Detailed description page of PRRDB2.0

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PRRID_1605 details
Primary information
PRRIDPRRID_1605
Ligand NameResveratrol (Res, 3,4’,5-trihydroxy-trans-stilbene)
Sourcegrapes and red wine (plant)
Sequence of ligandC1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
LengthNA
Typepolyphenol
OccurenceNatural
Role of Ligandinhibition of tumor initiation, anti‚Äêinflammatory, lipid modification, anti‚Äêoxidative, neuro- protective and anti-aging effects
Name of receptorToll-like receptor 4 (TLR4) ( myd88, NF-κB)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte
Domaincell surface
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedELISA
PMID24818579
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1605
Ligand NameResveratrol (Res, 3,4’,5-trihydroxy-trans-stilbene)
Sourcegrapes and red wine (plant)
Sequence of ligandC1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
LengthNA
Typepolyphenol
OccurenceNatural
Role of Ligandinhibition of tumor initiation, anti‚Äêinflammatory, lipid modification, anti‚Äêoxidative, neuro- protective and anti-aging effects
Name of receptorToll-like receptor 4 (TLR4) ( myd88, NF-κB)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte
Domaincell surface
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedELISA
PMID24818579
Year of Publication2014
Pubchem assayPubchem_assay