Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_2464 | NA Click for more detail | S. iniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | tbToll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Scophthalmus maximus | Liver and spleen | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NF-κB-mediated in ammatory cytokine pro- duction. | ELISA | 28495564 | 2017 | NA |
| PRRID_2464 | NA Click for more detail | S. iniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | tbToll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Scophthalmus maximus | Liver and spleen | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NF-κB-mediated in ammatory cytokine pro- duction. | ELISA | 28495564 | 2017 | NA |
| PRRID_2465 | NA Click for more detail | E.Tarda(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | tbToll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Scophthalmus maximus | Liver and kidney | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | ELISA | 28495564 | 2017 | NA |
| PRRID_2465 | NA Click for more detail | E.Tarda(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | tbToll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Scophthalmus maximus | Liver and kidney | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | ELISA | 28495564 | 2017 | NA |
| PRRID_2466 | NA Click for more detail | HIRRV (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | tbToll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Scophthalmus maximus | Gills and kidney | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | ELISA | 28495564 | 2017 | NA |
| PRRID_2466 | NA Click for more detail | HIRRV (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | tbToll-like receptor 22 (TLR22) | Toll-like receptor (TLR) | Scophthalmus maximus | Gills and kidney | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | ELISA | 28495564 | 2017 | NA |
| PRRID_2467 | NA Click for more detail | F. solani (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | upregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Human corneal epithelial cells (HCECs) | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | decreased AMP mRNA upregulation | RT-PCR, antifungal assay | 28460048 | 2017 | Pubchem_assay |
| PRRID_2467 | NA Click for more detail | F. solani (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | upregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Human corneal epithelial cells (HCECs) | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | decreased AMP mRNA upregulation | RT-PCR, antifungal assay | 28460048 | 2017 | Pubchem_assay |
| PRRID_2468 | NA Click for more detail | F. solani (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Upregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism. | Dectin-1 | C type Lectin (CTL/CLR) | Human | Human corneal epithelial cells (HCECs) | NA | Q9BXN2.fasta | Q9BXN2 | 247 | decreased AMP mRNA upregulation | RT-PCR, antifungal assay | 28460048 | 2017 | Pubchem_assay |
| PRRID_2468 | NA Click for more detail | F. solani (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Upregulate AMPs hBD2 and LL37 at the mRNA and protein level via a TLR2- and Dectin-1– mediated mechanism. | Dectin-1 | C type Lectin (CTL/CLR) | Human | Human corneal epithelial cells (HCECs) | NA | Q9BXN2.fasta | Q9BXN2 | 247 | decreased AMP mRNA upregulation | RT-PCR, antifungal assay | 28460048 | 2017 | Pubchem_assay |
| PRRID_2469 | NA Click for more detail | Grass carp reovirus (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | ScToll-like receptor 2 (TLR2)2 | Toll-like receptor (TLR) | Squaliobarbus curriculus | head kidney and spleen | 19 leucine rich repeats (LRRs), a transmembrane (TM) and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | NF-κB activation that up-regulates secretion of proinflammatory cytokines. | qRT-PCR | 28442418 | 2017 | NA |
| PRRID_2469 | NA Click for more detail | Grass carp reovirus (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | ScToll-like receptor 2 (TLR2)2 | Toll-like receptor (TLR) | Squaliobarbus curriculus | head kidney and spleen | 19 leucine rich repeats (LRRs), a transmembrane (TM) and a Toll/interleukin-1 receptor (TIR) domain. | NA | NA | NA | NF-κB activation that up-regulates secretion of proinflammatory cytokines. | qRT-PCR | 28442418 | 2017 | NA |
| PRRID_2470 | NA Click for more detail | Gram-negative and Gram-positive bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | rMjGCTL | C type Lectin (CTL/CLR) | Marsupenaeus japonicus | Hemocytes | CRD with a QAP motif. | NA | NA | NA | acts as an opsonin by bind- ing directly to hemocytes to activate their adhesive state for their encapsulation. | Bacterial agglutination assay | 28374848 | 2017 | NA |
| PRRID_2470 | NA Click for more detail | Gram-negative and Gram-positive bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | rMjGCTL | C type Lectin (CTL/CLR) | Marsupenaeus japonicus | Hemocytes | CRD with a QAP motif. | NA | NA | NA | acts as an opsonin by bind- ing directly to hemocytes to activate their adhesive state for their encapsulation. | Bacterial agglutination assay | 28374848 | 2017 | NA |
| PRRID_2471 | NA Click for more detail | white spot syndrome virus (WSSV) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | PcToll4 | Toll-like receptor (TLR) | Procambarus clarkii | All tested tissue | A single peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT do- mains, an LRR NT domain, a transmembrane region, and a TIR domain. | NA | NA | NA | regulates the expressions of AMPs against WSSV | qRT-PCR | 28213041 | 2017 | NA |
| PRRID_2471 | NA Click for more detail | white spot syndrome virus (WSSV) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | PcToll4 | Toll-like receptor (TLR) | Procambarus clarkii | All tested tissue | A single peptide, 13 LRR domains, 3 LRR TYP domains, 2 LRR CT do- mains, an LRR NT domain, a transmembrane region, and a TIR domain. | NA | NA | NA | regulates the expressions of AMPs against WSSV | qRT-PCR | 28213041 | 2017 | NA |
