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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 771
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1303Ubiquitin-derived peptide (Ub2) STLHLVLRLRGGFreeFreeNoneLinear12LCationicNaturalUbiquitin derived Mycobacterium smegmatis M. smegmatis mc2 1551.5 fold reduction in bacterial colony as compared to control at 60 μM of peptideIn vitroNANANANA NANAPore formation in Mycobacterial membranemspA gene which form porins in membrane, peptide increase the expression of this geneNANA200919682257
antitb_1304Ubiquitin-derived peptide (Ub2) STLHLVLRLRGGFreeFreeNoneLinear12LCationicNaturalUbiquitin derived Mycobacterium smegmatis M. smegmatis mc2 1552.5 fold reduction in bacterial colony as compared to control at75 μM In vitroNANANANA NANAPore formation in Mycobacterial membranemspA gene which form porins in membrane, peptide increase the expression of this geneNANA200919682257
antitb_1305Ubiquitin-derived peptide (Ub2) STLHLVLRLRGGFreeFreeNoneLinear12LCationicNaturalUbiquitin derived Mycobacterium smegmatis M. smegmatis mc2 1553 fold reduction in bacterial colony as compared to control at100 μM In vitroNANANANA NANAPore formation in Mycobacterial membranemspA gene which form porins in membrane, peptide increase the expression of this geneNANA200919682257
antitb_1306D-(V13K) D1KWKSFLKTFKSAKKTVLHTALKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 70.7 μg/mLIn vitroHuman erythrocyteNAHC50 = 421.5 μg/mLNA NANANANANANA201120858205
antitb_1307D-(V13K,A20L) D2KWKSFLKTFKSAKKTVLHTLLKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 83.7 μg/mLIn vitroHuman erythrocyteNAHC50 = 83 μg/mLNA NANANANANANA201120858205
antitb_1308D-(V13K,A12L,A20L) D3KWKSFLKTFKSLKKTVLHTLLKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 109.2 μg/mLIn vitroHuman erythrocyteNAHC50 = 14 μg/mLNA NANANANANANA201120858205
antitb_1309D-(V13K,A12L,A20L,A23L) D4KWKSFLKTFKSLKKTVLHTLLKLISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 200 μg/mLIn vitroHuman erythrocyteNAHC50 = 3.5 μg/mLNA NANANANANANA201120858205
antitb_1310D-(V13K,A12L,A20L,A23L,V16K) D5KWKSFLKTFKSLKKTKLHTLLKLISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 35.2 μg/mLIn vitroHuman erythrocyteNAHC50 = 47 μg/mLNA NANANANANANA201120858205
antitb_1311D-(V13K) D1KWKSFLKTFKSAKKTVLHTALKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = 57 μg/mLIn vitroHuman erythrocyteNAHC50 = 7.4 μg/mLNA NANANANANANA201120858205
antitb_1312D-(V13K,A20L) D2KWKSFLKTFKSAKKTVLHTLLKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = 72 μg/mLIn vitroHuman erythrocyteNAHC50 = 12 μg/mLNA NANANANANANA201120858205
antitb_1313D-(V13K,A12L,A20L) D3KWKSFLKTFKSLKKTVLHTLLKAISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = 100 μg/mLIn vitroHuman erythrocyteNAHC50 = 0.14 μg/mLNA NANANANANANA201120858205
antitb_1314D-(V13K,A12L,A20L,A23L) D4KWKSFLKTFKSLKKTVLHTLLKLISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = Ie μg/mL(inactive)In vitroHuman erythrocyteNAHC50 = Ie μg/mL(inactive)NA NANANANANANA201120858205
antitb_1315D-(V13K,A12L,A20L,A23L,V16K) D5KWKSFLKTFKSLKKTKLHTLLKLISSAcetylationAmidationNoneLinear26LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv multidrug resistant strain vertuloMIC = 49 μg/mLIn vitroHuman erythrocyteNAHC50 = 1.0 μg/mLNA NANANANANANA201120858205
antitb_1316L-LL37LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNFreeFreeNoneLinear31LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = Ie μg/mL(inactive)In vitroHuman erythrocyteNAHC50 = 43.5 μg/mLNA NANANANANANA201120858205
antitb_1318Peptoid 1 H-(NLys-Nspe-Nspe)4-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 14.1μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 14.1μMNA NANANANANANA201121464254
antitb_13191-C134mer H-Ntridec-NLys-Nspe-Nspe-NLys-NH2FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycine, Ntridec = N-(tridecyl)glycineLinear5LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 6.6 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = >100 μMNA NANANANANANA201121464254
antitb_132014merH-NLys-Nspe-Nspe-NLys-NH2FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear4LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvNAIn vitroRaw 264.7 and J774 mouse macrophageNANon toxicNA NANANANANANA201121464254
