| Primary information |
|---|
| ID | 1037 |
| Peptide Name | Colutellin A |
| Sequence | VISIIPV |
| Length | 7 |
| Chirality | L |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | None |
| Linear/ Cyclic | Cyclic |
| Nature | Natural |
| Source of Origin | Endophytic fungus Colletotrichum dematium |
| Target | Inhibit IL-2 production by activated CD4+ T-cells |
| Mechanism of Action | Inhibiting the calcineurin pathway |
| In vitro/In vivo | Both |
| Cell Line | Peripheral blood mononuclear cells (PBMCs) |
| Inhibition Concentartion | 167.3±0.38 nM for CD4+ T cell activation of IL-2 production |
| In vivo Model | C57/B6 mice |
| Assay | MIC assay, Immunosuppression and toxicity test |
| Lethal Dose | MIC of 3.6 mg/ml (48 h) against Botrytis cinerea and Sclerotinia sclerotiorum. |
| Combination Therapy | NA |
| Pubmed ID | 18599825 |
| Year of Publication | 2008 |
| 3-D Structure |  View in Jmol or Download Structure |
