Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0378 | Pseudomonas aeruginosa Click for more detail | Pseudomonas aeruginosa (Bacteria) | NA | NA | Whole organism | Natural | P. aeruginosa activates NF-kappaB and MAPK, leads to the producion of proinflammatory cytokines. | Mannose receptor | Mannose receptor (MR) | Human | Monocytes | NA | P22897.fasta | P22897 | 1456 | It has the role in the inflammation. | ELISA | 19197942 | 2009 | Pubchem Assay |
| PRRID_0378 | Pseudomonas aeruginosa Click for more detail | Pseudomonas aeruginosa (Bacteria) | NA | NA | Whole organism | Natural | P. aeruginosa activates NF-kappaB and MAPK, leads to the producion of proinflammatory cytokines. | Mannose receptor | Mannose receptor (MR) | Human | Monocytes | NA | P22897.fasta | P22897 | 1456 | It has the role in the inflammation. | ELISA | 19197942 | 2009 | Pubchem Assay |
| PRRID_0379 | SIMRA Compound 1 Click for more detail | NA | 5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0379 | SIMRA Compound 1 Click for more detail | NA | 5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0380 | SIMRA Compound 1 Click for more detail | NA | 5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0380 | SIMRA Compound 1 Click for more detail | NA | 5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0381 | SIMRA Compound 1 Click for more detail | NA | 5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0381 | SIMRA Compound 1 Click for more detail | NA | 5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0382 | SIMRA Compound 2 Click for more detail | NA | 5'-UG*CUG*CUUG*UG*-X-G*UG*UUCG*UCG*U-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0382 | SIMRA Compound 2 Click for more detail | NA | 5'-UG*CUG*CUUG*UG*-X-G*UG*UUCG*UCG*U-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0383 | SIMRA Compound 2 Click for more detail | NA | 5'-UG*CUG*CUUG*UG*-X-G*UG*UUCG*UCG*U-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0383 | SIMRA Compound 2 Click for more detail | NA | 5'-UG*CUG*CUUG*UG*-X-G*UG*UUCG*UCG*U-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0384 | SIMRA Compound 2 Click for more detail | NA | 5'-UG*CUG*CUUG*UG*-X-G*UG*UUCG*UCG*U-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0384 | SIMRA Compound 2 Click for more detail | NA | 5'-UG*CUG*CUUG*UG*-X-G*UG*UUCG*UCG*U-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0385 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0385 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0386 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0386 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0387 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | PBMCs | NA | NA | NA | NA | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | NA |
| PRRID_0387 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | PBMCs | NA | NA | NA | NA | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | NA |
| PRRID_0388 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | pDCs | NA | NA | NA | NA | This induces the inflammatory response. | NA | 19269175 | 2009 | NA |
| PRRID_0388 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | pDCs | NA | NA | NA | NA | This induces the inflammatory response. | NA | 19269175 | 2009 | NA |
| PRRID_0390 | SIMRA Compound 4 Click for more detail | NA | 5'-U*GCU*GCUUGUG-X-GUGUUCGU*CGU*-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0390 | SIMRA Compound 4 Click for more detail | NA | 5'-U*GCU*GCUUGUG-X-GUGUUCGU*CGU*-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0391 | SIMRA Compound 4 Click for more detail | NA | 5'-U*GCU*GCUUGUG-X-GUGUUCGU*CGU*-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0391 | SIMRA Compound 4 Click for more detail | NA | 5'-U*GCU*GCUUGUG-X-GUGUUCGU*CGU*-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0392 | SIMRA Compound 4 Click for more detail | NA | 5'-U*GCU*GCUUGUG-X-GUGUUCGU*CGU*-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0392 | SIMRA Compound 4 Click for more detail | NA | 5'-U*GCU*GCUUGUG-X-GUGUUCGU*CGU*-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0393 | SIMRA Compound 5 Click for more detail | NA | 5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0393 | SIMRA Compound 5 Click for more detail | NA | 5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0394 | SIMRA Compound 5 Click for more detail | NA | 5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0394 | SIMRA Compound 5 Click for more detail | NA | 5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0395 | SIMRA Compound 5 Click for more detail | NA | 5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0395 | SIMRA Compound 5 Click for more detail | NA | 5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0396 | SIMRA Compound 6 Click for more detail | NA | 5'-UGUUGUGUGA*C-X-CA*GUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0396 | SIMRA Compound 6 Click for more detail | NA | 5'-UGUUGUGUGA*C-X-CA*GUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | HEK293XL cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0397 | SIMRA Compound 6 Click for more detail | NA | 5'-UGUUGUGUGA*C-X-CA*GUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0397 | SIMRA Compound 6 Click for more detail | NA | 5'-UGUUGUGUGA*C-X-CA*GUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | PBMC assay | 19269175 | 2009 | Pubchem Assay |
