Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_3613	Adenovirus	Adenovirus CD55-TRAIL	DNA	Adenoviridae	Virus expressingTRAIL gene	No	Virus in combination with luteolin (25 micromolar)	No	Shanghai cell collection	Human colorectal cancer cell line	HT-29	5000 cells per well	NA	MTT assay	10 MOI	50% cell viability after 96 hours	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29039580
OV_3614	Adenovirus	Adenovirus CD55-TRAIL	DNA	Adenoviridae	Virus expressingTRAIL gene	No	Virus in combination with luteolin (25 micromolar)	No	Shanghai cell collection	Human colorectal cancer cell line	HT-29	5000 cells per well	NA	MTT assay	15 MOI	60% cell viability after 24 hours	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29039580
OV_3615	Adenovirus	Adenovirus CD55-TRAIL	DNA	Adenoviridae	Virus expressingTRAIL gene	No	Virus in combination with luteolin (25 micromolar)	No	Shanghai cell collection	Human colorectal cancer cell line	HT-29	5000 cells per well	NA	MTT assay	15 MOI	40% cell viability after 48 hours	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29039580
OV_3616	Adenovirus	Adenovirus CD55-TRAIL	DNA	Adenoviridae	Virus expressingTRAIL gene	No	Virus in combination with luteolin (25 micromolar)	No	Shanghai cell collection	Human colorectal cancer cell line	HT-29	5000 cells per well	NA	MTT assay	15 MOI	40% cell viability after 72 hours	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29039580
OV_3617	Adenovirus	Adenovirus CD55-TRAIL	DNA	Adenoviridae	Virus expressingTRAIL gene	No	Virus in combination with luteolin (25 micromolar)	No	Shanghai cell collection	Human colorectal cancer cell line	HT-29	5000 cells per well	NA	MTT assay	15 MOI	22% cell viability after 96 hours	No	No	NA	No response	NA	Virus in combination with induce apiptosis in cancer cell	NA	NA	29039580
OV_3618	Adenovirus	Adenovirus CD55-TRAIL	DNA	Adenoviridae	Virus expressingTRAIL gene	No	Virus in combination with luteolin (50mg/kg)	No	Shanghai cell collection	Human colorectal cancer cell line	HT-29	NA	NA	NA	NA	NA	Balb/c nude mice xenograft for HT29 cell line (8.0E+6)	2.0E+9 pfu	NA	Decrease in tumor volume to below 2000mm after 30 days comapred to control 4000mm	Intratumoral	Virus in combination with induce apiptosis in cancer cell	NA	NA	29039580
OV_4081	Adenovirus	Adenovirus ZD55	DNA	Adenoviridae	Virus encoded with drosophila dNK gene	No	Virus in combination with drug BVDU(10mg/kg)	No	Shanghai cell collection	Human breast cell line	MCF-7	1.0E+4 cells per well	NA	MTT assay	1 MOI	Significant reduction in cell growth	No	No	NA	No response	NA	Virus induced apoptosis in cancer cell	NA	NA	26203222
OV_4082	Adenovirus	Adenovirus ZD55	DNA	Adenoviridae	Virus encoded with drosophila dNK gene	No	Virus in combination with drug DFDC(10mg/kg)	No	Shanghai cell collection	Human breast cell line	MCF-7	1.0E+4 cells per well	NA	MTT assay	1 MOI	Significant reduction in cell growth	No	No	NA	No response	NA	Virus induced apoptosis in cancer cell	NA	NA	26203222
OV_4083	Adenovirus	Adenovirus ZD55	DNA	Adenoviridae	Virus encoded with drosophila dNK gene	No	Virus in combination with drug DFDC(10mg/kg)	No	Shanghai cell collection	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for MCF7 (1.0E+7)	1.0E+9 pfu	NA	Virus and drug prolongs the mice survival and reduction in tumor volume to 1000mm compared to control 3000mm after 60 days	Intratumoral	Virus induced apoptosis in cancer cell	NA	NA	26203222
OV_4110	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human colon carcinoma cell line	Caco-2	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	80% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4111	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human lung cancer cell line	A549	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	90% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4112	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human osteosarcoma cell line	U2OS	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	95% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4113	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human fibroblast cell line BJ	BJ	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	95% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4114	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human colon carcinoma cell line	Caco-2	1.0E+5 cells per well	NA	MTT assay	1 MOI	40% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4115	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human lung cancer cell line	Caco-2	1.0E+5 cells per well	NA	MTT assay	1 MOI	50% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4116	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human osteosarcoma cell line	U2OS	1.0E+5 cells per well	NA	MTT assay	1 MOI	90% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4117	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human fibroblast cell line	BJ	1.0E+5 cells per well	NA	MTT assay	1 MOI	95% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4118	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human colon carcinoma cell line	Caco-2	1.0E+5 cells per well	NA	MTT assay	10 MOI	10% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4119	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human lung cancer cell line	Caco-2	1.0E+5 cells per well	NA	MTT assay	10 MOI	20% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4120	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human osteosarcoma cell line	U2OS	1.0E+5 cells per well	NA	MTT assay	10 MOI	90% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4121	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human fibroblast cell line	BJ	1.0E+5 cells per