Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_2087 | Glycerol monomycolate (MMG, GroMM) Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Human | NA | NA | Q9ULY5.fasta | Q9ULY5 | 219 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2087 | Glycerol monomycolate (MMG, GroMM) Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Human | NA | NA | Q9ULY5.fasta | Q9ULY5 | 219 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2089 | Glycolipids Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Mincle | C type Lectin (CTL/CLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28801521 | 2017 | NA |
| PRRID_2089 | Glycolipids Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Mincle | C type Lectin (CTL/CLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28801521 | 2017 | NA |
| PRRID_2094 | GW4064 Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | GW4064 attenuated LPS-induced ileum injury and mitochondria dysfunction by sup- pressed TLR4/MyD88 signaling-mediated inflammation and apoptosis. | Farnesoid X receptor (FXR) | Pattern recognition receptor (PRR) | Mice | Macrophages | NA | Q60641.fasta | Q60641 | 488 | role in enteroprotection and mucosal injury by regulating inflammatory responses and barrier function in the intestinal tract. | RT-qPCR | 28647362 | 2017 | Pubchem_assay |
| PRRID_2094 | GW4064 Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | GW4064 attenuated LPS-induced ileum injury and mitochondria dysfunction by sup- pressed TLR4/MyD88 signaling-mediated inflammation and apoptosis. | Farnesoid X receptor (FXR) | Pattern recognition receptor (PRR) | Mice | Macrophages | NA | Q60641.fasta | Q60641 | 488 | role in enteroprotection and mucosal injury by regulating inflammatory responses and barrier function in the intestinal tract. | RT-qPCR | 28647362 | 2017 | Pubchem_assay |
| PRRID_2095 | H. pylori-derived components Click for more detail | H. pylori (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | gastrointestinal epithelial cells | LRR and TIR domain | O60603.fasta | O60603 | 784 | transcription factor NF-κB is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS) | qRT-PCR | 28427896 | 2017 | Pubchem_assay |
| PRRID_2095 | H. pylori-derived components Click for more detail | H. pylori (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | gastrointestinal epithelial cells | LRR and TIR domain | O60603.fasta | O60603 | 784 | transcription factor NF-κB is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS) | qRT-PCR | 28427896 | 2017 | Pubchem_assay |
| PRRID_2096 | H. pylori-derived components Click for more detail | H. pylori (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | gastrointestinal epithelial cells | LRR and TIR domain | O00206.fasta | O00206 | 839 | transcription factor NF-κB is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS) | qRT-PCR | 28427896 | 2017 | Pubchem_assay |
| PRRID_2096 | H. pylori-derived components Click for more detail | H. pylori (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | gastrointestinal epithelial cells | LRR and TIR domain | O00206.fasta | O00206 | 839 | transcription factor NF-κB is activated and leads to the quick expression of proinflammatory cytokines, chemokines and inducible nitric oxide synthase (iNOS) | qRT-PCR | 28427896 | 2017 | Pubchem_assay |
| PRRID_2152 | Hemozoin Click for more detail | Plasmodium falciparum (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Plasmodium falciparum-infected erythro- cytes, that co-purifies with the parasite product hemozoin, stimulates NOD2 in a RIP2/CARD9- dependent manner to drive nitric oxide production by macrophages | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Hemozoin-mediated induction of NOS | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2152 | Hemozoin Click for more detail | Plasmodium falciparum (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Plasmodium falciparum-infected erythro- cytes, that co-purifies with the parasite product hemozoin, stimulates NOD2 in a RIP2/CARD9- dependent manner to drive nitric oxide production by macrophages | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Hemozoin-mediated induction of NOS | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2157 | hexavalent lactoside Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2157 | hexavalent lactoside Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2209 | Imidazoquinoline Click for more detail | NA | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Synthesis of IFNα, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infection | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | NA | NA | 29028369 | 2017 | Pubchem_assay |
