| Primary information |
|---|
| OV_ID | OV_4485 |
| Virus Name | Herpes simplex virus |
| Strain | RH2 |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Mutant for Gamma 34.5 gene and gB gene |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | Murine squamous cell carcinoma |
| Cell line | SCCVII |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 10 MOI |
| In-vitro result | 50% cell survival after 12 hours |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | Virus induced apoptosis |
| Immunogenic effect | Increased extracellular ATP and HMGB1, indicating immunogenic cell death |
| Clinical trial | NA |
| PMID | 26987291 |