| 1002 | Cyclosporin A (CsA) | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | Fungus | Reduction of the IL-2 surface receptor CD25 expression (76%±11 after 24 hrs and 62%±7.3 after 36 hrs), also reduces TNF-α expression (23%±1.8) | Inhibits the production of IL-2 | In vitro | Human peripheral Lymphocytes and purified T cells | NA | None | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1003 | Native kalata B1 | GLPVCGETCVGGTCNTPGCTCSWPVCTRN | 29 | L | None | None | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic (head to tail | Natural cyclotide | A cyclotide isolated from Oldenlandia affinis DC. (Rubiaceae) | Reduction of the IL-2 surface receptor CD25 expression (79%±10 after 24 hrs and 46%±18 after 36 hrs), also reduces TNF-α expression (23%±11) | Suppress T-cell polyfunctionality and arrest the proliferation of immune-competent cells through inhibiting IL-2 biology at more than one site as IL-2) surface receptor as well as IL-2 cytokine secretion and IL-2 gene expression. | In vitro | Human peripheral Lymphocytes | 2.9±1.3 micromolar for Lymphocytes (PBMCs) | NA | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1004 | Native kalata B2 | GLPVCGETCVGGTCNTPGCTCSWPVCTRN | 29 | L | None | None | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic (head to tail | Natural cyclotide | A cyclotide isolated from Oldenlandia affinis DC. (Rubiaceae) | Reduction of the IL-2 surface receptor CD25 expression (79%±10 after 24 hrs and 46%±18 after 36 hrs), also reduces TNF-α expression (23%±11) | Suppress T-cell polyfunctionality and arrest the proliferation of immune-competent cells through inhibiting IL-2 biology at more than one site as IL-2) surface receptor as well as IL-2 cytokine secretion and IL-2 gene expression. | In vitro | Purified T cells | 2.4±0.5 micromolar for purified T cells | NA | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1005 | kalata B1 mutants [T20K] | GLPVCGETCVGGTCNTPGCKCSWPVCTRN | 29 | L | Addition of Cysteine | Thioester linker | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic (head to tail | Synthetic | NA | Reduction of the IL-2 surface receptor CD25 expression (79%±10 after 24 hrs and 46%±18 after 36 hrs), also reduces TNF-α expression (23%±11) | Suppress T-cell polyfunctionality and arrest the proliferation of immune-competent cells through inhibiting IL-2 biology at more than one site as IL-2) surface receptor as well as IL-2 cytokine secretion and IL-2 gene expression. | In vitro | Human peripheral Lymphocytes | 1.9±0.6 micromolar for Lymphocytes (PBMCs) | NA | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1006 | kalata B1 mutants [T20K] | GLPVCGETCVGGTCNTPGCKCSWPVCTRN | 29 | L | Addition of Cysteine | Thioester linker | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic (head to tail | Synthetic | NA | Reduction of the IL-2 surface receptor CD25 expression (79%±10 after 24 hrs and 46%±18 after 36 hrs), also reduces TNF-α expression (23%±11) | Suppress T-cell polyfunctionality and arrest the proliferation of immune-competent cells through inhibiting IL-2 biology at more than one site as IL-2) surface receptor as well as IL-2 cytokine secretion and IL-2 gene expression. | In vitro | Purified T cells | 2.7±0.6 micromolar for purified T cells | NA | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1007 | kalata B1 mutants [N29K] | GLPVCGETCVGGTCNTPGCTCSWPVCTRK | 29 | L | Addition of Cysteine | Thioester linker | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic (head to tail | Synthetic | NA | Reduction of the IL-2 surface receptor CD25 expression (79%±10 after 24 hrs and 46%±18 after 36 hrs), also reduces TNF-α expression (23%±11) | Suppress T-cell polyfunctionality and arrest the proliferation of immune-competent cells through inhibiting IL-2 biology at more than one site as IL-2) surface receptor as well as IL-2 cytokine secretion and IL-2 gene expression. | In vitro | Human peripheral Lymphocytes | 3.2±0.6 micromolar for Lymphocytes (PBMCs) | NA | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1008 | kalata B1 mutants [N29K] | GLPVCGETCVGGTCNTPGCTCSWPVCTRK | 29 | L | Addition of Cysteine | Thioester linker | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic (head to tail | Synthetic | NA | Reduction of the IL-2 surface receptor CD25 expression (79%±10 after 24 hrs and 46%±18 after 36 hrs), also reduces TNF-α expression (23%±11) | Suppress T-cell polyfunctionality and arrest the proliferation of