| PRRID_2472 | NA Click for more detail | Klebsiella pneumoniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | NA | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2472 | NA Click for more detail | Klebsiella pneumoniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | NA | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2473 | NA Click for more detail | Mycobacterium tuberculosis, Mycobacterium bovis (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | NA | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2473 | NA Click for more detail | Mycobacterium tuberculosis, Mycobacterium bovis (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | NA | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2474 | NA Click for more detail | Blastomyces dermatitidis(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | Mice | NA | NA | Q9Z2H6.fasta | Q9Z2H6 | 219 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2474 | NA Click for more detail | Blastomyces dermatitidis(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | Mice | NA | NA | Q9Z2H6.fasta | Q9Z2H6 | 219 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2475 | NA Click for more detail | Candida albicans(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Controversial role in infection models | NA | 28167651 | 2017 | NA |
| PRRID_2475 | NA Click for more detail | Candida albicans(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Controversial role in infection models | NA | 28167651 | 2017 | NA |
| PRRID_2476 | NA Click for more detail | Cryptococcus neoformans(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | Infection model | NA | CRAC motif | NA | NA | NA | Protective role in infection disease. | NA | 28167651 | 2017 | NA |
| PRRID_2476 | NA Click for more detail | Cryptococcus neoformans(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mcl (Clec4d) | Syk-coupled CLR | Infection model | NA | CRAC motif | NA | NA | NA | Protective role in infection disease. | NA | 28167651 | 2017 | NA |
| PRRID_2477 | NA Click for more detail | H. pylori (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2477 | NA Click for more detail | H. pylori (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2478 | NA Click for more detail | Klebsiella pneumoniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2478 | NA Click for more detail | Klebsiella pneumoniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2479 | NA Click for more detail | S. pneumoniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2479 | NA Click for more detail | S. pneumoniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2480 | NA Click for more detail | M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Mice | NA | NA | Q9R0Q8.fasta | Q9R0Q8 | 214 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2480 | NA Click for more detail | M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Mice | NA | NA | Q9R0Q8.fasta | Q9R0Q8 | 214 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2481 | NA Click for more detail | M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Human | NA | NA | Q9ULY5.fasta | Q9ULY5 | 219 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2481 | NA Click for more detail | M. tuberculosis, M. bovis, Mycobacterium smegmatis (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Human | NA | NA | Q9ULY5.fasta | Q9ULY5 | 219 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2482 | NA Click for more detail | Haemophilus influenzae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2482 | NA Click for more detail | Haemophilus influenzae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2483 | NA Click for more detail | Mycobacterium spp.(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2483 | NA Click for more detail | Mycobacterium spp.(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2484 | NA Click for more detail | Coccidioidis posadasii(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2484 | NA Click for more detail | Coccidioidis posadasii(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2485 | NA Click for more detail | Coccidioidis posadasii(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Human | NA | NA | Q9BXN2.fasta | Q9BXN2 | 247 | protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2485 | NA Click for more detail | Coccidioidis posadasii(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Human | NA | NA | Q9BXN2.fasta | Q9BXN2 | 247 | protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2486 | NA Click for more detail | Coccidioidis immitis(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2486 | NA Click for more detail | Coccidioidis immitis(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2487 | NA Click for more detail | H. capsulatum (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2487 | NA Click for more detail | H. capsulatum (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2488 | NA Click for more detail | M. audouinii (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2488 | NA Click for more detail | M. audouinii (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2489 | NA Click for more detail | Penicillium marneffei (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2489 | NA Click for more detail | Penicillium marneffei (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2490 | NA Click for more detail | Pneumocystis carnii (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2490 | NA Click for more detail | Pneumocystis carnii (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2491 | NA Click for more detail | Fungi (T. rubrum, yeast) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2491 | NA Click for more detail | Fungi (T. rubrum, yeast) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2492 | NA Click for more detail | Fungi (T. rubrum, yeast) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Human | NA | NA | Q9BXN2.fasta | Q9BXN2 | 247 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2492 | NA Click for more detail | Fungi (T. rubrum, yeast) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Human | NA | NA | Q9BXN2.fasta | Q9BXN2 | 247 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2493 | NA Click for more detail | Trichosporon asahii (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2493 | NA Click for more detail | Trichosporon asahii (fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2494 | NA Click for more detail | S. pneumoniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | collectin kidney 1 (CL-K1) | C type Lectin (CTL/CLR) | Mice | NA | NA | Q3SXB8.fasta | Q3SXB8 | 272 | binds to microbes and activates the lectin complement pathway | NA | 28068663 | 2017 | Pubchem_assay |
