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Details of TopicalPdb ID 1074

PRIMARY INFORMATION
ID1074
PMID22890441
Year2012
Sequenceβ-Ala-H
NameN-acetyl- L -carnosine
Length2
N-Terminal ModificationAcetylation
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical Modificationβ-Alanine
Origin of PeptideSynthetic
Nature of Peptide/CargoAntioxidant
MechanismIt acts as antioxidant with its hydroxyl-radical-, singlet oxygen-scavenging and lipid peroxidase activities.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFranz diffusion cell, HPLC
EnhancerEnhancer molecule hydrodispersion gel - 1,2-pentylene glycol (HDG-PG) used in the formulation applied
Properties of enhancerAmphiphilicity of PG improves solubility
Concentration20mg of formulation
Incubation time1000 minutes
Tissue permeability (value with units)>8% of applied dose
Tissue SampleAcceptor compartment of Franz diffusion cell
Ex vivo/In vivo/In vitroex vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESCC(=O)NC[C@@H](C)C(=O)N[C@@H](Cc1nc[nH]c1)C=O