Browse result page of TopicalPdb

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ID	Sequence	Name	Nature of peptide or cargo	Assay	Tissue permeability	Tissue Sample	PUBMED ID
ID1001	SequenceACSSSPSKHCG	NameTD1	Nature of peptide or cargoTD1 enhances the transdermal delivery of macromolecules	AssayFranz diffusion cells	Tissue permeabilitySignificant increase in permeability of the peptide can be seen by the addition of ATP.The amount of protein that permeated the skin was determined with ELISA	Tissue SampleMale SD rats skin cells	PUBMED ID25269793
ID1002	SequenceAAPV	NameAAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=0.46 μg/cm2/h, Permeability coefficient=1.50×10−4Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1003	SequenceAAPV	NameC6(D)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=2.29 μg/cm2/h, Permeability coefficient=7.6×10−4 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1004	SequenceAAPV	NameC6(L)-Laa- AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=0.50 μg/cm2/h, Permeability coefficient=1.6×10−4 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1005	SequenceAAPV	NameC8(D,L)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=10.08 μg/cm2/h, Permeability coefficient= 3.3×10−3 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1006	SequenceAAPV	NameC8(D)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=7.42 μg/cm2/h, Permeability coefficient=1.90×10−2 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1007	SequenceAAPV	NameC8(L)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=1.37 μg/cm2/h, Permeability coefficient=4.50×10−4 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1008	SequenceAAPV	NameC10(D,L)-Laa-AAPV	Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively	AssayFranz diffusion cell, HPLC	Tissue permeabilityEpidermal flux=8.92 μg/cm2/h, Permeability coefficient=2.9×10−3 Kp(cm/h)	Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin	PUBMED ID24842663
ID1009	SequenceRRRRRRRRRRRLILV LLAI	Name11R-No. 10	Nature of peptide or cargoMelanogenesis inhibitory peptide	AssayConfocal microscope	Tissue permeabilityWhen TMR-11R was topically applied for 24 h, the signals were only observed on the surface of the skin. In contrast, 12 h later, strong signals were detected showing that TMR-11R had arrived at the skin basal layer. Moreover, 24 and 48 hours later, the signals had spread out more and were stronger in both epidermis and dermis	Tissue SampleSkin from the back of a brown guinea pig	PUBMED ID24602570
ID1010	SequenceGKRR	NameR4 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 25.16 ± 2.31 , Q48 (mg) 1167.05 ± 50.10 Drug content in skin (mg/cm2) 146 ± 6.44	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1011	SequenceGKRR	NameR4 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 43.74 ± 4.15 , Q48(mg) 2064.72 ± 100.05 Drug content in skin (mg/cm2) 180 ± 8.23	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1012	SequenceGKRR	NameR4 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1013	SequenceGKKKRRRR	NameR8 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1014	SequenceGKKKRRRR	NameR8 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1015	SequenceGKKKRRRR	NameR8 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 78.07 ± 7.52, Q48 (mg) 3666.44 ± 162.70 Drug content in skin (mg/cm2) 378± 15.11	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1016	SequenceGKKKKKKKRRRRRRRR	NameR16 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 21.43 ± 1.32 , Q48 (mg) 856.29 ± 39.50 Drug content in skin (mg/cm2) 151 ± 4.64	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1017	SequenceGKKKKKKKRRRRRRRR	NameR16 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 23.46 ± 2.04 , Q48 (mg) 1106.03 ± 53.80 Drug content in skin (mg/cm2) 155 ± 4.85	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1018	SequenceGKKKKKKKRRRRRRRR	NameR16 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 27.16 ± 2.65, Q48 (mg) 1256.61 ± 55.70, Drug content in skin (mg/cm2) 156 ± 6.26	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1019	SequenceKETWWETWWTEWSQP KKKRKV	NamePep-1	Nature of peptide or cargoCell penetrating peptide	AssayIn vivo imaging	Tissue permeabilitySignificant permeability of the peptide can be seen in in vivo images	Tissue SampleMouse skin cells	PUBMED ID23601371
ID1020	SequenceACSSSPSKHCG	NameTDN	Nature of peptide or cargoTD-1 has been testified to enhanced insulin transdermal delivery through hair follicles	AssayConfocal Laser Scanning Microscopy	Tissue permeabilitySignificant permeability of the peptide can be seen in confocal images	Tissue SampleMale SD rats skin cells	PUBMED ID23391375
ID1021	SequenceACSSKKSKHCG	NameTD-34	Nature of peptide or cargoTD-1 has been testified to enhanced insulin transdermal delivery through hair follicles	AssayConfocal Laser Scanning Microscopy	Tissue permeabilitySignificant permeability of the peptide can be seen in confocal images	Tissue SampleMale SD rats skin cells	PUBMED ID23391375
