Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0389 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | On stimulation, production of significant amount of IL-12, KC, and IP-10 takes place. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice | Macropahges | NA | NA | NA | NA | This induces the inflammatory response. | cell-based assays | 19269175 | 2009 | NA |
| PRRID_0389 | SIMRA Compound 3 Click for more detail | NA | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' | 23 | Nucleic Acid | Synthetic | On stimulation, production of significant amount of IL-12, KC, and IP-10 takes place. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice | Macropahges | NA | NA | NA | NA | This induces the inflammatory response. | cell-based assays | 19269175 | 2009 | NA |
| PRRID_0399 | Streptococcus gordonii Click for more detail | S. gordonii (Bacteria) | NA | NA | Whole organism | Natural | Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Bone-marrow derived Dendritic cells | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells. | ELISA | 19284500 | 2009 | Pubchem Assay |
| PRRID_0399 | Streptococcus gordonii Click for more detail | S. gordonii (Bacteria) | NA | NA | Whole organism | Natural | Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Bone-marrow derived Dendritic cells | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells. | ELISA | 19284500 | 2009 | Pubchem Assay |
| PRRID_0401 | 1,3 beta glucan Click for more detail | Sparassis crispa (fungi) | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Carbohydrate | Natural | Anti-tumour properties | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It can induce the phenotypic and functional maturation of DCs. | NA | 20699131 | 2010 | Pubchem Assay |
| PRRID_0401 | 1,3 beta glucan Click for more detail | Sparassis crispa (fungi) | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Carbohydrate | Natural | Anti-tumour properties | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It can induce the phenotypic and functional maturation of DCs. | NA | 20699131 | 2010 | Pubchem Assay |
| PRRID_0403 | 5'-triphosphated RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | RIG-1 | Rig-like receptor (RLR) | Mice (Murine) | Cytoplasm | NA | Q6Q899.fasta | Q6Q899 | 926 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0403 | 5'-triphosphated RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | RIG-1 | Rig-like receptor (RLR) | Mice (Murine) | Cytoplasm | NA | Q6Q899.fasta | Q6Q899 | 926 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0412 | Arabinosylated lipoarabinomannan (Ara-LAM) Click for more detail | Mycobacterium tuberculosis (Bacteria) | NA | NA | Glycolipid | Natural | It triggers downstream signalling via MyD88, lead to the ativation of NF- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Leishmania donovani infected Mice | macropahge | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis | EMSA and ELISA | 20500089 | 2010 | Pubchem Assay |
| PRRID_0412 | Arabinosylated lipoarabinomannan (Ara-LAM) Click for more detail | Mycobacterium tuberculosis (Bacteria) | NA | NA | Glycolipid | Natural | It triggers downstream signalling via MyD88, lead to the ativation of NF- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Leishmania donovani infected Mice | macropahge | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis | EMSA and ELISA | 20500089 | 2010 | Pubchem Assay |
| PRRID_0421 | Bacterial Antigen Click for more detail | B. abortus 544(Bacteria) | NA | NA | NA | Natural | It's binding leads to the bacterial uptake via phagocytosis | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Trophoblast giant cells | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis. | Bacterial Infection assay | 20471681 | 2010 | Pubchem Assay |
| PRRID_0421 | Bacterial Antigen Click for more detail | B. abortus 544(Bacteria) | NA | NA | NA | Natural | It's binding leads to the bacterial uptake via phagocytosis | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Trophoblast giant cells | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis. | Bacterial Infection assay | 20471681 | 2010 | Pubchem Assay |
| PRRID_0422 | Bacterial Antigen Click for more detail | B. abortus 545(Bacteria) | NA | NA | NA | Natural | It's binding leads to the bacterial uptake via phagocytosis | class B scavenger receptor type I (SR-BI) | Scavenger receptor (SR) | Mice | Trophoblast giant cells and J774 cells | NA | Q61009.fasta | Q61009 | 509 | It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis. | Bacterial Infection assay | 20471681 | 2010 | Pubchem Assay |
| PRRID_0422 | Bacterial Antigen Click for more detail | B. abortus 545(Bacteria) | NA | NA | NA | Natural | It's binding leads to the bacterial uptake via phagocytosis | class B scavenger receptor type I (SR-BI) | Scavenger receptor (SR) | Mice | Trophoblast giant cells and J774 cells | NA | Q61009.fasta | Q61009 | 509 | It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis. | Bacterial Infection assay | 20471681 | 2010 | Pubchem Assay |
| PRRID_0423 | Bacterial Antigen Click for more detail | L. monocytogenes (Bacteria) | NA | NA | NA | Natural | It's binding leads to the bacterial uptake via phagocytosis | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Trophoblast giant cells | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis. | Bacterial Infection assay | 20471681 | 2010 | Pubchem Assay |
