Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0389	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	On stimulation, production of significant amount of IL-12, KC, and IP-10 takes place.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	Macropahges	NA	NA	NA	NA	This induces the inflammatory response.	cell-based assays	19269175	2009	NA
PRRID_0389	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	On stimulation, production of significant amount of IL-12, KC, and IP-10 takes place.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	Macropahges	NA	NA	NA	NA	This induces the inflammatory response.	cell-based assays	19269175	2009	NA
PRRID_0399	Streptococcus gordonii Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0399	Streptococcus gordonii Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0401	1,3 beta glucan Click for more detail	Sparassis crispa (fungi)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	Anti-tumour properties	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It can induce the phenotypic and functional maturation of DCs.	NA	20699131	2010	Pubchem Assay
PRRID_0401	1,3 beta glucan Click for more detail	Sparassis crispa (fungi)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	Anti-tumour properties	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It can induce the phenotypic and functional maturation of DCs.	NA	20699131	2010	Pubchem Assay
PRRID_0403	5'-triphosphated RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	RIG-1	Rig-like receptor (RLR)	Mice (Murine)	Cytoplasm	NA	Q6Q899.fasta	Q6Q899	926	NA	NA	20739519	2010	Pubchem Assay
PRRID_0403	5'-triphosphated RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	RIG-1	Rig-like receptor (RLR)	Mice (Murine)	Cytoplasm	NA	Q6Q899.fasta	Q6Q899	926	NA	NA	20739519	2010	Pubchem Assay
PRRID_0412	Arabinosylated lipoarabinomannan (Ara-LAM) Click for more detail	Mycobacterium tuberculosis (Bacteria)	NA	NA	Glycolipid	Natural	It triggers downstream signalling via MyD88, lead to the ativation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Leishmania donovani infected Mice	macropahge	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis	EMSA and ELISA	20500089	2010	Pubchem Assay
PRRID_0412	Arabinosylated lipoarabinomannan (Ara-LAM) Click for more detail	Mycobacterium tuberculosis (Bacteria)	NA	NA	Glycolipid	Natural	It triggers downstream signalling via MyD88, lead to the ativation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Leishmania donovani infected Mice	macropahge	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis	EMSA and ELISA	20500089	2010	Pubchem Assay
PRRID_0421	Bacterial Antigen Click for more detail	B. abortus 544(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0421	Bacterial Antigen Click for more detail	B. abortus 544(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0422	Bacterial Antigen Click for more detail	B. abortus 545(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	class B scavenger receptor type I (SR-BI)	Scavenger receptor (SR)	Mice	Trophoblast giant cells and J774 cells	NA	Q61009.fasta	Q61009	509	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0422	Bacterial Antigen Click for more detail	B. abortus 545(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	class B scavenger receptor type I (SR-BI)	Scavenger receptor (SR)	Mice	Trophoblast giant cells and J774 cells	NA	Q61009.fasta	Q61009	509	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0423	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0423	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0424	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	class B scavenger receptor type I (SR-BI)	Scavenger receptor (SR)	Mice	Trophoblast giant cells and J774 cells	NA	Q61009.fasta	Q61009	509	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	NA	20471681	2010	Pubchem Assay
PRRID_0424	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	class B scavenger receptor type I (SR-BI)	Scavenger receptor (SR)	Mice	Trophoblast giant cells and J774 cells	NA	Q61009.fasta	Q61009	509	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	NA	20471681	2010	Pubchem Assay
PRRID_0425	Bacterial Antigen Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	It led to the activation of NF-Œ∫B and stimulate the production of cytokines IL-6 and TNF-‚ç∫	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Primary microglia and astrocytes	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It has the immunostimulatory role.	ELISA	20226841	2010	Pubchem Assay
PRRID_0425	Bacterial Antigen Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	It led to the activation of NF-Œ∫B and stimulate the production of cytokines IL-6 and TNF-‚ç∫	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Primary microglia and astrocytes	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It has the immunostimulatory role.	ELISA	20226841	2010	Pubchem Assay
PRRID_0428	BsaK Click for more detail	Burkholderia pseudomallei(Bacteria)	MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ	197	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0428	BsaK Click for more detail	Burkholderia pseudomallei(Bacteria)	MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ	197	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0449	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Microglia	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvement	NA	20706642	2010	Pubchem Assay
