Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0033	Acetylated LDL Click for more detail	NA	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	Acetylated LDL is a potent ligand for MARCO	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0033	Acetylated LDL Click for more detail	NA	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	Acetylated LDL is a potent ligand for MARCO	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0037	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole cell	Natural	E.coli binds with MARCO with high affinity.	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0037	Escherichia coli Click for more detail	E. coli(Bacteria)	NA	NA	Whole cell	Natural	E.coli binds with MARCO with high affinity.	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0043	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole cell	Natural	S. aureus binds with MARCO with high affinity	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0043	Staphylococcus aureus Click for more detail	S. aureus (Bacteria)	NA	NA	Whole cell	Natural	S. aureus binds with MARCO with high affinity	Macrophage receptor with collagenous structure (MARCO)	Scavenger receptor (SR)	Mice	Macrophages	NA	A2RT24.fasta	A2RT24	518	It plays a role in immunological reactions.	Immunoprecipitation	7867067	1995	Pubchem Assay
PRRID_0048	Apoptotic thymocytes Click for more detail	Host (Endogenous) (others)	NA	NA	Whole cell	Natural	Apoptotic thymocytes interacts with Scavenger receptor class A, which leads to the uptake and degradation.	Scavenger receptor class A	Scavenger receptor (SR)	Mice	Thymic macrophages	NA	Q68EF1.fasta	Q68EF1	474	SR-A may play a role in the clearance of dying cells in the thymus.	Phagocytosis Assay	8901603	1996	Pubchem Assay
PRRID_0048	Apoptotic thymocytes Click for more detail	Host (Endogenous) (others)	NA	NA	Whole cell	Natural	Apoptotic thymocytes interacts with Scavenger receptor class A, which leads to the uptake and degradation.	Scavenger receptor class A	Scavenger receptor (SR)	Mice	Thymic macrophages	NA	Q68EF1.fasta	Q68EF1	474	SR-A may play a role in the clearance of dying cells in the thymus.	Phagocytosis Assay	8901603	1996	Pubchem Assay
PRRID_0057	Acetylated LDL Click for more detail	Endogenous (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	elicit innate immune response	Scavenger receptor A II	Scavenger receptor (SR)	Mice	Macrophages	NA	Q08857.fasta	Q08857	472	production of pro-inflammatory cytokines	NA	9069289	1997	Pubchem Assay
PRRID_0057	Acetylated LDL Click for more detail	Endogenous (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	elicit innate immune response	Scavenger receptor A II	Scavenger receptor (SR)	Mice	Macrophages	NA	Q08857.fasta	Q08857	472	production of pro-inflammatory cytokines	NA	9069289	1997	Pubchem Assay
PRRID_0059	Advanced Glycation End Products (AGE) Click for more detail	Endogenous (others)	NA	NA	Others	Natural	elicit innate immune response	Scavenger receptor A II	Scavenger receptor (SR)	Mice	Macrophages	NA	Q08857.fasta	Q08857	472	production of pro-inflammatory cytokines	NA	9069289	1997	Pubchem Assay
PRRID_0059	Advanced Glycation End Products (AGE) Click for more detail	Endogenous (others)	NA	NA	Others	Natural	elicit innate immune response	Scavenger receptor A II	Scavenger receptor (SR)	Mice	Macrophages	NA	Q08857.fasta	Q08857	472	production of pro-inflammatory cytokines	NA	9069289	1997	Pubchem Assay
PRRID_0064	oxidized LDL (OxLDL) Click for more detail	Endogenous (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	elicit innate immune response	Scavenger receptor A II	Scavenger receptor (SR)	Mice	Macrophages	NA	Q08857.fasta	Q08857	472	production of pro-inflammatory cytokines	NA	9069289	1997	Pubchem Assay
PRRID_0064	oxidized LDL (OxLDL) Click for more detail	Endogenous (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	elicit innate immune response	Scavenger receptor A II	Scavenger receptor (SR)	Mice	Macrophages	NA	Q08857.fasta	Q08857	472	production of pro-inflammatory cytokines	NA	9069289	1997	Pubchem Assay
