Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0964 | surfactant protein-A Click for more detail | Endogenous (others) | MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF | 248 | Protein | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0964 | surfactant protein-A Click for more detail | Endogenous (others) | MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF | 248 | Protein | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0966 | Triacylated lipopeptides Click for more detail | Bacteria | NA | NA | Lipopeptides | Natural | elicit innate immune response | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Human | Myeloid cells, T, B and NK cells, microglia, astrocytes | NA | Q15399.fasta | Q15399 | 786 | NA | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0966 | Triacylated lipopeptides Click for more detail | Bacteria | NA | NA | Lipopeptides | Natural | elicit innate immune response | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Human | Myeloid cells, T, B and NK cells, microglia, astrocytes | NA | Q15399.fasta | Q15399 | 786 | NA | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0968 | Type III repeat extra domain A of fibronectin Click for more detail | Endogenous (others) | MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHVTFY | 749 | Damage-associated molecular patterns (DAMPs) | Natural | potent stimulus for collagen production, myofibroblast differentiation, and wound healing in vitro and increased the mechanical stiffness of human organotypic skin equivalents | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0968 | Type III repeat extra domain A of fibronectin Click for more detail | Endogenous (others) | MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHVTFY | 749 | Damage-associated molecular patterns (DAMPs) | Natural | potent stimulus for collagen production, myofibroblast differentiation, and wound healing in vitro and increased the mechanical stiffness of human organotypic skin equivalents | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0969 | Unmethylated CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0969 | Unmethylated CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0971 | Uropathogenic E. coli Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | Myeloid cells, uroepithelial cells | NA | NA | NA | NA | TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion. | NA | 21982558 | 2011 | NA |
| PRRID_0971 | Uropathogenic E. coli Click for more detail | Bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | Myeloid cells, uroepithelial cells | NA | NA | NA | NA | TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion. | NA | 21982558 | 2011 | NA |
| PRRID_0972 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0972 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0973 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0973 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | induction of proinflammatory cytokines | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0976 | ANA773 Click for more detail | Anadys Pharmaceuticals (others) | NA | NA | prodrug of isatoribine | Synthetic | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | NA | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0976 | ANA773 Click for more detail | Anadys Pharmaceuticals (others) | NA | NA | prodrug of isatoribine | Synthetic | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | NA | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0977 | ATP Click for more detail | NA | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O | NA | Small molecule | Natural | immunostimulant | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | PBMCs | NA | Q9HC29.fasta | Q9HC29 | 1040 | induction of IL-6 and IL-8 | ELISA | 22998942 | 2012 | Pubchem Assay |
| PRRID_0977 | ATP Click for more detail | NA | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O | NA | Small molecule | Natural | immunostimulant | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | PBMCs | NA | Q9HC29.fasta | Q9HC29 | 1040 | induction of IL-6 and IL-8 | ELISA | 22998942 | 2012 | Pubchem Assay |
| PRRID_0978 | Budding memebrane Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | Block virion release | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_0978 | Budding memebrane Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | Block virion release | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_0979 | Capsid Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | IRF3 | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_0979 | Capsid Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | IRF3 | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_0980 | Capsid Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | AP-1, NF-kB | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_0980 | Capsid Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | AP-1, NF-kB | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_0981 | Capsid Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | Capsid disruption | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_0981 | Capsid Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | Capsid disruption | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_0984 | Cevarix Click for more detail | GlaxoSmithKline (others) | NA | NA | AS04 + HPV 16 & 18 L1 antigen | Synthetic | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0984 | Cevarix Click for more detail | GlaxoSmithKline (others) | NA | NA | AS04 + HPV 16 & 18 L1 antigen | Synthetic | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0985 | CPG10101 Click for more detail | Coley Pharmaceuticals(others) | NA | NA | CpG ODN | Synthetic | Immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0985 | CPG10101 Click for more detail | Coley Pharmaceuticals(others) | NA | NA | CpG ODN | Synthetic | Immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0988 | dNTPs Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | dNs + ppp | NA | 22982943 | 2012 | Pubchem Assay |
