PRIMARY INFORMATION |
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ID | 1064 |
PMID | 22890441 |
Year | 2012 |
Sequence | β-Ala-H |
Name | N-acetyl- L -carnosine |
Length | 2 |
N-Terminal Modification | Acetylation |
C-Terminal Modification | Free |
Linear/ Cyclic | Linear |
Chirality | L |
Chemical Modification | β-Alanine |
Origin of Peptide | Synthetic |
Nature of Peptide/Cargo | Antioxidant |
Mechanism | It acts as antioxidant with its hydroxyl-radical-, singlet oxygen-scavenging and lipid peroxidase activities. |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | Franz diffusion cell, HPLC |
Enhancer | Enhancer molecule hydrodispersion gel - 1,2-pentylene glycol (HDG-PG) used in the formulation applied |
Properties of enhancer | Amphiphilicity of PG improves solubility |
Concentration | 20mg of formulation |
Incubation time | 300 minutes |
Tissue permeability (value with units) | 25% of applied dose |
Tissue Sample | Dermis of human breast skin |
Ex vivo/In vivo/In vitro | ex vivo |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | CC(=O)NC[C@@H](C)C(=O)N[C@@H](Cc1nc[nH]c1)C=O |