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Details of TopicalPdb ID 1047

PRIMARY INFORMATION
ID1047
PMID22890441
Year2012
Sequenceβ-Ala-H
NameN-acetyl- L -carnosine
Length2
N-Terminal ModificationAcetylation
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical Modificationβ-Alanine
Origin of PeptideSynthetic
Nature of Peptide/CargoAntioxidant
MechanismIt acts as antioxidant with its hydroxyl-radical-, singlet oxygen-scavenging and lipid peroxidase activities.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFranz diffusion cell, HPLC
EnhancerEnhancer molecule hydrodispersion gel (HDG) used in the formulation applied
Properties of enhancerAmphiphilicity of PG improves solubility
Concentration20mg of formulation
Incubation time300 minutes
Tissue permeability (value with units)~3% of applied dose
Tissue SampleStratum corneum of human breast skin
Ex vivo/In vivo/In vitroex vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESCC(=O)NC[C@@H](C)C(=O)N[C@@H](Cc1nc[nH]c1)C=O