Primary information |
---|
PRRID | PRRID_1604 |
Ligand Name | Resveratrol (Res, 3,4’,5-trihydroxy-trans-stilbene) |
Source | grapes and other plants (plant) |
Sequence of ligand | C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O |
Length | NA |
Type | polyphenol |
Occurence | Natural |
Role of Ligand | anti-inflammatory agent and influence macrophage activation |
Name of receptor | Toll-like receptor 4 (TLR4) |
Type of receptor | Toll-like receptor (TLR) |
Source | Endotoxemic Mice |
Localization | monocyte/macrophages |
Domain | cell surface |
Sequence of Receptor | Q9QUK6.fasta |
Swiss prot ID | Q9QUK6 |
Length Of Receptor | 835 |
Function | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system |
Assay used | qRT-PCR, immunofluorescence assay, western blot |
PMID | 24802390 |
Year of Publication | 2014 |
Pubchem assay | Pubchem_assay |
Primary information |
---|
PRRID | PRRID_1604 |
Ligand Name | Resveratrol (Res, 3,4’,5-trihydroxy-trans-stilbene) |
Source | grapes and other plants (plant) |
Sequence of ligand | C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O |
Length | NA |
Type | polyphenol |
Occurence | Natural |
Role of Ligand | anti-inflammatory agent and influence macrophage activation |
Name of receptor | Toll-like receptor 4 (TLR4) |
Type of receptor | Toll-like receptor (TLR) |
Source | Endotoxemic Mice |
Localization | monocyte/macrophages |
Domain | cell surface |
Sequence of Receptor | Q9QUK6.fasta |
Swiss prot ID | Q9QUK6 |
Length Of Receptor | 835 |
Function | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system |
Assay used | qRT-PCR, immunofluorescence assay, western blot |
PMID | 24802390 |
Year of Publication | 2014 |
Pubchem assay | Pubchem_assay |