Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0964	surfactant protein-A Click for more detail	Endogenous (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0964	surfactant protein-A Click for more detail	Endogenous (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0966	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Myeloid cells, T, B and NK cells, microglia, astrocytes	NA	Q15399.fasta	Q15399	786	NA	NA	21982558	2011	Pubchem Assay
PRRID_0966	Triacylated lipopeptides Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Myeloid cells, T, B and NK cells, microglia, astrocytes	NA	Q15399.fasta	Q15399	786	NA	NA	21982558	2011	Pubchem Assay
PRRID_0968	Type III repeat extra domain A of fibronectin Click for more detail	Endogenous (others)	MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHVTFY	749	Damage-associated molecular patterns (DAMPs)	Natural	potent stimulus for collagen production, myofibroblast differentiation, and wound healing in vitro and increased the mechanical stiffness of human organotypic skin equivalents	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0968	Type III repeat extra domain A of fibronectin Click for more detail	Endogenous (others)	MEEESGEELGLDRSTPKDFHFYHMDLYDSEDRLHLFPEENTRMRKVVQAEMANESRGAGDGKAQRDLQEEVDELVHLYGLEDDHELGDEFVDENIPRTGVSEYPPYMMKRRDPAREQRDWRLSGEAAEAEDLGFGGWGSAGQCQDLREAYRYTHGRASEEYECYVIPEEEDEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFANHLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLDTCKELMETIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDVEISAQPEFEDQTLDFSDVEQLMGSINTIPAPSAPVINPQVPNSATGSSVRVCWSLYSDDTVESYQLSYRPVQDSSPGTDQAEFTVTVKETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPPIIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRSYIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSDTHFTRCVAVMGNLIPVRGHHYWEVEVDEHLDYRVGVAFADVRKQEDLGANCLSWCMRHTFASSRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLEKPGCLKVHNGISMPKHVTFY	749	Damage-associated molecular patterns (DAMPs)	Natural	potent stimulus for collagen production, myofibroblast differentiation, and wound healing in vitro and increased the mechanical stiffness of human organotypic skin equivalents	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0969	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	21982558	2011	Pubchem Assay
PRRID_0969	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	21982558	2011	Pubchem Assay
PRRID_0971	Uropathogenic E. coli Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	Myeloid cells, uroepithelial cells	NA	NA	NA	NA	TLR11 plays a fundamental role in both the¬†innate¬†and¬†adaptive¬†immune responses, through the activation of¬†Tumor necrosis factor-alpha,the¬†Interleukin 12¬†(IL-12) response and¬†Interferon-gamma¬†(IFN-gamma) secretion.	NA	21982558	2011	NA
PRRID_0971	Uropathogenic E. coli Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	Myeloid cells, uroepithelial cells	NA	NA	NA	NA	TLR11 plays a fundamental role in both the¬†innate¬†and¬†adaptive¬†immune responses, through the activation of¬†Tumor necrosis factor-alpha,the¬†Interleukin 12¬†(IL-12) response and¬†Interferon-gamma¬†(IFN-gamma) secretion.	NA	21982558	2011	NA
PRRID_0972	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	induction of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0972	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	induction of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0973	Zymosan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	induction of proinflammatory cytokines	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0973	Zymosan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	induction of proinflammatory cytokines	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0976	ANA773 Click for more detail	Anadys Pharmaceuticals (others)	NA	NA	prodrug of isatoribine	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0976	ANA773 Click for more detail	Anadys Pharmaceuticals (others)	NA	NA	prodrug of isatoribine	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0977	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Small molecule	Natural	immunostimulant	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	PBMCs	NA	Q9HC29.fasta	Q9HC29	1040	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_0977	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Small molecule	Natural	immunostimulant	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	PBMCs	NA	Q9HC29.fasta	Q9HC29	1040	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_0978	Budding memebrane Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	Block virion release	NA	22999945	2012	Pubchem Assay
PRRID_0978	Budding memebrane Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	Block virion release	NA	22999945	2012	Pubchem Assay
PRRID_0979	Capsid Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	IRF3	NA	22999945	2012	Pubchem Assay
PRRID_0979	Capsid Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	IRF3	NA	22999945	2012	Pubchem Assay
PRRID_0980	Capsid Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	AP-1, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_0980	Capsid Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	AP-1, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_0981	Capsid Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	Capsid disruption	NA	22999945	2012	Pubchem Assay
PRRID_0981	Capsid Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	Capsid disruption	NA	22999945	2012	Pubchem Assay
PRRID_0984	Cevarix Click for more detail	GlaxoSmithKline (others)	NA	NA	AS04 + HPV 16 & 18 L1 antigen	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0984	Cevarix Click for more detail	GlaxoSmithKline (others)	NA	NA	AS04 + HPV 16 & 18 L1 antigen	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0985	CPG10101 Click for more detail	Coley Pharmaceuticals(others)	NA	NA	CpG ODN	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0985	CPG10101 Click for more detail	Coley Pharmaceuticals(others)	NA	NA	CpG ODN	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0988	dNTPs Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	dNs + ppp	NA	22982943	2012	Pubchem Assay