| PRRID_2209 | Imidazoquinoline Click for more detail | NA | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Synthesis of IFNα, inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of DCs , Produce type I IFNs and other cytokines, maturation of pDCs, stimulate T-cells ,Reduces plasma virus concentration in chronic hepatitis C infection | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | NA | NA | 29028369 | 2017 | Pubchem_assay |
| PRRID_2215 | Ju-6 Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2215 | Ju-6 Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2220 | Laminarin Click for more detail | NA | C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2220 | Laminarin Click for more detail | NA | C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2221 | Ligand on parenchymal/ inflammatory cells in liver Click for more detail | Endogenous (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2221 | Ligand on parenchymal/ inflammatory cells in liver Click for more detail | Endogenous (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Infection model | NA | NA | NA | NA | NA | Protective role in infection model | NA | 28167651 | 2017 | NA |
| PRRID_2226 | lipomannas Click for more detail | Mycobacteria (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | causes tuberculosis-like systemic infection in sh and in other ectotherms | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | THP‚Äê1 macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA | 29183333 | 2017 | Pubchem_assay |
| PRRID_2226 | lipomannas Click for more detail | Mycobacteria (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | causes tuberculosis-like systemic infection in sh and in other ectotherms | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | THP‚Äê1 macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA | 29183333 | 2017 | Pubchem_assay |
| PRRID_2227 | lipomannas Click for more detail | Mycobacteria (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | causes tuberculosis-like systemic infection in sh and in other ectotherms | CR3 | Complement Receptor | Human | THP‚Äê1 macrophages | NA | NA | NA | NA | NA | THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA | 29183333 | 2017 | NA |
| PRRID_2227 | lipomannas Click for more detail | Mycobacteria (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | causes tuberculosis-like systemic infection in sh and in other ectotherms | CR3 | Complement Receptor | Human | THP‚Äê1 macrophages | NA | NA | NA | NA | NA | THP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA | 29183333 | 2017 | NA |
| PRRID_2288 | Lipoprotein Click for more detail | S. gordonii (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | apical periodontitis | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | PDL cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | induces IL-8 production through activation of TLR2 in human PDL cells. | ELISA | 28963931 | 2017 | Pubchem_assay |
| PRRID_2288 | Lipoprotein Click for more detail | S. gordonii (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | apical periodontitis | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | PDL cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | induces IL-8 production through activation of TLR2 in human PDL cells. | ELISA | 28963931 | 2017 | Pubchem_assay |
| PRRID_2289 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | mononuclear phagocytes | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | mRNA ‚Üë in aging | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2289 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | mononuclear phagocytes | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | mRNA ‚Üë in aging | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2290 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Brain | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | mRNA ‚Üë in plaque- associated brain tissue of AD model mice | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2290 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Brain | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | mRNA ‚Üë in plaque- associated brain tissue of AD model mice | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2291 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | (hippocampus, entorhinal cortex, superior frontal gyrus, post-central gyrus) | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | mRNA ‚Üë in aging and AD | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2291 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | (hippocampus, entorhinal cortex, superior frontal gyrus, post-central gyrus) | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | mRNA ‚Üë in aging and AD | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2292 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Rat | hippocampus (microglia) | Leucine-rich Repeat (LRR) Domain | Q6YGU2.fasta | Q6YGU2 | 784 | mRNA ‚Üë in postoperative cognitive dysfunction in senile animals | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2292 