| PRRID_0423 | Bacterial Antigen Click for more detail | L. monocytogenes (Bacteria) | NA | NA | NA | Natural | It's binding leads to the bacterial uptake via phagocytosis | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Trophoblast giant cells | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis. | Bacterial Infection assay | 20471681 | 2010 | Pubchem Assay |
| PRRID_0424 | Bacterial Antigen Click for more detail | L. monocytogenes (Bacteria) | NA | NA | NA | Natural | It's binding leads to the bacterial uptake via phagocytosis | class B scavenger receptor type I (SR-BI) | Scavenger receptor (SR) | Mice | Trophoblast giant cells and J774 cells | NA | Q61009.fasta | Q61009 | 509 | It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis. | NA | 20471681 | 2010 | Pubchem Assay |
| PRRID_0424 | Bacterial Antigen Click for more detail | L. monocytogenes (Bacteria) | NA | NA | NA | Natural | It's binding leads to the bacterial uptake via phagocytosis | class B scavenger receptor type I (SR-BI) | Scavenger receptor (SR) | Mice | Trophoblast giant cells and J774 cells | NA | Q61009.fasta | Q61009 | 509 | It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis. | NA | 20471681 | 2010 | Pubchem Assay |
| PRRID_0425 | Bacterial Antigen Click for more detail | S. aureus (Bacteria) | NA | NA | Whole organism | Natural | It led to the activation of NF-κB and stimulate the production of cytokines IL-6 and TNF-⍺ | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Primary microglia and astrocytes | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It has the immunostimulatory role. | ELISA | 20226841 | 2010 | Pubchem Assay |
| PRRID_0425 | Bacterial Antigen Click for more detail | S. aureus (Bacteria) | NA | NA | Whole organism | Natural | It led to the activation of NF-κB and stimulate the production of cytokines IL-6 and TNF-⍺ | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Primary microglia and astrocytes | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It has the immunostimulatory role. | ELISA | 20226841 | 2010 | Pubchem Assay |
| PRRID_0428 | BsaK Click for more detail | Burkholderia pseudomallei(Bacteria) | MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ | 197 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0428 | BsaK Click for more detail | Burkholderia pseudomallei(Bacteria) | MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ | 197 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0449 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvement | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0449 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvement | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0450 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | APP transgenic Mice | microglia | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | clearance of Aβ from microglial cells | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0450 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | APP transgenic Mice | microglia | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | clearance of Aβ from microglial cells | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0451 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Their binding induces Th1 response and promote an increase in IFN- | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It helps in the immunization of the mice to become more efficient | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0451 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | Their binding induces Th1 response and promote an increase in IFN- | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It helps in the immunization of the mice to become more efficient | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0453 | CpG ODN 1826 Click for more detail | Bacteria | 5’-tccatgacgttcctgacgtt-3’ | 20 | Nucleic Acid | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | NA | 20696824 | 2010 | Pubchem Assay |
| PRRID_0453 | CpG ODN 1826 Click for more detail | Bacteria | 5’-tccatgacgttcctgacgtt-3’ | 20 | Nucleic Acid | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | NA | NA | 20696824 | 2010 | Pubchem Assay |
| PRRID_0454 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It delays the onset of prion disease by degrading the prions | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0454 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | NA | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It delays the onset of prion disease by degrading the prions | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0455 | Cpn60.2 Click for more detail | M. tuberculosis (Bacteria) | MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF | 540 | Protein | Natural | Their binding stabilize the interaction between the M. tuberculosis bacillus and the aveolar macrophage. | cluster of differentiation 43 (CD43) | Pattern recognition receptor (PRR) | C57BL/6 Mice | NA | NA | P15702.fasta | P15702 | 395 | It controls growth of the bacteria in a mouse model of tuberculosis and that TNFa mediates apoptosis of infected CD43+/+ aveolar macrophage,CD43 recognizes the mycobacterial Cpn60.2 which acts as a danger signal for the innate immune system | ELISA | 20633027 | 2010 | Pubchem Assay |
