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The total number entries retrieved from this search are 178
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Note: Potential Biomarker with * indicates these signatures are candidate biomarkers extracted from experiments on mice, rat or cell lines and they are not validated on human patients'cohort.
Biomarker IDBiomarkerBiomoleculeSubjectRegulationBiomarker's typeExperimentLevel of significanceSourcePMID
2001ROBO1Protein and RNAsHumanUpregulated (1.5 fold) DiagnosticHCC v/s Normal p < 0.05 (for protein); p < 0.001 (for mRNA)Tissue28977866
2014GLUT3ProteinHuman Cell linesEmbryonal HB but not fetal HB tissues express GLUT3 Potential Diagnostic *Embryonal v/s fetal HB (Subtypes of Hepatoblastoma) p < 0.0001Tissue28923827
2015LDHBProteinHuman Cell linesEmbryonal HB but not fetal HB tissues express LDHB proteins Potential Diagnostic *Embryonal v/s fetal HB (Subtypes of Hepatoblastoma) p < 0.01Tissue28923827
2016G6PCProteinHuman Cell linesFetal HBs express G6PC preferentially than embryonal. Potential Diagnostic *Embryonal v/s fetal HB (Subtypes of Hepatoblastoma) p < 0.0001Tissue28923827
2020AFP, AFP-L3, PIVKA-II, and UltrasoundProtein + TechniqueHumanNA DiagnosticNormal vs cancer NASerum28757516
2024eIF5ProteinHumanUpregulated in chronic hepatitis B (HBV)-associated HCC DiagnosticNormal vs cancer p < 0.001Tissue28715695
2027HMGB1ProteinHumanUpregulated in HCC PredictiveHCC treated with sorafenib and with HAIC v/s Patients with Pre-treatment. p < 0.05Tissue28474222
2031FGA, ITIHProteinHumanUpregulated in the liver cancer cell lines DiagnosticMalignant vs Benign tumor of HCC p < 0.05Serum28376075
2041AFPProtein HumanNA Diagnostic and PrognosticHCC vs CHB (Chronic hepatitis B); significantly associated with tumor node-metastasis (TNM) stage p < 0.001Serum28189396
2042AFP, Promoter methylation of HCCS1Protein and RNAHumanNA Diagnostic and PrognosticHCC vs CHB (Chronic hepatitis B); significantly associated with tumor node-metastasis (TNM) stage p < 0.05Serum28189396
2043RKIPProteinHumanDownregulated in liver cancer cell. DiagnosticCancer v/s Normal NATissue28071612
2050PKM2ProteinHumanUpregulated in HCC (16 fold) DiagnosticModerately and well differentiated grades v/s poorly differentiated grades of HCC and ICC p < 0.01Tissue27203546
2051EpCAMProteinHumanUpregulated for CTCs in patients with HCC. DiagnosticHCC v/s Normal p = 0.595Blood27034142
2052EMAProteinHumanUpregulated for CTCs in patients with HCC. DiagnosticHCC v/s Normal p < 0.05Blood27034142
2053CFL1ProteinHuman cell lines and Mice Upregulated in HBV-HCC Diagnostic and PrognosticHBV-HCC vs normal p < 0.05Tissue27708241
2054ADFPProteinHuman cell lines and Mice Upregulated in HBV-associated HCC Diagnostic and PrognosticHBV-HCC vs normal p < 0.05Tissue27708241
2055TRIM32ProteinHumanUpregulated in HCC tumor tissues and HCC cell lines. Diagnostic and PrognosticHCC v/s Normal; significant predictor for the overall survival time of HCC patients and positively correlated with histological grade, tumor sizes of patients p < 0.05Tissue27573002
2058HIF1AProteinHumanUpregulated in at both an mRNA and protein level in patients with PLC Diagnostic and PrognosticCancer v/s Normal; predict survival of patients p < 0.05Tissue27173353
2059VEGFProteinHumanUpregulated in at both an mRNA and protein level in patients with PLC Diagnostic and PrognosticCancer v/s Normal; predict survival of patients p < 0.05Tissue27173353
2085Estrogen , Estradiol, AFPProtein + SteroidHumanDownregulated in liver cancer cell. DiagnosticNormal vs liver cancer p < 0.05Serum27060391
2087AFPProteinHumanDownregulated in liver cancer cell. DiagnosticNormal vs liver cancer p < 0.06Serum27060391
2103AFP-L3ProteinHumanUpregulated in AFP-negative HCC patients DiagnosticNormal vs HCC p < 0.01Tissue26770061
2104GP73ProteinHumanUpregulated in AFP-negative HCC patients DiagnosticNormal vs HCC p < 0.01Tissue26770061
2105AFP-L3, GP73 (combined)ProteinHumanUpregulated in AFP-negative HCC patients DiagnosticNormal vs HCC p < 0.01Tissue26770061
2106TOPO2ProteinHumanDownregulated in nucleolus of HCC DiagnosticNormal vs HCC NATissue26722553
