| Detailed information |
|---|
| CancerLivER ID | 2042 |
| Biomarker | AFP, Promoter methylation of HCCS1 |
| Biomarker Name/Symbol (given in Publication) | AFP + Promoter methylation of HCCS1 |
| Biomolecule | Protein and RNA |
| Subject | Human |
| Degree of Validity | HCCS1 promoter methylation +AFP for discriminating patients with HCC from CHB and validated on independent dataset |
| Experimental Condition | HCC vs CHB (Chronic hepatitis B); significantly associated with tumor node-metastasis (TNM) stage |
| Cancer type | Hepatocellular carcinoma, Chronic hepatitis B |
| Regulation | NA |
| Level of significance | p < 0.05 |
| Source | Serum |
| PMID | 28189396 |
| Type of Biomarker | Diagnostic and Prognostic |
| Pathway | pro-apoptotic pathway |
| Cohort | 120 patients with HCC, 146 patients with chronic hepatitis B (CHB) and 27 healthy controls (HCs) in training daatset and 63 patients with HCC and 44 patients with CHB in validation dataset. |
| Sensitivity | 81.70% |
| Specificity | NA |
| Accuracy | NA |
| AUC | NA |
| Disease | Human HCC and Human CHB |
| Year of Publication | 2017 |
| Clinical trial | NO |
| Clinical trial (NCT Number) | NA |