PRRID_0449	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Microglia	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvement	NA	20706642	2010	Pubchem Assay
PRRID_0450	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	APP transgenic Mice	microglia	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	clearance of AŒ≤ from microglial cells	NA	20706642	2010	Pubchem Assay
PRRID_0450	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	APP transgenic Mice	microglia	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	clearance of AŒ≤ from microglial cells	NA	20706642	2010	Pubchem Assay
PRRID_0451	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Their binding induces Th1 response and promote an increase in IFN-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It helps in the immunization of the mice to become more efficient	NA	20636030	2010	Pubchem Assay
PRRID_0451	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Their binding induces Th1 response and promote an increase in IFN-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It helps in the immunization of the mice to become more efficient	NA	20636030	2010	Pubchem Assay
PRRID_0453	CpG ODN 1826 Click for more detail	Bacteria	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	Macropahges	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	20696824	2010	Pubchem Assay
PRRID_0453	CpG ODN 1826 Click for more detail	Bacteria	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	Macropahges	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	20696824	2010	Pubchem Assay
PRRID_0454	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It delays the onset of prion disease by degrading the prions	NA	20706642	2010	Pubchem Assay
PRRID_0454	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It delays the onset of prion disease by degrading the prions	NA	20706642	2010	Pubchem Assay
PRRID_0455	Cpn60.2 Click for more detail	M. tuberculosis (Bacteria)	MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF	540	Protein	Natural	Their binding stabilize the interaction between the M. tuberculosis bacillus and the aveolar macrophage.	cluster of differentiation 43 (CD43)	Pattern recognition receptor (PRR)	C57BL/6 Mice	NA	NA	P15702.fasta	P15702	395	It controls growth of the bacteria in a mouse model of tuberculosis and that TNFa mediates apoptosis of infected CD43+/+ aveolar macrophage,CD43 recognizes the mycobacterial Cpn60.2 which acts as a danger signal for the innate immune system	ELISA	20633027	2010	Pubchem Assay
PRRID_0455	Cpn60.2 Click for more detail	M. tuberculosis (Bacteria)	MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF	540	Protein	Natural	Their binding stabilize the interaction between the M. tuberculosis bacillus and the aveolar macrophage.	cluster of differentiation 43 (CD43)	Pattern recognition receptor (PRR)	C57BL/6 Mice	NA	NA	P15702.fasta	P15702	395	It controls growth of the bacteria in a mouse model of tuberculosis and that TNFa mediates apoptosis of infected CD43+/+ aveolar macrophage,CD43 recognizes the mycobacterial Cpn60.2 which acts as a danger signal for the innate immune system	ELISA	20633027	2010	Pubchem Assay
PRRID_0458	cy2-labeled SitC-His Click for more detail	S. aureus (Bacteria)	NA	NA	Lipoprotein	Natural	It induce release of IL-6 in primary murine keratinocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Keratinocytes	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induce intracellular accumulation of TLR2	NA	20679445	2010	Pubchem Assay
PRRID_0458	cy2-labeled SitC-His Click for more detail	S. aureus (Bacteria)	NA	NA	Lipoprotein	Natural	It induce release of IL-6 in primary murine keratinocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Keratinocytes	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induce intracellular accumulation of TLR2	NA	20679445	2010	Pubchem Assay
PRRID_0459	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8BHB0.fasta	Q8BHB0	953	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0459	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8BHB0.fasta	Q8BHB0	953	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0460	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0460	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0464	diaminopimelic acid (C12-iEDAP) Click for more detail	Gram-negative and Gram-positive bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Muropeptide	Natural	It's binding to NOD1 induce NFŒ∫B activation, activation of MAP kinases and expression of chemokines CCL5 (RANTES) and CXCL1 (KC) and of nitric oxide	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	C57BL/6 Mice	liver and Hepatocytes	NA	Q8BHB0.fasta	Q8BHB0	953	It helps in attracting leukocytes to the liver during infection and for hepatic NLRs to augment innate immune responses to pathogens.	Immunoblotting and EMSA	20615568	2010	Pubchem Assay