PRRID_0065	Acetylated LDL Click for more detail	Host (Endogenous) (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	AcLDL pretreatment increased expression of macrosialin	Microsialin	Scavenger receptor (SR)	Mice	Peritoneal macrophages	NA	A0A0R4J1C8.fasta	A0A0R4J1C8	335	It leads to the binding and uptake of oxidised form of LDL by resident mouse peritoneal macrophages.	Endocytic degradation assays	9598839	1998	Pubchem Assay
PRRID_0065	Acetylated LDL Click for more detail	Host (Endogenous) (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	AcLDL pretreatment increased expression of macrosialin	Microsialin	Scavenger receptor (SR)	Mice	Peritoneal macrophages	NA	A0A0R4J1C8.fasta	A0A0R4J1C8	335	It leads to the binding and uptake of oxidised form of LDL by resident mouse peritoneal macrophages.	Endocytic degradation assays	9598839	1998	Pubchem Assay
PRRID_0070	Minimally oxidized LDL (MM-LDL) Click for more detail	Host (Endogenous) (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	MM-LDL pretreatment induced a clear increase of cell association and increase both mRNAlevels and protein levels of scavenger receptor A, CD36, and macrosialin.	Microsialin	Scavenger receptor (SR)	Mice	Peritoneal macrophages	NA	A0A0R4J1C8.fasta	A0A0R4J1C8	335	It leads to the binding and uptake of oxidised form of LDL by resident mouse peritoneal macrophages.	Endocytic degradation assays	9598839	1998	Pubchem Assay
PRRID_0070	Minimally oxidized LDL (MM-LDL) Click for more detail	Host (Endogenous) (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	MM-LDL pretreatment induced a clear increase of cell association and increase both mRNAlevels and protein levels of scavenger receptor A, CD36, and macrosialin.	Microsialin	Scavenger receptor (SR)	Mice	Peritoneal macrophages	NA	A0A0R4J1C8.fasta	A0A0R4J1C8	335	It leads to the binding and uptake of oxidised form of LDL by resident mouse peritoneal macrophages.	Endocytic degradation assays	9598839	1998	Pubchem Assay
PRRID_0071	oxidized LDL (OxLDL) Click for more detail	Host (Endogenous) (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	OxLDL pretreatment increased expression of macrosialin.	Microsialin	Scavenger receptor (SR)	Mice	Peritoneal macrophages	NA	A0A0R4J1C8.fasta	A0A0R4J1C8	335	It leads to the binding and uptake of oxidised form of LDL by resident mouse peritoneal macrophages.	Endocytic degradation assays	9598839	1998	Pubchem Assay
PRRID_0071	oxidized LDL (OxLDL) Click for more detail	Host (Endogenous) (others)	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	OxLDL pretreatment increased expression of macrosialin.	Microsialin	Scavenger receptor (SR)	Mice	Peritoneal macrophages	NA	A0A0R4J1C8.fasta	A0A0R4J1C8	335	It leads to the binding and uptake of oxidised form of LDL by resident mouse peritoneal macrophages.	Endocytic degradation assays	9598839	1998	Pubchem Assay
PRRID_0081	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	NA	Q9NR96.fasta	Q9NR96	1032	induce type I interferons (IFN) and other cytokines production.	NA	11130078	2000	Pubchem Assay
PRRID_0081	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	NA	Q9NR96.fasta	Q9NR96	1032	induce type I interferons (IFN) and other cytokines production.	NA	11130078	2000	Pubchem Assay
PRRID_0082	ER-112022 Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Synthetic	It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Raw 264.7 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has the role in immuno inflammation.	ELISA	11032843	2000	Pubchem Assay
PRRID_0082	ER-112022 Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Synthetic	It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Raw 264.7 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has the role in immuno inflammation.	ELISA	11032843	2000	Pubchem Assay
PRRID_0090	Not Determined Click for more detail	herpes simplex virus (virus)	NA	NA	Others	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUN7.fasta	Q9QUN7	784	NA	NA	11062499	2000	Pubchem Assay
PRRID_0090	Not Determined Click for more detail	herpes simplex virus (virus)	NA	NA	Others	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUN7.fasta	Q9QUN7	784	NA	NA	11062499	2000	Pubchem Assay
PRRID_0096	viral hemagglutinin (HA) Click for more detail	Influenza A (virus)	MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICI	566	NA	Natural	Immunostimulant	NA	NA	Mice (Murine)	Macrophages	NA	NA	NA	NA	NA	ELISA	0	2000	NA
