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KWKSFLKTFKSLKKTKLHTLLKLISS details |
| Primary information | |
|---|---|
| ID | antitb_1310, |
| Name | 20858205 |
| N-Terminal modification | D-(V13K,A12L,A20L,A23L,V16K) D5 |
| C-Terminal Modification | KWKSFLKTFKSLKKTKLHTLLKLISS |
| Chemical Modification | Acetylation |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 26 |
| Source | L |
| Origin | Cationic |
| Species | Synthetic |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
| Cell Line | MIC = 35.2 μg/mL |
| Inhibition Concentration | In vitro |
| Sequence | 2011 |
| Cytotoxicity | Human erythrocyte |
| In vivo Model | NA |
| Lethal Dose | HC50 = 47 μg/mL |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1315, |
| Name | 20858205 |
| N-Terminal modification | D-(V13K,A12L,A20L,A23L,V16K) D5 |
| C-Terminal Modification | KWKSFLKTFKSLKKTKLHTLLKLISS |
| Chemical Modification | Acetylation |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 26 |
| Source | L |
| Origin | Cationic |
| Species | Synthetic |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv multidrug resistant strain vertulo |
| Cell Line | MIC = 49 μg/mL |
| Inhibition Concentration | In vitro |
| Sequence | 2011 |
| Cytotoxicity | Human erythrocyte |
| In vivo Model | NA |
| Lethal Dose | HC50 = 1.0 μg/mL |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1530, |
| Name | 25613372 |
| N-Terminal modification | D5 |
| C-Terminal Modification | KWKSFLKTFKSLKKTKLHTLLKLISS |
| Chemical Modification | Acetylation |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 27 |
| Source | L |
| Origin | Cationic |
| Species | Protein derived |
| Strain | Derived from Human cationic antimicrobial protein 18 (hCAP18) |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
| Cell Line | MIC = 35.2 μg/ml |
| Inhibition Concentration | in vitro |
| Sequence | 2015 |
| Cytotoxicity | Human macrophage THP1 |
| In vivo Model | NA |
| Lethal Dose | No cytotoxicity |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | Induce expression of IL-8and MCP-1 |
| Combination Therapy | In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteria |
| Other activities | Bacterial cell membrane |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1531, |
| Name | 25613372 |
| N-Terminal modification | D5 |
| C-Terminal Modification | KWKSFLKTFKSLKKTKLHTLLKLISS |
| Chemical Modification | Acetylation |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 27 |
| Source | L |
| Origin | Cationic |
| Species | Protein derived |
| Strain | Derived from Human cationic antimicrobial protein 18 (hCAP18) |
| Inhibition Concentration | Mycobacterium tuberculosis |
| In Vitro/ In vivo | Mycobacterium tuberculosis MDR-TB |
| Cell Line | MIC = 49 μg/ml |
| Inhibition Concentration | in vitro |
| Sequence | 2015 |
| Cytotoxicity | Human macrophage THP1 |
| In vivo Model | NA |
| Lethal Dose | No cytotoxicity |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | Induce expression of IL-8and MCP-1 |
| Combination Therapy | In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteria |
| Other activities | Bacterial cell membrane |
| PMID | NA |
| Year of Publication | NA |
| Tertiary Structure (Technique) | Not Predicted), |