Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0983	CBLB613 Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	reduced radiation-induced cytopenia and increased bone marrow cellularity in irradiated mice	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	CD2F1 Mice	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	22175300	2012	NA
PRRID_0983	CBLB613 Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	reduced radiation-induced cytopenia and increased bone marrow cellularity in irradiated mice	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	CD2F1 Mice	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	22175300	2012	NA
PRRID_0984	Cevarix Click for more detail	GlaxoSmithKline (others)	NA	NA	AS04 + HPV 16 & 18 L1 antigen	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0984	Cevarix Click for more detail	GlaxoSmithKline (others)	NA	NA	AS04 + HPV 16 & 18 L1 antigen	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0985	CPG10101 Click for more detail	Coley Pharmaceuticals(others)	NA	NA	CpG ODN	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0985	CPG10101 Click for more detail	Coley Pharmaceuticals(others)	NA	NA	CpG ODN	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0989	Fendrix Click for more detail	GlaxoSmithKline (others)	NA	NA	AS04 + HBV surface antigen	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0989	Fendrix Click for more detail	GlaxoSmithKline (others)	NA	NA	AS04 + HBV surface antigen	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0994	Heplisav (ISS-1018) Click for more detail	Dynavax Technologies(others)	NA	NA	CpG ODN + HBV surface antigen	NA	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0994	Heplisav (ISS-1018) Click for more detail	Dynavax Technologies(others)	NA	NA	CpG ODN + HBV surface antigen	NA	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0996	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Neutralizing antibodies	NA	22982943	2012	NA
PRRID_0996	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Neutralizing antibodies	NA	22982943	2012	NA
PRRID_0997	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Antagonists Hyaluronidase	NA	22982943	2012	NA
PRRID_0997	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	NA	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Antagonists Hyaluronidase	NA	22982943	2012	NA
PRRID_0998	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Antagonists Hyaluronidase	NA	22982943	2012	NA
PRRID_0998	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Antagonists Hyaluronidase	NA	22982943	2012	NA
PRRID_0999	Imiquimod Click for more detail	3M Pharma (others)	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0999	Imiquimod Click for more detail	3M Pharma (others)	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1000	IMO-2125 Click for more detail	Idera Pharmaceuticals (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1000	IMO-2125 Click for more detail	Idera Pharmaceuticals (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1002	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	PBMCs	NA	O60603.fasta	O60603	784	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_1002	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	PBMCs	NA	O60603.fasta	O60603	784	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_1003	Mitochondrial DNA Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR9 antagonists	NA	22982943	2012	NA
PRRID_1003	Mitochondrial DNA Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR9 antagonists	NA	22982943	2012	NA
PRRID_1007	NA Click for more detail	B. fragilis(Bacteria)	NA	NA	NA	NA	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q15399.fasta	Q15399	786	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_1007	NA Click for more detail	B. fragilis(Bacteria)	NA	NA	NA	NA	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q15399.fasta	Q15399	786	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_1010	NFPs in combination with mitochondrial transcription factor Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR9 antagonists	NA	22982943	2012	NA
PRRID_1010	NFPs in combination with mitochondrial transcription factor Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	TLR9 antagonists	NA	22982943	2012	NA
PRRID_1011	Nuclear DNA Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Deoxyribonucleases TLR9 antagonists	NA	22982943	2012	NA
PRRID_1011	Nuclear DNA Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Deoxyribonucleases TLR9 antagonists	NA	22982943	2012	NA
PRRID_1012	Resquimod Click for more detail	3M Pharma (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	NA
PRRID_1012	Resquimod Click for more detail	3M Pharma (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	NA
