The Total number of records shown on this page is 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_2265	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	SNB19	NA	NA	MTS assay	10 MOI	60% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2266	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	LN-18	NA	NA	MTS assay	10 MOI	30% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_2267	Herpes simplex virus	Equine Herpesvirus type-1	DNA	Herpesviridae	None	Yes	No	No	NA	Human glioma cell line	A-172	NA	NA	MTS assay	10 MOI	30% cell survival after 48 hours	No	No	NA	No response	NA	NA	NA	NA	22205738
OV_3138	Herpes simplex virus	HSV-HSV-GR	DNA	Herpesviridae	Deletion of gamma 34.5 gene and insertion of GR and mcherry	Yes	No	No	National cell bak of Iran	Murine breast cancer cell line	4T1	NA	NA	Photomicrography and flow cytometry	1 MOI	27.9% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	30936930
OV_3139	Herpes simplex virus	HSV-HSV-GR	DNA	Herpesviridae	Deletion of gamma 34.5 gene and insertion of GR and mcherry	Yes	No	No	National cell bak of Iran	Murine breast cancer cell line	TC-1	NA	NA	Photomicrography and flow cytometry	1 MOI	21.2% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	30936930
OV_3140	Herpes simplex virus	HSV-HSV-GR	DNA	Herpesviridae	Deletion of gamma 34.5 gene and insertion of GR and mcherry	Yes	No	No	National cell bak of Iran	Murine breast cancer cell line	CT-26	NA	NA	Photomicrography and flow cytometry	1 MOI	21.3% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	30936930
OV_3141	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	5 MOI	50% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3142	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	10 MOI	25% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3143	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	20 MOI	18% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3144	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	5 MOI	50% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3145	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	10 MOI	30% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3146	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	20 MOI	25% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3147	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	10 MOI	90% cell viability after day 1	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3148	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	10 MOI	60% cell viability after day 2	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3149	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	10 MOI	40% cell viability after day 3	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3150	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	10 MOI	10% cell viability after day 4	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3151	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	10 MOI	90% cell viability after day 1	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3152	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	10 MOI	80% cell viability after day 2	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3153	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	10 MOI	70% cell viability after day 3	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3154	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	10 MOI	40% cell viability after day 4	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3155	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	NA	NA	NA	NA	NA	Mouse model xenograft for SW620 (1.0E+6)	5.0E+8 pfu	NA	Reduction in tumor volume below 200mm as compared to control 2500mm after 24 days	Intratumoral	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3156	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	Yes	No	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	NA	NA	NA	NA	NA	Mouse model xenograft for LS174T (1.0E+6)	5.0E+8 pfu	NA	Reduction in tumor volume below 500mm as compared to control 3000mm after 24 days	Intratumoral	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3157	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	No	Virus in combination with rapamycin (5nM)	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	5 MOI	60% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3158	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	No	Virus in combination with rapamycin (10nM)	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	10 MOI	50% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3159	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	No	Virus in combination with rapamycin (20nM)	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	SW620	2000 cells per well	NA	CCK-8 assay	20 MOI	40% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3160	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	No	Virus in combination with rapamycin (5nM)	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	5 MOI	70% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3161	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	No	Virus in combination with rapamycin (10nM)	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	10 MOI	50% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3162	Herpes simplex virus	SPDD-UG	DNA	Adenoviridae	Virus expressing SNORD44 gene and GAS5 gene	No	Virus in combination with rapamycin (20nM)	No	Cell bank of type culture collection of chinese academy of science	Human colon carcinoma cell line	LS174T	2000 cells per well	NA	CCK-8 assay	20 MOI	40% cell viability	No	No	NA	No response	NA	Caspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line	NA	NA	28530127