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Rat | hippocampus (microglia) | Leucine-rich Repeat (LRR) Domain | Q6YGU2.fasta | Q6YGU2 | 784 | mRNA ‚Üë in postoperative cognitive dysfunction in senile animals | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2293 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | involved in both amyloid-β uptake and inflammatory cytokine production | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2293 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | involved in both amyloid-β uptake and inflammatory cytokine production | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2294 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Brain(neurons) | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | protein ‚Üë in PD | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2294 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Brain(neurons) | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | protein ‚Üë in PD | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2295 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Rat | brain (vasculature) | Leucine-rich Repeat (LRR) Domain | Q6YGU2.fasta | Q6YGU2 | 784 | protein ‚Üë, activation in ischemic stroke | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2295 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Rat | brain (vasculature) | Leucine-rich Repeat (LRR) Domain | Q6YGU2.fasta | Q6YGU2 | 784 | protein ‚Üë, activation in ischemic stroke | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2296 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Neurons(cortex) | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | protein ‚Üë, proapoptotic in ischemia | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2296 | Lipoprotein Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Neurons(cortex) | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | protein ‚Üë, proapoptotic in ischemia | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2309 | Long ds RNA Click for more detail | EMCV, poliovirus and coxasackie virus; Rotavirus, dengue virus, WNV, murine hepatitis virus(virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | filament formation mediated receptor tetramerization | MDA5 | Rig-like receptor (RLR) | Human | Cytoplasm, all mammalian cell types | NA | Q53TB6.fasta | Q53TB6 | 435 | MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2309 | Long ds RNA Click for more detail | EMCV, poliovirus and coxasackie virus; Rotavirus, dengue virus, WNV, murine hepatitis virus(virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | filament formation mediated receptor tetramerization | MDA5 | Rig-like receptor (RLR) | Human | Cytoplasm, all mammalian cell types | NA | Q53TB6.fasta | Q53TB6 | 435 | MAVS-TRAF3-TBK1/ IKKe-IRF3. MAVS-FADD/ TRAF6-IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2311 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Z-loop proteolytic cleavage, and receptor dimer conformational change | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Endosomes. pDCs and B cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2311 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | SeV, flu virus, coxsackie virus, vaccinia virus, MV, RSV, retrovirus (virus) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Z-loop proteolytic cleavage, and receptor dimer conformational change | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Endosomes. pDCs and B cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | MyD88-IRAK4/ IRAK1-IRF7. MyD88-IRAF6- IKKs-NF-jB | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2322 | Malassezia furfur, glycolipid Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Mice | NA | NA | Q9R0Q8.fasta | Q9R0Q8 | 214 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2322 | Malassezia furfur, glycolipid Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Mincle(Clec4e) | Syk-coupled CLR | Mice | NA | NA | Q9R0Q8.fasta | Q9R0Q8 | 214 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2329 | Mannose and fucose Click for more detail | L. monocytogenes (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Activation of CLEC5A | CLEC5A | C type Lectin (CTL/CLR) | Human | monocytes, macrophages and neutrophils. | NA | Q14DL9.fasta | Q14DL9 | 165 | secretion of proinflammatory cytokines such as TNF, IL-6, CXCL-8, and IP-10. | Binding assay | 28824166 | 2017 | Pubchem_assay |
| PRRID_2329 | Mannose and fucose Click for more detail | L. monocytogenes (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Activation of CLEC5A | CLEC5A | C type Lectin (CTL/CLR) | Human | monocytes, macrophages and neutrophils. | NA | Q14DL9.fasta | Q14DL9 | 165 | secretion of proinflammatory cytokines such as TNF, IL-6, CXCL-8, and IP-10. | Binding assay | 28824166 | 2017 | Pubchem_assay |
