Detailed description page of Selected OV_ID


OV_4080 details
Primary information
OV_IDOV_4080
Virus Name Herpes simplex virus
StrainM002
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for gamma 34.5 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing murine IL-12 gene
Source of cell lineDuke university medical centre
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismNude mice xenograft for medulloblastoma cell line D341 (5 × 10⁵)
In-vivo virus concentration1 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultIncrease the survival time of mice from 30 days to above 60 days
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectIncreased expression of CD133 and CD15
Clinical trialNA
PMID26188016