns (PAMPs) | Natural | associated with chronic inflammatory conditions | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | fibrinogen-like domain (FBG) | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24823872 | 2014 | Pubchem_assay |
| PRRID_1673 | Uropathogenic E. coli Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | Cell Surface (Exogenous) | Q6R5P0.fasta | Q6R5P0 | 926 | TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion. | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1673 | Uropathogenic E. coli Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | Cell Surface (Exogenous) | Q6R5P0.fasta | Q6R5P0 | 926 | TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion. | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1674 | VTX-2337 Click for more detail | mimics viral single-stranded ribonucleic acid (ssRNA) (virus) | CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N | NA | Pattern-associated molecular patterns (PAMPs) | Natural | stimulates TLR8 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | TLR8 is expressed on mDCs, monocytes, and NK cells in humans | cell compartment | P58682.fasta | P58682 | 1032 | TLR8 is expected to stimulate the release of distinct inflammatory mediators, including Th1- polarizing cytokines, chemokines, and other acute phase proteins | NA | 24807889 | 2014 | Pubchem_assay |
| PRRID_1674 | VTX-2337 Click for more detail | mimics viral single-stranded ribonucleic acid (ssRNA) (virus) | CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N | NA | Pattern-associated molecular patterns (PAMPs) | Natural | stimulates TLR8 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | TLR8 is expressed on mDCs, monocytes, and NK cells in humans | cell compartment | P58682.fasta | P58682 | 1032 | TLR8 is expected to stimulate the release of distinct inflammatory mediators, including Th1- polarizing cytokines, chemokines, and other acute phase proteins | NA | 24807889 | 2014 | Pubchem_assay |
| PRRID_1675 | VTX-2337 Click for more detail | mimics viral single-stranded ribonucleic acid (ssRNA) (virus) | CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N | NA | Pattern-associated molecular patterns (PAMPs) | Natural | stimulates TLR8 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | TLR8 is expressed on mDCs, monocytes, and NK cells in humans | cell compartment | Q9NR97.fasta | Q9NR97 | 1041 | TLR8 is expected to stimulate the release of distinct inflammatory mediators, including Th1- polarizing cytokines, chemokines, and other acute phase proteins | NA | 24807889 | 2014 | Pubchem_assay |
| PRRID_1675 | VTX-2337 Click for more detail | mimics viral single-stranded ribonucleic acid (ssRNA) (virus) | CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCCC4)N=C(C1)N | NA | Pattern-associated molecular patterns (PAMPs) | Natural | stimulates TLR8 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | TLR8 is expressed on mDCs, monocytes, and NK cells in humans | cell compartment | Q9NR97.fasta | Q9NR97 | 1041 | TLR8 is expected to stimulate the release of distinct inflammatory mediators, including Th1- polarizing cytokines, chemokines, and other acute phase proteins | NA | 24807889 | 2014 | Pubchem_assay |
| PRRID_1704 | NS1 protein Click for more detail | Dengue virus(virus) | DMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGM | 137 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | NA | NA | 27293318 | 2016 | Pubchem_assay |
| PRRID_1704 | NS1 protein Click for more detail | Dengue virus(virus) | DMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGM | 137 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | NA | NA | 27293318 | 2016 | Pubchem_assay |
| PRRID_1705 | NS1 protein Click for more detail | Dengue virus(virus) | DMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGM | 137 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1705 | NS1 protein Click for more detail | Dengue virus(virus) | DMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGM | 137 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1707 | 3M-002 Click for more detail | NA | CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | RDToll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Chinese raccoon dog | peripheral blood mononuclear cells (PBMCs) | 19 leucine-rich repeats (LRRs) in the extracel- lular domain and a cytoplasmic TIR domain | NA | NA | NA | proinflammatory cytokines TNF- a and IFN-a upregulation | qRT-PCR | 27481482 | 2016 | NA |