PRRID_1014	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosome	NA	Q9NYK1.fasta	Q9NYK1	1049	IRF7, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_1014	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosome	NA	Q9NYK1.fasta	Q9NYK1	1049	IRF7, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_1015	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosome	NA	Q9NR97.fasta	Q9NR97	1041	IRF7, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_1015	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosome	NA	Q9NR97.fasta	Q9NR97	1041	IRF7, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_1018	Vax102 Click for more detail	Vaxinnate Corporation (others)	NA	NA	Flagellin + FLU M2e antigen	Synthetic	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1018	Vax102 Click for more detail	Vaxinnate Corporation (others)	NA	NA	Flagellin + FLU M2e antigen	Synthetic	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1019	Vax125 Click for more detail	Vaxinnate Corporation (others)	NA	NA	Flagellin + FLU HA antigen	Synthetic	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1019	Vax125 Click for more detail	Vaxinnate Corporation (others)	NA	NA	Flagellin + FLU HA antigen	Synthetic	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1020	1,3 beta glucan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60603.fasta	O60603	784	triggers the MyD88-dependent signaling pathway, leading to NF-kB activation	NF-	24098508	2013	Pubchem Assay
PRRID_1020	1,3 beta glucan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60603.fasta	O60603	784	triggers the MyD88-dependent signaling pathway, leading to NF-kB activation	NF-	24098508	2013	Pubchem Assay
PRRID_1025	Bacterial RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	Mice	NA	NA	Q6R5N8.fasta	Q6R5N8	991	NA	NA	23985302	2013	Pubchem Assay
PRRID_1025	Bacterial RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	Mice	NA	NA	Q6R5N8.fasta	Q6R5N8	991	NA	NA	23985302	2013	Pubchem Assay
PRRID_1026	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	23985302	2013	Pubchem Assay
PRRID_1026	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	23985302	2013	Pubchem Assay
PRRID_1027	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1027	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1028	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	23985302	2013	Pubchem Assay
PRRID_1028	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	23985302	2013	Pubchem Assay
PRRID_1029	DNA (immune complexes) Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1029	DNA (immune complexes) Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1030	DNA (immune complexes Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1030	DNA (immune complexes Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1031	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1031	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1032	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	TRIF via a C-terminal RHIM domain interaction with RIP1 or RIP3	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem Assay
PRRID_1032	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	TRIF via a C-terminal RHIM domain interaction with RIP1 or RIP3	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem Assay
PRRID_1033	dsRNA Click for more detail	viral or cellular origin (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem Assay
PRRID_1033	dsRNA Click for more detail	viral or cellular origin (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem Assay
PRRID_1034	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1034	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1035	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem Assay
PRRID_1035	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem Assay
PRRID_1036	EfLTA Click for more detail	Endogenous (others)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	play an important role in inducing non-specific resistance against a broad range of viral infections.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1036	EfLTA Click for more detail	Endogenous (others)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	play an important role in inducing non-specific resistance against a broad range of viral infections.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1037	EfLTA Click for more detail	Enterococcus faecalis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	LTA contributes to the inflammatory responses and to the production of chemokines through TLR2 signaling	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6 mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	triggers the MyD88-dependent signaling pathway, leading to NF-kB activation	ELISA, RT-PCR, Flow cytometric analysis	23964117	2013	Pubchem_assay
PRRID_1037	EfLTA Click for more detail	Enterococcus faecalis (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	LTA contributes to the inflammatory responses and to the production of chemokines through TLR2 signaling	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6 mice	Macrophages	NA	Q9QUN7.fasta	Q9QUN7	784	triggers the MyD88-dependent signaling pathway, leading to NF-kB activation	ELISA, RT-PCR, Flow cytometric analysis	23964117	2013	Pubchem_assay
