Primary information |
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ID | antitb_1331 |
Peptide Name | Innate defence regulator peptide HH2 |
Sequence | VQLRIRVAVIRA |
N-terminal Modification | Free |
C-terminal Modification | Free |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Length | 12 |
Chirality | L |
Nature | Cationic |
Source | Synthetic |
Origin | NA |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis H37Rv |
Inhibition Concentartion | NA |
In vitro/In vivo | Both |
Cell Line | Human U937 promonocytic cell line |
Inhibition Concentartion | NA |
Cytotoxicity | None |
In vivo Model | BALB/C |
Lethal Dose | 32 mg in 100 mL of saline solution (1 mg/kg) |
Immune Response | Increase expression of MCP-1,Gro-α and TNF-α |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | NA |
Other Activities | Antimicrobial against plasmodium aeruginosa/ S. aureus |
Pubmed ID | 23555622 |
Year of Publication | 2012 |
3-D Structure | View in Jmol or Download Structure |