| PRRID_2330 | Maturing conidia Click for more detail | Aspergillus fumigatus(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2330 | Maturing conidia Click for more detail | Aspergillus fumigatus(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Mice | NA | NA | Q6QLQ4.fasta | Q6QLQ4 | 244 | protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2331 | Maturing conidia Click for more detail | Aspergillus fumigatus(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Human | NA | NA | Q9BXN2.fasta | Q9BXN2 | 247 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2331 | Maturing conidia Click for more detail | Aspergillus fumigatus(fungi) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Dectin-1 (Clec7a) | Syk-coupled CLR | Human | NA | NA | Q9BXN2.fasta | Q9BXN2 | 247 | Protective role in infection model | NA | 28167651 | 2017 | Pubchem_assay |
| PRRID_2343 | Microbial DNA Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | Bacterial infection | DC-SIGN | C type Lectin (CTL/CLR) | Human | monocytes | NA | NA | NA | NA | NA | NA | 28976999 | 2017 | NA |
| PRRID_2343 | Microbial DNA Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | Bacterial infection | DC-SIGN | C type Lectin (CTL/CLR) | Human | monocytes | NA | NA | NA | NA | NA | NA | 28976999 | 2017 | NA |
| PRRID_2344 | Microfilarial protein (MfP) Click for more detail | W. bancrofti (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | binds to macrophage-TLR4 and triggers NF-κB activation that up-regulates secretion of proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NF-κB activation that up-regulates secretion of proinflammatory cytokines. | co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis. | 28453850 | 2017 | Pubchem_assay |
| PRRID_2344 | Microfilarial protein (MfP) Click for more detail | W. bancrofti (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | binds to macrophage-TLR4 and triggers NF-κB activation that up-regulates secretion of proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NF-κB activation that up-regulates secretion of proinflammatory cytokines. | co-immunoprecipitation, FITC-probing and Surface Plasmon Resonance analysis. | 28453850 | 2017 | Pubchem_assay |
| PRRID_2357 | Mycotoxin Click for more detail | Fungi | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Binding and activation btTOLL | BtToll | Toll-like receptor (TLR) | NA | 3rd nymphal instar. | TIR domain | NA | NA | NA | microbe detection, AMPs production, phagosome regulations, inflammatory signaling and activation | qRT-PCR | 28648996 | 2017 | NA |
| PRRID_2357 | Mycotoxin Click for more detail | Fungi | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Binding and activation btTOLL | BtToll | Toll-like receptor (TLR) | NA | 3rd nymphal instar. | TIR domain | NA | NA | NA | microbe detection, AMPs production, phagosome regulations, inflammatory signaling and activation | qRT-PCR | 28648996 | 2017 | NA |
| PRRID_2436 | NA Click for more detail | Enterovirus 71 (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | NA | NA | 29052054 | 2017 | Pubchem_assay |
| PRRID_2436 | NA Click for more detail | Enterovirus 71 (virus) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | NA | NA | 29052054 | 2017 | Pubchem_assay |
| PRRID_2437 | NA Click for more detail | CA16(others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | NA | NA | 29052054 | 2017 | Pubchem_assay |
| PRRID_2437 | NA Click for more detail | CA16(others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | NA | NA | 29052054 | 2017 | Pubchem_assay |
| PRRID_2438 | NA Click for more detail | S. cerevisiae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | CREP4 | C type Lectin (CTL/CLR) | B. glabRata | NA | NA | NA | NA | NA | NA | transcriptomic data | 29051762 | 2017 | NA |
| PRRID_2438 | NA Click for more detail | S. cerevisiae (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | CREP4 | C type Lectin (CTL/CLR) | B. glabRata | NA | NA | NA | NA | NA | NA | transcriptomic data | 29051762 | 2017 | NA |
| PRRID_2439 | NA Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | NA | hyal-adherins (H-type) | Lectins | NA | NA | NA | NA | NA | NA | induces pro-inflammatory cytokine response | NA | 29051762 | 2017 | NA |
| PRRID_2439 | NA Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | NA | hyal-adherins (H-type) | Lectins | NA | NA | NA | NA | NA | NA | induces pro-inflammatory cytokine response | NA | 29051762 | 2017 | NA |
| PRRID_2440 | NA Click for more detail | metazoan parasites (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | FREPs | Lectins | snails | NA | NA | NA | NA | NA | induces pro-inflammatory cytokine response | NA | 29051762 | 2017 | NA |
| PRRID_2440 | NA Click for more detail | metazoan parasites (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | FREPs | Lectins | snails | NA | NA | NA | NA | NA | induces pro-inflammatory cytokine response | NA | 29051762 | 2017 | NA |
