Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_1031 | DNA (viral) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1031 | DNA (viral) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1035 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1035 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 23985302 | 2013 | Pubchem Assay |
| PRRID_1039 | Extra domain A of fibronectin Click for more detail | Endogenous (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1039 | Extra domain A of fibronectin Click for more detail | Endogenous (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1041 | Fibrinogen Click for more detail | Endogenous (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1041 | Fibrinogen Click for more detail | Endogenous (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1045 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1045 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1047 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1047 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1053 | Glycolipids Click for more detail | Treponema maltophilum (others) | NA | NA | Carbohydrate | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1053 | Glycolipids Click for more detail | Treponema maltophilum (others) | NA | NA | Carbohydrate | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1059 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1059 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1061 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1061 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1063 | Heparan sulfate Click for more detail | NA | COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | induce the maturation of DCs | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | Q9QUK6.fasta | Q9QUK6 | 835 | a1-antitrypsin decreased serum heparan sulfate levels and GVHD | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1063 | Heparan sulfate Click for more detail | NA | COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | induce the maturation of DCs | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | Q9QUK6.fasta | Q9QUK6 | 835 | a1-antitrypsin decreased serum heparan sulfate levels and GVHD | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1068 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1068 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1070 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1070 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | play an important role in infectious inflammatory responses. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1073 | HSP-20 Click for more detail | Endogenous (others) | MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSVALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK | 160 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1073 | HSP-20 Click for more detail | Endogenous (others) | MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSVALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK | 160 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1075 | HSP-60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1075 | HSP-60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1077 | HSP-60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1077 | HSP-60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1079 | HSP-96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1079 | HSP-96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1081 | HSP-96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1081 | HSP-96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1083 | Hyaluronan Click for more detail | Endogenous (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1083 | Hyaluronan Click for more detail | Endogenous (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1087 | Lipid A Click for more detail | NA | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Fatty acid | Synthetic | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1087 | Lipid A Click for more detail | NA | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Fatty acid | Synthetic | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1094 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1094 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1095 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1095 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1100 | Lipoprotein Click for more detail | Gram-positive bacteria | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1100 | Lipoprotein Click for more detail | Gram-positive bacteria | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1105 | Macrophage activating lipoprotein-2 (MALP-2) Click for more detail | Mycoplasma fermentans (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | It primes macrophages for cytokines secretion | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1105 | Macrophage activating lipoprotein-2 (MALP-2) Click for more detail | Mycoplasma fermentans (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | It primes macrophages for cytokines secretion | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1108 | mRNA Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1108 | mRNA Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1110 | muramyl dipeptide (MDP) Click for more detail | Gram-positive and negative bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | a component of bacterial peptidoglycan, and induces NF-jB activation, leading to enhanced Th1 responses | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | graft-versus-host disease (GVHD) | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | NOD2 functions as a primary sensor of microbial products inducing inflammatory T-cell responses and also negatively regulates TLR-mediated responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1110 | muramyl dipeptide (MDP) Click for more detail | Gram-positive and negative bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | a component of bacterial peptidoglycan, and induces NF-jB activation, leading to enhanced Th1 responses | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | graft-versus-host disease (GVHD) | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | NOD2 functions as a primary sensor of microbial products inducing inflammatory T-cell responses and also negatively regulates TLR-mediated responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1119 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1119 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1123 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1123 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1126 | Porins Click for more detail | Neisseria meningitidis (Bacteria) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | NA |
| PRRID_1126 | Porins Click for more detail | Neisseria meningitidis (Bacteria) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | NA |