| PRRID_0455 | Cpn60.2 Click for more detail | M. tuberculosis (Bacteria) | MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF | 540 | Protein | Natural | Their binding stabilize the interaction between the M. tuberculosis bacillus and the aveolar macrophage. | cluster of differentiation 43 (CD43) | Pattern recognition receptor (PRR) | C57BL/6 Mice | NA | NA | P15702.fasta | P15702 | 395 | It controls growth of the bacteria in a mouse model of tuberculosis and that TNFa mediates apoptosis of infected CD43+/+ aveolar macrophage,CD43 recognizes the mycobacterial Cpn60.2 which acts as a danger signal for the innate immune system | ELISA | 20633027 | 2010 | Pubchem Assay |
| PRRID_0458 | cy2-labeled SitC-His Click for more detail | S. aureus (Bacteria) | NA | NA | Lipoprotein | Natural | It induce release of IL-6 in primary murine keratinocytes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Keratinocytes | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It induce intracellular accumulation of TLR2 | NA | 20679445 | 2010 | Pubchem Assay |
| PRRID_0458 | cy2-labeled SitC-His Click for more detail | S. aureus (Bacteria) | NA | NA | Lipoprotein | Natural | It induce release of IL-6 in primary murine keratinocytes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Keratinocytes | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It induce intracellular accumulation of TLR2 | NA | 20679445 | 2010 | Pubchem Assay |
| PRRID_0459 | Derivatives of peptidoglycans Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Peptidoglycan | Natural | The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS) | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice (Murine) | Aveolar macrphages | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It leads to the strong neutrophil infiltartion in the infected mice lungs | NA | 20685341 | 2010 | Pubchem Assay |
| PRRID_0459 | Derivatives of peptidoglycans Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Peptidoglycan | Natural | The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS) | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice (Murine) | Aveolar macrphages | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It leads to the strong neutrophil infiltartion in the infected mice lungs | NA | 20685341 | 2010 | Pubchem Assay |
| PRRID_0460 | Derivatives of peptidoglycans Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Peptidoglycan | Natural | The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS) | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Aveolar macrphages | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It leads to the strong neutrophil infiltartion in the infected mice lungs | NA | 20685341 | 2010 | Pubchem Assay |
| PRRID_0460 | Derivatives of peptidoglycans Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Peptidoglycan | Natural | The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS) | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Aveolar macrphages | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It leads to the strong neutrophil infiltartion in the infected mice lungs | NA | 20685341 | 2010 | Pubchem Assay |
| PRRID_0464 | diaminopimelic acid (C12-iEDAP) Click for more detail | Gram-negative and Gram-positive bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Muropeptide | Natural | It's binding to NOD1 induce NFκB activation, activation of MAP kinases and expression of chemokines CCL5 (RANTES) and CXCL1 (KC) and of nitric oxide | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | C57BL/6 Mice | liver and Hepatocytes | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It helps in attracting leukocytes to the liver during infection and for hepatic NLRs to augment innate immune responses to pathogens. | Immunoblotting and EMSA | 20615568 | 2010 | Pubchem Assay |
| PRRID_0464 | diaminopimelic acid (C12-iEDAP) Click for more detail | Gram-negative and Gram-positive bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Muropeptide | Natural | It's binding to NOD1 induce NFκB activation, activation of MAP kinases and expression of chemokines CCL5 (RANTES) and CXCL1 (KC) and of nitric oxide | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | C57BL/6 Mice | liver and Hepatocytes | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It helps in attracting leukocytes to the liver during infection and for hepatic NLRs to augment innate immune responses to pathogens. | Immunoblotting and EMSA | 20615568 | 2010 | Pubchem Assay |
| PRRID_0467 | DNA Click for more detail | Vaccinia(virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20709294 | 2010 | Pubchem Assay |
| PRRID_0467 | DNA Click for more detail | Vaccinia(virus) | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20709294 | 2010 | Pubchem Assay |
| PRRID_0468 | DNA Click for more detail | Cordyceps sinensis(fungi) | TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG | 685 | Nucleic Acid | Natural | Upon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Bone marrow-derived dendritic cells (BM-DCs). | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It exhibits immunomodulating activity against Cordyceps sinensis | Luciferase assay | 20451901 | 2010 | Pubchem Assay |
