Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1001 | SequenceACSSSPSKHCG | NameTD1 | Nature of peptide or cargoTD1 enhances the transdermal delivery of macromolecules | AssayFranz diffusion cells | Tissue permeabilitySignificant increase in permeability of the peptide can be seen by the addition of ATP.The amount of protein that permeated the skin was determined with ELISA | Tissue SampleMale SD rats skin cells | PUBMED ID25269793 |
| ID1002 | SequenceAAPV | NameAAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=0.46 μg/cm2/h, Permeability coefficient=1.50×10−4Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1003 | SequenceAAPV | NameC6(D)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=2.29 μg/cm2/h, Permeability coefficient=7.6×10−4 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1004 | SequenceAAPV | NameC6(L)-Laa- AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=0.50 μg/cm2/h, Permeability coefficient=1.6×10−4 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1005 | SequenceAAPV | NameC8(D,L)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=10.08 μg/cm2/h, Permeability coefficient= 3.3×10−3 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1006 | SequenceAAPV | NameC8(D)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=7.42 μg/cm2/h, Permeability coefficient=1.90×10−2 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1007 | SequenceAAPV | NameC8(L)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=1.37 μg/cm2/h, Permeability coefficient=4.50×10−4 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1008 | SequenceAAPV | NameC10(D,L)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=8.92 μg/cm2/h, Permeability coefficient=2.9×10−3 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1009 | SequenceRRRRRRRRRRRLILV LLAI | Name11R-No. 10 | Nature of peptide or cargoMelanogenesis inhibitory peptide | AssayConfocal microscope | Tissue permeabilityWhen TMR-11R was topically applied for 24 h, the signals were only observed on the surface of the skin. In contrast, 12 h later, strong signals were detected showing that TMR-11R had arrived at the skin basal layer. Moreover, 24 and 48 hours later, the signals had spread out more and were stronger in both epidermis and dermis | Tissue SampleSkin from the back of a brown guinea pig | PUBMED ID24602570 |
| ID1010 | SequenceGKRR | NameR4 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 25.16 ± 2.31 , Q48 (mg) 1167.05 ± 50.10 Drug content in skin (mg/cm2) 146 ± 6.44 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1011 | SequenceGKRR | NameR4 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 43.74 ± 4.15 , Q48(mg) 2064.72 ± 100.05 Drug content in skin (mg/cm2) 180 ± 8.23 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1012 | SequenceGKRR | NameR4 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1013 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1014 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1015 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 78.07 ± 7.52, Q48 (mg) 3666.44 ± 162.70 Drug content in skin (mg/cm2) 378± 15.11 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1016 | SequenceGKKKKKKKRRRRRRRR | NameR16 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 21.43 ± 1.32 , Q48 (mg) 856.29 ± 39.50 Drug content in skin (mg/cm2) 151 ± 4.64 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1017 | SequenceGKKKKKKKRRRRRRRR | NameR16 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 23.46 ± 2.04 , Q48 (mg) 1106.03 ± 53.80 Drug content in skin (mg/cm2) 155 ± 4.85 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1018 | SequenceGKKKKKKKRRRRRRRR | NameR16 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 27.16 ± 2.65, Q48 (mg) 1256.61 ± 55.70, Drug content in skin (mg/cm2) 156 ± 6.26 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1019 | SequenceKETWWETWWTEWSQP KKKRKV | NamePep-1 | Nature of peptide or cargoCell penetrating peptide | AssayIn vivo imaging | Tissue permeabilitySignificant permeability of the peptide can be seen in in vivo images | Tissue SampleMouse skin cells | PUBMED ID23601371 |
| ID1020 | SequenceACSSSPSKHCG | NameTDN | Nature of peptide or cargoTD-1 has been testified to enhanced insulin transdermal delivery through hair follicles | AssayConfocal Laser Scanning Microscopy | Tissue permeabilitySignificant permeability of the peptide can be seen in confocal images | Tissue SampleMale SD rats skin cells | PUBMED ID23391375 |
| ID1021 | SequenceACSSKKSKHCG | NameTD-34 | Nature of peptide or cargoTD-1 has been testified to enhanced insulin transdermal delivery through hair follicles | AssayConfocal Laser Scanning Microscopy | Tissue permeabilitySignificant permeability of the peptide can be seen in confocal images | Tissue SampleMale SD rats skin cells | PUBMED ID23391375 |