| PRRID_2441 | NA Click for more detail | S. mansoni (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | biomphalysin | aerolysin-like protein | NA | NA | one large domain that shares structure similarities with β-pore-forming and a small domain potentially involved in pathogens’ carbohydrate motifs recognition | NA | NA | NA | NA | NA | 29051762 | 2017 | NA |
| PRRID_2441 | NA Click for more detail | S. mansoni (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | biomphalysin | aerolysin-like protein | NA | NA | one large domain that shares structure similarities with β-pore-forming and a small domain potentially involved in pathogens’ carbohydrate motifs recognition | NA | NA | NA | NA | NA | 29051762 | 2017 | NA |
| PRRID_2442 | NA Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | CTL4 | C type Lectin (CTL/CLR) | Anopheles gambiae | NA | NA | B2FX81.fasta | B2FX81 | 150 | NA | NA | 29051762 | 2017 | Pubchem_assay |
| PRRID_2442 | NA Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | CTL4 | C type Lectin (CTL/CLR) | Anopheles gambiae | NA | NA | B2FX81.fasta | B2FX81 | 150 | NA | NA | 29051762 | 2017 | Pubchem_assay |
| PRRID_2448 | NA Click for more detail | Staphyloccocus aureus or Vibrio parahaemolyticus (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Innate immunity elicitor | EsSR-B1 | Scavenger receptor (SR) | Eriocheir sinensis | all tissue specially hemocytes | Class B SRs are type III transmembrane receptors with two transmembrane domains, | NA | NA | NA | phagocytosis of invading bacteria | qRT-PCR | 28916359 | 2017 | NA |
| PRRID_2448 | NA Click for more detail | Staphyloccocus aureus or Vibrio parahaemolyticus (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Innate immunity elicitor | EsSR-B1 | Scavenger receptor (SR) | Eriocheir sinensis | all tissue specially hemocytes | Class B SRs are type III transmembrane receptors with two transmembrane domains, | NA | NA | NA | phagocytosis of invading bacteria | qRT-PCR | 28916359 | 2017 | NA |
| PRRID_2449 | NA Click for more detail | Vibrio anguillarum (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | innate immunity elicitor | CgLRRIG-1 | Pattern recognition receptor (PRR) | oyster Crassostrea gigas | Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas. | Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain | NA | NA | NA | immune effectors or pro-inflammatory factors as well as PRRs in oyster. | PAMPs binding assay | 28889011 | 2017 | NA |
| PRRID_2449 | NA Click for more detail | Vibrio anguillarum (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | innate immunity elicitor | CgLRRIG-1 | Pattern recognition receptor (PRR) | oyster Crassostrea gigas | Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas. | Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain | NA | NA | NA | immune effectors or pro-inflammatory factors as well as PRRs in oyster. | PAMPs binding assay | 28889011 | 2017 | NA |
| PRRID_2450 | NA Click for more detail | Vibrio anguillarum (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | innate immunity elicitor | CgLRRIG-2 | Pattern recognition receptor (PRR) | oyster Crassostrea gigas | Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas. | Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain | NA | NA | NA | immune effectors or pro-inflammatory factors as well as PRRs in oyster. | PAMPs binding assay | 28889011 | 2017 | NA |
| PRRID_2450 | NA Click for more detail | Vibrio anguillarum (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | innate immunity elicitor | CgLRRIG-2 | Pattern recognition receptor (PRR) | oyster Crassostrea gigas | Muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas. | Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain | NA | NA | NA | immune effectors or pro-inflammatory factors as well as PRRs in oyster. | PAMPs binding assay | 28889011 | 2017 | NA |
| PRRID_2455 | NA Click for more detail | Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Stimulation of CfLRRop-4 | CfLRRop-4 | Pattern recognition receptor (PRR) | Zhikong scallop Chlamys farreri | hepatopancreas, gills and gonads | six LRR motifs plus one LRR_TYP | NA | NA | NA | NA | NA | 28807724 | 2017 | NA |
| PRRID_2455 | NA Click for more detail | Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Stimulation of CfLRRop-4 | CfLRRop-4 | Pattern recognition receptor (PRR) | Zhikong scallop Chlamys farreri | hepatopancreas, gills and gonads | six LRR motifs plus one LRR_TYP | NA | NA | NA | NA | NA | 28807724 | 2017 | NA |
| PRRID_2456 | NA Click for more detail | Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Stimulation of CfLRRop-5 | CfLRRop-5 | Pattern recognition receptor (PRR) | Zhikong scallop Chlamys farreri | hepatopancreas, gills and gonads | one LRRNT motif plus five LRR motifs, | NA | NA | NA | NA | NA | 28807724 | 2017 | NA |