| PRRID_0988 | dNTPs Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | SAMHD1/triphosphohydrolase | Pattern recognition receptor (PRR) | Human | Cytosol | NA | Q9Y3Z3.fasta | Q9Y3Z3 | 626 | dNs + ppp | NA | 22982943 | 2012 | Pubchem Assay |
| PRRID_0989 | Fendrix Click for more detail | GlaxoSmithKline (others) | NA | NA | AS04 + HBV surface antigen | Synthetic | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0989 | Fendrix Click for more detail | GlaxoSmithKline (others) | NA | NA | AS04 + HBV surface antigen | Synthetic | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0994 | Heplisav (ISS-1018) Click for more detail | Dynavax Technologies(others) | NA | NA | CpG ODN + HBV surface antigen | NA | Immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0994 | Heplisav (ISS-1018) Click for more detail | Dynavax Technologies(others) | NA | NA | CpG ODN + HBV surface antigen | NA | Immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0999 | Imiquimod Click for more detail | 3M Pharma (others) | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | NA | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_0999 | Imiquimod Click for more detail | 3M Pharma (others) | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | NA | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_1000 | IMO-2125 Click for more detail | Idera Pharmaceuticals (others) | NA | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_1000 | IMO-2125 Click for more detail | Idera Pharmaceuticals (others) | NA | NA | Nucleic Acid | Synthetic | Immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_1001 | ISD DNA (RT product) Click for more detail | NA | NA | NA | NA | NA | Immunostimulant | Unknown DNA sensor | Pattern recognition receptor (PRR) | Human | Cytosol | NA | NA | NA | NA | IRF3 | NA | 22982943 | 2012 | NA |
| PRRID_1001 | ISD DNA (RT product) Click for more detail | NA | NA | NA | NA | NA | Immunostimulant | Unknown DNA sensor | Pattern recognition receptor (PRR) | Human | Cytosol | NA | NA | NA | NA | IRF3 | NA | 22982943 | 2012 | NA |
| PRRID_1002 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | PBMCs | NA | O60603.fasta | O60603 | 784 | induction of IL-6 and IL-8 | ELISA | 22998942 | 2012 | Pubchem Assay |
| PRRID_1002 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | PBMCs | NA | O60603.fasta | O60603 | 784 | induction of IL-6 and IL-8 | ELISA | 22998942 | 2012 | Pubchem Assay |
| PRRID_1007 | NA Click for more detail | B. fragilis(Bacteria) | NA | NA | NA | NA | Immunostimulant | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q15399.fasta | Q15399 | 786 | induction of IL-6 and IL-8 | ELISA | 22998942 | 2012 | Pubchem Assay |
| PRRID_1007 | NA Click for more detail | B. fragilis(Bacteria) | NA | NA | NA | NA | Immunostimulant | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Human | PBMCs | NA | Q15399.fasta | Q15399 | 786 | induction of IL-6 and IL-8 | ELISA | 22998942 | 2012 | Pubchem Assay |
| PRRID_1008 | Negative sense DNA Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | APOBEC3a/Cytidine | Pattern recognition receptor (PRR) | Human | Cell surface | NA | P31941.fasta | P31941 | 199 | Hypermutation | NA | 22982943 | 2012 | Pubchem Assay |
| PRRID_1008 | Negative sense DNA Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | APOBEC3a/Cytidine | Pattern recognition receptor (PRR) | Human | Cell surface | NA | P31941.fasta | P31941 | 199 | Hypermutation | NA | 22982943 | 2012 | Pubchem Assay |
| PRRID_1012 | Resquimod Click for more detail | 3M Pharma (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | NA | NA | NA | NA | NA | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | NA |
| PRRID_1012 | Resquimod Click for more detail | 3M Pharma (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | NA | NA | NA | NA | NA | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | NA |
| PRRID_1014 | single-stranded RNA Click for more detail | NA | NA | NA | Nucleic Acid | Natural | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Endosome | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | IRF7, NF-kB | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_1014 | single-stranded RNA Click for more detail | NA | NA | NA | Nucleic Acid | Natural | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Endosome | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | IRF7, NF-kB | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_1015 | single-stranded RNA Click for more detail | NA | NA | NA | Nucleic Acid | Natural | Immunostimulant | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | Endosome | NA | Q9NR97.fasta | Q9NR97 | 1041 | IRF7, NF-kB | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_1015 | single-stranded RNA Click for more detail | NA | NA | NA | Nucleic Acid | Natural | Immunostimulant | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | Endosome | NA | Q9NR97.fasta | Q9NR97 | 1041 | IRF7, NF-kB | NA | 22999945 | 2012 | Pubchem Assay |
