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The total number entries retrieved from this search are| ID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
|---|---|---|---|---|---|---|---|
| 1002 | AAPV | AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=0.46 μg/cm2/h, Permeability coefficient=1.50×10−4Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1003 | AAPV | C6(D)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=2.29 μg/cm2/h, Permeability coefficient=7.6×10−4 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1004 | AAPV | C6(L)-Laa- AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=0.50 μg/cm2/h, Permeability coefficient=1.6×10−4 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1005 | AAPV | C8(D,L)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=10.08 μg/cm2/h, Permeability coefficient= 3.3×10−3 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1006 | AAPV | C8(D)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=7.42 μg/cm2/h, Permeability coefficient=1.90×10−2 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1007 | AAPV | C8(L)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=1.37 μg/cm2/h, Permeability coefficient=4.50×10−4 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1008 | AAPV | C10(D,L)-Laa-AAPV | It fits the P-P1 subsites of elastase and inhibits HNE competitively | Franz diffusion cell, HPLC | Epidermal flux=8.92 μg/cm2/h, Permeability coefficient=2.9×10−3 Kp(cm/h) | Human epidermal membranes were obtained by heat separation of whole skin | 24842663 |
| 1009 | RRRRRRRRRRRLILV LLAI | 11R-No. 10 | Melanogenesis inhibitory peptide | Confocal microscope | When TMR-11R was topically applied for 24 h, the signals were only observed on the surface of the skin. In contrast, 12 h later, strong signals were detected showing that TMR-11R had arrived at the skin basal layer. Moreover, 24 and 48 hours later, the signals had spread out more and were stronger in both epidermis and dermis | Skin from the back of a brown guinea pig | 24602570 |
| 1010 | GKRR | R4 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 25.16 ± 2.31 , Q48 (mg) 1167.05 ± 50.10 Drug content in skin (mg/cm2) 146 ± 6.44 | Human epidermal skin | 24134794 |
| 1011 | GKRR | R4 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 43.74 ± 4.15 , Q48(mg) 2064.72 ± 100.05 Drug content in skin (mg/cm2) 180 ± 8.23 | Human epidermal skin | 24134794 |
| 1012 | GKRR | R4 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Human epidermal skin | 24134794 |
| 1013 | GKKKRRRR | R8 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Human epidermal skin | 24134794 |
| 1014 | GKKKRRRR | R8 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Human epidermal skin | 24134794 |
| 1015 | GKKKRRRR | R8 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 78.07 ± 7.52, Q48 (mg) 3666.44 ± 162.70 Drug content in skin (mg/cm2) 378± 15.11 | Human epidermal skin | 24134794 |
| 1016 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 21.43 ± 1.32 , Q48 (mg) 856.29 ± 39.50 Drug content in skin (mg/cm2) 151 ± 4.64 | Human epidermal skin | 24134794 |
| 1017 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 23.46 ± 2.04 , Q48 (mg) 1106.03 ± 53.80 Drug content in skin (mg/cm2) 155 ± 4.85 | Human epidermal skin | 24134794 |
| 1018 | GKKKKKKKRRRRRRRR | R16 (arginine-terminated peptide dendrimers) | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | Franz diffusion cell | Flux (mg/cm2/h) 27.16 ± 2.65, Q48 (mg) 1256.61 ± 55.70, Drug content in skin (mg/cm2) 156 ± 6.26 | Human epidermal skin | 24134794 |
| 1019 | KETWWETWWTEWSQP KKKRKV | Pep-1 | Cell penetrating peptide | In vivo imaging | Significant permeability of the peptide can be seen in in vivo images | Mouse skin cells | 23601371 |
| 1023 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | TP could not pass through the skin due to the charge repulsion effect between the negative charge of the TP and the negative charge of the skin | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1024 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts0.10± 0.01 µg/cm2 and fluxes 0.60 ± 0.06 µg/cm2·h | Acceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1025 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 0.31 ± 0.04 µg/cm2 and fluxes 1.86 ± 0.24 µg/cm2·h | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1026 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 1.02 ± 0.05 µg/cm2 and fluxes 6.13± 0.28 µg/cm2·h | Acceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1027 | GRKKRRQRRRPPQRKC | Tat | Cell penetrating peptide | Vertical Franz diffusion cell | Cumulative amounts 4.29 ± 0.40 µg/cm2 and fluxes 25.73 ± 2.40 µg/cm2·h | Abdominal skin of Sprague–Dawley rats | 23311648 |
| 1028 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~0.5% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1029 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | >0.5% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1030 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | >1% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1031 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | <0.5% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1032 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | <0.5% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1033 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | >1.5% of applied dose | Epidermis of human breast skin | 22890441 |
| 1034 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~2% of applied dose | Epidermis of human breast skin | 22890441 |
| 1035 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | <4% of applied dose | Epidermis of human breast skin | 22890441 |
| 1036 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~0.5% of applied dose | Epidermis of human breast skin | 22890441 |
| 1037 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | <1% of applied dose | Epidermis of human breast skin | 22890441 |
| 1038 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | >8% of applied dose | Dermis of human breast skin | 22890441 |
| 1039 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | <4% of applied dose | Dermis of human breast skin | 22890441 |
| 1040 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | <18% of applied dose | Dermis of human breast skin | 22890441 |
| 1041 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~3% of applied dose | Dermis of human breast skin | 22890441 |
| 1042 | β-Ala-H | L -carnosine | Antioxidant | Franz diffusion cell, HPLC | >8% of applied dose | Dermis of human breast skin | 22890441 |
| 1043 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | >5% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1044 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~6% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1045 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~1.5% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1046 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~5% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1047 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~3% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1048 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~2% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1049 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~7% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1050 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~3% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1051 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | 2% of applied dose | Stratum corneum of human breast skin | 22890441 |
| 1052 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~11% of applied dose | Epidermis of human breast skin | 22890441 |
| 1053 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~9% of applied dose | Epidermis of human breast skin | 22890441 |
| 1054 | β-Ala-H | N-acetyl- L -carnosine | Antioxidant | Franz diffusion cell, HPLC | ~3% of applied dose | Epidermis of human breast skin | 22890441 |