Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1601	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1601	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1602	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58682.fasta	P58682	1032	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1602	Resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58682.fasta	P58682	1032	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1603	resistin (RSTN)] Click for more detail	Primates, rodents (others)	MKNLSFPLLFLFFLVPELLGSSMPLCPIDEAIDKKIKQDFNSLFPNAIKNIGLNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREEKVCHCQCARIDWTAARCCKLQVAS	114	Pattern-associated molecular patterns (PAMPs)	Natural	associated with atherosclerosis.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1603	resistin (RSTN)] Click for more detail	Primates, rodents (others)	MKNLSFPLLFLFFLVPELLGSSMPLCPIDEAIDKKIKQDFNSLFPNAIKNIGLNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREEKVCHCQCARIDWTAARCCKLQVAS	114	Pattern-associated molecular patterns (PAMPs)	Natural	associated with atherosclerosis.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1604	Resveratrol (Res, 3,4‚Äô,5-trihydroxy-trans-stilbene) Click for more detail	grapes and other plants (plant)	C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O	NA	polyphenol	Natural	anti-inflammatory agent and influence macrophage activation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemic Mice	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	qRT-PCR, immunofluorescence assay, western blot	24802390	2014	Pubchem_assay
PRRID_1604	Resveratrol (Res, 3,4‚Äô,5-trihydroxy-trans-stilbene) Click for more detail	grapes and other plants (plant)	C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O	NA	polyphenol	Natural	anti-inflammatory agent and influence macrophage activation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemic Mice	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	qRT-PCR, immunofluorescence assay, western blot	24802390	2014	Pubchem_assay
PRRID_1605	Resveratrol (Res, 3,4‚Äô,5-trihydroxy-trans-stilbene) Click for more detail	grapes and red wine (plant)	C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O	NA	polyphenol	Natural	inhibition of tumor initiation, anti‚Äêinflammatory, lipid modification, anti‚Äêoxidative, neuro- protective and anti-aging effects	Toll-like receptor 4 (TLR4) ( myd88, NF-Œ∫B)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24818579	2014	Pubchem_assay
PRRID_1605	Resveratrol (Res, 3,4‚Äô,5-trihydroxy-trans-stilbene) Click for more detail	grapes and red wine (plant)	C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O	NA	polyphenol	Natural	inhibition of tumor initiation, anti‚Äêinflammatory, lipid modification, anti‚Äêoxidative, neuro- protective and anti-aging effects	Toll-like receptor 4 (TLR4) ( myd88, NF-Œ∫B)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24818579	2014	Pubchem_assay
PRRID_1606	RNA Click for more detail	Enterovirus 71 (virus)	NA	NA	Nucleic Acid	Natural	The binding of ligand leads to the activation of the nuclear factor	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9NR96.fasta	Q9NR96	1032	This leads to the antiviral response against EV71	Cytokines assay	25078697	2014	Pubchem_assay
PRRID_1606	RNA Click for more detail	Enterovirus 71 (virus)	NA	NA	Nucleic Acid	Natural	The binding of ligand leads to the activation of the nuclear factor	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9NR96.fasta	Q9NR96	1032	This leads to the antiviral response against EV71	Cytokines assay	25078697	2014	Pubchem_assay
PRRID_1607	RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô -GGACGGAAAGACCCCGUGG- 3‚Äô	19	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1607	RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô -GGACGGAAAGACCCCGUGG- 3‚Äô	19	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1608	RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô -GGACGGAAAGACCCCGUGG- 3‚Äô	19	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1608	RNA oligoribonucleotides (ORN) Click for more detail	Virus	5‚Äô -GGACGGAAAGACCCCGUGG- 3‚Äô	19	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN)	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1609	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1609	S100 proteins Click for more detail	NA	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE	92	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1611	Saturated fatty acids Click for more detail	Host (Endogenous) (others)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24801735	2014	Pubchem_assay
PRRID_1611	Saturated fatty acids Click for more detail	Host (Endogenous) (others)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24801735	2014	Pubchem_assay
PRRID_1612	self DNA Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1612	self DNA Click for more detail	Host (Endogenous) (others)	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1614	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1614	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1615	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1615	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1616	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1616	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1617	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	ELISA	24825342	2014	Pubchem_assay
PRRID_1618	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Guinea Pig	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	NA	NA	NA	important role in the immune response to viral infection	Real-time RT-PCR, Calcium influx assay	24819048	2014	NA
