Detailed description page of PRRDB2.0

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PRRID_1083 details
Primary information
PRRIDPRRID_1083
Ligand NameHyaluronan
SourceEndogenous (others)
Sequence of ligandCC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O
LengthNA
TypeDamage-associated molecular patterns (DAMPs)
OccurenceNatural
Role of Ligandthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte
Domainsignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
Functionplays a fundamental role in pathogen recognition and activation of innate immunity
Assay usedNA
PMID23985302
Year of Publication2013
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1083
Ligand NameHyaluronan
SourceEndogenous (others)
Sequence of ligandCC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O
LengthNA
TypeDamage-associated molecular patterns (DAMPs)
OccurenceNatural
Role of Ligandthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte
Domainsignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
Functionplays a fundamental role in pathogen recognition and activation of innate immunity
Assay usedNA
PMID23985302
Year of Publication2013
Pubchem assayPubchem_assay