2108ABCC3ProteinRat and Humanoverexpressed in hepatocellular carcinoma Potential Diagnostic *Normal vs HCC p < 0.01Tissue26337276
2109DHCR24 Auto-antibodyProteinHumanUpregulated in CHC (Chronic Hepatitis C) v/s healthy PrognosticNormal vs Chronic heaptitis (CHV) p < 0.0001Serum26288822
2110DHCR24 Auto-antibodyProteinHumanDHCR24 was up-regulated in HCV-positive, but not HBV-positive tissues or HBV-negative, HCV-negative HCC PrognosticHCC vs Chronic heaptitis (CHV)/healthy/Liver cirrhosis p < 0.0001Serum26288822
2115Galectin-1ProteinHuman High pretreatment galectin-1 levels remained an independent predictor of shorter progression-free survival and overall survival PredictiveHCC patients treated with sorafenib vs HCC untreated patients p < 0.01Serum25850433
2117RNase AProteinHumanDownregulated in gastric cancer, liver cancer, pancreatic cancer, esophageal cancer, ovary cancer, cervical cancer, bladder cancer, kidney cancer and lung cancer DiagnosticCancer v/s Normal p < 0.01Serum24805924
2119KIAA1114ProteinHuman and Mice cell linesKIAA1114 is overexpressed in human liver cancer cell lines Potential Diagnostic *Normal cell line vs HCC cell line p < 0.05Tissue24713374
2126AFP (at a cut-off of 20 ng/mL)ProteinHumanUpregulated level in HCC DiagnosticHCC with cirrhosis v/s HCV-associated cirrhosis p < 0.05Serum24095974
2130VTNProteinHumanDownregulated in HCV-infected HCC patients DiagnosticNormal vs HCV-infected HCC patients, Normals vs non HCV-infected HCC p < 0.05Plasma23944848
2131SAPProteinHumanDownregulated in HCV-infected HCC patients DiagnosticNormal vs HCV-infected HCC patients, Normals vs non HCV-infected HCC p < 0.01Plasma23944848
2132CYP3A4ProteinHumanUpregulated in in hepatitis B virus-associated liver cirrhosis and stage I hepatocellular carcinoma, PrognosticHCC vs adjacent non-tumor and stageII v/s stage-III; predict early stage p < 0.05Tissue and Cells 23891548
2134ENO1ProteinHumanUpregulated in patients with precirrhotic stage of liver fibrosis than that in patients with cirrhosis/liver cancer/healthy individuals. PrognosticLiver fibrosis v/s cirrhosis/liver cancer/normal; predict early stage of disease p < 0.01Serum23458688
2135XPO4ProteinHumanUpregulated in paracancerous than in cancerous liver tissue PrognosticNormal vs HCC; predict survival of patients p < 0.0001Tissue23251252
2136TGFβ1ProteinHumanUpregulated in paracancerous than in cancerous liver tissue PrognosticNormal vs HCC; predict survival of patients p < 0.0001Tissue23251252
2137elF5A2ProteinHumanUpregulated in paracancerous than in cancerous liver tissue PrognosticNormal vs HCC; predict survival of patients p < 0.0001Tissue23251252
2138ANGPTL4ProteinHumanUpregulated in paracancerous than in cancerous liver tissue PrognosticNormal vs HCC; predict survival of patients p < 0.0001Tissue23251252
2139C3ProteinMale Wistar ratsUpregulated at very early stage in HCC Potential Diagnostic *Normal vs HCC p < 0.05Tissue23245919
2151DJ-1ProteinHumanUpregulated in HCC DiagnosticNormal vs HCC with Hepatitis C and without Hepatitis C p < 0.05Urine23074380
2152CAF-1ProteinHumanUpregulated in HCC DiagnosticNormal vs HCC with Hepatitis C and without Hepatitis C p < 0.05Urine23074380
2153HSP60ProteinHumanUpregulated in HCC DiagnosticNormal vs HCC with Hepatitis C and without Hepatitis C p < 0.05Urine23074380
2154DJ-1, CAF-1ProteinHumanUpregulated in HCC DiagnosticNormal vs HCC with Hepatitis C and without Hepatitis C p < 0.05Urine23074380
2155DJ-1, HSP60ProteinHumanUpregulated in HCC DiagnosticNormal vs HCC with Hepatitis C and without Hepatitis C p < 0.05Urine23074380
2156CAF-1, HSP60ProteinHumanUpregulated in HCC DiagnosticNormal vs HCC with Hepatitis C and without Hepatitis C p < 0.05Urine23074380
2157DJ-1, CAF-1, HSP60ProteinHumanUpregulated in HCC DiagnosticNormal vs HCC with Hepatitis C and without Hepatitis C p < 0.05Urine23074380
2158hnRNP KProteinHumanUpregulated in HCC DiagnosticEarly HCC vs Late HCC p < 0.01Serum22760167
2159hnRNP K, AFPProteinHumanUpregulated in HCC DiagnosticEarly HCC vs Late HCC p < 0.01Serum22760167

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