PRRID_1618	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Guinea Pig	plasmacytoid and myeloid DCs	Cell Compartment/Intracellular (Endosome)	NA	NA	NA	important role in the immune response to viral infection	Real-time RT-PCR, Calcium influx assay	24819048	2014	NA
PRRID_1619	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1619	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	induce the production of proinflammatory cytokines in pDC	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1620	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1620	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1621	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	important role in the immune response to viral infection	flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA	24814238	2014	Pubchem_assay
PRRID_1622	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	P58681.fasta	P58681	1050	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1622	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	P58681.fasta	P58681	1050	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1623	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1623	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1624	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1624	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1625	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1625	single-stranded RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1626	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1626	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell compartment	Q99MB1.fasta	Q99MB1	905	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1627	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1627	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1628	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1628	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1629	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1629	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1630	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	P58681.fasta	P58681	1050	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1630	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	P58681.fasta	P58681	1050	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1631	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1631	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	dendritic cells, macrophages, natural killer cells	cell compartment	P58682.fasta	P58682	1032	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1632	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1632	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1633	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1633	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1634	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	pDCs	TLR7 signalling via the adaptor MYD88	P58681.fasta	P58681	1050	activation of either nuclear factor-Œ∫B (NF-Œ∫B) or IFN-regulatory factor 7 (IRF7), which are transcription factors that are responsible for stimulating the expression of pro-inflammatory cytokines and type I IFNs, respectively.	NA	24762827	2014	Pubchem_assay
PRRID_1634	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	pDCs	TLR7 signalling via the adaptor MYD88	P58681.fasta	P58681	1050	activation of either nuclear factor-Œ∫B (NF-Œ∫B) or IFN-regulatory factor 7 (IRF7), which are transcription factors that are responsible for stimulating the expression of pro-inflammatory cytokines and type I IFNs, respectively.	NA	24762827	2014	Pubchem_assay
PRRID_1635	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	pDCs	TLR7 signalling via the adaptor MYD88	Q9NYK1.fasta	Q9NYK1	1049	activation of either nuclear factor-Œ∫B (NF-Œ∫B) or IFN-regulatory factor 7 (IRF7), which are transcription factors that are responsible for stimulating the expression of pro-inflammatory cytokines and type I IFNs, respectively.	NA	24762827	2014	Pubchem_assay
PRRID_1635	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	pDCs	TLR7 signalling via the adaptor MYD88	Q9NYK1.fasta	Q9NYK1	1049	activation of either nuclear factor-Œ∫B (NF-Œ∫B) or IFN-regulatory factor 7 (IRF7), which are transcription factors that are responsible for stimulating the expression of pro-inflammatory cytokines and type I IFNs, respectively.	NA	24762827	2014	Pubchem_assay
PRRID_1636	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages	LRR- and pyrin domain-containing 3 (NLRP3)	P58682.fasta	P58682	1032	production of IL-12 but not IFNŒ±	NA	24762827	2014	Pubchem_assay
PRRID_1636	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages	LRR- and pyrin domain-containing 3 (NLRP3)	P58682.fasta	P58682	1032	production of IL-12 but not IFNŒ±	NA	24762827	2014	Pubchem_assay
PRRID_1637	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1637	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1638	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1638	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1639	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	extracellular domains of leucine-rich repeat motifs	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1639	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	extracellular domains of leucine-rich repeat motifs	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1640	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	extracellular domains of leucine-rich repeat motifs	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1640	single-stranded RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	extracellular domains of leucine-rich repeat motifs	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24754320	2014	Pubchem_assay