OV_3177	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human edwig sarcoma cell line	RD-ES	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.0001 MOI	60% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3178	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human edwig sarcoma cell line	RD-ES	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.001 MOI	50% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3179	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human edwig sarcoma cell line	RD-ES	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.01 MOI	30% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3180	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human edwig sarcoma cell line	RD-ES	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.1 MOI	30% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3181	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human edwig sarcoma cell line	RD-ES	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	1 MOI	30% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3182	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human edwig sarcoma cell line	RD-ES	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	10 MOI	30% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3207	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human bone osteosarcoma cell line	143-B	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.0001 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3208	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human bone osteosarcoma cell line	143-B	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.001 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3209	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human bone osteosarcoma cell line	143-B	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.01 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3210	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human bone osteosarcoma cell line	143-B	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.1 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3211	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human bone osteosarcoma cell line	143-B	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	1 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3212	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human bone osteosarcoma cell line	143-B	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	10 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3237	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human canine osteosarcoma	D17	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.0001 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3238	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human canine osteosarcoma	D17	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.001 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3239	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human canine osteosarcoma	D17	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.01 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3240	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human canine osteosarcoma	D17	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.1 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3241	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human canine osteosarcoma	D17	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	1 MOI	90% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3242	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human canine osteosarcoma	D17	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	10 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3267	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human synovial sarcoma cell line	SW982	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.0001 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3268	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human synovial sarcoma cell line	SW982	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.001 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3269	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human synovial sarcoma cell line	SW982	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.01 MOI	80% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3270	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human synovial sarcoma cell line	SW982	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	0.1 MOI	75% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3271	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human synovial sarcoma cell line	SW982	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	1 MOI	75% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_3272	Herpes simplex virus	wild type	DNA	Herpesviridae	None	Yes	No	No	ATCC	Human synovial sarcoma cell line	SW982	90% confluence	NA	Crystal violet staining and absorbance at 595 nm	10 MOI	75% cell survival after 48 hours	No	No	NA	No response	NA	NA	Genration of memory immune response by incresing production of cytokines	NA	28568891
OV_4077	Herpes simplex virus	G207	DNA	Herpesviridae	Deletion mutant for gamma 34.5 gene and and lacZ insertion into Ul39 gene encodes for ICP6 gene	Yes	No	No	Duke university medical centre	NA	NA	NA	NA	NA	NA	NA	Nude mice xenograft for medulloblastoma cell line D425 (2.5E+5)	1.0E+7 pfu	NA	Increase the survival time of mice from 15 days to 25 days	Intratumoral	NA	Increased expression of CD133 and CD15	NA	26188016
