| Primary information |
|---|
| ID | 1139 |
| Peptide Name | Cyclosporin A (CsA) |
| Sequence | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] |
| Length | 11 |
| Chirality | Mix |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated |
| Linear/ Cyclic | Cyclic |
| Nature | Natural |
| Source of Origin | Fungus |
| Target | NA |
| Mechanism of Action | Inhibits virus-induced polykaryocyte formation and the production of infectious measles virus |
| In vitro/In vivo | In vitro |
| Cell Line | Vero cells (Persistently infected Vero cells (448-PI-Vero)) |
| Inhibition Concentartion | 5micromolar |
| In vivo Model | NA |
| Assay | NA |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 11509881 |
| Year of Publication | 2001 |
| 3-D Structure | NA |