| PRRID_0398 | SIMRA Compound 6 Click for more detail | NA | 5'-UGUUGUGUGA*C-X-CA*GUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0398 | SIMRA Compound 6 Click for more detail | NA | 5'-UGUUGUGUGA*C-X-CA*GUGUGUUGU-5' | 23 | Nucleic Acid | Synthetic | SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-γ, IFN-α, IL-12, TNF-α, MIP-1α, MIP-1β. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | pDCs | NA | Q9NR97.fasta | Q9NR97 | 1041 | This induces the inflammatory response. | NA | 19269175 | 2009 | Pubchem Assay |
| PRRID_0400 | Viral Genome Click for more detail | Rabies virus (virus) | NA | NA | Nucleic Acid | Natural | Rabies genome is a potent activator of TLR3 | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Neuronal cells | NA | O15455.fasta | O15455 | 904 | TLR3 is involved in the spatial arrangement of rabies virus–induced NBs and viral replication. | NA | 19247444 | 2009 | Pubchem Assay |
| PRRID_0400 | Viral Genome Click for more detail | Rabies virus (virus) | NA | NA | Nucleic Acid | Natural | Rabies genome is a potent activator of TLR3 | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Neuronal cells | NA | O15455.fasta | O15455 | 904 | TLR3 is involved in the spatial arrangement of rabies virus–induced NBs and viral replication. | NA | 19247444 | 2009 | Pubchem Assay |
| PRRID_0402 | 3pRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | Their binding leads to the enhanced production of IFN- | RIG-1 | Rig-like receptor (RLR) | Human | NK cells | NA | O95786.fasta | O95786 | 925 | It resulted in direct activation NK cells leading to high IFN-γ production in synergy with mDC-released soluble mediators induced by dsRNA | NA | 20639488 | 2010 | Pubchem Assay |
| PRRID_0402 | 3pRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | Their binding leads to the enhanced production of IFN- | RIG-1 | Rig-like receptor (RLR) | Human | NK cells | NA | O95786.fasta | O95786 | 925 | It resulted in direct activation NK cells leading to high IFN-γ production in synergy with mDC-released soluble mediators induced by dsRNA | NA | 20639488 | 2010 | Pubchem Assay |
| PRRID_0404 | A46R Click for more detail | Vaccinia(virus) | MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALANIYLIVFQYLSYLDYDTIYVSIYAGTLRA | 214 | Protein | Natural | Suppress NF-κB activation (Bind to MyD88, TRAM, and TRIF) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0404 | A46R Click for more detail | Vaccinia(virus) | MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALANIYLIVFQYLSYLDYDTIYVSIYAGTLRA | 214 | Protein | Natural | Suppress NF-κB activation (Bind to MyD88, TRAM, and TRIF) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0405 | A52R Click for more detail | Vaccinia(virus) | MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS | 190 | Protein | Natural | Suppress NF-κB activation (Bind to IRAK2) and | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0405 | A52R Click for more detail | Vaccinia(virus) | MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS | 190 | Protein | Natural | Suppress NF-κB activation (Bind to IRAK2) and | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0406 | A52R Click for more detail | Vaccinia(virus) | MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS | 190 | Protein | Natural | Activate p38 MAPK and JNK (Bind to TRAF6) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Induce IL-10 production | NA | 20672047 | 2010 | NA |
| PRRID_0406 | A52R Click for more detail | Vaccinia(virus) | MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS | 190 | Protein | Natural | Activate p38 MAPK and JNK (Bind to TRAF6) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Induce IL-10 production | NA | 20672047 | 2010 | NA |
| PRRID_0407 | acylated LprA Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | Induced IL-8 secretion | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Phagocytosis | ELISA | 20694006 | 2010 | Pubchem Assay |
| PRRID_0407 | acylated LprA Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | Induced IL-8 secretion | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Phagocytosis | ELISA | 20694006 | 2010 | Pubchem Assay |
| PRRID_0408 | acylated LprG Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | Delivery of glycolipds to TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Phagocytosis | ELISA | 20694006 | 2010 | Pubchem Assay |