| PRRID_1016 | ssDNA Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | TREX1/exonuclease | Pattern recognition receptor (PRR) | Human | Virion Cytosol | NA | Q9NSU2.fasta | Q9NSU2 | 314 | dNMPs | NA | 22982943 | 2012 | Pubchem Assay |
| PRRID_1016 | ssDNA Click for more detail | NA | NA | NA | NA | Natural | Immunostimulant | TREX1/exonuclease | Pattern recognition receptor (PRR) | Human | Virion Cytosol | NA | Q9NSU2.fasta | Q9NSU2 | 314 | dNMPs | NA | 22982943 | 2012 | Pubchem Assay |
| PRRID_1018 | Vax102 Click for more detail | Vaxinnate Corporation (others) | NA | NA | Flagellin + FLU M2e antigen | Synthetic | Immunostimulant | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | NA | NA | O60602.fasta | O60602 | 858 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_1018 | Vax102 Click for more detail | Vaxinnate Corporation (others) | NA | NA | Flagellin + FLU M2e antigen | Synthetic | Immunostimulant | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | NA | NA | O60602.fasta | O60602 | 858 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_1019 | Vax125 Click for more detail | Vaxinnate Corporation (others) | NA | NA | Flagellin + FLU HA antigen | Synthetic | Immunostimulant | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | NA | NA | O60602.fasta | O60602 | 858 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_1019 | Vax125 Click for more detail | Vaxinnate Corporation (others) | NA | NA | Flagellin + FLU HA antigen | Synthetic | Immunostimulant | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | NA | NA | O60602.fasta | O60602 | 858 | Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells. | NA | 23017246 | 2012 | Pubchem Assay |
| PRRID_1020 | 1,3 beta glucan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Carbohydrate | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | HEK293 cells | NA | O60603.fasta | O60603 | 784 | triggers the MyD88-dependent signaling pathway, leading to NF-kB activation | NF- | 24098508 | 2013 | Pubchem Assay |
| PRRID_1020 | 1,3 beta glucan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O | NA | Carbohydrate | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | HEK293 cells | NA | O60603.fasta | O60603 | 784 | triggers the MyD88-dependent signaling pathway, leading to NF-kB activation | NF- | 24098508 | 2013 | Pubchem Assay |
| PRRID_1022 | ATP Click for more detail | NA | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R) | NOD-like receptor (NLR) | Human | graft-versus-host disease (GVHD) | NA | Q96P20.fasta | Q96P20 | 1036 | Polymorphisms of P2X7R, NALP2 and NALP3 are associated with OS | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1022 | ATP Click for more detail | NA | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R) | NOD-like receptor (NLR) | Human | graft-versus-host disease (GVHD) | NA | Q96P20.fasta | Q96P20 | 1036 | Polymorphisms of P2X7R, NALP2 and NALP3 are associated with OS | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1028 | Bropirimine Click for more detail | NA | C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | experimental drug with anti-cancer and antiviral properties | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1028 | Bropirimine Click for more detail | NA | C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | experimental drug with anti-cancer and antiviral properties | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1030 | DNA (immune complexes Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1030 | DNA (immune complexes Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1033 | dsRNA Click for more detail | viral or cellular origin (virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | testis, epididymis, vasa deferens, prostate and prepuce | NA | O15455.fasta | O15455 | 904 | induce type I interferons (IFN) and other cytokines production. | RT-PCR, Quantitative real-time PCR | 23998272 | 2013 | Pubchem Assay |
| PRRID_1033 | dsRNA Click for more detail | viral or cellular origin (virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | testis, epididymis, vasa deferens, prostate and prepuce | NA | O15455.fasta | O15455 | 904 | induce type I interferons (IFN) and other cytokines production. | RT-PCR, Quantitative real-time PCR | 23998272 | 2013 | Pubchem Assay |
| PRRID_1034 | DNA (viral) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1034 | DNA (viral) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1036 | EfLTA Click for more detail | Endogenous (others) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | play an important role in inducing non-specific resistance against a broad range of viral infections. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | NA |
| PRRID_1036 | EfLTA Click for more detail | Endogenous (others) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | play an important role in inducing non-specific resistance against a broad range of viral infections. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | NA |
| PRRID_1038 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O15455.fasta | O15455 | 904 | induce type I interferons (IFN) and other cytokines production. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1038 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O15455.fasta | O15455 | 904 | induce type I interferons (IFN) and other cytokines production. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1040 | Extra domain A of fibronectin Click for more detail | Endogenous (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1040 | Extra domain A of fibronectin Click for more detail | Endogenous (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1043 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | testis, epididymis, vasa deferens, prostate and prepuce | NA | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | RT-PCR, Quantitative real-time PCR | 23998272 | 2013 | Pubchem_assay |