PRRID_0988	dNTPs Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	SAMHD1/triphosphohydrolase	Pattern recognition receptor (PRR)	Human	Cytosol	NA	Q9Y3Z3.fasta	Q9Y3Z3	626	dNs + ppp	NA	22982943	2012	Pubchem Assay
PRRID_0989	Fendrix Click for more detail	GlaxoSmithKline (others)	NA	NA	AS04 + HBV surface antigen	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0989	Fendrix Click for more detail	GlaxoSmithKline (others)	NA	NA	AS04 + HBV surface antigen	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0994	Heplisav (ISS-1018) Click for more detail	Dynavax Technologies(others)	NA	NA	CpG ODN + HBV surface antigen	NA	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0994	Heplisav (ISS-1018) Click for more detail	Dynavax Technologies(others)	NA	NA	CpG ODN + HBV surface antigen	NA	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0999	Imiquimod Click for more detail	3M Pharma (others)	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_0999	Imiquimod Click for more detail	3M Pharma (others)	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	NA	NA	Q9NYK1.fasta	Q9NYK1	1049	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1000	IMO-2125 Click for more detail	Idera Pharmaceuticals (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1000	IMO-2125 Click for more detail	Idera Pharmaceuticals (others)	NA	NA	Nucleic Acid	Synthetic	Immunostimulant	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	NA	Q9NR96.fasta	Q9NR96	1032	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1001	ISD DNA (RT product) Click for more detail	NA	NA	NA	NA	NA	Immunostimulant	Unknown DNA sensor	Pattern recognition receptor (PRR)	Human	Cytosol	NA	NA	NA	NA	IRF3	NA	22982943	2012	NA
PRRID_1001	ISD DNA (RT product) Click for more detail	NA	NA	NA	NA	NA	Immunostimulant	Unknown DNA sensor	Pattern recognition receptor (PRR)	Human	Cytosol	NA	NA	NA	NA	IRF3	NA	22982943	2012	NA
PRRID_1002	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	PBMCs	NA	O60603.fasta	O60603	784	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_1002	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	PBMCs	NA	O60603.fasta	O60603	784	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_1007	NA Click for more detail	B. fragilis(Bacteria)	NA	NA	NA	NA	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q15399.fasta	Q15399	786	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_1007	NA Click for more detail	B. fragilis(Bacteria)	NA	NA	NA	NA	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q15399.fasta	Q15399	786	induction of IL-6 and IL-8	ELISA	22998942	2012	Pubchem Assay
PRRID_1008	Negative sense DNA Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	APOBEC3a/Cytidine	Pattern recognition receptor (PRR)	Human	Cell surface	NA	P31941.fasta	P31941	199	Hypermutation	NA	22982943	2012	Pubchem Assay
PRRID_1008	Negative sense DNA Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	APOBEC3a/Cytidine	Pattern recognition receptor (PRR)	Human	Cell surface	NA	P31941.fasta	P31941	199	Hypermutation	NA	22982943	2012	Pubchem Assay
PRRID_1012	Resquimod Click for more detail	3M Pharma (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	NA
PRRID_1012	Resquimod Click for more detail	3M Pharma (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	Immunostimulant	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	NA
PRRID_1014	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosome	NA	Q9NYK1.fasta	Q9NYK1	1049	IRF7, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_1014	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Endosome	NA	Q9NYK1.fasta	Q9NYK1	1049	IRF7, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_1015	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosome	NA	Q9NR97.fasta	Q9NR97	1041	IRF7, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_1015	single-stranded RNA Click for more detail	NA	NA	NA	Nucleic Acid	Natural	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Endosome	NA	Q9NR97.fasta	Q9NR97	1041	IRF7, NF-kB	NA	22999945	2012	Pubchem Assay
PRRID_1016	ssDNA Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	TREX1/exonuclease	Pattern recognition receptor (PRR)	Human	Virion Cytosol	NA	Q9NSU2.fasta	Q9NSU2	314	dNMPs	NA	22982943	2012	Pubchem Assay
PRRID_1016	ssDNA Click for more detail	NA	NA	NA	NA	Natural	Immunostimulant	TREX1/exonuclease	Pattern recognition receptor (PRR)	Human	Virion Cytosol	NA	Q9NSU2.fasta	Q9NSU2	314	dNMPs	NA	22982943	2012	Pubchem Assay
PRRID_1018	Vax102 Click for more detail	Vaxinnate Corporation (others)	NA	NA	Flagellin + FLU M2e antigen	Synthetic	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1018	Vax102 Click for more detail	Vaxinnate Corporation (others)	NA	NA	Flagellin + FLU M2e antigen	Synthetic	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1019	Vax125 Click for more detail	Vaxinnate Corporation (others)	NA	NA	Flagellin + FLU HA antigen	Synthetic	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1019	Vax125 Click for more detail	Vaxinnate Corporation (others)	NA	NA	Flagellin + FLU HA antigen	Synthetic	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	Recognition of extracellular PAMPs Activation leads to pro-inflammatory cytokines and type I IFNs production Set the pace for an adaptive immune response via T and B cells.	NA	23017246	2012	Pubchem Assay
PRRID_1020	1,3 beta glucan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60603.fasta	O60603	784	triggers the MyD88-dependent signaling pathway, leading to NF-kB activation	NF-	24098508	2013	Pubchem Assay
