PRIMARY INFORMATION |
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ID | 1301 |
PMID | 3684299 |
Year | 1987 |
Sequence | SYSMEHFRWGKPV |
Name | α-Melanocyte stimulating hormone (MSH) |
Length | 13 |
N-Terminal Modification | Acetylation |
C-Terminal Modification | Amidation |
Linear/ Cyclic | Linear |
Chirality | L |
Chemical Modification | None |
Origin of Peptide | α-MSH |
Nature of Peptide/Cargo | Controls pigmentary changes in many vertebrates and melanin synthesis within epidermal melanocytes is responsible for melanin pigmentation of the skin, hair, and feathers in man, birds and other mammals. |
Mechanism | It stimulates pheomelanin-to-eumelanin shift in the follicular melanocytes |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | Light and electron microscopy |
Enhancer | Hairs were plucked as a pretreatment control |
Properties of enhancer | Not mentioned |
Concentration | 0.5 ml aliquots of melanotropins in poly-ethelene glycol ointment base (26% PEG '400 and 74% PEG 3350 |
Incubation time | Once in 24 hours for 7 days. |
Tissue permeability (value with units) | 10-7 and 10-8 concentrations turned yellow hair brown |
Tissue Sample | Melanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect |
Ex vivo/In vivo/In vitro | in vivo |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |