Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1277	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It directly interacts with TLR 5 and induces immune response	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	mast cells	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1277	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It directly interacts with TLR 5 and induces immune response	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	mast cells	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1278	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24807166	2014	Pubchem_assay
PRRID_1278	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24807166	2014	Pubchem_assay
PRRID_1279	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24807166	2014	Pubchem_assay
PRRID_1279	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24807166	2014	Pubchem_assay
PRRID_1280	Flagellin Click for more detail	Salmonella typhimurium(Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q5GR02.fasta	Q5GR02	862	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1280	Flagellin Click for more detail	Salmonella typhimurium(Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Chicken	splenocytes	cell surface	Q5GR02.fasta	Q5GR02	862	TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-c	ELISA	24797722	2014	Pubchem_assay
PRRID_1281	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	medullary collecting duct (MCD) cells	cell surface	Q9JLF7.fasta	Q9JLF7	859	TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs)	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1281	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	medullary collecting duct (MCD) cells	cell surface	Q9JLF7.fasta	Q9JLF7	859	TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs)	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1282	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	medullary collecting duct (MCD) cells	cell surface	O60602.fasta	O60602	858	TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs)	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1282	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	medullary collecting duct (MCD) cells	cell surface	O60602.fasta	O60602	858	TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs)	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1283	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	functions as a critical innate sensor for flagellated bacteria in all mucous organs	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Neutrophils	cell surface	Q9JLF7.fasta	Q9JLF7	859	important role in intestinal homeostasis mediating the immune adaptation to symbiotic microflora as well as defense against pathogenic bacterial infection	ELISA	24778236	2014	Pubchem_assay
PRRID_1283	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	functions as a critical innate sensor for flagellated bacteria in all mucous organs	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Neutrophils	cell surface	Q9JLF7.fasta	Q9JLF7	859	important role in intestinal homeostasis mediating the immune adaptation to symbiotic microflora as well as defense against pathogenic bacterial infection	ELISA	24778236	2014	Pubchem_assay
PRRID_1284	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	ELISA	24771854	2014	Pubchem_assay
PRRID_1284	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	ELISA	24771854	2014	Pubchem_assay
PRRID_1285	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	ELISA	24771854	2014	Pubchem_assay
PRRID_1285	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	ELISA	24771854	2014	Pubchem_assay
PRRID_1286	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	ELISA	24771328	2014	Pubchem_assay
PRRID_1286	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	cell surface	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	ELISA	24771328	2014	Pubchem_assay
PRRID_1287	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	ELISA	24771328	2014	Pubchem_assay
PRRID_1287	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	cell surface	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	ELISA	24771328	2014	Pubchem_assay
PRRID_1288	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	Cell Surface (Exogenous)	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1288	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	Cell Surface (Exogenous)	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1289	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	Cell Surface (Exogenous)	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1289	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	Cell Surface (Exogenous)	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1290	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24754320	2014	Pubchem_assay
PRRID_1290	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24754320	2014	Pubchem_assay
PRRID_1291	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24754320	2014	Pubchem_assay
PRRID_1291	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	24754320	2014	Pubchem_assay
PRRID_1292	Flagellin Click for more detail	Salmonella typhimurium(Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	induced significant up-regulation of IL-1b and IL-8	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1292	Flagellin Click for more detail	Salmonella typhimurium(Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	induced significant up-regulation of IL-1b and IL-8	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1293	Flagellin Click for more detail	Vibrio anguillarum (Bacteria)	MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG	377	Protein	Natural	Flagellin induced expres- sion of inflammatory cytokines	Toll-like receptor 5M (TLR5M)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin	Real-time PCR	24736205	2014	NA
PRRID_1293	Flagellin Click for more detail	Vibrio anguillarum (Bacteria)	MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG	377	Protein	Natural	Flagellin induced expres- sion of inflammatory cytokines	Toll-like receptor 5M (TLR5M)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin	Real-time PCR	24736205	2014	NA
PRRID_1294	Flagellin Click for more detail	Vibrio anguillarum (Bacteria)	MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG	377	Protein	Natural	Flagellin induced expres- sion of inflammatory cytokines	Toll-like receptor 5s (TLR5s)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	predominanlty in liver	NA	NA	NA	NA	it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin	Real-time PCR	24736205	2014	NA
PRRID_1294	Flagellin Click for more detail	Vibrio anguillarum (Bacteria)	MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG	377	Protein	Natural	Flagellin induced expres- sion of inflammatory cytokines	Toll-like receptor 5s (TLR5s)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	predominanlty in liver	NA	NA	NA	NA	it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin	Real-time PCR	24736205	2014	NA
PRRID_1295	Flagellin Click for more detail	Salmonella typhimurium strain 14028 (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	flagellin activates not only macro- phages, monocytes, and dendritic cells but also intestinal and pul- monary epithelial cells, leading to the release of proinflammatory mediators	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocytes and immature dendritic cells, as well as on epithelial cells	NA	O60602.fasta	O60602	858	activation of TLR5 by flagellin inhibits colon tumor growth in vivo and elicits potent antitumor activity	ELISA	24709011	2014	Pubchem_assay
PRRID_1295	Flagellin Click for more detail	Salmonella typhimurium strain 14028 (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	flagellin activates not only macro- phages, monocytes, and dendritic cells but also intestinal and pul- monary epithelial cells, leading to the release of proinflammatory mediators	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocytes and immature dendritic cells, as well as on epithelial cells	NA	O60602.fasta	O60602	858	activation of TLR5 by flagellin inhibits colon tumor growth in vivo and elicits potent antitumor activity	ELISA	24709011	2014	Pubchem_assay
PRRID_1298	FSL-1 Click for more detail	Mycoplasma salivarium (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	NA	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	mast cells	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	Real-time PCR	24818634	2014	NA
PRRID_1298	FSL-1 Click for more detail	Mycoplasma salivarium (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	NA	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	mast cells	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	Real-time PCR	24818634	2014	NA
PRRID_1299	FSL-1 Click for more detail	Mycoplasma salivarium (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	NA	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	European and African Children	NA	MyD88	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24743542	2014	NA
PRRID_1299	FSL-1 Click for more detail	Mycoplasma salivarium (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	NA	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	European and African Children	NA	MyD88	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA	24743542	2014	NA
PRRID_1300	FSL-1 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	mast cells	NA	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	Real-time PCR	24736205	2014	NA
PRRID_1300	FSL-1 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	mast cells	NA	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	Real-time PCR	24736205	2014	NA
PRRID_1303	GAS lipoprotein (group A streptococcus) Click for more detail	Streptococcus pyogenes (Bacteria)	NA	NA	Lipopeptides	Synthetic	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1303	GAS lipoprotein (group A streptococcus) Click for more detail	Streptococcus pyogenes (Bacteria)	NA	NA	Lipopeptides	Synthetic	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6J mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Toll/IL-1R (TIR) domain-containing adaptor molecule MyD88 (myeloid differentiation factor 88)-dependent pathway	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24712905	2014	Pubchem_assay
PRRID_1306	Glycolipids Click for more detail	Mycobacteria (Bacteria)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24801735	2014	Pubchem_assay
PRRID_1306	Glycolipids Click for more detail	Mycobacteria (Bacteria)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24801735	2014	Pubchem_assay
PRRID_1381	internalized flagellin Click for more detail	Salmonella typhimurium or Legionella pneumophila (Bacteria)	KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL	76	Protein	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	medullary collecting duct (MCD) cells	intracellular receptors	Q3UP24.fasta	Q3UP24	1024	assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1Œ≤ and IL-18	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1381	internalized flagellin Click for more detail	Salmonella typhimurium or Legionella pneumophila (Bacteria)	KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL	76	Protein	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	medullary collecting duct (MCD) cells	intracellular receptors	Q3UP24.fasta	Q3UP24	1024	assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1Œ≤ and IL-18	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1382	internalized flagellin Click for more detail	Salmonella typhimurium or Legionella pneumophila (Bacteria)	KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL	76	Protein	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Human	medullary collecting duct (MCD) cells	intracellular receptors	Q9NPP4.fasta	Q9NPP4	1024	assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1Œ≤ and IL-18	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1382	internalized flagellin Click for more detail	Salmonella typhimurium or Legionella pneumophila (Bacteria)	KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL	76	Protein	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Human	medullary collecting duct (MCD) cells	intracellular receptors	Q9NPP4.fasta	Q9NPP4	1024	assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1Œ≤ and IL-18	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1389	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1389	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1390	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1390	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1392	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell surface	Q9EPQ1.fasta	Q9EPQ1	795	NA	NA	24807166	2014	Pubchem_assay
PRRID_1392	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell surface	Q9EPQ1.fasta	Q9EPQ1	795	NA	NA	24807166	2014	Pubchem_assay
PRRID_1393	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs and B-lymphocytes	Cell surface	Q15399.fasta	Q15399	786	NA	NA	24807166	2014	Pubchem_assay
PRRID_1393	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs and B-lymphocytes	Cell surface	Q15399.fasta	Q15399	786	NA	NA	24807166	2014	Pubchem_assay
