Detailed description page of Selected OV_ID


OV_4204 details
Primary information
OV_IDOV_4204
Virus Name Adenovirus
StrainAd-CXCR4-DAL1
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus expressing DAL-1 gene under promoter CXXR4
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice subcutaneously xenograft for A549 cell (2 × 10⁶)
In-vivo virus concentration1 × 10⁹ PFU, every other day for 3 times
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 1.5 centimeter cube after 28 days compared to control 7 centimeter cube
Mode of deliveryIntratumoral
Pathway inductionVirus induce apoptosis process leads to cancer cell death
Immunogenic effectNA
Clinical trialNA
PMID26280082