| Primary information |
|---|
| OV_ID | OV_4518 |
| Virus Name | Adenovirus |
| Strain | Ad5/3-D24-GMCSF |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Ad5/3-delta24 has a 24 base-pair deletion in constant region 2 of the E1A gene and armed wirh human GMCSF |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with 4-HP-CP (0.001mg/ml) |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Human breast cancer triple negative cell line |
| Cell line | MDA-MB-436 |
| Concentration of cell line | 1000 |
| In-vitro toxicity | NA |
| Assay | MTS assay |
| In-vitro virus concentration | 100 VP/cell |
| In-vitro result | 35% cancer cell survival after 5 days |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | NA |
| Immunogenic effect | Virus induced tumor specific T-cell response |
| Clinical trial | NA |
| PMID | 27057453 |