| Primary information |
|---|
| ID | 1036 |
| Peptide Name | Cyclosporin A |
| Sequence | cyclo[Abu-Sar-N(Me)Leu-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)] |
| Length | 11 |
| Chirality | Mix |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | Bmt = butenyl-methyl-threonine, Abu = L-alpha-aminobutyric acid, Sar = sarcosine, N(Me) = Amino acid is N-methylated |
| Linear/ Cyclic | Cyclic |
| Nature | Natural |
| Source of Origin | From fungus Trichoderma polysporum |
| Target | Inhibit IL-2 production by activated CD4+ T-cells |
| Mechanism of Action | Inhibiting the calcineurin pathway |
| In vitro/In vivo | Both |
| Cell Line | Peripheral blood mononuclear cells (PBMCs) |
| Inhibition Concentartion | 61.8 nM for CD4+ T cell activation of IL-2 production |
| In vivo Model | C57/B6 mice |
| Assay | MIC assay, Immunosuppression and toxicity test |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 18599825 |
| Year of Publication | 2008 |
| 3-D Structure | NA |