PRRID_0096	viral hemagglutinin (HA) Click for more detail	Influenza A (virus)	MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICI	566	NA	Natural	Immunostimulant	NA	NA	Mice (Murine)	Macrophages	NA	NA	NA	NA	NA	ELISA	0	2000	NA
PRRID_0100	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	NA	Q9JLF7.fasta	Q9JLF7	859	NA	tandem mass spectrometry	0	2001	Pubchem Assay
PRRID_0100	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	NA	Q9JLF7.fasta	Q9JLF7	859	NA	tandem mass spectrometry	0	2001	Pubchem Assay
PRRID_0116	Fragments of heparan sulphate Click for more detail	Host (Endogenous) (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Proteoglycan	Natural	Heparan sulfate induces nuclear translocation of NF-kappaB.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Bone-Marrow culture	NA	Q9QUK6.fasta	Q9QUK6	835	TLR4 plays the role in the activation and maturation of dendritic cells, thus suggesting that vertebrate TLR monitor perturbations to the well-being of tissues.	EMSA	11994480	2002	Pubchem Assay
PRRID_0116	Fragments of heparan sulphate Click for more detail	Host (Endogenous) (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Proteoglycan	Natural	Heparan sulfate induces nuclear translocation of NF-kappaB.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Bone-Marrow culture	NA	Q9QUK6.fasta	Q9QUK6	835	TLR4 plays the role in the activation and maturation of dendritic cells, thus suggesting that vertebrate TLR monitor perturbations to the well-being of tissues.	EMSA	11994480	2002	Pubchem Assay
PRRID_0129	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	5MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	LRR	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0129	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	5MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	LRR	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0130	Hemagglutinin Click for more detail	virus (measles virus)	MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR	617	Glycoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	NA	ELISA	12163593	2002	Pubchem Assay
PRRID_0130	Hemagglutinin Click for more detail	virus (measles virus)	MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR	617	Glycoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	NA	ELISA	12163593	2002	Pubchem Assay
PRRID_0131	Hyaluronic acid Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Carbohydrate	Natural	potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Bone Marrow‚Äìderived DCs	transmembrane domain that associates with the intra- cellular adaptor protein MyD88	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	11781369	2002	Pubchem Assay
PRRID_0131	Hyaluronic acid Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Carbohydrate	Natural	potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Bone Marrow‚Äìderived DCs	transmembrane domain that associates with the intra- cellular adaptor protein MyD88	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	11781369	2002	Pubchem Assay
PRRID_0132	Hypochlorite modified HDL Click for more detail	Host (Endogenous) (others)	CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C	NA	Lipoprotein	Natural	It has a high affinity for the Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1).	Lectin-like oxidized LDLreceptor 1	C type Lectin (CTL/CLR)	Mice (Murine)	CHO Cells‚ÄîldlA cells	NA	Q9EQ09.fasta	Q9EQ09	363	It impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport.	NA	12070141	2002	Pubchem Assay
PRRID_0132	Hypochlorite modified HDL Click for more detail	Host (Endogenous) (others)	CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C	NA	Lipoprotein	Natural	It has a high affinity for the Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1).	Lectin-like oxidized LDLreceptor 1	C type Lectin (CTL/CLR)	Mice (Murine)	CHO Cells‚ÄîldlA cells	NA	Q9EQ09.fasta	Q9EQ09	363	It impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport.	NA	12070141	2002	Pubchem Assay
