| Primary information |
|---|
| ID | 1045 |
| Peptide Name | Cyclolinopeptide A (CLA) |
| Sequence | VPPFFLIIL |
| Length | 9 |
| Chirality | L |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | None |
| Linear/ Cyclic | Cyclic |
| Nature | Natural |
| Source of Origin | isolated from linseed oil |
| Target | Cyclophilin A, IL-1α, IL-2 |
| Mechanism of Action | it binds to cyclophilin A and inhibits the action of Interleukin-1-alpha and Interleukin-2 |
| In vitro/In vivo | Both |
| Cell Line | SRBC (Sheep red blood cells) |
| Inhibition Concentartion | dose combinations: 0.1 mg/ml of CLA and 0.25 mM of MTX exhibited suppressive, synergistic action |
| In vivo Model | 12-week-old BALB/c female mice |
| Assay | Secondary humoral immune response |
| Lethal Dose | NA |
| Combination Therapy | Methotrexate (MTX) |
| Pubmed ID | 21839548 |
| Year of Publication | 2011 |
| 3-D Structure |  View in Jmol or Download Structure |