| PRRID_0468 | DNA Click for more detail | Cordyceps sinensis(fungi) | TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG | 685 | Nucleic Acid | Natural | Upon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Bone marrow-derived dendritic cells (BM-DCs). | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It exhibits immunomodulating activity against Cordyceps sinensis | Luciferase assay | 20451901 | 2010 | Pubchem Assay |
| PRRID_0470 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | NA | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0470 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | NA | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0471 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | NA | Leucine-rich Repeat (LRR) Domain | P58682.fasta | P58682 | 1032 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0471 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | NA | Leucine-rich Repeat (LRR) Domain | P58682.fasta | P58682 | 1032 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0472 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | RIG-1 | Rig-like receptor (RLR) | Mice (Murine) | Cytoplasm | NA | Q6Q899.fasta | Q6Q899 | 926 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0472 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | RIG-1 | Rig-like receptor (RLR) | Mice (Murine) | Cytoplasm | NA | Q6Q899.fasta | Q6Q899 | 926 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0473 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | MDA5 | Rig-like receptor (RLR) | Mice (Murine) | Cytoplasm | NA | Q8R5F7.fasta | Q8R5F7 | 1025 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0473 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | NA | MDA5 | Rig-like receptor (RLR) | Mice (Murine) | Cytoplasm | NA | Q8R5F7.fasta | Q8R5F7 | 1025 | NA | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0478 | dsDNA Click for more detail | HSV-1 (virus) | NA | NA | Nucleic Acid | Natural | it mediate IFNs and cytokine production | ZBP-1 or DAI | DNA receptor | Mice (Murine) | Cytoplasm | NA | Q9QY24.fasta | Q9QY24 | 411 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0478 | dsDNA Click for more detail | HSV-1 (virus) | NA | NA | Nucleic Acid | Natural | it mediate IFNs and cytokine production | ZBP-1 or DAI | DNA receptor | Mice (Murine) | Cytoplasm | NA | Q9QY24.fasta | Q9QY24 | 411 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0479 | dsDNA Click for more detail | HSV-1 (virus) | NA | NA | Nucleic Acid | Natural | It mediate IFNs and cytokine production | RNA Pol-III | DNA receptor | Mice (Murine) | Cytoplasm | NA | Q9D483.fasta | Q9D483 | 533 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0479 | dsDNA Click for more detail | HSV-1 (virus) | NA | NA | Nucleic Acid | Natural | It mediate IFNs and cytokine production | RNA Pol-III | DNA receptor | Mice (Murine) | Cytoplasm | NA | Q9D483.fasta | Q9D483 | 533 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0480 | dsDNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | It activates caspase-1 and release proinflammatory cytokines | AIM2 | Pattern recognition receptor (PRR) | Mice (Murine) | Cytoplasm | NA | Q91VJ1.fasta | Q91VJ1 | 354 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0480 | dsDNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | It activates caspase-1 and release proinflammatory cytokines | AIM2 | Pattern recognition receptor (PRR) | Mice (Murine) | Cytoplasm | NA | Q91VJ1.fasta | Q91VJ1 | 354 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0481 | dsDNA Click for more detail | Ectromelia(virus) | NA | NA | Nucleic Acid | Natural | It is necessary for IL-6 production | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | dendritic cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leads to the inflammation of the cell | NA | 20709294 | 2010 | Pubchem Assay |
| PRRID_0481 | dsDNA Click for more detail | Ectromelia(virus) | NA | NA | Nucleic Acid | Natural | It is necessary for IL-6 production | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | dendritic cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leads to the inflammation of the cell | NA | 20709294 | 2010 | Pubchem Assay |
| PRRID_0487 | dsDNA Click for more detail | Vaccinia(virus) | NA | NA | Nucleic Acid | Natural | It induces the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | HEK293 cells, PDCs | LRR | P58682.fasta | P58682 | 1032 | TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection. | ELISA | 20308556 | 2010 | Pubchem Assay |
| PRRID_0487 | dsDNA Click for more detail | Vaccinia(virus) | NA | NA | Nucleic Acid | Natural | It induces the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | HEK293 cells, PDCs | LRR | P58682.fasta | P58682 | 1032 | TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection. | ELISA | 20308556 | 2010 | Pubchem Assay |
| PRRID_0492 | EDA Click for more detail | Mice (others) | NA | NA | Organic Compound | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It helps in collateral vessels growth or Arteriogenesis. | NA | 20708624 | 2010 | Pubchem Assay |