PRRID_0133	Hypochlorite modified HDL Click for more detail	Host (Endogenous) (others)	CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C	NA	Lipoprotein	Natural	It has a high affinity for the Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1).	Scavenger receptor class B, type I (SR-BI)	Scavenger receptor (SR)	Mice (Murine)	CHO Cells‚ÄîldlA cells	NA	Q06BI8.fasta	Q06BI8	494	It impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport.	NA	12070141	2002	Pubchem Assay
PRRID_0133	Hypochlorite modified HDL Click for more detail	Host (Endogenous) (others)	CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C	NA	Lipoprotein	Natural	It has a high affinity for the Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1).	Scavenger receptor class B, type I (SR-BI)	Scavenger receptor (SR)	Mice (Murine)	CHO Cells‚ÄîldlA cells	NA	Q06BI8.fasta	Q06BI8	494	It impairs high density lipoprotein-dependent selective lipid uptake and reverse cholesterol transport.	NA	12070141	2002	Pubchem Assay
PRRID_0142	Neisserial porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	It leads to the induction of NF-kappaB nuclear translocation.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	It has the role in immunopotentiating activity, such as by stimulate B cells and up-regulate the surface expression of B7-2.	NF-kB luciferase reporter assay	11823477	2002	Pubchem Assay
PRRID_0142	Neisserial porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	It leads to the induction of NF-kappaB nuclear translocation.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	It has the role in immunopotentiating activity, such as by stimulate B cells and up-regulate the surface expression of B7-2.	NF-kB luciferase reporter assay	11823477	2002	Pubchem Assay
PRRID_0148	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0148	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0149	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0149	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0151	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0151	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0152	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0152	7-deazadG Click for more detail	Guanosine (others)	C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0154	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0154	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0155	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0155	7-deazaguanosine (7-deazaG) Click for more detail	Guanosine (others)	C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0157	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0157	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0158	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0158	7-Thia-8-oxoguanosine (TOG) Click for more detail	Guanosine (others)	C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0160	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0160	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0161	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0161	9-hexyl-guanine Click for more detail	Guanosine (others)	CCN1C=NC2=C1NC(=NC2=O)N	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0163	C12-iE-DAP Click for more detail	Chemical derivative of iE-DAP(others)	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Synthetic	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0163	C12-iE-DAP Click for more detail	Chemical derivative of iE-DAP(others)	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Synthetic	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0173	iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail	Bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0173	iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail	Bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Peptide	Natural	elicit innate immune response	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Macrophages	NA	Q8BHB0.fasta	Q8BHB0	953	mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan.	ELISA	12796777	2003	Pubchem Assay