antitb_13211-Pro9 H-(NLys-Nspe-Nspe)2-NLys-Nspe-L-Pro-NLys-Nspe-Nspe-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 14.5 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 50 μMNA NANANANANANA201121464254
antitb_13221-11mer H-(NLys-Nspe-Nspe)3-NLys-Nspe-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear11LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 14.46 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 50μMNA NANANANANANA201121464254
antitb_13231-Nssb H-(NLys-Nssb-Nssb)4-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nssb = (S)-N-(sec-butyl)glycineLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = >100 μMIn vitroRaw 264.7 and J774 mouse macrophageNANon toxicNA NANANANANANA201121464254
antitb_1324Peptoid 1 H-(NLys-Nspe-Nspe)4-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear12LCationicSyntheticNAMycobacterium bovis Mycobacterium bovis BCGMIC = 12.5-25 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 14.1μMNA NANANANANANA201121464254
antitb_13251-C134mer H-Ntridec-NLys-Nspe-Nspe-NLys-NH2FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycine, Ntridec = N-(tridecyl)glycineLinear5LCationicSyntheticNAMycobacterium bovis Mycobacterium bovis BCGMIC = 6.3 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = >100 μMNA NANANANANANA201121464254
antitb_132614merH-NLys-Nspe-Nspe-NLys-NH2FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear4LCationicSyntheticNAMycobacterium bovis Mycobacterium bovis BCGMIC = >100 μMIn vitroRaw 264.7 and J774 mouse macrophageNANon toxicNA NANANANANANA201121464254
antitb_13271-Pro9 H-(NLys-Nspe-Nspe)2-NLys-Nspe-L-Pro-NLys-Nspe-Nspe-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear12LCationicSyntheticNAMycobacterium bovis Mycobacterium bovis BCGMIC = 12.5-25 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 50μMNA NANANANANANA201121464254
antitb_13281-11mer H-(NLys-Nspe-Nspe)3-NLys-Nspe-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nspe = (S)-N-(1-phenylethyl)glycineLinear11LCationicSyntheticNAMycobacterium bovis Mycobacterium bovis BCGMIC = 12.5-25 μMIn vitroRaw 264.7 and J774 mouse macrophageNALD50 = 50μMNA NANANANANANA201121464254
antitb_13291-Nssb H-(NLys-Nssb-Nssb)4-NH2 FreeAmidationNlys = N-(4-aminobutyl)glycine, Nssb = (S)-N-(sec-butyl)glycineLinear12LCationicSyntheticNAMycobacterium bovis Mycobacterium bovis BCGMIC = >100 μMIn vitroRaw 264.7 and J774 mouse macrophageNANon toxicNA NANANANANANA201121464254
antitb_1330Human beta casein fragment (54-59)VEPIPYFreeFreeNoneLinear6LCationicProtein derivedHuman beta casein proteinMycobacterium bovis Mycobacterium bovis BCGMIC = 25μMin vitroTHP 1 cell linesCells treated with 10 mM and 20 mM peptide showed 17.13% and 29.56% increase in clearance of BCG NANA NAIncrease expression of IL-8, MCP-1, MIP-1β, TNF-αNANANANA201223029305
antitb_1331Innate defence regulator peptide HH2VQLRIRVAVIRA FreeFreeNoneLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvNABothHuman U937 promonocytic cell line NANoneBALB/C 32 mg in 100 mL of saline solution (1 mg/kg) Increase expression of MCP-1,Gro-α and TNF-αNANANAAntimicrobial against plasmodium aeruginosa/ S. aureus201223555622
antitb_1332Innate defence regulator peptide 1002VQRWLIVWRIRK FreeFreeNoneLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 29.3 ± 11.8 mg/mLBothHuman U937 promonocytic cell line NANoneBALB/C 32 mg in 100 mL of saline solution (1 mg/kg) Increase expression of MCP-1,Gro-α and TNF-αNANANAAntimicrobial against plasmodium aeruginosa/ S. aureus201223555622
antitb_1333Innate defence regulator peptide 1018VRLIVAVRIWRR FreeFreeNoneLinear12LCationicSyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis H37RvMIC = 16.4± 5.4 mg/mL BothHuman U937 promonocytic cell line NANoneBALB/C 32 mg in 100 mL of saline solution (1 mg/kg) Increase expression of MCP-1,Gro-α and TNF-αNANANAAntimicrobial against plasmodium aeruginosa/ S. aureus201223555622
antitb_1353Peptide KSlKKVVFKVKFKFreeFreeNoneLinear10LCationicSyntheticNAMycobacterium smegmatisMycobacterium smegmatis ATCC 607MIC = 6.25μg/mlIn vitroMouse erythrocyteNANoneNA NANANANANAantifungal, antibacterial against C.albicans19989756752