| PRRID_2494 | NA Click for more detail | S. pneumoniae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | collectin kidney 1 (CL-K1) | C type Lectin (CTL/CLR) | Mice | NA | NA | Q3SXB8.fasta | Q3SXB8 | 272 | binds to microbes and activates the lectin complement pathway | NA | 28068663 | 2017 | Pubchem_assay |
| PRRID_2499 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Microglia | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | NLRP3 inflammasome activation in AD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2499 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Microglia | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | NLRP3 inflammasome activation in AD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2500 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2500 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2501 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Brain | NA | Q96P20.fasta | Q96P20 | 1036 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2501 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Brain | NA | Q96P20.fasta | Q96P20 | 1036 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2502 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Rat | primary astrocytes | NA | D4A523.fasta | D4A523 | 1035 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2502 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Rat | primary astrocytes | NA | D4A523.fasta | D4A523 | 1035 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2503 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | substantia nigra | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2503 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | substantia nigra | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2521 | ODN2006 Click for more detail | NA | 5’-tcgtcgttttgtcgttttgtcgtt-3’ | 24 | Pattern-associated molecular patterns (PAMPs) | Synthetic | anti- inflammatory activity | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | U937 cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | NA | 29113797 | 2017 | Pubchem_assay |
| PRRID_2521 | ODN2006 Click for more detail | NA | 5’-tcgtcgttttgtcgttttgtcgtt-3’ | 24 | Pattern-associated molecular patterns (PAMPs) | Synthetic | anti- inflammatory activity | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | U937 cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | NA | 29113797 | 2017 | Pubchem_assay |
| PRRID_2524 | ODN2006 Click for more detail | NA | 5’-tcgtcgttttgtcgttttgtcgtt-3’ | 24 | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Peripheral blood mononuclear cells (PBMC) | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | NA | 29039348 | 2017 | Pubchem_assay |
| PRRID_2524 | ODN2006 Click for more detail | NA | 5’-tcgtcgttttgtcgttttgtcgtt-3’ | 24 | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Peripheral blood mononuclear cells (PBMC) | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | NA | 29039348 | 2017 | Pubchem_assay |
| PRRID_2527 | P2Y2PalIC2 Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | innate immunity elicitor | FPR2(Formyl peptide Receptor2) | Pattern recognition receptor (PRR) | Human | Neutrophils | Seven alpha helical transmembrane domains | P25090.fasta | P25090 | 351 | tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation, | Neutrophil NADPH oxidase assay | 28881079 | 2017 | Pubchem_assay |
| PRRID_2527 | P2Y2PalIC2 Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | innate immunity elicitor | FPR2(Formyl peptide Receptor2) | Pattern recognition receptor (PRR) | Human | Neutrophils | Seven alpha helical transmembrane domains | P25090.fasta | P25090 | 351 | tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation, | Neutrophil NADPH oxidase assay | 28881079 | 2017 | Pubchem_assay |
| PRRID_2528 | P2Y2PalIC3 Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | innate immunity elicitor | FPR2(Formyl peptide Receptor2) | Pattern recognition receptor (PRR) | Human | Neutrophils | Seven alpha helical transmembrane domains | P25090.fasta | P25090 | 351 | tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation, | Neutrophil NADPH oxidase assay | 28881079 | 2017 | Pubchem_assay |
| PRRID_2528 | P2Y2PalIC3 Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | innate immunity elicitor | FPR2(Formyl peptide Receptor2) | Pattern recognition receptor (PRR) | Human | Neutrophils | Seven alpha helical transmembrane domains | P25090.fasta | P25090 | 351 | tissue homeostasis, host defence reactivity and regulation of immune reactions and inflammation, | Neutrophil NADPH oxidase assay | 28881079 | 2017 | Pubchem_assay |
| PRRID_2529 | Palmitic acid Click for more detail | NA | CCCCCCCCCCCCCCCC(=O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | PA may func- tion as a dietary immune modifier (DIM) resulting in the induction of chronic inflammation, such as that seen in type 2 diabetes. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Dendritic cell | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | production of IL-1β in human DCs through an inflammasome dependent mechanism | qRT-PCR | 28463985 | 2017 | Pubchem_assay |
| PRRID_2529 | Palmitic acid Click for more detail | NA | CCCCCCCCCCCCCCCC(=O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | PA may func- tion as a dietary immune modifier (DIM) resulting in the induction of chronic inflammation, such as that seen in type 2 diabetes. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Dendritic cell | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | production of IL-1β in human DCs through an inflammasome dependent mechanism | qRT-PCR | 28463985 | 2017 | Pubchem_assay |