immune-competent cells through inhibiting IL-2 biology at more than one site as IL-2) surface receptor as well as IL-2 cytokine secretion and IL-2 gene expression. | In vitro | Purified T cells | 2.1±0.9 micromolar for purified T cells | NA | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1009 | kalata B1 mutants [G18K] | GLPVCGETCVGGTCNTPKCTCSWPVCTRN | 29 | L | Addition of Cysteine | Thioester linker | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic (head to tail | Synthetic | NA | Reduction of the IL-2 surface receptor CD25 expression (79%±10 after 24 hrs and 46%±18 after 36 hrs), also reduces TNF-α expression (23%±11) | Suppress T-cell polyfunctionality and arrest the proliferation of immune-competent cells through inhibiting IL-2 biology at more than one site as IL-2) surface receptor as well as IL-2 cytokine secretion and IL-2 gene expression. | In vitro | Human peripheral Lymphocytes | 4.4±0.5 micromolar for Lymphocytes (PBMCs) | NA | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1010 | kalata B1 mutants [G18K] | GLPVCGETCVGGTCNTPKCTCSWPVCTRN | 29 | L | Addition of Cysteine | Thioester linker | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic (head to tail | Synthetic | NA | Reduction of the IL-2 surface receptor CD25 expression (79%±10 after 24 hrs and 46%±18 after 36 hrs), also reduces TNF-α expression (23%±11) | Suppress T-cell polyfunctionality and arrest the proliferation of immune-competent cells through inhibiting IL-2 biology at more than one site as IL-2) surface receptor as well as IL-2 cytokine secretion and IL-2 gene expression. | In vitro | Purified T cells | 3.2±1.8 micromolar for purified T cells | NA | Cell Proliferation assay, Ca2+ release assay, Cytokines release assay | NA | NA | 23840803 | 2013 |
| 1036 | Cyclosporin A | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | From fungus Trichoderma polysporum | Inhibit IL-2 production by activated CD4+ T-cells | Inhibiting the calcineurin pathway | Both | Peripheral blood mononuclear cells (PBMCs) | 61.8 nM for CD4+ T cell activation of IL-2 production | C57/B6 mice | MIC assay, Immunosuppression and toxicity test | NA | NA | 18599825 | 2008 |
| 1037 | Colutellin A | VISIIPV | 7 | L | None | None | None | Cyclic | Natural | Endophytic fungus Colletotrichum dematium | Inhibit IL-2 production by activated CD4+ T-cells | Inhibiting the calcineurin pathway | Both | Peripheral blood mononuclear cells (PBMCs) | 167.3±0.38 nM for CD4+ T cell activation of IL-2 production | C57/B6 mice | MIC assay, Immunosuppression and toxicity test | MIC of 3.6 mg/ml (48 h) against Botrytis cinerea and Sclerotinia sclerotiorum. | NA | 18599825 | 2008 |
| 1044 | Cyclosporin A | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | From fungus Trichoderma polysporum | Ca2+-dependent permeability transition | Inhibit the Ca2+ dependent permeability transition | In vivo | NA | NA | Male Sprague-Dawley rat | NA | NA | NA | 2470734 | 1989 |
| 1045 | Cyclolinopeptide A (CLA) | VPPFFLIIL | 9 | L | None | None | None | Cyclic | Natural | isolated from linseed oil | Cyclophilin A, IL-1α, IL-2 | it binds to cyclophilin A and inhibits the action of Interleukin-1-alpha and Interleukin-2 | Both | SRBC (Sheep red blood cells) | dose combinations: 0.1 mg/ml of CLA and 0.25 mM of MTX exhibited suppressive, synergistic action | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | Methotrexate (MTX) | 21839548 | 2011 |
| 1046 | CLA analogue1 | LVPPFFLII | 9 | L | None | None | Ethylene bridge (-CH2-CH2-) between phenylalanine nitrogens | Cyclic | Synthetic | Analog of cyclolinopeptide A (CLA) | NA | NA | Both | SRBC (Sheep red blood cells) | NA | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | NA | 21839548 | 2011 |
| 1047 | CLA analogue2 | LVPPffLII | 9 | Mix | None | None | Ethylene bridge (-CH2-CH2-) between phenylalanine nitrogens | Cyclic | Synthetic | Analog of cyclolinopeptide A (CLA) | NA | NA | Both | SRBC (Sheep red blood cells) | NA | 12-week-old BALB/c female mice | Secondary humoral immune response | NA | NA | 21839548 | 2011 |
| 1063 | Kalata B1 | GLPVCGETCVGGTCNTPGCTCSWPVCTRN | 29 | L | None | None | Three cystine knot Disulfide connectivity (CI-CIV, CII-CV and CIII-CVI) | Cyclic | Natural | From Oldenlandia affinis Plant Extract | NA | Inhibits the growth of the Lymphocytes in a cytostatic fashion | In vitro | Human Peripheral Blood Mononuclear Cells | 3.9±0.5 micromolar for antiproliferative effect on PBMC | NA | Cell Proliferation assay, Cell division assay | 14 micromolar of the peptide are cytotoxic to the cells | NA | 22272797 | 2012 |