PRRID_1020	1,3 beta glucan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Carbohydrate	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60603.fasta	O60603	784	triggers the MyD88-dependent signaling pathway, leading to NF-kB activation	NF-	24098508	2013	Pubchem Assay
PRRID_1022	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R)	NOD-like receptor (NLR)	Human	graft-versus-host disease (GVHD)	NA	Q96P20.fasta	Q96P20	1036	Polymorphisms of P2X7R, NALP2 and NALP3 are associated with OS	NA	23985302	2013	Pubchem Assay
PRRID_1022	ATP Click for more detail	NA	C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R)	NOD-like receptor (NLR)	Human	graft-versus-host disease (GVHD)	NA	Q96P20.fasta	Q96P20	1036	Polymorphisms of P2X7R, NALP2 and NALP3 are associated with OS	NA	23985302	2013	Pubchem Assay
PRRID_1028	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	23985302	2013	Pubchem Assay
PRRID_1028	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	23985302	2013	Pubchem Assay
PRRID_1030	DNA (immune complexes Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1030	DNA (immune complexes Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1033	dsRNA Click for more detail	viral or cellular origin (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem Assay
PRRID_1033	dsRNA Click for more detail	viral or cellular origin (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem Assay
PRRID_1034	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1034	DNA (viral) Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem Assay
PRRID_1036	EfLTA Click for more detail	Endogenous (others)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	play an important role in inducing non-specific resistance against a broad range of viral infections.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1036	EfLTA Click for more detail	Endogenous (others)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	play an important role in inducing non-specific resistance against a broad range of viral infections.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1038	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1038	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	23985302	2013	Pubchem_assay
PRRID_1040	Extra domain A of fibronectin Click for more detail	Endogenous (others)	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1040	Extra domain A of fibronectin Click for more detail	Endogenous (others)	MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP	2386	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1043	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1043	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1044	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1044	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1046	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1046	cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	mimic bacterial and viral DNA and was also shown to be involved in GVHD	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1048	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NF-	24098508	2013	Pubchem_assay
PRRID_1048	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NF-	24098508	2013	Pubchem_assay
PRRID_1050	FSL-1 Click for more detail	synthetic lipoprotein (others)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NF-	24098508	2013	NA
PRRID_1050	FSL-1 Click for more detail	synthetic lipoprotein (others)	CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Lipoprotein	Synthetic	mimic parts of bacterial lipoproteins	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	HEK293 cells	NA	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NF-	24098508	2013	NA
PRRID_1052	Glycolipids Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	Play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1052	Glycolipids Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	Play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1054	H protein Click for more detail	fimbriae of Escherichia coli (Bacteria)	MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ	137	Protein	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1054	H protein Click for more detail	fimbriae of Escherichia coli (Bacteria)	MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ	137	Protein	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1055	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), CD91, CD24, CD14 and CD40	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	NA	NA	NA	HSP70 expression was correlated with high graft-versus-host responses	NA	23985302	2013	NA
PRRID_1055	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), CD91, CD24, CD14 and CD40	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	NA	NA	NA	HSP70 expression was correlated with high graft-versus-host responses	NA	23985302	2013	NA
PRRID_1056	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), CD91, CD24, CD14 and CD40	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	NA	NA	NA	Recipient HSP polymorphisms are associated with GVHD	NA	23985302	2013	NA
PRRID_1056	Heat shock protein Click for more detail	NA	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), CD91, CD24, CD14 and CD40	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	NA	NA	NA	Recipient HSP polymorphisms are associated with GVHD	NA	23985302	2013	NA
PRRID_1057	Heat-shock protein 70 Click for more detail	Host (Endogenous) (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1057	Heat-shock protein 70 Click for more detail	Host (Endogenous) (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	human peripheral blood mononuclear cells (hPBMCs)	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24016850	2013	Pubchem_assay
PRRID_1058	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1058	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs	extracellular domains of leucine-rich repeat motifs	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay

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