| PRRID_0492 | EDA Click for more detail | Mice (others) | NA | NA | Organic Compound | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It helps in collateral vessels growth or Arteriogenesis. | NA | 20708624 | 2010 | Pubchem Assay |
| PRRID_0495 | endotoxin-free poly(I:C) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11 | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 Mice (experimental model of lung allergic exacerbation) | Airway Epithilium and Dedritic cells | Leucine-rich Repeat (LRR) Domain | Q99MB1.fasta | Q99MB1 | 905 | It significantly increased the airway hyperresponsiveness, the lung inflammation | ELISA | 20505141 | 2010 | Pubchem Assay |
| PRRID_0495 | endotoxin-free poly(I:C) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11 | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 Mice (experimental model of lung allergic exacerbation) | Airway Epithilium and Dedritic cells | Leucine-rich Repeat (LRR) Domain | Q99MB1.fasta | Q99MB1 | 905 | It significantly increased the airway hyperresponsiveness, the lung inflammation | ELISA | 20505141 | 2010 | Pubchem Assay |
| PRRID_0497 | EprJ and EscI Click for more detail | E. coli(Bacteria) | MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE | 95,231 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0497 | EprJ and EscI Click for more detail | E. coli(Bacteria) | MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE | 95,231 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0504 | fibrinogen and heat-shock proteins Click for more detail | Endogenous (others) | MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ | 481 | Protein | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0504 | fibrinogen and heat-shock proteins Click for more detail | Endogenous (others) | MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ | 481 | Protein | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0505 | Fibronectin Click for more detail | Endogenous (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Glycoprotein | Natural | It binds to the TLR4 and induce the release of pro-inflammatory cytokines via NF- | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Primary Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | it increases bacterial phagocytosis and intracellular killing by murine microglial cells | NA | 20599470 | 2010 | Pubchem Assay |
| PRRID_0505 | Fibronectin Click for more detail | Endogenous (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Glycoprotein | Natural | It binds to the TLR4 and induce the release of pro-inflammatory cytokines via NF- | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Primary Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | it increases bacterial phagocytosis and intracellular killing by murine microglial cells | NA | 20599470 | 2010 | Pubchem Assay |
| PRRID_0507 | FimH Click for more detail | Escherichia coli strain EC99 (O78) (Bacteria) | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ | 300 | Protein | Natural | It activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicity | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Natural Killer cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It aids innate protection against cancer or microbial infections. | Chromium (51Cr) release assay for NK cytotoxicity | 20442710 | 2010 | Pubchem Assay |
| PRRID_0507 | FimH Click for more detail | Escherichia coli strain EC99 (O78) (Bacteria) | MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ | 300 | Protein | Natural | It activates both NK cells to induce cytokines [interferon (IFN)-γ and tumor necrosis factor (TNF)-α] and cytotoxicity | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Natural Killer cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It aids innate protection against cancer or microbial infections. | Chromium (51Cr) release assay for NK cytotoxicity | 20442710 | 2010 | Pubchem Assay |
| PRRID_0510 | Flagellin Click for more detail | Salmonella muenchen (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates NF-KB and MAPKs and induced significant production of the different cytokines | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | Liver, Lung, Kideny, Intestine | Leucine-rich Repeat (LRR) Domain | Q9JLF7.fasta | Q9JLF7 | 859 | It has the role in the inflammation. | NA | 20731882 | 2010 | Pubchem Assay |
| PRRID_0510 | Flagellin Click for more detail | Salmonella muenchen (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates NF-KB and MAPKs and induced significant production of the different cytokines | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | Liver, Lung, Kideny, Intestine | Leucine-rich Repeat (LRR) Domain | Q9JLF7.fasta | Q9JLF7 | 859 | It has the role in the inflammation. | NA | 20731882 | 2010 | Pubchem Assay |
| PRRID_0526 | FSL-1 Click for more detail | Mycoplasma salivarium (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | embryonic mouse telencephalon and NPC | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | its activation inhibits NPC proliferation and decreases cell proliferation. | NA | 20456021 | 2010 | Pubchem Assay |