| PRRID_1707 | 3M-002 Click for more detail | NA | CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | RDToll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Chinese raccoon dog | peripheral blood mononuclear cells (PBMCs) | 19 leucine-rich repeats (LRRs) in the extracel- lular domain and a cytoplasmic TIR domain | NA | NA | NA | proinflammatory cytokines TNF- a and IFN-a upregulation | qRT-PCR | 27481482 | 2016 | NA |
| PRRID_1708 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | immunostimulant | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | NA | NA | NA | Controversial (induce or inhibit) | NA | 27120222 | 2016 | NA |
| PRRID_1708 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | immunostimulant | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | NA | NA | NA | Controversial (induce or inhibit) | NA | 27120222 | 2016 | NA |
| PRRID_1709 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q99MB1.fasta | Q99MB1 | 905 | Controversial (induce or inhibit) | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1709 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q99MB1.fasta | Q99MB1 | 905 | Controversial (induce or inhibit) | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1710 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | NA | NA | NA | attenuates asthma | NA | 27120222 | 2016 | NA |
| PRRID_1710 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | NA | NA | NA | attenuates asthma | NA | 27120222 | 2016 | NA |
| PRRID_1711 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | NA | NA | NA | Attenuate or inhibit | NA | 27120222 | 2016 | NA |
| PRRID_1711 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | NA | NA | NA | Attenuate or inhibit | NA | 27120222 | 2016 | NA |
| PRRID_1712 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | Attenuate or inhibit | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1712 | Agonist Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | Attenuate or inhibit | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1713 | Agonist Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Controversial (induce or inhibit) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | NA | NA | NA | Expansion of Tregs in OVA-induced asthma model | NA | 27120222 | 2016 | NA |
| PRRID_1713 | Agonist Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Controversial (induce or inhibit) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | NA | NA | NA | Expansion of Tregs in OVA-induced asthma model | NA | 27120222 | 2016 | NA |
| PRRID_1714 | Agonist Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q99MB1.fasta | Q99MB1 | 905 | NFκB↑ | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1714 | Agonist Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q99MB1.fasta | Q99MB1 | 905 | NFκB↑ | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1716 | b-1,3-glucans. Click for more detail | Bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Fenneropenaeus merguiensis | Hepatopancreas | NA | NA | NA | NA | Activate NF-KB | ELISA | 27431930 | 2016 | NA |
| PRRID_1716 | b-1,3-glucans. Click for more detail | Bacteria | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP) | Pattern recognition receptor (PRR) | Fenneropenaeus merguiensis | Hepatopancreas | NA | NA | NA | NA | Activate NF-KB | ELISA | 27431930 | 2016 | NA |
| PRRID_1717 | Bacterial 23S ribosomal RNA Click for more detail | Bacteria | GGUUAAGCGACUAAGCGUACACGGUGGAUGCCCUGGCAGUCAGAGGCGAUGAAGGACGUGCUAAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAACCGUUAUAACCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUUCGACACACUAUCAUUAACUGAAUCCAUAGGUUAAUGAGGCGAACCGGGGGAACUGAAACAUCUAAGUACCCCGAGGAAAAGAAAUCAACCGAGAUUCCCCCAGUAGCGGCGAGCGAACGGGGAGCAGCCCAGAGCCUGAAUCAGUGUGUGUGUUAGUGGAAGCGUCUGGAAAGGCGUGCGAUACAGGGUGACAGCCCCGUACACAAAAAUGCACAUGCUGUGAGCUCGAUGAGUAGGGCGGGACACGUGGUAUCCUGUCUGAAUAUGGGGGGACCAUCCUCCAAGGCUAAAUACUCCUGACUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGCGAAAAGAACCCCGGCGAGGGGAGUGAAAAAGAACCUGAAACCGUGUACGUACAAGCAGUGGGAGCACGCUUAGGCGUGUGACUGCGUACCUUUUGUAUAAUGGGUCAGCGACUUAUAUUCUGUAGCAAGGUUAACCGAAUAGGGGAGCCGAAGGGAAACCGAGUCUUAACUGGGCGUUAAGUUGCAGGGUAUAGACCCGAAACCCGGUGAUCUAGCCAUGGGCAGGUUGAAGGUUGGGUAACACUAACUGGAGGACCGAACCGACUAAUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGGAGAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUGAAUUCAUCUCCGGGGGUAGAGCACUGUUUCGGCAAGGGGGUCAUCCCGACUUACCAACCCGAUGCAAACUGCGAAUACCGGAGAAUGUUAUCACGGGAGACACACGGCGGGUGCUAACGUCCGUCGUGAAGAGGGAAACAACCCAGACCGCCAGCUA | 2905 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 13 (TLR13) | Toll-like receptor (TLR) | Mice | Plasma membrane | extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain | Q6R5N8.fasta | Q6R5N8 | 991 | Activate NF-KB | NA | 27756604 | 2016 | Pubchem_assay |
