| Detailed information |
|---|
| CancerLivER ID | 2134 |
| Biomarker | ENO1 |
| Biomarker Name/Symbol (given in Publication) | Alpha enolase |
| Biomolecule | Protein |
| Subject | Human |
| Degree of Validity | Alpha-enolase can be a potential prognostic factor for liver fibrosis diagnosis and validated on independent dataset |
| Experimental Condition | Liver fibrosis v/s cirrhosis/liver cancer/normal; predict early stage of disease |
| Cancer type | Human liver cancer |
| Regulation | Upregulated in patients with precirrhotic stage of liver fibrosis than that in patients with cirrhosis/liver cancer/healthy individuals. |
| Level of significance | p < 0.01 |
| Source | Serum |
| PMID | 23458688 |
| Type of Biomarker | Prognostic |
| Pathway | c-Jun NH2-terminal kinase (JNK) signaling pathway, |
| Cohort | Sera from 180 liver fibrosis patients (125 patients with precirrhotic stage (stage 0-3) of liver fibrosis and 25 patients with liver cirrhosis) and 30 Normal human sera (NHS); Validation dataset: 84 liver cancer and 74 Normal human sera (NHS) |
| Sensitivity | NA |
| Specificity | NA |
| Accuracy | NA |
| AUC | NA |
| Disease | Human liver cancer |
| Year of Publication | 2013 |
| Clinical trial | NO |
| Clinical trial (NCT Number) | NA |