| PRRID_0408 | acylated LprG Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | Delivery of glycolipds to TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Phagocytosis | ELISA | 20694006 | 2010 | Pubchem Assay |
| PRRID_0426 | Bacterial DNA Click for more detail | Porphyromonas gingivalis and Tannerella forsythia (Bacteria) | NA | NA | Nucleic Acid | Natural | It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF- | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Monocytic cells (THP-1 cells) | LRR | Q9NR96.fasta | Q9NR96 | 1032 | Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway. | ELISA | 20331800 | 2010 | Pubchem Assay |
| PRRID_0426 | Bacterial DNA Click for more detail | Porphyromonas gingivalis and Tannerella forsythia (Bacteria) | NA | NA | Nucleic Acid | Natural | It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF- | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Monocytic cells (THP-1 cells) | LRR | Q9NR96.fasta | Q9NR96 | 1032 | Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway. | ELISA | 20331800 | 2010 | Pubchem Assay |
| PRRID_0435 | CL097 Click for more detail | derivative of the imidazoquinoline compound R848(others) | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N | NA | Nucleic Acid | Synthetic | The binding induces the production of IL-6, IL-10, TNF-‚ç∫ and IL-23 | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | Lamina propria DCs obtained from the human GI tract | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It induces intestinal inflammation and potentially alter the homeostatic response to commensal flora | NA | 20483758 | 2010 | NA |
| PRRID_0435 | CL097 Click for more detail | derivative of the imidazoquinoline compound R848(others) | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N | NA | Nucleic Acid | Synthetic | The binding induces the production of IL-6, IL-10, TNF-‚ç∫ and IL-23 | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | Lamina propria DCs obtained from the human GI tract | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It induces intestinal inflammation and potentially alter the homeostatic response to commensal flora | NA | 20483758 | 2010 | NA |
| PRRID_0436 | Compound A Click for more detail | NA | NA | NA | Chemical Compunds | Synthetic | it induces IL-6 production in murine macrophage | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | NA |
| PRRID_0436 | Compound A Click for more detail | NA | NA | NA | Chemical Compunds | Synthetic | it induces IL-6 production in murine macrophage | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | NA |
| PRRID_0437 | Compound B Click for more detail | 3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others) | NA | NA | Chemical Compunds | Synthetic | it induces TNF-‚ç∫ production from human monocytes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | Pubchem Assay |
| PRRID_0437 | Compound B Click for more detail | 3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others) | NA | NA | Chemical Compunds | Synthetic | it induces TNF-‚ç∫ production from human monocytes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | Pubchem Assay |
| PRRID_0438 | Compound C Click for more detail | 3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others) | NA | NA | Chemical Compunds | Synthetic | it induces TNF-‚ç∫ production from human monocytes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | Pubchem Assay |
| PRRID_0438 | Compound C Click for more detail | 3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others) | NA | NA | Chemical Compunds | Synthetic | it induces TNF-‚ç∫ production from human monocytes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | Pubchem Assay |
| PRRID_0439 | Compound E Click for more detail | N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others) | NA | NA | Chemical Compunds | Synthetic | it induces TNF-‚ç∫ production from human monocytes | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | NA |
| PRRID_0439 | Compound E Click for more detail | N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others) | NA | NA | Chemical Compunds | Synthetic | it induces TNF-‚ç∫ production from human monocytes | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | NA |
| PRRID_0440 | Compound F Click for more detail | N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others) | NA | NA | Chemical Compunds | Synthetic | it induces TNF-‚ç∫ production from human monocytes | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | NA |
| PRRID_0440 | Compound F Click for more detail | N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others) | NA | NA | Chemical Compunds | Synthetic | it induces TNF-‚ç∫ production from human monocytes | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Peripheral blood monocytes and macrophages | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It casues inflammation in the respective cells | ELISA | 20504771 | 2010 | NA |