| PRRID_1717 | Bacterial 23S ribosomal RNA Click for more detail | Bacteria | GGUUAAGCGACUAAGCGUACACGGUGGAUGCCCUGGCAGUCAGAGGCGAUGAAGGACGUGCUAAUCUGCGAUAAGCGUCGGUAAGGUGAUAUGAACCGUUAUAACCGGCGAUUUCCGAAUGGGGAAACCCAGUGUGUUUCGACACACUAUCAUUAACUGAAUCCAUAGGUUAAUGAGGCGAACCGGGGGAACUGAAACAUCUAAGUACCCCGAGGAAAAGAAAUCAACCGAGAUUCCCCCAGUAGCGGCGAGCGAACGGGGAGCAGCCCAGAGCCUGAAUCAGUGUGUGUGUUAGUGGAAGCGUCUGGAAAGGCGUGCGAUACAGGGUGACAGCCCCGUACACAAAAAUGCACAUGCUGUGAGCUCGAUGAGUAGGGCGGGACACGUGGUAUCCUGUCUGAAUAUGGGGGGACCAUCCUCCAAGGCUAAAUACUCCUGACUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGCGAAAAGAACCCCGGCGAGGGGAGUGAAAAAGAACCUGAAACCGUGUACGUACAAGCAGUGGGAGCACGCUUAGGCGUGUGACUGCGUACCUUUUGUAUAAUGGGUCAGCGACUUAUAUUCUGUAGCAAGGUUAACCGAAUAGGGGAGCCGAAGGGAAACCGAGUCUUAACUGGGCGUUAAGUUGCAGGGUAUAGACCCGAAACCCGGUGAUCUAGCCAUGGGCAGGUUGAAGGUUGGGUAACACUAACUGGAGGACCGAACCGACUAAUGUUGAAAAAUUAGCGGAUGACUUGUGGCUGGGGGUGAAAGGCCAAUCAAACCGGGAGAUAGCUGGUUCUCCCCGAAAGCUAUUUAGGUAGCGCCUCGUGAAUUCAUCUCCGGGGGUAGAGCACUGUUUCGGCAAGGGGGUCAUCCCGACUUACCAACCCGAUGCAAACUGCGAAUACCGGAGAAUGUUAUCACGGGAGACACACGGCGGGUGCUAACGUCCGUCGUGAAGAGGGAAACAACCCAGACCGCCAGCUA | 2905 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 13 (TLR13) | Toll-like receptor (TLR) | Mice | Plasma membrane | extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain | Q6R5N8.fasta | Q6R5N8 | 991 | Activate NF-KB | NA | 27756604 | 2016 | Pubchem_assay |
| PRRID_1718 | BpA Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Activation of caspase1 | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1718 | BpA Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Activation of caspase1 | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1719 | BpA Click for more detail | Brugia pahangi(others) | TTCTTCTTTCCATTCTTTTCCTTTCATCGTCAATTGTAGCACGGTTAAGCAATTCAGCTAATAAACACTACTTCTGCTTGATGCGTACAGGTGCCGAGGTATTGTTTATTGGCTGAGTGCTATACCTCCAGTATTCATCG | 140 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | lymphatic vessels | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Activation of caspaseÔòª | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1719 | BpA Click for more detail | Brugia pahangi(others) | TTCTTCTTTCCATTCTTTTCCTTTCATCGTCAATTGTAGCACGGTTAAGCAATTCAGCTAATAAACACTACTTCTGCTTGATGCGTACAGGTGCCGAGGTATTGTTTATTGGCTGAGTGCTATACCTCCAGTATTCATCG | 140 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | lymphatic vessels | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Activation of caspaseÔòª | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1720 | Calcineurin B Click for more detail | NA | MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV | 170 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1720 | Calcineurin B Click for more detail | NA | MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV | 170 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1721 | cathepsin cysteine Click for more detail | S. mansoni (others) | MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN | 340 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q99MB1.fasta | Q99MB1 | 905 | Activate STAT1 | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1721 | cathepsin cysteine Click for more detail | S. mansoni (others) | MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN | 340 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q99MB1.fasta | Q99MB1 | 905 | Activate STAT1 | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1722 | cathepsin cysteine Click for more detail | Schistosoma mansoni, Fasciola hepatica (Bacteria) | MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN | 340 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | NA | NA | Q99MB1.fasta | Q99MB1 | 905 | Dampen TRIF signaling by degradation of TLR3Ôòª | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1722 | cathepsin cysteine Click for more detail | Schistosoma mansoni, Fasciola hepatica (Bacteria) | MLTSILCIASLITFLEAHISVKNEKFEPLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCESCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVIAGRIN | 340 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | NA | NA | Q99MB1.fasta | Q99MB1 | 905 | Dampen TRIF signaling by degradation of TLR3Ôòª | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1723 | Chitin Click for more detail | Fungi | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | OsCEBiP | Receptor like proteins (RLP) | Rice | NA | a lysine motif (LysM) receptor-like protein (RLP) | NA | NA | NA | to trigger immune re- sponses. | isothermal titration calorimetry (ITC) | 27238968 | 2016 | NA |