| 1064 | Antamanide | VPPAFFPPFF | 10 | L | None | None | None | Cyclic | Natural | Isolated from the poisonous mushroom Amanita phalloides | Peptidyl-prolyl cis-trans isomerase CyP-D | Inhibit mitochondrial permeability transition pore | Both | HeLa Cells | NA | C57BL/6 mice | Cell Viability assay, Ca2+ retention capacity assay | NA | NA | 21297983 | 2011 |
| 1065 | Cyclolinopeptide A (CLA) | VPPFFLIIL | 9 | L | None | None | None | Cyclic | Synthetic | NA | NA | Inhibition of the action of interleukin-1 and interleukin-2 | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1066 | Antamanide | VPPAFFPPFF | 10 | L | None | None | None | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1067 | Cycloamanide A (CyA A) | VFFAGP | 6 | L | None | None | None | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1068 | [D-Phe3]CyA A | VFfAGP | 6 | Mix | None | None | None | Cyclic | Synthetic | NA | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1069 | Cycloamanide B (CyA B) | FFFPIPS | 7 | L | None | None | None | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1070 | [D-Ser]CyA B | FFFPIPs | 7 | Mix | None | None | None | Cyclic | Synthetic | NA | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1071 | Cycloamanide C | LPMLGFLV | 8 | L | None | None | R and S sulfoxide on methionine | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1072 | Cycloamanide D | LPMLGFLP | 8 | L | None | None | R and S sulfoxide on methionine | Cyclic | Natural | Isolated from the mushroom Amanita phalloides | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1073 | Retro-[D-Phe3]CyA A | fFVPGA | 6 | Mix | None | None | None | Cyclic | Synthetic | NA | NA | Not investigated | Both | SRBC (sheep red blood cells) | NA | CBA/Iiw mice 8-10 weeks | Humoral immune response test,PFC (plaque froming cell) test, DTH (delayed type hypersensitivity) test | NA | NA | 8441706 | 1992 |
| 1089 | Cyclosporin A (CyA) | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | Fungi | IL-1, IL-8, TNF-α | Inhibits the expression of cytokine genes; lower the activity of T cells and their immune response | In vitro | Murine KC line PAM 212,human squamous carcinoma line COLO-16 | 4.5micromolar | NA | Thymocyte co-stimulator assay | NA | NA | 8148271 | 1994 |
| 1090 | Cyclosporin A (CyA) | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | Fungi | IL-1, lL-8, TNF-α | Inhibits the expression of cytokine genes; lower the activity of T cells and their immune response | In vitro | Normal human KCs | 2micromolar | NA | Thymocyte co-stimulator assay | NA | NA | 8148271 | 1994 |
| 1111 | Collutellin A | VISIIPV | 7 | L | None | None | None | Cyclic | Natural | Colletotrichum dematium (fungus) | IL-2 | Reduces IL2 production | In vitro | C57/B6 mice spleen cells | 167.3+/-0.38 nM | C57/B6 mice | NA | NA | NA | 24333193 | 2014 |
| 1112 | Antamides | VPPAFFPPFF | 10 | L | None | None | None | Cyclic | Natural | Amanita phalloides spp. (fungus) | NA | Inhibition of mitochondrial permeability transition pores | Both | fibroblasts | NA | C57BL/6 mice | NA | NA | NA | 24333193 | 2014 |
| 1113 | Cyclosporin A | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | Tolypocladium inflatum (fungus) | Calcineurin | Inhibition of calcineurin by complex with cyclophilins | Both | Murine KC line PAM 212,human squamous carcinoma line COLO-16 | NA | Sprague Dawley rats | NA | NA | NA | 24333193 | 2014 |
| 1114 | Didemnin A/B | not available | 0 | L | None | None | None | Cyclic | Natural | Trididemnum solidum (tunicate) | eEFA1 and PPT-1 | Blocks protein and RNA synthesis, binds to eEFA1 and PPT-1 | In vivo | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1115 | FK506 (tracrolimus) Ascomycin (pimecrolimus,SDZ ASM 981) | not available | 0 | L | None | None | None | Cyclic | Natural | Streptomyces tsukubaensis (bacteria) | Calcineurin | Inhibition of calcineurin by complex with FK binding proteins | Both | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1116 | Homophymines | not available | 0 | L | None | None | None | Cyclic | Natural | Homophymia spp. (marine sponge) | NA | Antiproliferative, mechanism unknown | In vitro | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1117 | Geodiamolides H | not available | 0 | L | None | None | None | Cyclic | Natural | Geodia corticostylifera (marine sponge) | Actin