well	NA	MTT assay	10 MOI	90% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4122	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human colon carcinoma cell line	Caco-2	1.0E+5 cells per well	NA	MTT assay	100 MOI	5% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4123	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human lung cancer cell line	Caco-2	1.0E+5 cells per well	NA	MTT assay	100 MOI	30% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4124	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human osteosarcoma cell line	U2OS	1.0E+5 cells per well	NA	MTT assay	100 MOI	95% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4125	Adenovirus	Ad-CCL20-CD40L	DNA	Adenoviridae	Addition of CCL20 and CD40L gene near by TERT promoter	Yes	No	virus expressing CCL20 chemokine gene	ATCC	Human fibroblast cell line	BJ	1.0E+5 cells per well	NA	MTT assay	100 MOI	95% cell survival after 7 days	No	No	NA	No response	NA	NA	NA	NA	26208317
OV_4126	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (0.01 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	100 vp/cell	80% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4127	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (1 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	1000 vp/cell	50% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4128	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (10 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	10000 vp/cell	20% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4129	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (100 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	100000 vp/cell	100% cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4130	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (1000 ng/ml)	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	1000000 vp/cell	100% cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4131	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	100 vp/cell	100% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4132	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	1000 vp/cell	85% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4133	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	10000 vp/cell	35% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4134	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	100000 vp/cell	20% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4135	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	BxPC-3	3.0E+3 cells per well	NA	MTT assay	1000000 vp/cell	100% cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4136	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (1000 ng/ml)	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	1 vp/cell	100% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4137	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (10000 ng/ml)	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	10 vp/cell	100% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4138	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (100000 ng/ml)	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	100 vp/cell	70% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4139	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (1000000 ng/ml)	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	1000 vp/cell	20% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4140	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (10000000 ng/ml)	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	10000 vp/cell	100% cancer cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4141	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with drug Gemcitabine (100000000 ng/ml)	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	100000 vp/cell	100% cancer cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4142	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	1 vp/cell	100% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4143	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	10 vp/cell	100% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4144	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	100 vp/cell	100% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4145	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	1000 vp/cell	40% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4146	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	10000 vp/cell	10% cell survival	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4147	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	3.0E+3 cells per well	NA	MTT assay	100000 vp/cell	100% cancer cell killing	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4148	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with gemcitabine (160mg/kg)	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for BxPC-3 (5.0E+5)	5.0E+10 VP per cell	NA	Median survival time increased from 22 days to 57 days with combined tretament	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4149	Adenovirus	AduPARE1A	DNA	Adenoviridae	Addition of E1A gene upstream of uPAR promoter	No	Virus in combination with gemcitabine (160mg/kg)	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice xenograft for PANC-1 (5.0E+5)	5.0E+10 VP per cell	NA	Median survival time increased from 37 days to 79.5 days with combined tretament	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26227809