| PRRID_1723 | Chitin Click for more detail | Fungi | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | OsCEBiP | Receptor like proteins (RLP) | Rice | NA | a lysine motif (LysM) receptor-like protein (RLP) | NA | NA | NA | to trigger immune re- sponses. | isothermal titration calorimetry (ITC) | 27238968 | 2016 | NA |
| PRRID_1726 | DIP Click for more detail | D. indusiata(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | RAW264.7 cells | NA | NA | NA | NA | up-regulation of nitric oxide (NO), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) production as well as the mRNA expression levels of iNOS, IL-1β, IL-6 and TNF-α in macrophages. | Flow cytometry and confocal laser-scanning microscopy analyses | 27293036 | 2016 | NA |
| PRRID_1726 | DIP Click for more detail | D. indusiata(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | RAW264.7 cells | NA | NA | NA | NA | up-regulation of nitric oxide (NO), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) production as well as the mRNA expression levels of iNOS, IL-1β, IL-6 and TNF-α in macrophages. | Flow cytometry and confocal laser-scanning microscopy analyses | 27293036 | 2016 | NA |
| PRRID_1731 | ES-62 Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | ERK‚Üë, P38 or JNK | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1731 | ES-62 Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | ERK‚Üë, P38 or JNK | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1732 | ES-62 Click for more detail | Acanthocheilonema viteae(others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Acanthocheilonema viteae/lymphatic tissue | NA | Q9QUK6.fasta | Q9QUK6 | 835 | ERK↑, P38 or JNK MAP↓, Transient NFκB, Block mast cell degranulation | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1732 | ES-62 Click for more detail | Acanthocheilonema viteae(others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Acanthocheilonema viteae/lymphatic tissue | NA | Q9QUK6.fasta | Q9QUK6 | 835 | ERK↑, P38 or JNK MAP↓, Transient NFκB, Block mast cell degranulation | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1733 | Fag Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Endotoxemia (amelioration) | NA | NA | NA | NA | NA | Inhibits LPS mediated classical activation | NA | 27120222 | 2016 | NA |
| PRRID_1733 | Fag Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Endotoxemia (amelioration) | NA | NA | NA | NA | NA | Inhibits LPS mediated classical activation | NA | 27120222 | 2016 | NA |
| PRRID_1734 | Fag Click for more detail | Setaria Digitata (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | abdominal cavity | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Inhibits LPS mediated classical activation | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1734 | Fag Click for more detail | Setaria Digitata (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | abdominal cavity | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Inhibits LPS mediated classical activation | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1735 | FhHDM-1 Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Sepsis (amelioration) | NA | NA | NA | NA | NA | Binding to LPS and inhibits signaling | NA | 27120222 | 2016 | NA |
| PRRID_1735 | FhHDM-1 Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Sepsis (amelioration) | NA | NA | NA | NA | NA | Binding to LPS and inhibits signaling | NA | 27120222 | 2016 | NA |