OV_4078	Herpes simplex virus	G207	DNA	Herpesviridae	Deletion mutant for gamma 34.5 gene and and lacZ insertion into Ul39 gene encodes for ICP6 gene	Yes	No	No	Duke university medical centre	NA	NA	NA	NA	NA	NA	NA	Nude mice xenograft for medulloblastoma cell line D341 (5.0E+5)	1.0E+7 pfu	NA	Increase the survival time of mice from 32 days to above 60 days	Intratumoral	NA	Increased expression of CD133 and CD15	NA	26188016
OV_4079	Herpes simplex virus	M002	DNA	Herpesviridae	Deletion mutant for gamma 34.5 gene	Yes	No	Virus expressing murine IL-12 gene	Duke university medical centre	NA	NA	NA	NA	NA	NA	NA	Nude mice xenograft for medulloblastoma cell line D425 (2.5E+5)	1.0E+7 pfu	NA	Increase the survival time of mice from 20 days to above 90 days	Intratumoral	NA	Increased expression of CD133 and CD15	NA	26188016
OV_4080	Herpes simplex virus	M002	DNA	Herpesviridae	Deletion mutant for gamma 34.5 gene	Yes	No	Virus expressing murine IL-12 gene	Duke university medical centre	NA	NA	NA	NA	NA	NA	NA	Nude mice xenograft for medulloblastoma cell line D341 (5.0E+5)	1.0E+7 pfu	NA	Increase the survival time of mice from 30 days to above 60 days	Intratumoral	NA	Increased expression of CD133 and CD15	NA	26188016
OV_4442	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN3	4000 to 5000 cells per well	NA	MTS assay	0.03 MOI	78% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4443	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN3	4000 to 5000 cells per well	NA	MTS assay	0.1 MOI	18% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4444	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN3	4000 to 5000 cells per well	NA	MTS assay	0.3 MOI	1% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4445	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN3	4000 to 5000 cells per well	NA	MTS assay	1 MOI	100% cell killing after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4446	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN7	4000 to 5000 cells per well	NA	MTS assay	0.001 MOI	68% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4447	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN7	4000 to 5000 cells per well	NA	MTS assay	0.003 MOI	40% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4448	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN7	4000 to 5000 cells per well	NA	MTS assay	0.01 MOI	22% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4449	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN7	4000 to 5000 cells per well	NA	MTS assay	0.03 MOI	18% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4450	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN7	4000 to 5000 cells per well	NA	MTS assay	0.1 MOI	16% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4451	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN7	4000 to 5000 cells per well	NA	MTS assay	0.3 MOI	16% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4452	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN7	4000 to 5000 cells per well	NA	MTS assay	1 MOI	16% cell survival after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4453	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN465	4000 to 5000 cells per well	NA	MTS assay	0.04 MOI	45% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4454	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN475	4000 to 5000 cells per well	NA	MTS assay	0.04 MOI	45% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4455	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN298	4000 to 5000 cells per well	NA	MTS assay	0.04 MOI	70% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4456	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN1	4000 to 5000 cells per well	NA	MTS assay	0.04 MOI	30% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4457	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN465	4000 to 5000 cells per well	NA	MTS assay	0.11 MOI	30% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4458	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN475	4000 to 5000 cells per well	NA	MTS assay	0.11 MOI	35% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4459	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN298	4000 to 5000 cells per well	NA	MTS assay	0.11 MOI	55% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4460	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN1	4000 to 5000 cells per well	NA	MTS assay	0.11 MOI	20% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4461	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN465	4000 to 5000 cells per well	NA	MTS assay	0.33 MOI	20% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4462	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN475	4000 to 5000 cells per well	NA	MTS assay	0.33 MOI	20% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4463	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN298	4000 to 5000 cells per well	NA	MTS assay	0.33 MOI	50% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4464	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN1	4000 to 5000 cells per well	NA	MTS assay	0.33 MOI	10% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4465	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN465	4000 to 5000 cells per well	NA	MTS assay	1 MOI	15% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4466	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN475	