PRRID_1038	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1038	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1039	Extra domain A of fibronectin Click for more detail	Endogenous (others)	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1039	Extra domain A of fibronectin Click for more detail	Endogenous (others)	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1040	Extra domain A of fibronectin Click for more detail	Endogenous (others)	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1040	Extra domain A of fibronectin Click for more detail	Endogenous (others)	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1041	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1041	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1042	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	Toll/IL-1R (TIR) domain	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem_assay
PRRID_1042	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	TRIF mutant (C57BL/6J-Ticam1Lps2) mice	bone marrow-derived macrophage (BMDM) culture	Toll/IL-1R (TIR) domain	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations	24019532	2013	Pubchem_assay
PRRID_1043	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1043	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1044	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1044	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1045	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1045	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1046	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1046	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1047	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1047	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	graft-versus-host disease (GVHD)	NA	Q9JLF7.fasta	Q9JLF7	859	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1048	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NF-	24098508	2013	Pubchem_assay
PRRID_1048	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NF-	24098508	2013	Pubchem_assay
PRRID_1049	Flagellin Click for more detail	Pseudomonas aeruginosa (Bacteria)	MALTVNTNIASLNTQRNLNASSNDLNTSLQRLTTGYRINSAKDDAAGLQISNRLSNQISGLNVATRNANDGISLAQTAEGALQQSTNILQRIRDLALQSANGSNSDADRAALQKEVAAQQAELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTIVTGYVQLNSPTAYSVSGTGTQASQVFGNASAAQKSSVASVDISTADGAQNAIAVVDNALAAIDAQRADLGAVQNRFKNTIDNLTNISENATNARSRIKDTDFAAETAALSKNQVLQQAGTAILAQANQLPQAVLSLLR	488	Protein	Natural	involved in the upregulation of airway serous secretion	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Swine	tracheal submucosal acinar glands	NA	NA	NA	NA	TLR5 is also involved in the airway mucosal defense systems as a unique endogenous potentiator of elec- trolyte-water secretion from submucosal gland acinar cells and that NO/cGMP/cGK signaling is involved in this rapid TLR5 signaling pathway	RT-PCR, Intracellular calcium assays	24097563	2013	NA
PRRID_1049	Flagellin Click for more detail	Pseudomonas aeruginosa (Bacteria)	MALTVNTNIASLNTQRNLNASSNDLNTSLQRLTTGYRINSAKDDAAGLQISNRLSNQISGLNVATRNANDGISLAQTAEGALQQSTNILQRIRDLALQSANGSNSDADRAALQKEVAAQQAELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTIVTGYVQLNSPTAYSVSGTGTQASQVFGNASAAQKSSVASVDISTADGAQNAIAVVDNALAAIDAQRADLGAVQNRFKNTIDNLTNISENATNARSRIKDTDFAAETAALSKNQVLQQAGTAILAQANQLPQAVLSLLR	488	Protein	Natural	involved in the upregulation of airway serous secretion	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Swine	tracheal submucosal acinar glands	NA	NA	NA	NA	TLR5 is also involved in the airway mucosal defense systems as a unique endogenous potentiator of elec- trolyte-water secretion from submucosal gland acinar cells and that NO/cGMP/cGK signaling is involved in this rapid TLR5 signaling pathway	RT-PCR, Intracellular calcium assays	24097563	2013	NA
PRRID_1050	FSL-1 Click for more detail	synthetic lipoprotein (others)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NF-	24098508	2013	NA
PRRID_1050	FSL-1 Click for more detail	synthetic lipoprotein (others)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NF-	24098508	2013	NA
PRRID_1051	Glucan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	CgToll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C. gigas	HEK293 cells	NA	NA	NA	NA	NA	NF-	24098508	2013	NA
PRRID_1051	Glucan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	CgToll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C. gigas	HEK293 cells	NA	NA	NA	NA	NA	NF-	24098508	2013	NA
PRRID_1052	Glycolipids Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	Play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1052	Glycolipids Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	Play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1053	Glycolipids Click for more detail	Treponema maltophilum (others)	NA	NA	Carbohydrate	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay
PRRID_1053	Glycolipids Click for more detail	Treponema maltophilum (others)	NA	NA	Carbohydrate	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	Pubchem_assay

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