filaments | Disorganization of actin filaments | In vitro | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1118 | Hymenistatin I | not available | 0 | L | None | None | None | Cyclic | Natural | Hymeniucidon spp. (marine sponge) | NA | Modulation of the IL2 cell response (comparable with rapamycin) | In vivo | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1119 | Jasplakinolide | not available | 0 | L | None | None | None | Cyclic | Natural | Jaspis splendens (marine sponge) | Actin | Actin stabilization, induces actin polymerization | In vitro | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1120 | Sirolimus (rapamycin), everolimus (and derivatives) | not available | 0 | L | None | None | None | Cyclic | Natural | Streptomyces hygroscopius (bacteria) | mTOR | Inhibition of mTOR | Both | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1122 | Curcacycline B (Orbitide) | LGSPILLGI | 9 | L | None | None | None | Cyclic | Natural | Jatropha curcas (plant) | PPIase | PPIase inhbitior | In vitro | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1123 | Cycloleonurinin (Orbitide) | GPTQYPPYYlTP | 13 | Mix | None | None | None | Cyclic | Natural | Leonurus heterophyllus (plant) | NA | Not known | In vitro | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1124 | Cyclolinopeptide A/B (Orbitide) | IMLIPPFFV | 9 | L | None | None | None | Cyclic | Natural | Linum usitatissimum (plant) | Calcineurin | CYPA binding and calcineurin inhibition | In vivo | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1126 | Kalata B1 (Cyclotide) | GLPVCGETCVGGTCNTPGCTCSWPVCTRN | 29 | L | None | None | Three Disulfide linkage (CI-CIV, CII-CV and CIII-CVI) | Cyclic | Natural | Oldenlandia affinis (plant) | IL-2 | Antiproliferative, IL2-dependent mechanism | Both | NA | NA | NA | NA | NA | NA | 24333193 | 2014 |
| 1134 | Thalassospiramide A | not available | 0 | L | None | None | None | Cyclic | Natural | α-proteobacterium (strain CNJ-328) | IL-5 | Inhibition of IL-5 | In vitro | lymphocytes | 10 micromolar | NA | NA | NA | NA | 17373804 | 2007 |
| 1135 | Thalassospiramide B | not available | 0 | L | None | None | None | Cyclic | Natural | α-proteobacterium (strain CNJ-328) | IL-5 | Inhibition of IL-6 | In vitro | lymphocytes | 5 micromolar | NA | NA | NA | NA | 17373804 | 2007 |
| 1139 | Cyclosporin A (CsA) | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | Fungus | NA | Inhibits virus-induced polykaryocyte formation and the production of infectious measles virus | In vitro | Vero cells (Persistently infected Vero cells (448-PI-Vero)) | 5micromolar | NA | NA | NA | NA | 11509881 | 2001 |
| 1145 | Cyclosporin A (CsA) | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | Fungus | NA | Not Available | In vivo | NA | NA | Eight- to 12-week-old male Lewis.lW (RTI.u) and Lewis.lA (RTI.')rats | Graft transplation assay | NA | NA | 10666482 | 2000 |
| 1173 | Cyclosporin A | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] | 11 | Mix | None | None | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated | Cyclic | Natural | Fungus | NA | Not Available | In vivo | NA | NA | CBA/Ca and (CBA/Ca X C57BL6)F1 mice | Plaque-forming cell (PFC) assay | NA | NA | 6159410 | 1980 |
| 1202 | A1HS1 | II-Sta-PYVPL | 8 | L | None | None | Sta = (3S, 4S) -4- amino-3-hydroxy-6-methyl-heptanoic acid(C8H17NO3) | Cyclic | Synthetic | NA | Lymphocytes, Macrophages | Influence of phagocytic function of macrophages, and the retarding effect of the proliferation of Lymphocytes | Both | Spleen Lymphocyte | NA | BALB / C mice | Delayed-type hypersensitivity (DTH) test, Lymphocyte Proliferation test, MTT | NA | | CN 101289499 B | 2010 |
| 1203 | A3HS1 | IIPPYV-Sta-L | 8 | L | None | None | Sta = Statine | Cyclic | Synthetic | NA | Lymphocytes, Macrophages | Influence of phagocytic function of macrophages, and the retarding effect of the proliferation of Lymphocytes | Both | Spleen Lymphocyte | NA | BALB / C mice | Delayed-type hypersensitivity (DTH) test, Lymphocyte Proliferation test, MTT | NA | | CN 101289498 B | 2010 |
| 1204 | A4HS1 | II-Sta-Sta-YVPL | 8 | L | None | None | Sta = Statine | Cyclic | Synthetic | NA | Lymphocytes, Macrophages | Influence of phagocytic function of macrophages, and the retarding effect of the proliferation of Lymphocytes | Both | Spleen Lymphocyte | NA | BALB / C mice | Delayed-type hypersensitivity (DTH) test, Lymphocyte Proliferation test, MTT | NA | | CN 101289497 A | 2008 |