4000 to 5000 cells per well	NA	MTS assay	1 MOI	15% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4467	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN298	4000 to 5000 cells per well	NA	MTS assay	1 MOI	30% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4468	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN1	4000 to 5000 cells per well	NA	MTS assay	1 MOI	5% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4469	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN465	4000 to 5000 cells per well	NA	MTS assay	3 MOI	10% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4470	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN475	4000 to 5000 cells per well	NA	MTS assay	3 MOI	12% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4471	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN298	4000 to 5000 cells per well	NA	MTS assay	3 MOI	25% cell viablity after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4472	Herpes simplex virus	G47-delta-mCherry	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	Human patient	malignant leningioma	MN1	4000 to 5000 cells per well	NA	MTS assay	3 MOI	100% cell killing after 96 hours	No	No	NA	No response	NA	NA	NA	NA	26951380
OV_4473	Herpes simplex virus	G47-delta	DNA	Herpesviridae	Deletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	SCID mice orthotopic xenograft for MN3 cell (75000 cells)	2.0E+6 pfu on day 14 and 25 post tumor cell implantation	NA	Survival time increased from control 80 days to 160 days in virus trated group	Intratumoral	NA	NA	NA	26951380
OV_4483	Herpes simplex virus	RH2	DNA	Herpesviridae	Mutant for Gamma 34.5 gene and gB gene	Yes	No	No	NA	Murine squamous cell carcinoma	SCCVII	NA	NA	MTT assay	10 MOI	70% cell survival after 12 hours	No	No	NA	No response	NA	Virus induced apoptosis	Increased extracellular ATP and HMGB1, indicating immunogenic cell death	NA	26987291
OV_4484	Herpes simplex virus	RH2	DNA	Herpesviridae	Mutant for Gamma 34.5 gene and gB gene	Yes	No	No	NA	Murine squamous cell carcinoma	SCCVII	NA	NA	MTT assay	10 MOI	60% cell survival after 12 hours	No	No	NA	No response	NA	Virus induced apoptosis	Increased extracellular ATP and HMGB1, indicating immunogenic cell death	NA	26987291
OV_4485	Herpes simplex virus	RH2	DNA	Herpesviridae	Mutant for Gamma 34.5 gene and gB gene	Yes	No	No	NA	Murine squamous cell carcinoma	SCCVII	NA	NA	MTT assay	10 MOI	50% cell survival after 12 hours	No	No	NA	No response	NA	Virus induced apoptosis	Increased extracellular ATP and HMGB1, indicating immunogenic cell death	NA	26987291
OV_4486	Herpes simplex virus	RH2	DNA	Herpesviridae	Mutant for Gamma 34.5 gene and gB gene	Yes	No	No	NA	Murine squamous cell carcinoma	SCCVII	NA	NA	MTT assay	100 MOI	50% cell survival after 12 hours	No	No	NA	No response	NA	Virus induced apoptosis	Increased extracellular ATP and HMGB1, indicating immunogenic cell death	NA	26987291
OV_4487	Herpes simplex virus	RH2	DNA	Herpesviridae	Mutant for Gamma 34.5 gene and gB gene	Yes	No	No	NA	Murine squamous cell carcinoma	SCCVII	NA	NA	MTT assay	100 MOI	40% cell survival after 12 hours	No	No	NA	No response	NA	Virus induced apoptosis	Increased extracellular ATP and HMGB1, indicating immunogenic cell death	NA	26987291
OV_4488	Herpes simplex virus	RH2	DNA	Herpesviridae	Mutant for Gamma 34.5 gene and gB gene	Yes	No	No	NA	Murine squamous cell carcinoma	SCCVII	NA	NA	MTT assay	100 MOI	30% cell survival after 12 hours	No	No	NA	No response	NA	Virus induced apoptosis	Increased extracellular ATP and HMGB1, indicating immunogenic cell death	NA	26987291
OV_4489	Herpes simplex virus	RH2	DNA	Herpesviridae	Mutant for Gamma 34.5 gene and gB gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	C3H mice subcutaneous implanted for SCCVII (1.0E+6)	50 microliter of RH2 virus, 3 times at interval of 2 days	NA	Tumor volume was less than 1587 cubic mm in treated mice compared to control 2996 cubic mm after 25 days	Intratumoral	Virus induced apoptosis	Increased extracellular ATP and HMGB1, indicating immunogenic cell death	NA	26987291
OV_4656	Herpes simplex virus	RAMBO	DNA	Herpesviridae	Antiangiogenic Vstat120 expressing virus	Yes	No	No	NA	Human squamous cell carcinoma cell line	CAL27	NA	NA	Statistical analysis	0.001 MOI	82% cell viability after 2 days	No	No	NA	No response	NA	NA	Induce antitumor immune response	NA	27119105
OV_4657	Herpes simplex virus	RAMBO	DNA	Herpesviridae	Antiangiogenic Vstat120 expressing virus	Yes	No	No	NA	Human squamous cell carcinoma cell line	CAL27	NA	NA	Statistical analysis	0.005 MOI	42% cell viability after 2 days	No	No	NA	No response	NA	NA	Induce antitumor immune response	NA	27119105
OV_4658	Herpes simplex virus	RAMBO	DNA	Herpesviridae	Antiangiogenic Vstat120 expressing virus	Yes	No	No	NA	Human squamous cell carcinoma cell line	CAL27	NA	NA	Statistical analysis	0.01 MOI	38% cell viability after 2 days	No	No	NA	No response	NA	NA	Induce antitumor immune response	NA	27119105
OV_4659	Herpes simplex virus	RAMBO	DNA	Herpesviridae	Antiangiogenic Vstat120 expressing virus	Yes	No	No	NA	Human squamous cell carcinoma cell line	CAL27	NA	NA	Statistical analysis	0.05 MOI	30% cell viability after 2 days	No	No	NA	No response	NA	NA	Induce antitumor immune response	NA	27119105
OV_4660	Herpes simplex virus	RAMBO	DNA	Herpesviridae	Antiangiogenic Vstat120 expressing virus	Yes	No	No	NA	Human squamous cell carcinoma cell line	CAL27	NA	NA	Statistical analysis	0.1 MOI	30% cell viability after 2 days	No	No	NA	No response	NA	NA	Induce antitumor immune response	NA	27119105