| PRRID_1736 | FhHDM-1 Click for more detail | Fasciola hepatica (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Fasciola hepatica/Liver | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Binding to LPS and inhibits signaling | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1736 | FhHDM-1 Click for more detail | Fasciola hepatica (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Fasciola hepatica/Liver | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Binding to LPS and inhibits signaling | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1741 | Flavolipin Click for more detail | Flavobacterium meningosepticum (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1741 | Flavolipin Click for more detail | Flavobacterium meningosepticum (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1749 | HDM Click for more detail | Helminths (others) | RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN | 70 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Alter the response of B cells (‚ÜëIgGÔõú) | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1749 | HDM Click for more detail | Helminths (others) | RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN | 70 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Alter the response of B cells (‚ÜëIgGÔõú) | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1750 | HDM Click for more detail | Schistosoma mansoni, Fasciola hepatica (Bacteria) | RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN | 70 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Alter the response of B cells (‚ÜëIgGÔõú) | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1750 | HDM Click for more detail | Schistosoma mansoni, Fasciola hepatica (Bacteria) | RPSEESREKLRESGRKMVKALRDAVTKAYEKARDRAMAYLAKDNLGEKITEVITILLNRLTDRLEKYAGN | 70 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Alter the response of B cells (‚ÜëIgGÔõú) | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1751 | Heat shock protein Click for more detail | O. tsutsugamushi (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 572 | Pattern-associated molecular patterns (PAMPs) | Natural | Cause Scrub typhus, immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | HEK293 cells | TIR domain | Q9QUN7.fasta | Q9QUN7 | 784 | secretion of TNF-α and IL-6 by dendritic cells | ELISA | 27620720 | 2016 | Pubchem_assay |
| PRRID_1751 | Heat shock protein Click for more detail | O. tsutsugamushi (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 572 | Pattern-associated molecular patterns (PAMPs) | Natural | Cause Scrub typhus, immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | HEK293 cells | TIR domain | Q9QUN7.fasta | Q9QUN7 | 784 | secretion of TNF-α and IL-6 by dendritic cells | ELISA | 27620720 | 2016 | Pubchem_assay |
| PRRID_1752 | High-mannose and fucose glycans Click for more detail | Mycobacterium spp., H. pylori, Lactobacillus spp., Leishmania spp., HIV-1, Dengue virus, Measles vir | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | DC-SIGN | C type Lectin (CTL/CLR) | Human | NA | NA | Q9H2X3.fasta | Q9H2X3 | 399 | Pathogen recognition; Antigen uptake; APC/T cell interactions; Cell migration | NA | 27999992 | 2016 | Pubchem_assay |
| PRRID_1752 | High-mannose and fucose glycans Click for more detail | Mycobacterium spp., H. pylori, Lactobacillus spp., Leishmania spp., HIV-1, Dengue virus, Measles vir | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | DC-SIGN | C type Lectin (CTL/CLR) | Human | NA | NA | Q9H2X3.fasta | Q9H2X3 | 399 | Pathogen recognition; Antigen uptake; APC/T cell interactions; Cell migration | NA | 27999992 | 2016 | Pubchem_assay |
| PRRID_1753 | High-mannose glycans Click for more detail | M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-2 | C type Lectin (CTL/CLR) | Human | NA | NA | Q6EIG7.fasta | Q6EIG7 | 209 | Pathogen recognition; antigen uptake | NA | 27999992 | 2016 | Pubchem_assay |
| PRRID_1753 | High-mannose glycans Click for more detail | M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-2 | C type Lectin (CTL/CLR) | Human | NA | NA | Q6EIG7.fasta | Q6EIG7 | 209 | Pathogen recognition; antigen uptake | NA | 27999992 | 2016 | Pubchem_assay |
| PRRID_1754 | HSP Gp96 Click for more detail | NA | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1754 | HSP Gp96 Click for more detail | NA | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1755 | HSP70L1 Click for more detail | NA | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1755 | HSP70L1 Click for more detail | NA | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | Activate NF-Kb | NA | 27293318 | 2016 | NA |
| PRRID_1756 | Lewis antigens Click for more detail | Mycobacterium spp., H. pylori, Lactobacillus spp., Leishmania spp., HIV-1, Dengue virus, Measles vir | CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)O)O)O)CO)O)NC(=O)C)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | DC-SIGN | C type Lectin (CTL/CLR) | Human | NA | NA | Q9H2X3.fasta | Q9H2X3 | 399 | Pathogen recognition; Antigen uptake; APC/T cell interactions; Cell migration | NA | 27999992 | 2016 | Pubchem_assay |
