| PRIMARY INFORMATION |
|---|
| ID | 1301 |
| PMID | 3684299 |
| Year | 1987 |
| Sequence | SYSMEHFRWGKPV |
| Name | α-Melanocyte stimulating hormone (MSH) |
| Length | 13 |
| N-Terminal Modification | Acetylation |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | None |
| Origin of Peptide | α-MSH |
| Nature of Peptide/Cargo | Controls pigmentary changes in many vertebrates and melanin synthesis within epidermal melanocytes is responsible for melanin pigmentation of the skin, hair, and feathers in man, birds and other mammals. |
| Mechanism | It stimulates pheomelanin-to-eumelanin shift in the follicular melanocytes |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Light and electron microscopy |
| Enhancer | Hairs were plucked as a pretreatment control |
| Properties of enhancer | Not mentioned |
| Concentration | 0.5 ml aliquots of melanotropins in poly-ethelene glycol ointment base (26% PEG '400 and 74% PEG 3350 |
| Incubation time | Once in 24 hours for 7 days. |
| Tissue permeability (value with units) | 10-7 and 10-8 concentrations turned yellow hair brown |
| Tissue Sample | Melanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