| ID1022 | SequenceACSSSPSKHCG | NameTD1 | Nature of peptide or cargoTD1 enhances the transdermal delivery of macromolecules | AssayFranz diffusion cells, immunity fluorescence techniques | Tissue permeabilitySignificant permeability of the peptide can be seen. The amount of protein that permeated the skin was determined with immunity fluorescence techniques | Tissue SampleMale SD rats skin cells | PUBMED ID23385091 |
| ID1023 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityTP could not pass through the skin due to the charge repulsion effect between the negative charge of the TP and the negative charge of the skin | Tissue SampleAbdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1024 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityCumulative amounts0.10± 0.01 µg/cm2 and fluxes 0.60 ± 0.06 µg/cm2·h | Tissue SampleAcceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1025 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityCumulative amounts 0.31 ± 0.04 µg/cm2 and fluxes 1.86 ± 0.24 µg/cm2·h | Tissue SampleAbdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1026 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityCumulative amounts 1.02 ± 0.05 µg/cm2 and fluxes 6.13± 0.28 µg/cm2·h | Tissue SampleAcceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1027 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityCumulative amounts 4.29 ± 0.40 µg/cm2 and fluxes 25.73 ± 2.40 µg/cm2·h | Tissue SampleAbdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1028 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~0.5% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1029 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability>0.5% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1030 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability>1% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1031 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability<0.5% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1032 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability<0.5% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1033 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability>1.5% of applied dose | Tissue SampleEpidermis of human breast skin | PUBMED ID22890441 |
| ID1034 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~2% of applied dose | Tissue SampleEpidermis of human breast skin | PUBMED ID22890441 |
| ID1035 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability<4% of applied dose | Tissue SampleEpidermis of human breast skin | PUBMED ID22890441 |
| ID1036 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~0.5% of applied dose | Tissue SampleEpidermis of human breast skin | PUBMED ID22890441 |
| ID1037 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability<1% of applied dose | Tissue SampleEpidermis of human breast skin | PUBMED ID22890441 |
| ID1038 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability>8% of applied dose | Tissue SampleDermis of human breast skin | PUBMED ID22890441 |
| ID1039 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability<4% of applied dose | Tissue SampleDermis of human breast skin | PUBMED ID22890441 |
| ID1040 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability<18% of applied dose | Tissue SampleDermis of human breast skin | PUBMED ID22890441 |
| ID1041 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~3% of applied dose | Tissue SampleDermis of human breast skin | PUBMED ID22890441 |
| ID1042 | Sequenceβ-Ala-H | NameL -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability>8% of applied dose | Tissue SampleDermis of human breast skin | PUBMED ID22890441 |
| ID1043 | Sequenceβ-Ala-H | NameN-acetyl- L -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability>5% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1044 | Sequenceβ-Ala-H | NameN-acetyl- L -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~6% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1045 | Sequenceβ-Ala-H | NameN-acetyl- L -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~1.5% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1046 | Sequenceβ-Ala-H | NameN-acetyl- L -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~5% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1047 | Sequenceβ-Ala-H | NameN-acetyl- L -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~3% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1048 | Sequenceβ-Ala-H | NameN-acetyl- L -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~2% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1049 | Sequenceβ-Ala-H | NameN-acetyl- L -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~7% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |
| ID1050 | Sequenceβ-Ala-H | NameN-acetyl- L -carnosine | Nature of peptide or cargoAntioxidant | AssayFranz diffusion cell, HPLC | Tissue permeability~3% of applied dose | Tissue SampleStratum corneum of human breast skin | PUBMED ID22890441 |