Detailed description page of Selected OV_ID


OV_4077 details
Primary information
OV_IDOV_4077
Virus Name Herpes simplex virus
StrainG207
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for gamma 34.5 gene and and lacZ insertion into Ul39 gene encodes for ICP6 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineDuke university medical centre
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismNude mice xenograft for medulloblastoma cell line D425 (2.5 × 10⁵)
In-vivo virus concentration1 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultIncrease the survival time of mice from 15 days to 25 days
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectIncreased expression of CD133 and CD15
Clinical trialNA
PMID26188016