PRRID_0464	diaminopimelic acid (C12-iEDAP) Click for more detail	Gram-negative and Gram-positive bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Muropeptide	Natural	It's binding to NOD1 induce NFŒ∫B activation, activation of MAP kinases and expression of chemokines CCL5 (RANTES) and CXCL1 (KC) and of nitric oxide	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	C57BL/6 Mice	liver and Hepatocytes	NA	Q8BHB0.fasta	Q8BHB0	953	It helps in attracting leukocytes to the liver during infection and for hepatic NLRs to augment innate immune responses to pathogens.	Immunoblotting and EMSA	20615568	2010	Pubchem Assay
PRRID_0467	DNA Click for more detail	Vaccinia(virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20709294	2010	Pubchem Assay
PRRID_0467	DNA Click for more detail	Vaccinia(virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20709294	2010	Pubchem Assay
PRRID_0468	DNA Click for more detail	Cordyceps sinensis(fungi)	TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG	685	Nucleic Acid	Natural	Upon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Bone marrow-derived dendritic cells (BM-DCs).	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It exhibits immunomodulating activity against Cordyceps sinensis	Luciferase assay	20451901	2010	Pubchem Assay
PRRID_0468	DNA Click for more detail	Cordyceps sinensis(fungi)	TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG	685	Nucleic Acid	Natural	Upon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Bone marrow-derived dendritic cells (BM-DCs).	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It exhibits immunomodulating activity against Cordyceps sinensis	Luciferase assay	20451901	2010	Pubchem Assay
PRRID_0470	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	NA	NA	20739519	2010	Pubchem Assay
PRRID_0470	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	NA	NA	20739519	2010	Pubchem Assay
PRRID_0471	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	NA	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	NA	NA	20739519	2010	Pubchem Assay
PRRID_0471	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	NA	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	NA	NA	20739519	2010	Pubchem Assay
PRRID_0472	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	RIG-1	Rig-like receptor (RLR)	Mice (Murine)	Cytoplasm	NA	Q6Q899.fasta	Q6Q899	926	NA	NA	20739519	2010	Pubchem Assay
PRRID_0472	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	RIG-1	Rig-like receptor (RLR)	Mice (Murine)	Cytoplasm	NA	Q6Q899.fasta	Q6Q899	926	NA	NA	20739519	2010	Pubchem Assay
PRRID_0473	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	MDA5	Rig-like receptor (RLR)	Mice (Murine)	Cytoplasm	NA	Q8R5F7.fasta	Q8R5F7	1025	NA	NA	20739519	2010	Pubchem Assay
PRRID_0473	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	NA	MDA5	Rig-like receptor (RLR)	Mice (Murine)	Cytoplasm	NA	Q8R5F7.fasta	Q8R5F7	1025	NA	NA	20739519	2010	Pubchem Assay
PRRID_0478	dsDNA Click for more detail	HSV-1 (virus)	NA	NA	Nucleic Acid	Natural	it mediate IFNs and cytokine production	ZBP-1 or DAI	DNA receptor	Mice (Murine)	Cytoplasm	NA	Q9QY24.fasta	Q9QY24	411	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0478	dsDNA Click for more detail	HSV-1 (virus)	NA	NA	Nucleic Acid	Natural	it mediate IFNs and cytokine production	ZBP-1 or DAI	DNA receptor	Mice (Murine)	Cytoplasm	NA	Q9QY24.fasta	Q9QY24	411	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0479	dsDNA Click for more detail	HSV-1 (virus)	NA	NA	Nucleic Acid	Natural	It mediate IFNs and cytokine production	RNA Pol-III	DNA receptor	Mice (Murine)	Cytoplasm	NA	Q9D483.fasta	Q9D483	533	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0479	dsDNA Click for more detail	HSV-1 (virus)	NA	NA	Nucleic Acid	Natural	It mediate IFNs and cytokine production	RNA Pol-III	DNA receptor	Mice (Murine)	Cytoplasm	NA	Q9D483.fasta	Q9D483	533	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0480	dsDNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	It activates caspase-1 and release proinflammatory cytokines	AIM2	Pattern recognition receptor (PRR)	Mice (Murine)	Cytoplasm	NA	Q91VJ1.fasta	Q91VJ1	354	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0480	dsDNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	It activates caspase-1 and release proinflammatory cytokines	AIM2	Pattern recognition receptor (PRR)	Mice (Murine)	Cytoplasm	NA	Q91VJ1.fasta	Q91VJ1	354	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0481	dsDNA Click for more detail	Ectromelia(virus)	NA	NA	Nucleic Acid	Natural	It is necessary for IL-6 production	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leads to the inflammation of the cell	NA	20709294	2010	Pubchem Assay
PRRID_0481	dsDNA Click for more detail	Ectromelia(virus)	NA	NA	Nucleic Acid	Natural	It is necessary for IL-6 production	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leads to the inflammation of the cell	NA	20709294	2010	Pubchem Assay
PRRID_0487	dsDNA Click for more detail	Vaccinia(virus)	NA	NA	Nucleic Acid	Natural	It induces the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells, PDCs	LRR	P58682.fasta	P58682	1032	TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection.	ELISA	20308556	2010	Pubchem Assay
