Browse result page of TopicalPdb

Please click on the ID to see detailed information about each entry.

The total number entries retrieved from this search are

ID	Sequence	Name	Nature of peptide or cargo	Assay	Tissue permeability	Tissue Sample	PUBMED ID
ID1043	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1044	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~6% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1045	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~1.5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1046	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~5% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1047	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~3% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1048	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~2% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1049	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~7% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1050	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~3% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1051	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability2% of applied dose	Tissue SampleStratum corneum of human breast skin	PUBMED ID22890441
ID1052	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~11% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1053	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~9% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1054	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~3% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1055	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~10% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1056	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~7% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1057	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~5% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1058	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~12% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1059	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>4% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1060	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~4% of applied dose	Tissue SampleEpidermis of human breast skin	PUBMED ID22890441
ID1061	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>36% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1062	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>26% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1063	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~26% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1064	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability25% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1065	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability20% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1066	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~20% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1067	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~26% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1068	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability13% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1069	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability14% of applied dose	Tissue SampleDermis of human breast skin	PUBMED ID22890441
ID1070	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability9.5% of applied dose	Tissue SampleAcceptor compartment of Franz diffusion cell	PUBMED ID22890441
ID1071	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~7% of applied dose	Tissue SampleAcceptor compartment of Franz diffusion cell	PUBMED ID22890441
ID1072	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>19% of applied dose	Tissue SampleAcceptor compartment of Franz diffusion cell	PUBMED ID22890441
ID1073	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability21% of applied dose	Tissue SampleAcceptor compartment of Franz diffusion cell	PUBMED ID22890441
ID1074	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability>8% of applied dose	Tissue SampleAcceptor compartment of Franz diffusion cell	PUBMED ID22890441
ID1075	Sequenceβ-Ala-H	NameN-acetyl- L -carnosine	Nature of peptide or cargoAntioxidant	AssayFranz diffusion cell, HPLC	Tissue permeability~15% of applied dose	Tissue SampleAcceptor compartment of Franz diffusion cell	PUBMED ID22890441
ID1110	SequenceYTSLIHSLIEESQNQQ EKNEQELLELDKWAS LWNWF	NameN-acetylated T20	Nature of peptide or cargoFusion inhibitor	AssayReal-time PCR	Tissue permeabilityIC50 of 51.2 microM (230 ng/ml; 95% confidence interval, 198 to 267 ng/ml; n 8 independent experiments with 4 donor tissues)	Tissue SampleVaginal epithelial sheet	PUBMED ID19949052
ID1289	SequenceGrGDIPASSKGGGGS rLLLLLLr	NameRGD peptide matrix	Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site	AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.	Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 57% (32 patients)	Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle	PUBMED ID8080985
ID1290	SequenceGrGDIPASSKGGGGS rLLLLLLr	NameRGD peptide matrix	Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site	AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.	Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 55% (23 patients)	Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle	PUBMED ID8080985
ID1291	SequenceGrGDIPASSKGGGGS rLLLLLLr	NameRGD peptide matrix	Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site	AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.	Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 54% (21 patients)	Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle	PUBMED ID8080985
ID1292	SequenceGrGDIPASSKGGGGS rLLLLLLr	NameRGD peptide matrix	Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site	AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.	Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 56% (20 patients)	Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle	PUBMED ID8080985
ID1293	SequenceGrGDIPASSKGGGGS rLLLLLLr	NameRGD peptide matrix	Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site	AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.	Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 58% (16 patients)	Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle	PUBMED ID8080985
ID1294	SequenceGrGDIPASSKGGGGS rLLLLLLr	NameRGD peptide matrix	Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site	AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done.	Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 61% (14 patients)	Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle	PUBMED ID8080985
ID1301	SequenceSYSMEHFRWGKPV	Nameα-Melanocyte stimulating hormone (MSH)	Nature of peptide or cargoControls pigmentary changes in many vertebrates and melanin synthesis within epidermal melanocytes is responsible for melanin pigmentation of the skin, hair, and feathers in man, birds and other mammals.	AssayLight and electron microscopy	Tissue permeability10-7 and 10-8 concentrations turned yellow hair brown	Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect	PUBMED ID3684299
ID1302	SequenceSYS-Nle-EHfRWGKPV	Name[Nle4, D-Phe7]-alpha-MSH	Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone	AssayLight and electron microscopy	Tissue permeability10-7 to 10-12 concentrations turned yellow hair brown	Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect	PUBMED ID3684299
ID1303	SequenceNle-EHfRWGK	Name[Nle4, D-Phe7]-alpha-MSH4-11	Nature of peptide or cargoNot mentioned	AssayLight and electron microscopy	Tissue permeability10-8 to 10-14 concentrations turned yellow hair brown	Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect	PUBMED ID3684299
ID1304	SequenceNle-EHfRWG	Name[Nle4, D-Phe7]-alpha-MSH4-10	Nature of peptide or cargoNot mentioned	AssayLight and electron microscopy	Tissue permeability10-8 to 10-14 concentrations turned yellow hair brown	Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect	PUBMED ID3684299
ID1306	SequenceSYS-Nle-EHfRWGKPV	Name(Nle4, D-Phe7]-α-MSH	Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice	AssayElectron microscopy and Light microscopy	Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.	Tissue Sampledorsal trunk of mice (C57BL/6JA y)	PUBMED ID3624899
ID1307	SequenceNle-EHfFRWGK	NameAc-[Nle4, D-Phe7]-α- MSH4–11-NH2	Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice	AssayElectron microscopy and Light microscopy	Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.	Tissue Sampledorsal trunk of mice (C57BL/6JA y)	PUBMED ID3624899
ID1308	SequenceNle-EH-FRWG	NameAc-[Nle4, D-Phe7]-α-MSH4–10-NH2	Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice	AssayElectron microscopy and Light microscopy	Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.	Tissue Sampledorsal trunk of mice (C57BL/6JA y)	PUBMED ID3624899
ID1309	SequenceSYSMEHFRWGKPV	Nameα-Melanocyte stimulating hormone (MSH)	Nature of peptide or cargoControls pigmentary changes in many vertebrates and melanin synthesis within epidermal melanocytes is responsible for melanin pigmentation of the skin, hair, and feathers in man, birds and other mammals.	AssayElectron microscopic examination	Tissue permeabilityMinimal effective dose=10-8to10-9M. It stimulated eumelanogenesis in all hair emerging from the areas previously plucked.	Tissue SamplePosterior dorsum of mice (C57BL/6JA y)	PUBMED ID3573985
ID1310	SequenceSYS-Nle-EHfRWGKPV	Name(Nle4, D-Phe7)-a-MSH	Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone	AssayElectron microscopic examination	Tissue permeabilityMinimal effective dose=10-12M. It is transdermally delivered systemically to hair follicles throughout the body to induce follicular melanogenesis. Microscopic examination revealed eumelanin within hair bulbs by 24 hours after topical application of the analogue.	Tissue SamplePosterior dorsum of mice (C57BL/6JA y)	PUBMED ID3573985
ID1311	SequenceSYS-Nle-EHfRWGKPV	Name[Nle4, D-Phe7]-alpha-MSH	Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.	AssayFrog Skin Bioassay	Tissue permeabilityPercent positive samples of transdermal delivery :65% (15/23)	Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation	PUBMED ID2845208