| PRRID_0441 | core protein Click for more detail | Hepatitis C Virus (virus) | MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA | 319 | Protein | Natural | Induce cytokines responses through nuclear translocation of nuclear factor-kB (NF-kB) subunits | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Antigen presenting cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It reduces the IL-6 production in these cells | NA | 20677943 | 2010 | Pubchem Assay |
| PRRID_0441 | core protein Click for more detail | Hepatitis C Virus (virus) | MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA | 319 | Protein | Natural | Induce cytokines responses through nuclear translocation of nuclear factor-kB (NF-kB) subunits | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Antigen presenting cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It reduces the IL-6 production in these cells | NA | 20677943 | 2010 | Pubchem Assay |
| PRRID_0442 | core protein Click for more detail | Hepatitis C Virus (virus) | MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA | 319 | Protein | Natural | Activate MAP kinase pathway, NF-κB, and AP-1 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocytes and Kupffer cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Dysfunction of pDCs by enhanced production of IL-10 and TNF- α | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0442 | core protein Click for more detail | Hepatitis C Virus (virus) | MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA | 319 | Protein | Natural | Activate MAP kinase pathway, NF-κB, and AP-1 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocytes and Kupffer cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Dysfunction of pDCs by enhanced production of IL-10 and TNF- α | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0443 | CpG DNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0443 | CpG DNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0445 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0445 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0446 | CpG motif Click for more detail | HSV-1 (virus) | NA | NA | Nucleic Acid | Natural | It's binding leads to the release of the arra of cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | DCs | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It recognize and raise the inflammatory response | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0446 | CpG motif Click for more detail | HSV-1 (virus) | NA | NA | Nucleic Acid | Natural | It's binding leads to the release of the arra of cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | DCs | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It recognize and raise the inflammatory response | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0447 | CpG motif Click for more detail | HSV-2 (virus) | NA | NA | Nucleic Acid | Natural | It's binding leads to the release of the arra of cytokines | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | DCs | Leucine-rich Repeat (LRR) Domain | Q9BXR5.fasta | Q9BXR5 | 811 | It recognize and raise the inflammatory response | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0447 | CpG motif Click for more detail | HSV-2 (virus) | NA | NA | Nucleic Acid | Natural | It's binding leads to the release of the arra of cytokines | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | DCs | Leucine-rich Repeat (LRR) Domain | Q9BXR5.fasta | Q9BXR5 | 811 | It recognize and raise the inflammatory response | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0448 | CpG motif Click for more detail | murine CMV (virus) | NA | NA | Nucleic Acid | Natural | It's binding leads to the release of the arra of cytokines | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | DCs | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It recognize and raise the inflammatory response | NA | 20713890 | 2010 | NA |
| PRRID_0448 | CpG motif Click for more detail | murine CMV (virus) | NA | NA | Nucleic Acid | Natural | It's binding leads to the release of the arra of cytokines | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | DCs | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It recognize and raise the inflammatory response | NA | 20713890 | 2010 | NA |
| PRRID_0452 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0452 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0457 | Curli (amyloid fibrils) Click for more detail | E. coli strain MC4100(Bacteria) | MNTLLLLAALSSQITFNTTQQGDVYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS | 110 | Protein | Natural | The binding of curli mediates the immune respionse cooperatively | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | cervical cancer | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It elicits the immune response via NF- | ELISA | 20497180 | 2010 | NA |