| PRRID_2456 | NA Click for more detail | Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Stimulation of CfLRRop-5 | CfLRRop-5 | Pattern recognition receptor (PRR) | Zhikong scallop Chlamys farreri | hepatopancreas, gills and gonads | one LRRNT motif plus five LRR motifs, | NA | NA | NA | NA | NA | 28807724 | 2017 | NA |
| PRRID_2457 | NA Click for more detail | Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Stimulation of CfLRRop-6 | CfLRRop-6 | Pattern recognition receptor (PRR) | Zhikong scallop Chlamys farreri | hepatopancreas, gills and gonads | merely three LRR motifs | NA | NA | NA | NA | NA | 28807724 | 2017 | NA |
| PRRID_2457 | NA Click for more detail | Vibrio anguillarum, Micrococcus luteus and Pichia pastoris (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Stimulation of CfLRRop-6 | CfLRRop-6 | Pattern recognition receptor (PRR) | Zhikong scallop Chlamys farreri | hepatopancreas, gills and gonads | merely three LRR motifs | NA | NA | NA | NA | NA | 28807724 | 2017 | NA |
| PRRID_2458 | NA Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | substantia nigra | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2458 | NA Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | substantia nigra | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2459 | NA Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Binding and activation btTOLL | BtToll | Toll-like receptor (TLR) | Bemisia tabaci (Gennadius) | 3rd nymphal instar. | TIR domain | NA | NA | NA | Microbe detection, AMPs production, phagosome regulations, inflammatory signaling and activation | qRT-PCR | 28648996 | 2017 | NA |
| PRRID_2459 | NA Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Binding and activation btTOLL | BtToll | Toll-like receptor (TLR) | Bemisia tabaci (Gennadius) | 3rd nymphal instar. | TIR domain | NA | NA | NA | Microbe detection, AMPs production, phagosome regulations, inflammatory signaling and activation | qRT-PCR | 28648996 | 2017 | NA |
| PRRID_2460 | NA Click for more detail | A.hydrophilla(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Activation of CLR. | CaNTC | C type Lectin (CTL/CLR) | Carassius auratus | liver, spleen and head-kidney | Carbohydrate recognition domain (CRD) | NA | NA | NA | pathogen recognition in Qihe 538 crucian carp | Microbial binding assay | 28602683 | 2017 | NA |
| PRRID_2460 | NA Click for more detail | A.hydrophilla(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Activation of CLR. | CaNTC | C type Lectin (CTL/CLR) | Carassius auratus | liver, spleen and head-kidney | Carbohydrate recognition domain (CRD) | NA | NA | NA | pathogen recognition in Qihe 538 crucian carp | Microbial binding assay | 28602683 | 2017 | NA |
| PRRID_2461 | NA Click for more detail | A.hydrophilla(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Pf_Toll-like receptor (TLR18) | Toll-like receptor (TLR) | Pelteobagrus fulvidraco | spleen, head kidney, trunk kidney, liver and blood | Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain | NA | NA | NA | activate NF-κB. | qRT-PCR | 28546018 | 2017 | NA |
| PRRID_2461 | NA Click for more detail | A.hydrophilla(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Pf_Toll-like receptor (TLR18) | Toll-like receptor (TLR) | Pelteobagrus fulvidraco | spleen, head kidney, trunk kidney, liver and blood | Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain | NA | NA | NA | activate NF-κB. | qRT-PCR | 28546018 | 2017 | NA |
| PRRID_2462 | NA Click for more detail | A.hydrophilla(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Pf_Toll-like receptor 19 (TLR19) | Toll-like receptor (TLR) | Pelteobagrus fulvidraco | spleen, head kidney, trunk kidney, liver and blood | Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain | NA | NA | NA | activate NF-κB. | qRT-PCR | 28546018 | 2017 | NA |
| PRRID_2462 | NA Click for more detail | A.hydrophilla(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Pf_Toll-like receptor 19 (TLR19) | Toll-like receptor (TLR) | Pelteobagrus fulvidraco | spleen, head kidney, trunk kidney, liver and blood | Leucine-rich repeats (LRRs), a transmembrane domain and a Toll/interleukin-I receptor domain | NA | NA | NA | activate NF-κB. | qRT-PCR | 28546018 | 2017 | NA |
| PRRID_2463 | NA Click for more detail | A.hydrophilla(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Pf_Toll-like receptor 21 (TLR21) | Toll-like receptor (TLR) | Pelteobagrus fulvidraco | spleen, head kidney, trunk kidney, liver and blood | LRR and TIR domain | NA | NA | NA | activate NF-κB. | qRT-PCR | 28546018 | 2017 | NA |
| PRRID_2463 | NA Click for more detail | A.hydrophilla(Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Immunostimulant | Pf_Toll-like receptor 21 (TLR21) | Toll-like receptor (TLR) | Pelteobagrus fulvidraco | spleen, head kidney, trunk kidney, liver and blood | LRR and TIR domain | NA | NA | NA | activate NF-κB. | qRT-PCR | 28546018 | 2017 | NA |