| PRRID_1043 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | testis, epididymis, vasa deferens, prostate and prepuce | NA | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | RT-PCR, Quantitative real-time PCR | 23998272 | 2013 | Pubchem_assay |
| PRRID_1044 | Fibrinogen Click for more detail | Endogenous (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1044 | Fibrinogen Click for more detail | Endogenous (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1046 | cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | mimic bacterial and viral DNA and was also shown to be involved in GVHD | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | graft-versus-host disease (GVHD) | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1046 | cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | mimic bacterial and viral DNA and was also shown to be involved in GVHD | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | graft-versus-host disease (GVHD) | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1048 | Flagellin Click for more detail | S. typhimurium (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | HEK293 cells | NA | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NF- | 24098508 | 2013 | Pubchem_assay |
| PRRID_1048 | Flagellin Click for more detail | S. typhimurium (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | HEK293 cells | NA | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NF- | 24098508 | 2013 | Pubchem_assay |
| PRRID_1050 | FSL-1 Click for more detail | synthetic lipoprotein (others) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | mimic parts of bacterial lipoproteins | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Human | HEK293 cells | NA | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NF- | 24098508 | 2013 | NA |
| PRRID_1050 | FSL-1 Click for more detail | synthetic lipoprotein (others) | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Lipoprotein | Synthetic | mimic parts of bacterial lipoproteins | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Human | HEK293 cells | NA | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NF- | 24098508 | 2013 | NA |
| PRRID_1052 | Glycolipids Click for more detail | Endogenous (others) | NA | NA | Protein | Natural | Play an important role in infectious inflammatory responses. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | NA |
| PRRID_1052 | Glycolipids Click for more detail | Endogenous (others) | NA | NA | Protein | Natural | Play an important role in infectious inflammatory responses. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | NA |
| PRRID_1054 | H protein Click for more detail | fimbriae of Escherichia coli (Bacteria) | MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ | 137 | Protein | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human peripheral blood mononuclear cells (hPBMCs) | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24016850 | 2013 | Pubchem_assay |
| PRRID_1054 | H protein Click for more detail | fimbriae of Escherichia coli (Bacteria) | MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ | 137 | Protein | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human peripheral blood mononuclear cells (hPBMCs) | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24016850 | 2013 | Pubchem_assay |
| PRRID_1055 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), CD91, CD24, CD14 and CD40 | Toll-like receptor (TLR) | Human | graft-versus-host disease (GVHD) | NA | NA | NA | NA | HSP70 expression was correlated with high graft-versus-host responses | NA | 23985302 | 2013 | NA |
| PRRID_1055 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), CD91, CD24, CD14 and CD40 | Toll-like receptor (TLR) | Human | graft-versus-host disease (GVHD) | NA | NA | NA | NA | HSP70 expression was correlated with high graft-versus-host responses | NA | 23985302 | 2013 | NA |
| PRRID_1056 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), CD91, CD24, CD14 and CD40 | Toll-like receptor (TLR) | Human | graft-versus-host disease (GVHD) | NA | NA | NA | NA | Recipient HSP polymorphisms are associated with GVHD | NA | 23985302 | 2013 | NA |
| PRRID_1056 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), CD91, CD24, CD14 and CD40 | Toll-like receptor (TLR) | Human | graft-versus-host disease (GVHD) | NA | NA | NA | NA | Recipient HSP polymorphisms are associated with GVHD | NA | 23985302 | 2013 | NA |
| PRRID_1057 | Heat-shock protein 70 Click for more detail | Host (Endogenous) (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Protein | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human peripheral blood mononuclear cells (hPBMCs) | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24016850 | 2013 | Pubchem_assay |
| PRRID_1057 | Heat-shock protein 70 Click for more detail | Host (Endogenous) (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Protein | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human peripheral blood mononuclear cells (hPBMCs) | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24016850 | 2013 | Pubchem_assay |
| PRRID_1058 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1058 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 23985302 | 2013 | Pubchem_assay |