PRRID_0177	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58681.fasta	P58681	1050	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0177	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58681.fasta	P58681	1050	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0182	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0182	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0183	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0183	PIM2 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0184	PIM6 Click for more detail	Mycobacterium bovis Bacillus Calmette Guerin (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0184	PIM6 Click for more detail	Mycobacterium bovis Bacillus Calmette Guerin (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0185	PIM6 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0185	PIM6 Click for more detail	Mtb H37Rv (Bacteria)	NA	NA	Carbohydrate	Natural	It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Primary Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response.	ELISA	12775723	2003	Pubchem Assay
PRRID_0186	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58682.fasta	P58682	1032	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0186	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	Spleenocytes	NA	P58682.fasta	P58682	1032	It leads to the endosomal maturation.	ELISA	14579267	2003	Pubchem Assay
PRRID_0192	Advillin Click for more detail	Host (Endogenous) (others)	MSLSSAFRAVSNDPRIITWRIEKMELALVPLSAHGNFYEGDCYIVLSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVEMSWDSFNRGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPGLMTVLQDTLGRRSMIKPAVSDEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKIFSTGKIAKIFQDKFDVSLLHTKPEVAAQERMVDDGKGQVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPHYILYIWQGRHASRDELAASAYRAVEVDQQFDGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNEEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELVDLLCDGNADTVAEGQEPPEFWDLLGGKTAYANDKRLQQETLDVQVRLFECSNKTGRFLVTEVTDFTQEDLSPGDVMLLDTWDQVFLWIGAEANATEKKGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITADMKNATLYLNPSDGEPKYYPVEVLLKGQNQELPEDVDPAKKENYLSEQDFVSVFGITRGQFTALPGWKQLQLKKERGLF	819	Protein	Natural	It induces neurite-like outgrowth.	Scavenger receptor expressed by endothelial cells 1 (SREC-I)	Scavenger receptor (SR)	Mice (Murine)	Fibroblastic L cells	Cytoplasmic domain	Q5ND28.fasta	Q5ND28	820	SREC-I lead to changes in cell morphology.	NA	15247299	2004	Pubchem Assay
PRRID_0192	Advillin Click for more detail	Host (Endogenous) (others)	MSLSSAFRAVSNDPRIITWRIEKMELALVPLSAHGNFYEGDCYIVLSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVEMSWDSFNRGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPGLMTVLQDTLGRRSMIKPAVSDEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKIFSTGKIAKIFQDKFDVSLLHTKPEVAAQERMVDDGKGQVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPHYILYIWQGRHASRDELAASAYRAVEVDQQFDGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNEEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELVDLLCDGNADTVAEGQEPPEFWDLLGGKTAYANDKRLQQETLDVQVRLFECSNKTGRFLVTEVTDFTQEDLSPGDVMLLDTWDQVFLWIGAEANATEKKGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITADMKNATLYLNPSDGEPKYYPVEVLLKGQNQELPEDVDPAKKENYLSEQDFVSVFGITRGQFTALPGWKQLQLKKERGLF	819	Protein	Natural	It induces neurite-like outgrowth.	Scavenger receptor expressed by endothelial cells 1 (SREC-I)	Scavenger receptor (SR)	Mice (Murine)	Fibroblastic L cells	Cytoplasmic domain	Q5ND28.fasta	Q5ND28	820	SREC-I lead to changes in cell morphology.	NA	15247299	2004	Pubchem Assay
PRRID_0197	Envelope protein Click for more detail	virus (Mouse Mammary Tumor Virus)	NA	NA	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	NA	NA	14694089	2004	Pubchem Assay
PRRID_0197	Envelope protein Click for more detail	virus (Mouse Mammary Tumor Virus)	NA	NA	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	NA	NA	14694089	2004	Pubchem Assay
PRRID_0198	glucuronoxylomannan Click for more detail	Cryptococcus neoformans(fungi)	NA	NA	Carbohydrate	Natural	It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Lung	NA	Q9QUK6.fasta	Q9QUK6	835	It leads to the inflammatory response against the fungi Cryptococcus neoformans.	ELISA	15322035	2004	Pubchem Assay
PRRID_0198	glucuronoxylomannan Click for more detail	Cryptococcus neoformans(fungi)	NA	NA	Carbohydrate	Natural	It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Lung	NA	Q9QUK6.fasta	Q9QUK6	835	It leads to the inflammatory response against the fungi Cryptococcus neoformans.	ELISA	15322035	2004	Pubchem Assay
