Primary information |
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ID | 1044 |
Peptide Name | Cyclosporin A |
Sequence | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] |
Length | 11 |
Chirality | Mix |
N-terminal Modification | None |
C-terminal Modification | None |
Chemical Modification | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated |
Linear/ Cyclic | Cyclic |
Nature | Natural |
Source of Origin | From fungus Trichoderma polysporum |
Target | Ca2+-dependent permeability transition |
Mechanism of Action | Inhibit the Ca2+ dependent permeability transition |
In vitro/In vivo | In vivo |
Cell Line | NA |
Inhibition Concentartion | NA |
In vivo Model | Male Sprague-Dawley rat |
Assay | NA |
Lethal Dose | NA |
Combination Therapy | NA |
Pubmed ID | 2470734 |
Year of Publication | 1989 |
3-D Structure | NA |