PRRID_0487	dsDNA Click for more detail	Vaccinia(virus)	NA	NA	Nucleic Acid	Natural	It induces the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells, PDCs	LRR	P58682.fasta	P58682	1032	TLR8-MyD88-dependent pDC activation played a critical role in innate immune control of VV infection.	ELISA	20308556	2010	Pubchem Assay
PRRID_0492	EDA Click for more detail	Mice (others)	NA	NA	Organic Compound	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It helps in collateral vessels growth or Arteriogenesis.	NA	20708624	2010	Pubchem Assay
PRRID_0492	EDA Click for more detail	Mice (others)	NA	NA	Organic Compound	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It helps in collateral vessels growth or Arteriogenesis.	NA	20708624	2010	Pubchem Assay
PRRID_0495	endotoxin-free poly(I:C) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 Mice (experimental model of lung allergic exacerbation)	Airway Epithilium and Dedritic cells	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	It significantly increased the airway hyperresponsiveness, the lung inflammation	ELISA	20505141	2010	Pubchem Assay
PRRID_0495	endotoxin-free poly(I:C) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 Mice (experimental model of lung allergic exacerbation)	Airway Epithilium and Dedritic cells	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	It significantly increased the airway hyperresponsiveness, the lung inflammation	ELISA	20505141	2010	Pubchem Assay
PRRID_0497	EprJ and EscI Click for more detail	E. coli(Bacteria)	MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE	95,231	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0497	EprJ and EscI Click for more detail	E. coli(Bacteria)	MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE	95,231	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0504	fibrinogen and heat-shock proteins Click for more detail	Endogenous (others)	MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ	481	Protein	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20713100	2010	Pubchem Assay
PRRID_0504	fibrinogen and heat-shock proteins Click for more detail	Endogenous (others)	MRHLWLLLLLCVFSVQTQAADDDYDEPTDSLDARGHRPVDRRKEEPPSLRPAPPPISGGGYRARPAKATANQKKVERRPPDAGGCLHADTDMGVLCPTGCTLQQTLLNQERPIKSSIAELNNNIQSVSDTSSVTFQYLTLLKDMWKKKQAQVKENENVINEYSSILEDQRLYIDETVNDNIPLNLRVLRSILEDLRSKIQKLESDISAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDTSIKPYRVYCDMKTENGGWTVIQNRQDGSVDFGRKWDPYKKGFGNIATNEDAKKYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEASKYQVSVNKYKGTAGNALMDGASQLVGENRTMTIHNGMFFSTYDRDNDGWVTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGLYSWDMSKHGTDDGVVWMNWKGSWYSMRRMSMKIRPFFPQQ	481	Protein	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20713100	2010	Pubchem Assay
PRRID_0505	Fibronectin Click for more detail	Endogenous (others)	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Glycoprotein	Natural	It binds to the TLR4 and induce the release of pro-inflammatory cytokines via NF-	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Primary Microglia	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	it increases bacterial phagocytosis and intracellular killing by murine microglial cells	NA	20599470	2010	Pubchem Assay
PRRID_0505	Fibronectin Click for more detail	Endogenous (others)	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Glycoprotein	Natural	It binds to the TLR4 and induce the release of pro-inflammatory cytokines via NF-	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Primary Microglia	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	it increases bacterial phagocytosis and intracellular killing by murine microglial cells	NA	20599470	2010	Pubchem Assay
PRRID_0507	FimH Click for more detail	Escherichia coli strain EC99 (O78) (Bacteria)	MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	300	Protein	Natural	It activates both NK cells to induce cytokines [interferon (IFN)-Œ≥ and tumor necrosis factor (TNF)-Œ±] and cytotoxicity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Natural Killer cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It aids innate protection against cancer or microbial infections.	Chromium (51Cr) release assay for NK cytotoxicity	20442710	2010	Pubchem Assay
PRRID_0507	FimH Click for more detail	Escherichia coli strain EC99 (O78) (Bacteria)	MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	300	Protein	Natural	It activates both NK cells to induce cytokines [interferon (IFN)-Œ≥ and tumor necrosis factor (TNF)-Œ±] and cytotoxicity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Natural Killer cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It aids innate protection against cancer or microbial infections.	Chromium (51Cr) release assay for NK cytotoxicity	20442710	2010	Pubchem Assay
PRRID_0510	Flagellin Click for more detail	Salmonella muenchen (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates NF-KB and MAPKs and induced significant production of the different cytokines	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Liver, Lung, Kideny, Intestine	Leucine-rich Repeat (LRR) Domain	Q9JLF7.fasta	Q9JLF7	859	It has the role in the inflammation.	NA	20731882	2010	Pubchem Assay
