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1145 details |
| Primary information | |
|---|---|
| ID | 1145 |
| Peptide Name | Cyclosporin A (CsA) |
| Sequence | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] |
| Length | 11 |
| Chirality | Mix |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated |
| Linear/ Cyclic | Cyclic |
| Nature | Natural |
| Source of Origin | Fungus |
| Target | NA |
| Mechanism of Action | Not Available |
| In vitro/In vivo | In vivo |
| Cell Line | NA |
| Inhibition Concentartion | NA |
| In vivo Model | Eight- to 12-week-old male Lewis.lW (RTI.u) and Lewis.lA (RTI.')rats |
| Assay | Graft transplation assay |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 10666482 |
| Year of Publication | 2000 |
| 3-D Structure | NA |