| PRRID_1128 | Porins Click for more detail | Neisseria meningitidis (Bacteria) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | Q9QUN7.fasta | Q9QUN7 | 784 | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1128 | Porins Click for more detail | Neisseria meningitidis (Bacteria) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | Q9QUN7.fasta | Q9QUN7 | 784 | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1129 | profilin-like protein Click for more detail | T. gondii (others) | MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 165 | Protein | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | Cell Surface (Exogenous) | Q6R5P0.fasta | Q6R5P0 | 926 |  TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1129 | profilin-like protein Click for more detail | T. gondii (others) | MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 165 | Protein | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | Cell Surface (Exogenous) | Q6R5P0.fasta | Q6R5P0 | 926 |  TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion. | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1131 | R-848 Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | sufficient to permit access of activated T-cells to peripheral tissues and induce GVHD | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1131 | R-848 Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | sufficient to permit access of activated T-cells to peripheral tissues and induce GVHD | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1133 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1133 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1135 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, mast cells | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1135 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | immune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, mast cells | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1138 | Serum amyloid Click for more detail | Endogenous (others) | MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY | 122 | Carbohydrate | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1138 | Serum amyloid Click for more detail | Endogenous (others) | MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY | 122 | Carbohydrate | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1141 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1141 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1143 | single-stranded RNA Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Synthetic | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1143 | single-stranded RNA Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Synthetic | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1145 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, mast cells | Cell Compartment/Intracellular (Endosome) | P58682.fasta | P58682 | 1032 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1145 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, mast cells | Cell Compartment/Intracellular (Endosome) | P58682.fasta | P58682 | 1032 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1147 | single-stranded RNA Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, mast cells | Cell Compartment/Intracellular (Endosome) | P58682.fasta | P58682 | 1032 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1147 | single-stranded RNA Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, mast cells | Cell Compartment/Intracellular (Endosome) | P58682.fasta | P58682 | 1032 | important role in the immune response to viral infection | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1149 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | NA | NA | NA | induces anti-viral response | NA | 23985302 | 2013 | NA |
| PRRID_1149 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice | graft-versus-host disease (GVHD) | NA | NA | NA | NA | induces anti-viral response | NA | 23985302 | 2013 | NA |
| PRRID_1154 | Snapin A Click for more detail | Endogenous (others) | MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK | 136 | Pattern-associated molecular patterns (PAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1154 | Snapin A Click for more detail | Endogenous (others) | MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK | 136 | Pattern-associated molecular patterns (PAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1156 | Soluble tuberculosis factor Click for more detail | Endogenous (others) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1156 | Soluble tuberculosis factor Click for more detail | Endogenous (others) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1158 | surfactant protein-A Click for more detail | Endogenous (others) | MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF | 248 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1158 | surfactant protein-A Click for more detail | Endogenous (others) | MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF | 248 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1160 | Tenascin C Click for more detail | Endogenous (others) | MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS | 2110 and 2201 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1160 | Tenascin C Click for more detail | Endogenous (others) | MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS | 2110 and 2201 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1162 | Triacylated lipopeptides Click for more detail | Bacteria and mycobacteria | NA | NA | Lipopeptides | Natural | elicit innate immune response | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | NA |
| PRRID_1162 | Triacylated lipopeptides Click for more detail | Bacteria and mycobacteria | NA | NA | Lipopeptides | Natural | elicit innate immune response | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | NA |
| PRRID_1165 | Unmethylated CpG DNA Click for more detail | Host/microbial (others) | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1165 | Unmethylated CpG DNA Click for more detail | Host/microbial (others) | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1167 | Zymosan Click for more detail | Various pathogens (others) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1167 | Zymosan Click for more detail | Various pathogens (others) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1168 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1168 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 23985302 | 2013 | Pubchem_assay |
| PRRID_1170 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1170 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | elicit innate immune response | Toll-like receptor 6 /2 (TLR6/2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 23985302 | 2013 | NA |
| PRRID_1175 | 1-b-D-arabinofuranosylcytosine (Ara-C) Click for more detail | Lipid (PAMPS) (others) | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O | NA | Fatty acid | Synthetic | genotoxic anticancer agent | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) | B-cell lymphoma cell lines | cell surface | NA | NA | NA | an alkylating chemotherapeutic agent that induces immunogenic cell death and is commonly used to treat B-cell NHL | ELISA | 24799523 | 2014 | NA |
| PRRID_1175 | 1-b-D-arabinofuranosylcytosine (Ara-C) Click for more detail | Lipid (PAMPS) (others) | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O | NA | Fatty acid | Synthetic | genotoxic anticancer agent | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) | B-cell lymphoma cell lines | cell surface | NA | NA | NA | an alkylating chemotherapeutic agent that induces immunogenic cell death and is commonly used to treat B-cell NHL | ELISA | 24799523 | 2014 | NA |
| PRRID_1177 | 6-amino-9-benzyl-2- 106 (2-methoxyethoxy)-9H-purin-8-ol (SM360320) Click for more detail | NA | NC1=C2C(N(CC3=CC=CC=C3)C(O)=N2)=NC(OCCOC)=N1 | NA | Nucleic Acid | Synthetic | stimulates TLR7 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | pDCs | intracellular receptors | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA | 24814238 | 2014 | Pubchem_assay |
| PRRID_1177 | 6-amino-9-benzyl-2- 106 (2-methoxyethoxy)-9H-purin-8-ol (SM360320) Click for more detail | NA | NC1=C2C(N(CC3=CC=CC=C3)C(O)=N2)=NC(OCCOC)=N1 | NA | Nucleic Acid | Synthetic | stimulates TLR7 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | pDCs | intracellular receptors | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA | 24814238 | 2014 | Pubchem_assay |