PRRID_0510	Flagellin Click for more detail	Salmonella muenchen (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates NF-KB and MAPKs and induced significant production of the different cytokines	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Liver, Lung, Kideny, Intestine	Leucine-rich Repeat (LRR) Domain	Q9JLF7.fasta	Q9JLF7	859	It has the role in the inflammation.	NA	20731882	2010	Pubchem Assay
PRRID_0526	FSL-1 Click for more detail	Mycoplasma salivarium (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-Œ∫B which results in secretion of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	embryonic mouse telencephalon and NPC	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	its activation inhibits NPC proliferation and decreases cell proliferation.	NA	20456021	2010	Pubchem Assay
PRRID_0526	FSL-1 Click for more detail	Mycoplasma salivarium (Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-Œ∫B which results in secretion of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	embryonic mouse telencephalon and NPC	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	its activation inhibits NPC proliferation and decreases cell proliferation.	NA	20456021	2010	Pubchem Assay
PRRID_0528	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0528	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0529	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0529	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0531	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	HEK293	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It has the role in the inflammation.	NA	20543857	2010	Pubchem Assay
PRRID_0531	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	HEK293	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It has the role in the inflammation.	NA	20543857	2010	Pubchem Assay
PRRID_0533	genomic DNA Click for more detail	HSV-1 and HSV-2 (virus)	NA	NA	Nucleic Acid	Natural	It mediates tumor necrosis factor alpha and CCL5 production in murine macrophages	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0533	genomic DNA Click for more detail	HSV-1 and HSV-2 (virus)	NA	NA	Nucleic Acid	Natural	It mediates tumor necrosis factor alpha and CCL5 production in murine macrophages	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0535	Glycoinositol phospholipids Click for more detail	Trypanosoma (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20713100	2010	Pubchem Assay
PRRID_0535	Glycoinositol phospholipids Click for more detail	Trypanosoma (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20713100	2010	Pubchem Assay
PRRID_0537	Glycolipids Click for more detail	Treponema maltophilum (others)	NA	NA	Glycolipid	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0537	Glycolipids Click for more detail	Treponema maltophilum (others)	NA	NA	Glycolipid	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0540	Glycosylphosphatidyl inositol anchor Click for more detail	Trypanosoma Cruzi (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0540	Glycosylphosphatidyl inositol anchor Click for more detail	Trypanosoma Cruzi (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0554	hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail	Vibrio vulnificus (Bacteria)	MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY	4595	Protein	Natural	It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Macropahes	NA	Q8R4B8.fasta	Q8R4B8	1033	It leads to the pathogen clearance	ELISA	20348425	2010	Pubchem Assay
PRRID_0554	hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail	Vibrio vulnificus (Bacteria)	MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY	4595	Protein	Natural	It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Macropahes	NA	Q8R4B8.fasta	Q8R4B8	1033	It leads to the pathogen clearance	ELISA	20348425	2010	Pubchem Assay
PRRID_0555	hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail	Vibrio cholerae (Bacteria)	MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL	4558	Protein	Natural	It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Macrophages	NA	Q8R4B8.fasta	Q8R4B8	1033	It leads to the pathogen clearance	ELISA	20348425	2010	Pubchem Assay
PRRID_0555	hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail	Vibrio cholerae (Bacteria)	MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL	4558	Protein	Natural	It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Mice	Macrophages	NA	Q8R4B8.fasta	Q8R4B8	1033	It leads to the pathogen clearance	ELISA	20348425	2010	Pubchem Assay
PRRID_0557	Histoplasma strain 505 yeast cells Click for more detail	Histoplasma strain 505 (others)	NA	NA	Whole organism	Natural	The binding leads to the secretion of cytokines such as TNF-‚ç∫ and IL-6, via syk dependent pathway	CR3	Complement receptor	Mice (Murine)	Macropahges	lectin binding domain	NA	NA	NA	It is was responsible for phagocytosis and cytokine response.	Phagocytosis assay and ELISA	20360401	2010	NA
PRRID_0557	Histoplasma strain 505 yeast cells Click for more detail	Histoplasma strain 505 (others)	NA	NA	Whole organism	Natural	The binding leads to the secretion of cytokines such as TNF-‚ç∫ and IL-6, via syk dependent pathway	CR3	Complement receptor	Mice (Murine)	Macropahges	lectin binding domain	NA	NA	NA	It is was responsible for phagocytosis and cytokine response.	Phagocytosis assay and ELISA	20360401	2010	NA

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