PRRID_1394	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1394	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1395	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1395	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1403	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Bos indicus Sahiwal cattle breed	BTA8	cell surface	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	Polymerase Chain Reaction	24813219	2014	NA
PRRID_1403	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Bos indicus Sahiwal cattle breed	BTA8	cell surface	NA	NA	NA	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	Polymerase Chain Reaction	24813219	2014	NA
PRRID_1405	Lipopolysaccharide (LPS) Click for more detail	outer cell wall component of gram- negative bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	responsible for an endotoxin shock	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1405	Lipopolysaccharide (LPS) Click for more detail	outer cell wall component of gram- negative bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	responsible for an endotoxin shock	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1406	Lipopolysaccharide (LPS) Click for more detail	outer cell wall component of gram- negative bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	responsible for an endotoxin shock	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1406	Lipopolysaccharide (LPS) Click for more detail	outer cell wall component of gram- negative bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	responsible for an endotoxin shock	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1407	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemic Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 recognizes LPS and causes cell activation, including the production of NO and proinflammatory cytokines such as TNF-Œ± and IL-6	qRT-PCR, immunofluorescence assay, western blot	24802390	2014	Pubchem_assay
PRRID_1407	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemic Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 recognizes LPS and causes cell activation, including the production of NO and proinflammatory cytokines such as TNF-Œ± and IL-6	qRT-PCR, immunofluorescence assay, western blot	24802390	2014	Pubchem_assay
PRRID_1408	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24801735	2014	Pubchem_assay
PRRID_1408	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24801735	2014	Pubchem_assay
PRRID_1409	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli (0111:B4) (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Chicken	monocyte/macrophages	cell surface	Q7ZTG5.fasta	Q7ZTG5	843	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1409	Lipopolysaccharide (LPS) Click for more detail	Escherichia coli (0111:B4) (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Chicken	monocyte/macrophages	cell surface	Q7ZTG5.fasta	Q7ZTG5	843	TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response	ELISA	24797893	2014	Pubchem_assay
PRRID_1410	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1410	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1411	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell surface	O00206.fasta	O00206	839	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1411	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell surface	O00206.fasta	O00206	839	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1412	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1412	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1413	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	ischemic brain tissue	cell surface	O00206.fasta	O00206	839	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1413	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	ischemic brain tissue	cell surface	O00206.fasta	O00206	839	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1416	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	murine bladder epithelial cells and renal tubule cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1416	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	murine bladder epithelial cells and renal tubule cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1417	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	murine bladder epithelial cells and renal tubule cells	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1417	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	murine bladder epithelial cells and renal tubule cells	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1418	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	expressed as a pseudo-gene	Cell Compartment/Intracellular (Endosome)	Q6R5P0.fasta	Q6R5P0	926	TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1418	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	expressed as a pseudo-gene	Cell Compartment/Intracellular (Endosome)	Q6R5P0.fasta	Q6R5P0	926	TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1419	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	gingival epithelial cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	produce pro-inflammatory cytokines such as IL-8	ELISA	24773607	2014	Pubchem_assay
PRRID_1419	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	gingival epithelial cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	produce pro-inflammatory cytokines such as IL-8	ELISA	24773607	2014	Pubchem_assay
PRRID_1420	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	gingival epithelial cells	cell surface	O00206.fasta	O00206	839	produce pro-inflammatory cytokines such as IL-8	ELISA	24773607	2014	Pubchem_assay
PRRID_1420	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	gingival epithelial cells	cell surface	O00206.fasta	O00206	839	produce pro-inflammatory cytokines such as IL-8	ELISA	24773607	2014	Pubchem_assay
PRRID_1421	Lipopolysaccharide (LPS) Click for more detail	E. coli O26:B6(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24771854	2014	Pubchem_assay
PRRID_1421	Lipopolysaccharide (LPS) Click for more detail	E. coli O26:B6(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24771854	2014	Pubchem_assay
PRRID_1422	Lipopolysaccharide (LPS) Click for more detail	E. coli O26:B6(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24771854	2014	Pubchem_assay
PRRID_1422	Lipopolysaccharide (LPS) Click for more detail	E. coli O26:B6(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24771854	2014	Pubchem_assay
PRRID_1423	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling.	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24766885	2014	Pubchem_assay
PRRID_1423	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling.	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24766885	2014	Pubchem_assay

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