| Primary information |
|---|
| ID | 1089 |
| Peptide Name | Cyclosporin A (CyA) |
| Sequence | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] |
| Length | 11 |
| Chirality | Mix |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated |
| Linear/ Cyclic | Cyclic |
| Nature | Natural |
| Source of Origin | Fungi |
| Target | IL-1, IL-8, TNF-α |
| Mechanism of Action | Inhibits the expression of cytokine genes; lower the activity of T cells and their immune response |
| In vitro/In vivo | In vitro |
| Cell Line | Murine KC line PAM 212,human squamous carcinoma line COLO-16 |
| Inhibition Concentartion | 4.5micromolar |
| In vivo Model | NA |
| Assay | Thymocyte co-stimulator assay |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 8148271 |
| Year of Publication | 1994 |
| 3-D Structure | NA |