| PRRID_0457 | Curli (amyloid fibrils) Click for more detail | E. coli strain MC4100(Bacteria) | MNTLLLLAALSSQITFNTTQQGDVYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS | 110 | Protein | Natural | The binding of curli mediates the immune respionse cooperatively | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | cervical cancer | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It elicits the immune response via NF- | ELISA | 20497180 | 2010 | NA |
| PRRID_0463 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | NA |
| PRRID_0463 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | NA |
| PRRID_0465 | DNA Click for more detail | EBV(virus) | NA | NA | Nucleic Acid | Natural | It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Monocytes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It provides antiviral immunity | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0465 | DNA Click for more detail | EBV(virus) | NA | NA | Nucleic Acid | Natural | It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Monocytes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It provides antiviral immunity | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0466 | DNA Click for more detail | murine CMV (virus) | GTAATCTAACCACTTGTGTGTGTGTGTGTGTGTGTCGAGTCGTGTCGTCTGTACATTTGAGTCGTGCTGTCCGCACATTTTATTTATCTTTGTTCAGTGTGTTAGATTTCCCGAGGCATGGCTTTCCAAGGTACCAGTAGGACTTTAACTCAACAGTCCTCAGCGGCTACGTCTGACGATCTTCAAAAGATATTATTTAGCCCTGAAGCCATTAAGAAAATGGCTACTGAGTGTGACCTAGGCCGGCATCACTGGATGCGCGCTGATAATGCTATTTCAGTCCGGCCCCTCGTTCCCGAAGTAACCCACGGTCGTATTGCTTCTTTCTTTAAGTCTGGATATGATGTTGGTGAATTATGCTCAAAAGGATATATGAGCGTCCCTCAAGTGTTATGTGCTGTTACTCGAACAGTTTCCACTGATGCTGAAGGGTCCCTGAGAATTTACTTAGCTGATCTAGGCGACAAGGAGTTATCTCCTATAGACGGGCAGTGCGTTTCGTTACATAACCATGATCTTCCCGCTTTGGTGTCTTTCCAACCGACGTATGATTGTCCTATGGAAACAGTTGGGAATCGTAAGCGGTGTTTTGCTGTTGTTATCGAAAGACATGGTTACATTGGGTATACCGGTACCACAGCTAGCGTGTGTAGTAATTGGCAAGCAAGGTTTTCTTCTAAGAATAACAACTACACTCATATCGCAGCTGGGAAGACTCTAGTACTACCTTTCAACAGATTAGCCGAGCAAACAAAACCGTCAGCTGTCGCTCGCCTGTTGAAATCGCAATTGAACAACATTGAATCTTCGCAATATCTGTTAACGAACGCGAAGATTAATCAAAATGCGCGTAGTGAGTCCGAGGAATTAAATGTTGAGAGCCCTCCCGCCGCAATCGGGAGTTCTTCCGCGTCCCGCTCCGAAGCCTTCAGACCGCAGGTGGTTAACGGTCTTTAGCACTTTGGTGCGTATTAGTATATAAGTATTTGTGAGTCTGTAC | 2213 | Nucleic Acid | Natural | It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | PDCs | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | It provides antiviral immunity | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0466 | DNA Click for more detail | murine CMV (virus) | GTAATCTAACCACTTGTGTGTGTGTGTGTGTGTGTCGAGTCGTGTCGTCTGTACATTTGAGTCGTGCTGTCCGCACATTTTATTTATCTTTGTTCAGTGTGTTAGATTTCCCGAGGCATGGCTTTCCAAGGTACCAGTAGGACTTTAACTCAACAGTCCTCAGCGGCTACGTCTGACGATCTTCAAAAGATATTATTTAGCCCTGAAGCCATTAAGAAAATGGCTACTGAGTGTGACCTAGGCCGGCATCACTGGATGCGCGCTGATAATGCTATTTCAGTCCGGCCCCTCGTTCCCGAAGTAACCCACGGTCGTATTGCTTCTTTCTTTAAGTCTGGATATGATGTTGGTGAATTATGCTCAAAAGGATATATGAGCGTCCCTCAAGTGTTATGTGCTGTTACTCGAACAGTTTCCACTGATGCTGAAGGGTCCCTGAGAATTTACTTAGCTGATCTAGGCGACAAGGAGTTATCTCCTATAGACGGGCAGTGCGTTTCGTTACATAACCATGATCTTCCCGCTTTGGTGTCTTTCCAACCGACGTATGATTGTCCTATGGAAACAGTTGGGAATCGTAAGCGGTGTTTTGCTGTTGTTATCGAAAGACATGGTTACATTGGGTATACCGGTACCACAGCTAGCGTGTGTAGTAATTGGCAAGCAAGGTTTTCTTCTAAGAATAACAACTACACTCATATCGCAGCTGGGAAGACTCTAGTACTACCTTTCAACAGATTAGCCGAGCAAACAAAACCGTCAGCTGTCGCTCGCCTGTTGAAATCGCAATTGAACAACATTGAATCTTCGCAATATCTGTTAACGAACGCGAAGATTAATCAAAATGCGCGTAGTGAGTCCGAGGAATTAAATGTTGAGAGCCCTCCCGCCGCAATCGGGAGTTCTTCCGCGTCCCGCTCCGAAGCCTTCAGACCGCAGGTGGTTAACGGTCTTTAGCACTTTGGTGCGTATTAGTATATAAGTATTTGTGAGTCTGTAC | 2213 | Nucleic Acid | Natural | It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | PDCs | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | It provides antiviral immunity | NA | 20713890 | 2010 | Pubchem Assay |
| PRRID_0469 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Activates caspase-1 which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0469 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | Activates caspase-1 which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0474 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | The activation of NF-kB, MAP kinases and IRF3 and culminates in the production of inflammatory cytokines and type I IFNs | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0474 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | The activation of NF-kB, MAP kinases and IRF3 and culminates in the production of inflammatory cytokines and type I IFNs | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0482 | dsDNA Click for more detail | Rabies virus (virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0482 | dsDNA Click for more detail | Rabies virus (virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0483 | dsDNA Click for more detail | herpes simplex virus (virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0483 | dsDNA Click for more detail | herpes simplex virus (virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | NA | 20706642 | 2010 | Pubchem Assay |