OV_4194	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 1	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4195	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 2	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4196	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 3	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4197	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 4	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4198	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 5	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4199	Adenovirus	Ad-CXCR4-DAL1	DNA	Adenoviridae	Virus expressing DAL-1 gene under promoter CXXR4	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 1	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4200	Adenovirus	Ad-CXCR4-DAL1	DNA	Adenoviridae	Virus expressing DAL-1 gene under promoter CXXR4	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 2	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4201	Adenovirus	Ad-CXCR4-DAL1	DNA	Adenoviridae	Virus expressing DAL-1 gene under promoter CXXR4	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 3	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4202	Adenovirus	Ad-CXCR4-DAL1	DNA	Adenoviridae	Virus expressing DAL-1 gene under promoter CXXR4	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	100% cell viability after day 4	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4203	Adenovirus	Ad-CXCR4-DAL1	DNA	Adenoviridae	Virus expressing DAL-1 gene under promoter CXXR4	Yes	No	No	Cell bank of chinese academy of science	Human lung adenocarcinoma cell line	A549	1.0E+6 cells per well	NA	CCK-8 assay	100 MOI	10% cell viability after day 5	No	No	NA	No response	NA	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4204	Adenovirus	Ad-CXCR4-DAL1	DNA	Adenoviridae	Virus expressing DAL-1 gene under promoter CXXR4	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice subcutaneously xenograft for A549 cell (2.0E+6)	1.0E+9 pfu, every other day for 3 times	NA	Reduction in tumor volume to 1.5 centimeter cube after 28 days compared to control 7 centimeter cube	Intratumoral	Virus induce apoptosis process leads to cancer cell death	NA	NA	26280082
OV_4401	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Statistical method	16.64+/- 1.41	20% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4402	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Statistical method	57.46+/- 8.37	50% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4403	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Statistical method	96.31+/- 10.76	70% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4404	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a/carbo-15a	NA	NA	Statistical method	16.56+/- 2.78	20% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4405	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a/carbo-15a	NA	NA	Statistical method	52.17+/- 9.68	50% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4406	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a/carbo-15a	NA	NA	Statistical method	90.13+/- 14.42	70% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4407	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29	NA	NA	Statistical method	26.80+/- 7.82	20% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4408	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29	NA	NA	Statistical method	74.23+/- 18.19	50% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4409	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29	NA	NA	Statistical method	127.2+/- 39	70% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4410	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29/CP-5c	NA	NA	Statistical method	7.56+/- 1.96	20% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4411	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29/CP-5c	NA	NA	Statistical method	26.70+/- 5.90	50% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4412	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29/CP-5c	NA	NA	Statistical method	49.95+/- 9.01	70% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4413	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29/carbo-15d-1	NA	NA	Statistical method	20.13+/- 10.23	20% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4414	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29/carbo-15d-1	NA	NA	Statistical method	48.46+/- 19.03	50% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4415	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	ATCC	Human colon carcinoma	HT-29/carbo-15d-1	NA	NA	Statistical method	78.27+/- 25.11	70% cancer cell death	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4416	Adenovirus	ONYX-015	DNA	Adenoviridae	None	No	Virus in combination with melphalan (2.5 microgram)	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Flow cytometry	20 pfu	3% cancer cell death after day 3	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4417	Adenovirus	ONYX-015	DNA	Adenoviridae	None	No	Virus in combination with melphalan (5 microgram)	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Flow cytometry	20 pfu	6% cancer cell death after day 3	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4418	Adenovirus	ONYX-015	DNA	Adenoviridae	None	No	Virus in combination with melphalan (7.5 microgram)	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Flow cytometry	20 pfu	10% cancer cell death after day 3	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4419	Adenovirus	ONYX-015	DNA	Adenoviridae	None	No	Virus in combination with melphalan (2.5 microgram)	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Flow cytometry	20 pfu	3% cancer cell death after day 3	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4420	Adenovirus	ONYX-015	DNA	Adenoviridae	None	No	Virus in combination with melphalan (5 microgram)	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Flow cytometry	20 pfu	15% cancer cell death after day 3	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4421	Adenovirus	ONYX-015	DNA	Adenoviridae	None	No	Virus in combination with melphalan (7.5 microgram)	No	St. Joseph healthcare, London	Human head and neck squamous cell carcinoma	HN-5a	NA	NA	Flow cytometry	20 pfu	25% cancer cell death after day 3	No	No	NA	No response	NA	Increase in apoptosis upto 25%	NA	NA	26429639
