Detailed description page of Selected OV_ID


OV_4083 details
Primary information
OV_IDOV_4083
Virus Name Adenovirus
StrainAdenovirus ZD55
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus encoded with drosophila dNK gene
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with drug DFDC(10mg/kg)
Immune gene induction in virus genomeNo
Source of cell lineShanghai cell collection
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for MCF7 (1 × 10⁷)
In-vivo virus concentration1 × 10⁹ pfu
In-vivo toxicityNA
In-vivo resultVirus and drug prolongs the mice survival and reduction in tumor volume to 1000mm compared to control 3000mm after 60 days
Mode of deliveryIntratumoral
Pathway inductionVirus induced apoptosis in cancer cell
Immunogenic effectNA
Clinical trialNA
PMID26203222