ID1022	SequenceACSSSPSKHCG	NameTD1	Nature of peptide or cargoTD1 enhances the transdermal delivery of macromolecules	AssayFranz diffusion cells, immunity fluorescence techniques	Tissue permeabilitySignificant permeability of the peptide can be seen. The amount of protein that permeated the skin was determined with immunity fluorescence techniques	Tissue SampleMale SD rats skin cells	PUBMED ID23385091
ID1023	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityTP could not pass through the skin due to the charge repulsion effect between the negative charge of the TP and the negative charge of the skin	Tissue SampleAbdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1024	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityCumulative amounts0.10± 0.01 µg/cm2 and fluxes 0.60 ± 0.06 µg/cm2·h	Tissue SampleAcceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1025	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityCumulative amounts 0.31 ± 0.04 µg/cm2 and fluxes 1.86 ± 0.24 µg/cm2·h	Tissue SampleAbdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1026	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityCumulative amounts 1.02 ± 0.05 µg/cm2 and fluxes 6.13± 0.28 µg/cm2·h	Tissue SampleAcceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1027	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityCumulative amounts 4.29 ± 0.40 µg/cm2 and fluxes 25.73 ± 2.40 µg/cm2·h	Tissue SampleAbdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1028	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~0.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1029	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>0.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1030	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>1% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1031	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<0.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1032	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<0.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1033	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>1.5% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1034	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~2% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1035	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<4% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1036	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~0.5% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1037	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<1% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1038	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>8% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1039	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<4% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1040	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability<18% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1041	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~3% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1042	Sequenceβ-Ala-H	NameL -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>8% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1076	SequenceRRRRRRRR	NamePolyarginine	Nature of peptide or cargoCell penetrating peptide	AssayFranz cell system	Tissue permeabilityThe SC, epidermal and dermal retention of SP for SP-NLC-R11 was 10.92, 7.02 and 0.82 mg/g of skin, respectively and the SC, epidermal and dermal retention of KP for KP-NLC-R11 was 0.75, 0.44 and 0.17 mg/g of skin, respectively	Tissue SampleSkin from the dorsal surface of hairless rat	PUBMED ID22617521
ID1077	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.20 ± 0.05 mg/cm2 and fluxes 0.20 ± 0.05 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1078	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.43 ± 0.04 mg/cm2 and fluxes 0.14 ± 0.01 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1079	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.59 ± 0.12 mg/cm2 and fluxes 0.10 ± 0.02 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1080	SequenceCSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP	NamesCT	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.67 ± 0.10 mg/cm2 and fluxes 0.67 ± 0.10 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1081	SequenceCSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP	NamesCT	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.33 ± 0.09 mg/cm2 and fluxes 0.11 ± 0.03 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1082	SequenceCSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP	NamesCT	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.26 ± 0.02 mg/cm2 and fluxes 0.04 ± 0.00 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1083	SequenceRQIKIWFQNRRMKWKK	NamePenetratin (PEN)	Nature of peptide or cargoPenetrate through cell and nucleus membranes	AssayFranz diffusion cell system, HPLC with photodiode array detector	Tissue permeability2-fold higher	Tissue SamplePorcine ear skin	PUBMED ID22306174