| PRRID_2532 | particulate b-glucan Click for more detail | NA | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Blocking, non activating | NA | 28167651 | 2017 | NA |
| PRRID_2532 | particulate b-glucan Click for more detail | NA | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Blocking, non activating | NA | 28167651 | 2017 | NA |
| PRRID_2533 | pathogen ssRNA Click for more detail | flu virus, SeV and bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | potassium efflux-NEK7 involved NLRP3 inflammasome complex | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Cytoplasm. Ubiquitously expressed | NA | Q96P20.fasta | Q96P20 | 1036 | ASC-inflammasome- caspase-1-IL-1/IL-18 | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2533 | pathogen ssRNA Click for more detail | flu virus, SeV and bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | potassium efflux-NEK7 involved NLRP3 inflammasome complex | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Cytoplasm. Ubiquitously expressed | NA | Q96P20.fasta | Q96P20 | 1036 | ASC-inflammasome- caspase-1-IL-1/IL-18 | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2550 | periplasmic flagella Click for more detail | T. denticola (Bacteria) | MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ | 349 | Pattern-associated molecular patterns (PAMPs) | Natural | periodontal inflammation; | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 29084899 | 2017 | Pubchem_assay |
| PRRID_2550 | periplasmic flagella Click for more detail | T. denticola (Bacteria) | MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNTQ | 349 | Pattern-associated molecular patterns (PAMPs) | Natural | periodontal inflammation; | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 29084899 | 2017 | Pubchem_assay |
| PRRID_2552 | phosphatidyl-myo-inositol mannosides (PIM) Click for more detail | Mycobacteria (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | causes tuberculosis-like systemic infection in sh and in other ectotherms | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | THP‚Äê1 macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA | 29183333 | 2017 | Pubchem_assay |
| PRRID_2552 | phosphatidyl-myo-inositol mannosides (PIM) Click for more detail | Mycobacteria (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | causes tuberculosis-like systemic infection in sh and in other ectotherms | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | THP‚Äê1 macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA | 29183333 | 2017 | Pubchem_assay |
| PRRID_2553 | phosphatidyl-myo-inositol mannosides (PIM) Click for more detail | Mycobacteria (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | causes tuberculosis-like systemic infection in sh and in other ectotherms | CR3 | Complement Receptor | Human | THP‚Äê1 macrophages | NA | NA | NA | NA | NA | THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA | 29183333 | 2017 | NA |
| PRRID_2553 | phosphatidyl-myo-inositol mannosides (PIM) Click for more detail | Mycobacteria (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | causes tuberculosis-like systemic infection in sh and in other ectotherms | CR3 | Complement Receptor | Human | THP‚Äê1 macrophages | NA | NA | NA | NA | NA | THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA | 29183333 | 2017 | NA |
| PRRID_2580 | R837 Click for more detail | SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Z-loop proteolytic cleavage, and receptor dimer conformational change | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes. Innate immune cells except neutrophils and pDCs | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2580 | R837 Click for more detail | SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Z-loop proteolytic cleavage, and receptor dimer conformational change | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes. Innate immune cells except neutrophils and pDCs | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2581 | R848 Click for more detail | SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Z-loop proteolytic cleavage, and receptor dimer conformational change | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Endosomes. pDCs and B cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2581 | R848 Click for more detail | SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Z-loop proteolytic cleavage, and receptor dimer conformational change | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Endosomes. pDCs and B cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2582 | R848 Click for more detail | SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Z-loop proteolytic cleavage, and receptor dimer conformational change | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | Endosomes. Monocytes, macrophages and cDCs | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2582 | R848 Click for more detail | SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Z-loop proteolytic cleavage, and receptor dimer conformational change | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | Endosomes. Monocytes, macrophages and cDCs | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | MyD88-IRAK4/ IRAK1-IRAF6- IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2583 | rb-dsRNA Click for more detail | Rice- bran (plant) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | activate caspase 1 via TRIF, resulting in the release of IL-1b and LDH | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q99MB1.fasta | Q99MB1 | 905 | Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD, resulting in activation of the NLRP3 inflammasome | RT-qPCR | 28848065 | 2017 | Pubchem_assay |
| PRRID_2583 | rb-dsRNA Click for more detail | Rice- bran (plant) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | activate caspase 1 via TRIF, resulting in the release of IL-1b and LDH | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q99MB1.fasta | Q99MB1 | 905 | Caspase 1 activation is specifically induced by TLR3 signaling through TRIF/RIPK/ FADD, resulting in activation of the NLRP3 inflammasome | RT-qPCR | 28848065 | 2017 | Pubchem_assay |