| PRRID_1756 | Lewis antigens Click for more detail | Mycobacterium spp., H. pylori, Lactobacillus spp., Leishmania spp., HIV-1, Dengue virus, Measles vir | CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)O)O)O)CO)O)NC(=O)C)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | DC-SIGN | C type Lectin (CTL/CLR) | Human | NA | NA | Q9H2X3.fasta | Q9H2X3 | 399 | Pathogen recognition; Antigen uptake; APC/T cell interactions; Cell migration | NA | 27999992 | 2016 | Pubchem_assay |
| PRRID_1757 | Lipopeptides Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | F1QWS9.fasta | F1QWS9 | 818 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1757 | Lipopeptides Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Zebrafish | Plasma membrane | extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain | F1QWS9.fasta | F1QWS9 | 818 | induce IFN expression | NA | 27721456 | 2016 | Pubchem_assay |
| PRRID_1760 | lipophosphoglycans (LPG) Click for more detail | Leishmania infantum (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Causes visceral and cutaneous leishmaniasis, immunomodulatory | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | activate MAPKs and the NF-κB inhibitor p-IκBα, | NA | 27508930 | 2016 | Pubchem_assay |
| PRRID_1760 | lipophosphoglycans (LPG) Click for more detail | Leishmania infantum (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Causes visceral and cutaneous leishmaniasis, immunomodulatory | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | activate MAPKs and the NF-κB inhibitor p-IκBα, | NA | 27508930 | 2016 | Pubchem_assay |
| PRRID_1761 | lipophosphoglycans (LPG) Click for more detail | Leishmania braziliensis (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Causes visceral and cutaneous leishmaniasis, immunomodulatory | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | activate MAPKs and the NF-κB inhibitor p-IκBα, | NA | 27508930 | 2016 | Pubchem_assay |
| PRRID_1761 | lipophosphoglycans (LPG) Click for more detail | Leishmania braziliensis (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Causes visceral and cutaneous leishmaniasis, immunomodulatory | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | activate MAPKs and the NF-κB inhibitor p-IκBα, | NA | 27508930 | 2016 | Pubchem_assay |
| PRRID_1794 | LNFPlll Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Psoriasis, Type diabet, EAE (amelioration) | NA | NA | NA | NA | NA | NFκB↑ | NA | 27120222 | 2016 | NA |
| PRRID_1794 | LNFPlll Click for more detail | Helminths (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Psoriasis, Type diabet, EAE (amelioration) | NA | NA | NA | NA | NA | NFκB↑ | NA | 27120222 | 2016 | NA |
| PRRID_1795 | LNFPlll Click for more detail | S. mansoni (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | blood vessels(human and mice) | NA | Q9QUK6.fasta | Q9QUK6 | 835 | NFκB↑ | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1795 | LNFPlll Click for more detail | S. mansoni (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | blood vessels(human and mice) | NA | Q9QUK6.fasta | Q9QUK6 | 835 | NFκB↑ | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1798 | LPS (HDM and fungal allergens) Click for more detail | NA | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Controversial (induce or inhibit) | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1798 | LPS (HDM and fungal allergens) Click for more detail | NA | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | Controversial (induce or inhibit) | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1799 | Lyso-PS lipids Click for more detail | S. mansoni (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUN7.fasta | Q9QUN7 | 784 | ND | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1799 | Lyso-PS lipids Click for more detail | S. mansoni (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUN7.fasta | Q9QUN7 | 784 | ND | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1800 | Lyso-PS lipids Click for more detail | S. mansoni (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUN7.fasta | Q9QUN7 | 784 | ND | NA | 27120222 | 2016 | Pubchem_assay |
| PRRID_1800 | Lyso-PS lipids Click for more detail | S. mansoni (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUN7.fasta | Q9QUN7 | 784 | ND | NA | 27120222 | 2016 | Pubchem_assay |