antitb_1354Nk-lysinNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDFreeFreeInternal disuphide bond 13 -23Cyclic37LNANaturalPig cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25618IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA30 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1355NKLF1VTQAASRVCDKMKILRGVCKKIMRTFLRRFreeFreeInternal disulphide bond at residue between 9-13Cyclic29LNANaturalPig cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25619IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA31 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1356NKLF2VCDKMKILRGVCKKIMRTFLRRFreeFreeNoneCyclic22LNANaturalPig cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25620IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA32 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1357Gran F2VCRTGRSRWRDVCRNFMRRYQSRFreeFreeInternal disulphide bond at residue between 2-13Cyclic23LNANaturalHuman cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25621IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA33 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1358Gran F1VSNAATRVCRTGRSRWRDVCRNFMRRYQSRFreeFreeNoneLinear30LNANaturalHuman cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25622IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA34 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1359GranulysinTQRSVSNAATRVCRTGRSRWRDVCRNFMRRYQSRVTQGFreeFreeNoneLinear38LNANaturalHuman cytolytic lymphocytesMycobacterium tuberculosis Mycobacterium tuberculosis H37Rv ATCC 25623IC90 = 30 μMIn vitroHuman erythroleukaemia cell line K562 NA35 % cytolytic activity in range of 3 -7 μM peptide concentrationNA NANANANANAAntibacterial against bacillus megaterium, E.coli, P.aeuroginosaand S.aureus199910585872
antitb_1360PleurocidinGWGSFFKKAAHVGKHVGKAALTHYL FreeFreeNoneLinear25LNANaturalPleuronectes americanus Mycobacterium smegmatisMycobacterium smegmatisMIC = 80 μg/mlIn vitroNoneNANANA NANANANANAAntibacterial against P.aeruginosa, K.pneumoniae,S.aureus and C.albicans200010898673
antitb_1361PleurocidinGWGSFFKKAAHVGKHVGKAALTHYL FreeFreeNoneLinear25LNANaturalPleuronectes americanus Mycobacterium smegmatisMycobacterium smegmatisMIC = 20 μg/mlIn vitroNoneNANANA NANANANA185 μM OF D-CYCLOSERINE DRUG + 5.2 μM OF Peptide reduces ~ 4 time MIC of drug Antibacterial against P.aeruginosa, K.pneumoniae,S.aureus and C.albicans200010898673
antitb_1370Human neutrophil peptides-1 ACYCRIPACIAGERRYGTCIYQGRLWAFCCFreeFreeDisulphide linkage between cys2-cys30, cys4-cys19,cys9-cys29cyclic30LCationicSyntheticHuman neutrophilsMycobacterium tuberculosisMycobacterium tuberculosis H37 RaNAin vitroNoneNANANA NANANAMycobacterial genomic DNANAantibacterial against candida albicans200011375668
antitb_1371Mycobacterial tuberculosis DHFR tripeptide analogWYDFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 1.26 × 10−7in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1372Mycobacterial tuberculosis DHFR tripeptide analogWYEFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 5.02 × 10−6 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1373Mycobacterial tuberculosis DHFR tripeptide analogWPDFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 9.12 × 10−9 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1374Mycobacterial tuberculosis DHFR tripeptide analogWPEFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 1.02 × 10−6 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1375Mycobacterial tuberculosis DHFR tripeptide analogYPDFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 4.17 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1376Mycobacterial tuberculosis DHFR tripeptide analogYPEFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 2.75 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1377Mycobacterial tuberculosis DHFR tripeptide analogWYYFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 1.78 × 10−9 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1378Mycobacterial tuberculosis DHFR tripeptide analogWPYFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 9.55 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1379Mycobacterial tuberculosis DHFR tripeptide analogWYPFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 4.57 × 10−8 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148
antitb_1380Mycobacterial tuberculosis DHFR tripeptide analogWPWFreeFreeNoneLinear3LCationicSyntheticNAMycobacterium tuberculosisMycobacterium tuberculosisKd= 4.27 × 10−6 in silicoNANANANA NANANAmycobacteium tuberculosis DHFRNA200919697148