OV_4474	Adenovirus	oAD/DCN-shMet	DNA	Adenoviridae	Adenovirus conjugated with DCN and shMet	Yes	No	No	ATCC	Human lung carcinoma cell line	A549	70% confluence in 24 well plate	NA	MTT assay	1 MOI	65% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 140pg/ml compared to control 20 pg/ml	NA	26951927
OV_4475	Adenovirus	oAD/DCN-shMet/PP	DNA	Adenoviridae	Adenovirus conjugated with DCN, shMet and PEGylated at PAMAM	Yes	No	No	ATCC	Human lung carcinoma cell line	A549	70% confluence in 24 well plate	NA	MTT assay	1 MOI	58% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 40pg/ml compared to control 20 pg/ml	NA	26951927
OV_4476	Adenovirus	oAD/DCN-shMet/PPE	DNA	Adenoviridae	Adenovirus conjugated with DCN, shMet and Erbitux-conjugated PEGylated at PAMAM	Yes	No	No	ATCC	Human lung carcinoma cell line	A549	70% confluence in 24 well plate	NA	MTT assay	1 MOI	18% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 40pg/ml compared to control 20 pg/ml	NA	26951927
OV_4477	Adenovirus	oAD/DCN-shMet	DNA	Adenoviridae	Adenovirus conjugated with DCN and shMet	Yes	No	No	ATCC	Human breast cancer cell line	MCF-7	70% confluence in 24 well plate	NA	MTT assay	100 MOI	88% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 140pg/ml compared to control 20 pg/ml	NA	26951927
OV_4478	Adenovirus	oAD/DCN-shMet/PP	DNA	Adenoviridae	Adenovirus conjugated with DCN, shMet and PEGylated at PAMAM	Yes	No	No	ATCC	Human breast cancer cell line	MCF-7	70% confluence in 24 well plate	NA	MTT assay	100 MOI	85% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 40pg/ml compared to control 20 pg/ml	NA	26951927
OV_4479	Adenovirus	oAD/DCN-shMet/PPE	DNA	Adenoviridae	Adenovirus conjugated with DCN, shMet and Erbitux-conjugated PEGylated at PAMAM	Yes	No	No	ATCC	Human breast cancer cell line	MCF-7	70% confluence in 24 well plate	NA	MTT assay	100 MOI	82% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 40pg/ml compared to control 20 pg/ml	NA	26951927
OV_4480	Adenovirus	oAD/DCN-shMet	DNA	Adenoviridae	Adenovirus conjugated with DCN and shMet	Yes	No	No	ATCC	Human breast cancer cell line	HDF	70% confluence in 24 well plate	NA	MTT assay	20 MOI	90% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 140pg/ml compared to control 20 pg/ml	NA	26951927
OV_4481	Adenovirus	oAD/DCN-shMet/PP	DNA	Adenoviridae	Adenovirus conjugated with DCN, shMet and PEGylated at PAMAM	Yes	No	No	ATCC	Human breast cancer cell line	HDF	70% confluence in 24 well plate	NA	MTT assay	20 MOI	90% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 40pg/ml compared to control 20 pg/ml	NA	26951927
OV_4482	Adenovirus	oAD/DCN-shMet/PPE	DNA	Adenoviridae	Adenovirus conjugated with DCN, shMet and Erbitux-conjugated PEGylated at PAMAM	Yes	No	No	ATCC	Human breast cancer cell line	HDF	70% confluence in 24 well plate	NA	MTT assay	20 MOI	90% cancer cell survivalability after 48 hours	No	No	NA	No response	NA	NA	Increased in IL-6 level to 40pg/ml compared to control 20 pg/ml	NA	26951927
OV_4509	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	Yes	No	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	1 VP/cell	100% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4510	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	No	Virus in combination with 4-HP-CP (0.001mg/ml)	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	1 VP/cell	75% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4511	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	No	Virus in combination with 4-HP-CP (0.0025mg/ml)	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	1 VP/cell	75% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4512	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	No	Virus in combination with 4-HP-CP (0.005mg/ml)	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	1 VP/cell	62% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4513	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	Yes	No	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	10 VP/cell	90% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4514	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	No	Virus in combination with 4-HP-CP (0.001mg/ml)	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	10 VP/cell	70% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4515	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	No	Virus in combination with 4-HP-CP (0.0025mg/ml)	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	10 VP/cell	70% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4516	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	No	Virus in combination with 4-HP-CP (0.005mg/ml)	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	10 VP/cell	70% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4517	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	Yes	No	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	100 VP/cell	40% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453
OV_4518	Adenovirus	Ad5/3-D24-GMCSF	DNA	Adenoviridae	Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF	No	Virus in combination with 4-HP-CP (0.001mg/ml)	No	ATCC	Human breast cancer triple negative cell line	MDA-MB-436	1000 cells per well	NA	MTS assay	100 VP/cell	35% cancer cell survival after 5 days	No	No	NA	No response	NA	NA	Virus induced tumor specific T-cell response	NA	27057453

previous 1 2...10 11 12 131415 16 17 18 next