PRRID_1641	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1641	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58681.fasta	P58681	1050	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1642	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58682.fasta	P58682	1032	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1642	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Male BALB/c mice	Myeloid-derived suppressor cells (MDSCs)	Intracellular receptors	P58682.fasta	P58682	1032	important role in the immune response to viral infection	Functional assay	24748512	2014	Pubchem_assay
PRRID_1643	surfactant protein-A Click for more detail	Host (Endogenous) (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1643	surfactant protein-A Click for more detail	Host (Endogenous) (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1644	surfactant protein-A Click for more detail	Host (Endogenous) (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1644	surfactant protein-A Click for more detail	Host (Endogenous) (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1645	tacrolimus Click for more detail	NA	CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC	NA	NA	Synthetic	Immuno suppressive drug	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	lIver	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24820765	2014	Pubchem_assay
PRRID_1645	tacrolimus Click for more detail	NA	CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC	NA	NA	Synthetic	Immuno suppressive drug	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	lIver	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24820765	2014	Pubchem_assay
PRRID_1647	Tenascin C Click for more detail	Human (others)	MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS	2110	Pattern-associated molecular patterns (PAMPs)	Natural	TN-C clearly plays a role in cell signaling as evidenced by its ability to be induced during events such as trauma, inflammation, or cancer development.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24830024	2014	Pubchem_assay
PRRID_1647	Tenascin C Click for more detail	Human (others)	MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS	2110	Pattern-associated molecular patterns (PAMPs)	Natural	TN-C clearly plays a role in cell signaling as evidenced by its ability to be induced during events such as trauma, inflammation, or cancer development.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24830024	2014	Pubchem_assay
PRRID_1648	Tenascin C Click for more detail	Human (others)	MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS	2201	Pattern-associated molecular patterns (PAMPs)	Natural	associated with chronic inflammatory conditions	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	fibrinogen-like domain (FBG)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1648	Tenascin C Click for more detail	Human (others)	MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETS	2201	Pattern-associated molecular patterns (PAMPs)	Natural	associated with chronic inflammatory conditions	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	fibrinogen-like domain (FBG)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1649	TgPRF (T. gondii profilin-like protein) Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	potently activate the innate immune system through its specific recognition by TLR11, which plays an important role in T. gondii infection in mice	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Swiss albino mice brain	microglia/macrophages, astrocytes, and neurons	NA	Q6R5P0.fasta	Q6R5P0	926	TLR11 activation is unique in its ability to initiate a parasite-specific innate immune response. TLR11 is unusual in its recognition of T. gondii, because it senses the pathogen by recognizing a profilin released by the microbe rather than by directly interacting with the live parasite	Double-labeling immunohistochemistry, Real-time quantitative polymerase chain reaction (PCR)	24704432	2014	Pubchem_assay
PRRID_1649	TgPRF (T. gondii profilin-like protein) Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	potently activate the innate immune system through its specific recognition by TLR11, which plays an important role in T. gondii infection in mice	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Swiss albino mice brain	microglia/macrophages, astrocytes, and neurons	NA	Q6R5P0.fasta	Q6R5P0	926	TLR11 activation is unique in its ability to initiate a parasite-specific innate immune response. TLR11 is unusual in its recognition of T. gondii, because it senses the pathogen by recognizing a profilin released by the microbe rather than by directly interacting with the live parasite	Double-labeling immunohistochemistry, Real-time quantitative polymerase chain reaction (PCR)	24704432	2014	Pubchem_assay
PRRID_1652	Triacetylated lipoproteins Click for more detail	Bacteria	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	NA
PRRID_1652	Triacetylated lipoproteins Click for more detail	Bacteria	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	NA
PRRID_1653	Triacetylated lipoproteins Click for more detail	Bacteria	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	NA
PRRID_1653	Triacetylated lipoproteins Click for more detail	Bacteria	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	NA
PRRID_1654	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1654	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1655	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA
PRRID_1655	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell Surface (Exogenous)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	NA	24830024	2014	NA

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