PRRID_0199	glucuronoxylomannan Click for more detail	Cryptococcus neoformans(fungi)	NA	NA	Carbohydrate	Natural	It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response against the fungi Cryptococcus neoformans.	ELISA	15322035	2004	Pubchem Assay
PRRID_0199	glucuronoxylomannan Click for more detail	Cryptococcus neoformans(fungi)	NA	NA	Carbohydrate	Natural	It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung	NA	Q9QUN7.fasta	Q9QUN7	784	It leads to the inflammatory response against the fungi Cryptococcus neoformans.	ELISA	15322035	2004	Pubchem Assay
PRRID_0210	serum amyloid A Click for more detail	Host (Endogenous) (others)	MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY	122	Protein	Natural	Serum Amyloid A Is a Ligand for Scavenger Receptor Class B Type I and Inhibits High Density Lipoprotein Binding.	Scavenger receptor B-1 (SR-B1)	Scavenger receptor (SR)	Mice	Hepatocytes	NA	Q61009.fasta	Q61009	509	SR-BI plays a key role in SAA metabolism through its ability to interact with and internalize SAA and, moreover, SAA influences HDL cholesterol metabolism through its inhibitory effects on SR-BI-mediated selective lipid. uptake	NA	15561721	2004	Pubchem Assay
PRRID_0210	serum amyloid A Click for more detail	Host (Endogenous) (others)	MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY	122	Protein	Natural	Serum Amyloid A Is a Ligand for Scavenger Receptor Class B Type I and Inhibits High Density Lipoprotein Binding.	Scavenger receptor B-1 (SR-B1)	Scavenger receptor (SR)	Mice	Hepatocytes	NA	Q61009.fasta	Q61009	509	SR-BI plays a key role in SAA metabolism through its ability to interact with and internalize SAA and, moreover, SAA influences HDL cholesterol metabolism through its inhibitory effects on SR-BI-mediated selective lipid. uptake	NA	15561721	2004	Pubchem Assay
PRRID_0222	Hemozoin Click for more detail	protozoa (Plasmodium falciparum) (others)	CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]	NA	Others	Natural	immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Toll/interleukin 1 receptor domain	Q9NR96.fasta	Q9NR96	1032	abrogated HZ-induced cytokine production	NA	15630134	2005	Pubchem Assay
PRRID_0222	Hemozoin Click for more detail	protozoa (Plasmodium falciparum) (others)	CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]	NA	Others	Natural	immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Toll/interleukin 1 receptor domain	Q9NR96.fasta	Q9NR96	1032	abrogated HZ-induced cytokine production	NA	15630134	2005	Pubchem Assay
PRRID_0223	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58681.fasta	P58681	1050	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0223	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58681.fasta	P58681	1050	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0224	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58682.fasta	P58682	1032	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0224	Microparticles containingOVAand poly-U Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	BMDCs	NA	P58682.fasta	P58682	1032	It stimulates proinflammatory and antiviral responses.	ELISA	16278038	2005	Pubchem Assay
PRRID_0225	muramyl tetrapeptide Click for more detail	muramyl dipeptide derivative (others)	NA	NA	Peptide	Synthetic	Immunostimulant	Nucleotide-binding oligomerization domain protein 1	NOD-like receptor (NLR)	Mice (Murine)	NA	NA	Q8BHB0.fasta	Q8BHB0	953	NA	ELISA	16211083	2005	Pubchem Assay
PRRID_0225	muramyl tetrapeptide Click for more detail	muramyl dipeptide derivative (others)	NA	NA	Peptide	Synthetic	Immunostimulant	Nucleotide-binding oligomerization domain protein 1	NOD-like receptor (NLR)	Mice (Murine)	NA	NA	Q8BHB0.fasta	Q8BHB0	953	NA	ELISA	16211083	2005	Pubchem Assay
PRRID_0228	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay
PRRID_0228	Seeligeriolysin O ((rLSO483) Click for more detail	Listeria seeligeri (Bacteria)	MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ	530	Protein	Natural	It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	This leads to the inflammatory response.	Transfection and nuclear factor j-B reporter assay	16291660	2005	Pubchem Assay

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