| PRRID_0526 | FSL-1 Click for more detail | Mycoplasma salivarium (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | embryonic mouse telencephalon and NPC | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | its activation inhibits NPC proliferation and decreases cell proliferation. | NA | 20456021 | 2010 | Pubchem Assay |
| PRRID_0528 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0528 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0529 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58682.fasta | P58682 | 1032 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0529 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58682.fasta | P58682 | 1032 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0531 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | HEK293 | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It has the role in the inflammation. | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0531 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | HEK293 | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It has the role in the inflammation. | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0533 | genomic DNA Click for more detail | HSV-1 and HSV-2 (virus) | NA | NA | Nucleic Acid | Natural | It mediates tumor necrosis factor alpha and CCL5 production in murine macrophages | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | plasmacytoid dendritic cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0533 | genomic DNA Click for more detail | HSV-1 and HSV-2 (virus) | NA | NA | Nucleic Acid | Natural | It mediates tumor necrosis factor alpha and CCL5 production in murine macrophages | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | plasmacytoid dendritic cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0535 | Glycoinositol phospholipids Click for more detail | Trypanosoma (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0535 | Glycoinositol phospholipids Click for more detail | Trypanosoma (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0537 | Glycolipids Click for more detail | Treponema maltophilum (others) | NA | NA | Glycolipid | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0537 | Glycolipids Click for more detail | Treponema maltophilum (others) | NA | NA | Glycolipid | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0540 | Glycosylphosphatidyl inositol anchor Click for more detail | Trypanosoma Cruzi (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0540 | Glycosylphosphatidyl inositol anchor Click for more detail | Trypanosoma Cruzi (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0554 | hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail | Vibrio vulnificus (Bacteria) | MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY | 4595 | Protein | Natural | It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion. | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Macropahes | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | It leads to the pathogen clearance | ELISA | 20348425 | 2010 | Pubchem Assay |
| PRRID_0554 | hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail | Vibrio vulnificus (Bacteria) | MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY | 4595 | Protein | Natural | It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion. | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Macropahes | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | It leads to the pathogen clearance | ELISA | 20348425 | 2010 | Pubchem Assay |
| PRRID_0555 | hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail | Vibrio cholerae (Bacteria) | MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL | 4558 | Protein | Natural | It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion. | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Macrophages | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | It leads to the pathogen clearance | ELISA | 20348425 | 2010 | Pubchem Assay |
| PRRID_0555 | hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail | Vibrio cholerae (Bacteria) | MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL | 4558 | Protein | Natural | It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion. | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Macrophages | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | It leads to the pathogen clearance | ELISA | 20348425 | 2010 | Pubchem Assay |
| PRRID_0557 | Histoplasma strain 505 yeast cells Click for more detail | Histoplasma strain 505 (others) | NA | NA | Whole organism | Natural | The binding leads to the secretion of cytokines such as TNF-‚ç∫ and IL-6, via syk dependent pathway | CR3 | Complement receptor | Mice (Murine) | Macropahges | lectin binding domain | NA | NA | NA | It is was responsible for phagocytosis and cytokine response. | Phagocytosis assay and ELISA | 20360401 | 2010 | NA |
| PRRID_0557 | Histoplasma strain 505 yeast cells Click for more detail | Histoplasma strain 505 (others) | NA | NA | Whole organism | Natural | The binding leads to the secretion of cytokines such as TNF-‚ç∫ and IL-6, via syk dependent pathway | CR3 | Complement receptor | Mice (Murine) | Macropahges | lectin binding domain | NA | NA | NA | It is was responsible for phagocytosis and cytokine response. | Phagocytosis assay and ELISA | 20360401 | 2010 | NA |